Result of FASTA (omim) for
pFN21AE2732
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2732, 1608 aa
1>>>pF1KE2732 1608 - 1608 aa - 1608 aa
Library: /omim/omim.rfq.tfa
65089639 residues in 91964 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.7006+/-0.000547; mu= -6.9608+/- 0.035
mean_var=693.2315+/-146.196, 0's: 0 Z-trim(121.2): 1492 B-trim: 0 in 0/61
Lambda= 0.048712
statistics sampled from 36846 (38915) to 36846 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.423), width: 16
Scan time: 9.400
The best scores are: opt bits E(91964)
NP_005913 (OMIM: 602425) mitogen-activated protein (1608) 10787 775.3 0
NP_001288001 (OMIM: 602425) mitogen-activated prot (1604) 10743 772.3 0
XP_016866358 (OMIM: 602425) mitogen-activated prot (1517) 10126 728.9 8.7e-209
NP_006715 (OMIM: 602425) mitogen-activated protein (1558) 7919 573.8 4.3e-162
NP_001350511 (OMIM: 602425) mitogen-activated prot (1554) 7875 570.7 3.7e-161
NP_001278887 (OMIM: 602425) mitogen-activated prot (1061) 6948 505.3 1.2e-141
NP_001317360 (OMIM: 602539) mitogen-activated prot ( 622) 689 65.2 2.2e-09
NP_001350697 (OMIM: 602539) mitogen-activated prot ( 653) 689 65.2 2.3e-09
NP_002392 (OMIM: 602539) mitogen-activated protein ( 626) 687 65.0 2.4e-09
NP_976226 (OMIM: 602539) mitogen-activated protein ( 657) 687 65.1 2.5e-09
XP_024308320 (OMIM: 609487) mitogen-activated prot ( 619) 670 63.8 5.6e-09
NP_006600 (OMIM: 609487) mitogen-activated protein ( 619) 670 63.8 5.6e-09
XP_016864974 (OMIM: 600982,613762) mitogen-activat (1349) 580 57.9 7.2e-07
XP_016864973 (OMIM: 600982,613762) mitogen-activat (1375) 580 57.9 7.3e-07
NP_005912 (OMIM: 600982,613762) mitogen-activated (1512) 580 58.0 7.7e-07
XP_011543813 (OMIM: 300820) mitogen-activated prot ( 748) 565 56.6 1e-06
XP_011543812 (OMIM: 300820) mitogen-activated prot ( 871) 565 56.6 1.1e-06
XP_016866366 (OMIM: 602448) mitogen-activated prot (1181) 568 57.0 1.2e-06
XP_016866365 (OMIM: 602448) mitogen-activated prot (1191) 568 57.0 1.2e-06
XP_011534141 (OMIM: 602448) mitogen-activated prot (1286) 568 57.1 1.3e-06
NP_005914 (OMIM: 602448) mitogen-activated protein (1374) 568 57.1 1.3e-06
XP_016866364 (OMIM: 602448) mitogen-activated prot (1447) 568 57.1 1.4e-06
XP_016866363 (OMIM: 602448) mitogen-activated prot (1458) 568 57.1 1.4e-06
XP_011543810 (OMIM: 300820) mitogen-activated prot (1169) 565 56.8 1.4e-06
XP_016866362 (OMIM: 602448) mitogen-activated prot (1483) 568 57.1 1.4e-06
XP_016866361 (OMIM: 602448) mitogen-activated prot (1484) 568 57.1 1.4e-06
XP_016866360 (OMIM: 602448) mitogen-activated prot (1493) 568 57.2 1.4e-06
XP_016866359 (OMIM: 602448) mitogen-activated prot (1494) 568 57.2 1.4e-06
XP_011543809 (OMIM: 300820) mitogen-activated prot (1198) 565 56.8 1.4e-06
XP_016858260 (OMIM: 604468) mitogen-activated prot ( 869) 560 56.3 1.5e-06
NP_001001671 (OMIM: 300820) mitogen-activated prot (1313) 565 56.9 1.5e-06
NP_001284538 (OMIM: 604468) mitogen-activated prot (1280) 560 56.5 1.9e-06
NP_004663 (OMIM: 604468) mitogen-activated protein (1288) 560 56.5 1.9e-06
XP_011538703 (OMIM: 616563) STE20-like serine/thre ( 783) 531 54.2 5.6e-06
XP_024304332 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_016873336 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_016873338 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_016873339 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_024304330 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_016873337 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
NP_002567 (OMIM: 602590) serine/threonine-protein ( 545) 525 53.6 6e-06
XP_024304329 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_024304328 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_016873335 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_024304331 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06
XP_016861990 (OMIM: 605022) serine/threonine-prote ( 524) 524 53.5 6.2e-06
NP_002568 (OMIM: 605022) serine/threonine-protein ( 524) 524 53.5 6.2e-06
XP_011511172 (OMIM: 605022) serine/threonine-prote ( 524) 524 53.5 6.2e-06
NP_001311261 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.5 6.3e-06
NP_001311263 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.5 6.3e-06
>>NP_005913 (OMIM: 602425) mitogen-activated protein kin (1608 aa)
initn: 10787 init1: 10787 opt: 10787 Z-score: 4120.7 bits: 775.3 E(91964): 0
Smith-Waterman score: 10787; 100.0% identity (100.0% similar) in 1608 aa overlap (1-1608:1-1608)
10 20 30 40 50 60
pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600
pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1570 1580 1590 1600
>>NP_001288001 (OMIM: 602425) mitogen-activated protein (1604 aa)
initn: 7624 init1: 7624 opt: 10743 Z-score: 4104.0 bits: 772.3 E(91964): 0
Smith-Waterman score: 10743; 99.8% identity (99.8% similar) in 1608 aa overlap (1-1608:1-1604)
10 20 30 40 50 60
pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT--
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
1500 1510 1520 1530 1540 1550
1570 1580 1590 1600
pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1560 1570 1580 1590 1600
>>XP_016866358 (OMIM: 602425) mitogen-activated protein (1517 aa)
initn: 10126 init1: 10126 opt: 10126 Z-score: 3869.9 bits: 728.9 E(91964): 8.7e-209
Smith-Waterman score: 10126; 99.9% identity (100.0% similar) in 1517 aa overlap (92-1608:1-1517)
70 80 90 100 110 120
pF1KE2 KSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPN
::::::::::::::::::::::::::::::
XP_016 MKRMSTKHQRNNVGRPASRSNLKEKMNAPN
10 20 30
130 140 150 160 170 180
pF1KE2 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIPD
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
XP_016 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPD
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE2 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE2 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE2 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE2 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE2 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE2 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE2 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE2 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE2 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE2 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA
640 650 660 670 680 690
790 800 810 820 830 840
pF1KE2 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL
700 710 720 730 740 750
850 860 870 880 890 900
pF1KE2 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL
760 770 780 790 800 810
910 920 930 940 950 960
pF1KE2 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA
820 830 840 850 860 870
970 980 990 1000 1010 1020
pF1KE2 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD
880 890 900 910 920 930
1030 1040 1050 1060 1070 1080
pF1KE2 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC
940 950 960 970 980 990
1090 1100 1110 1120 1130 1140
pF1KE2 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY
1000 1010 1020 1030 1040 1050
1150 1160 1170 1180 1190 1200
pF1KE2 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVA
1060 1070 1080 1090 1100 1110
1210 1220 1230 1240 1250 1260
pF1KE2 ASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA
1120 1130 1140 1150 1160 1170
1270 1280 1290 1300 1310 1320
pF1KE2 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV
1180 1190 1200 1210 1220 1230
1330 1340 1350 1360 1370 1380
pF1KE2 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH
1240 1250 1260 1270 1280 1290
1390 1400 1410 1420 1430 1440
pF1KE2 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR
1300 1310 1320 1330 1340 1350
1450 1460 1470 1480 1490 1500
pF1KE2 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS
1360 1370 1380 1390 1400 1410
1510 1520 1530 1540 1550 1560
pF1KE2 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG
1420 1430 1440 1450 1460 1470
1570 1580 1590 1600
pF1KE2 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1480 1490 1500 1510
>>NP_006715 (OMIM: 602425) mitogen-activated protein kin (1558 aa)
initn: 7910 init1: 7910 opt: 7919 Z-score: 3031.6 bits: 573.8 E(91964): 4.3e-162
Smith-Waterman score: 10365; 96.9% identity (96.9% similar) in 1608 aa overlap (1-1608:1-1558)
10 20 30 40 50 60
pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
::::::::::::::::::::::::::::::::::
NP_006 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF--------------------------
1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
::::::::::::::::::::::::::::::::::::
NP_006 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
1180 1190 1200 1210
1270 1280 1290 1300 1310 1320
pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
1220 1230 1240 1250 1260 1270
1330 1340 1350 1360 1370 1380
pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
1280 1290 1300 1310 1320 1330
1390 1400 1410 1420 1430 1440
pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
1340 1350 1360 1370 1380 1390
1450 1460 1470 1480 1490 1500
pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
