Result of FASTA (omim) for
pFN21AE2694
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2694, 1249 aa
1>>>pF1KE2694 1249 - 1249 aa - 1249 aa
Library: /omim/omim.rfq.tfa
62035967 residues in 87258 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.9958+/-0.000521; mu= -18.1094+/- 0.033
mean_var=856.1176+/-175.687, 0's: 0 Z-trim(123.8): 185 B-trim: 0 in 0/62
Lambda= 0.043834
statistics sampled from 44683 (44901) to 44683 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.515), width: 16
Scan time: 17.050
The best scores are: opt bits E(87258)
NP_071934 (OMIM: 610982,613237,614455) inverted fo (1249) 8320 542.9 5.1e-153
XP_005268061 (OMIM: 610982,613237,614455) PREDICTE (1281) 8320 542.9 5.2e-153
XP_016877084 (OMIM: 610982,613237,614455) PREDICTE (1281) 8320 542.9 5.2e-153
NP_001026884 (OMIM: 610982,613237,614455) inverted (1240) 8200 535.3 9.8e-151
XP_005268062 (OMIM: 610982,613237,614455) PREDICTE (1272) 8200 535.3 9.9e-151
NP_116103 (OMIM: 610982,613237,614455) inverted fo ( 234) 1503 111.0 1e-23
XP_011535875 (OMIM: 124900,602121,616632) PREDICTE (1250) 884 72.7 1.8e-11
NP_001300936 (OMIM: 124900,602121,616632) protein (1250) 884 72.7 1.8e-11
XP_011535874 (OMIM: 124900,602121,616632) PREDICTE (1260) 884 72.7 1.8e-11
NP_001073280 (OMIM: 124900,602121,616632) protein (1263) 884 72.7 1.8e-11
NP_005210 (OMIM: 124900,602121,616632) protein dia (1272) 884 72.7 1.9e-11
NP_006720 (OMIM: 300108,300511) protein diaphanous (1101) 841 69.9 1.1e-10
NP_009293 (OMIM: 300108,300511) protein diaphanous (1096) 837 69.6 1.3e-10
NP_112194 (OMIM: 609129,614567) protein diaphanous ( 849) 779 65.8 1.4e-09
XP_011533560 (OMIM: 609129,614567) PREDICTED: prot (1136) 783 66