1400 1410 1420 1430 1440 1450
1510 1520 1530 1540 1550 1560
pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
1460 1470 1480 1490 1500 1510
1570 1580 1590 1600
pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1520 1530 1540 1550
>>NP_001350511 (OMIM: 602425) mitogen-activated protein (1554 aa)
initn: 10573 init1: 7624 opt: 7875 Z-score: 3014.9 bits: 570.7 E(91964): 3.7e-161
Smith-Waterman score: 10321; 96.6% identity (96.6% similar) in 1608 aa overlap (1-1608:1-1554)
10 20 30 40 50 60
pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT--
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
::::::::::::::::::::::::::::::::
NP_001 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF--------------------------
1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
::::::::::::::::::::::::::::::::::::
NP_001 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
1180 1190 1200
1270 1280 1290 1300 1310 1320
pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
1210 1220 1230 1240 1250 1260
1330 1340 1350 1360 1370 1380
pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
1270 1280 1290 1300 1310 1320
1390 1400 1410 1420 1430 1440
pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
1330 1340 1350 1360 1370 1380
1450 1460 1470 1480 1490 1500
pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
1390 1400 1410 1420 1430 1440
1510 1520 1530 1540 1550 1560
pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
1450 1460 1470 1480 1490 1500
1570 1580 1590 1600
pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1510 1520 1530 1540 1550
>>NP_001278887 (OMIM: 602425) mitogen-activated protein (1061 aa)
initn: 6939 init1: 6939 opt: 6948 Z-score: 2664.6 bits: 505.3 E(91964): 1.2e-141
Smith-Waterman score: 6948; 98.6% identity (99.1% similar) in 1058 aa overlap (552-1608:4-1061)
530 540 550 560 570 580
pF1KE2 LTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDR-PVEFSEFPDPMWGS
::.:. : . .. .:::::::::::
NP_001 MYIGSIQKDRTTRSRDGACRSQFSEFPDPMWGS
10 20 30
590 600 610 620 630 640
pF1KE2 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA
40 50 60 70 80 90
650 660 670 680 690 700
pF1KE2 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV
100 110 120 130 140 150
710 720 730 740 750 760
pF1KE2 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK
160 170 180 190 200 210
770 780 790 800 810 820
pF1KE2 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK
220 230 240 250 260 270
830 840 850 860 870 880
pF1KE2 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL
280 290 300 310 320 330
890 900 910 920 930 940
pF1KE2 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM
340 350 360 370 380 390
950 960 970 980 990 1000
pF1KE2 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR
400 410 420 430 440 450
1010 1020 1030 1040 1050 1060
pF1KE2 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ
460 470 480 490 500 510
1070 1080 1090 1100 1110 1120
pF1KE2 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA
520 530 540 550 560 570
1130 1140 1150 1160 1170 1180
pF1KE2 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP
580 590 600 610 620 630
1190 1200 1210 1220 1230 1240
pF1KE2 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA
640 650 660 670 680 690
1250 1260 1270 1280 1290 1300
pF1KE2 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS
700 710 720 730 740 750
1310 1320 1330 1340 1350 1360
pF1KE2 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC
760 770 780 790 800 810
1370 1380 1390 1400 1410 1420
pF1KE2 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME
820 830 840 850 860 870
1430 1440 1450 1460 1470 1480
pF1KE2 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG
880 890 900 910 920 930
1490 1500 1510 1520 1530 1540
pF1KE2 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT
940 950 960 970 980 990
1550 1560 1570 1580 1590 1600
pF1KE2 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF
1000 1010 1020 1030 1040 1050
pF1KE2 VKVCTDEE
::::::::
NP_001 VKVCTDEE
1060
>>NP_001317360 (OMIM: 602539) mitogen-activated protein (622 aa)
initn: 527 init1: 216 opt: 689 Z-score: 290.0 bits: 65.2 E(91964): 2.2e-09
Smith-Waterman score: 690; 29.0% identity (59.0% similar) in 507 aa overlap (1121-1603:120-620)
1100 1110 1120 1130 1140 1150
pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR
:... .: ..::: :. .:
NP_001 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
90 100 110 120 130 140
1160 1170 1180 1190 1200 1210
pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG
... .: . :: . . . . :. . . . : .. .. . .. : .
NP_001 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS
150 160 170 180 190 200
1220 1230 1240 1250 1260
pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAEL-QFRSLSRHSSPTEERDEPAYPRGDSSG
.. . .:::... ..: : . ... . .:. . . .:. : .: ..:
NP_001 EQCMLDPLSSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGG
210 220 230 240 250 260
1270 1280 1290 1300 1310 1320
pF1KE2 STRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQVCDTPK
. : ... . .. .: . :. : .. : .: .:. : : :.
NP_001 TYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLD-PR
270 280 290 300 310 320
1330 1340 1350 1360 1370
pF1KE2 SY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGELMAMKE
. .:.. : :.: : :.::. .:.: .:.:: : .::::. .: :.
NP_001 GRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ
330 340 350 360 370 380
1380 1390 1400 1410 1420
pF1KE2 IRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCDEGTL-
..:.:.. .: ::.. :........: .:.:.: : : . ::::: :..
NP_001 VQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVK
390 400 410 420 430 440
1430 1440 1450 1460 1470 1480
pF1KE2 EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSV
.... : : : : : :..:: ... :: . :::::::::::. :.: .:::::: :
NP_001 DQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK
450 460 470 480 490 500
1490 1500 1510 1520 1530 1540
pF1KE2 KLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWH
.:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: : ::
NP_001 RLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTEKPPWA
510 520 530 540 550 560
1550 1560 1570 1580 1590 1600
pF1KE2 EYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTD
::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :...
NP_001 EYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFAQLMY
570 580 590 600 610 620
pF1KE2 EE
>>NP_001350697 (OMIM: 602539) mitogen-activated protein (653 aa)
initn: 527 init1: 216 opt: 689 Z-score: 289.8 bits: 65.2 E(91964): 2.3e-09
Smith-Waterman score: 690; 29.0% identity (59.0% similar) in 507 aa overlap (1121-1603:151-651)
1100 1110 1120 1130 1140 1150
pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR
:... .: ..::: :. .:
NP_001 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
130 140 150 160 170 180
1160 1170 1180 1190 1200 1210
pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG
... .: . :: . . . . :. . . . : .. .. . .. : .
NP_001 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS
190 200 210 220 230 240
1220 1230 1240 1250 1260
pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAEL-QFRSLSRHSSPTEERDEPAYPRGDSSG
.. . .:::... ..: : . ... . .:. . . .:. : .: ..:
NP_001 EQCMLDPLSSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGG
250 260 270 280 290 300
1270 1280 1290 1300 1310 1320
pF1KE2 STRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQVCDTPK
. : ... . .. .: . :. : .. : .: .:. : : :.
NP_001 TYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLD-PR
310 320 330 340 350
1330 1340 1350 1360 1370
pF1KE2 SY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGELMAMKE
. .:.. : :.: : :.::. .:.: .:.:: : .::::. .: :.
NP_001 GRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ
360 370 380 390 400 410
1380 1390 1400 1410 1420
pF1KE2 IRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCDEGTL-
..:.:.. .: ::.. :........: .:.:.: : : . ::::: :..
NP_001 VQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVK
420 430 440 450 460 470
1430 1440 1450 1460 1470 1480
pF1KE2 EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSV
.... : : : : : :..:: ... :: . :::::::::::. :.: .:::::: :
NP_001 DQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK
480 490 500 510 520 530
1490 1500 1510 1520 1530 1540
pF1KE2 KLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWH
.:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: : ::
NP_001 RLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTEKPPWA
540 550 560 570 580 590
1550 1560 1570 1580 1590 1600
pF1KE2 EYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTD
::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :...
NP_001 EYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFAQLMY
600 610 620 630 640 650
pF1KE2 EE
>>NP_002392 (OMIM: 602539) mitogen-activated protein kin (626 aa)
initn: 561 init1: 216 opt: 687 Z-score: 289.2 bits: 65.0 E(91964): 2.4e-09
Smith-Waterman score: 703; 29.9% identity (59.2% similar) in 512 aa overlap (1121-1603:120-624)
1100 1110 1120 1130 1140 1150
pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR
:... .: ..::: :. .:
NP_002 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
90 100 110 120 130 140
1160 1170 1180 1190 1200 1210
pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG
... .: . :: . . . . :. . . . : .. .. . .. : .
NP_002 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS
150 160 170 180 190 200
1220 1230 1240 1250 1260
pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR
.. . .:::... ..: :: :. . . : .:: .: ..:.: . : .
NP_002 EQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK
210 220 230 240 250 260
1270 1280 1290 1300 1310 1320
pF1KE2 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV
: ..:. : ... . .. .: . :. : .. : .: .:. :
NP_002 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY
270 280 290 300 310 320
1330 1340 1350 1360
pF1KE2 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL
: :.. .:.. : :.: : :.::. .:.: .:.:: : .::::.
NP_002 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE
330 340 350 360 370 380
1370 1380 1390 1400 1410 1420
pF1KE2 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD
.: :...:.:.. .: ::.. :........: .:.:.: : : . :::::
NP_002 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP
390 400 410 420 430 440
1430 1440 1450 1460 1470 1480
pF1KE2 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD
:.. .... : : : : : :..:: ... :: . :::::::::::. :.: .::::
NP_002 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD
450 460 470 480 490 500
1490 1500 1510 1520 1530 1540
pF1KE2 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG
:: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.:
NP_002 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE
510 520 530 540 550 560
1550 1560 1570 1580 1590 1600
pF1KE2 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
: :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :.
NP_002 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFA
570 580 590 600 610 620
pF1KE2 KVCTDEE
..
NP_002 QLMY
>>NP_976226 (OMIM: 602539) mitogen-activated protein kin (657 aa)
initn: 561 init1: 216 opt: 687 Z-score: 289.0 bits: 65.1 E(91964): 2.5e-09
Smith-Waterman score: 703; 29.9% identity (59.2% similar) in 512 aa overlap (1121-1603:151-655)
1100 1110 1120 1130 1140 1150
pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR
:... .: ..::: :. .:
NP_976 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
130 140 150 160 170 180
1160 1170 1180 1190 1200 1210
pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG
... .: . :: . . . . :. . . . : .. .. . .. : .
NP_976 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS
190 200 210 220 230 240
1220 1230 1240 1250 1260
pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR
.. . .:::... ..: :: :. . . : .:: .: ..:.: . : .
NP_976 EQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK
250 260 270 280 290
1270 1280 1290 1300 1310 1320
pF1KE2 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV
: ..:. : ... . .. .: . :. : .. : .: .:. :
NP_976 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY
300 310 320 330 340 350
1330 1340 1350 1360
pF1KE2 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL
: :.. .:.. : :.: : :.::. .:.: .:.:: : .::::.
NP_976 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE
360 370 380 390 400 410
1370 1380 1390 1400 1410 1420
pF1KE2 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD
.: :...:.:.. .: ::.. :........: .:.:.: : : . :::::
NP_976 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP
420 430 440 450 460 470
1430 1440 1450 1460 1470 1480
pF1KE2 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD
:.. .... : : : : : :..:: ... :: . :::::::::::. :.: .::::
NP_976 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD
480 490 500 510 520 530
1490 1500 1510 1520 1530 1540
pF1KE2 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG
:: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.:
NP_976 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE
540 550 560 570 580 590
1550 1560 1570 1580 1590 1600
pF1KE2 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
: :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :.
NP_976 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFA
600 610 620 630 640 650
pF1KE2 KVCTDEE
..
NP_976 QLMY
1608 residues in 1 query sequences
65089639 residues in 91964 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Oct 2 18:32:26 2018 done: Tue Oct 2 18:32:27 2018
Total Scan time: 9.400 Total Display time: 0.420
Function used was FASTA [36.3.4 Apr, 2011]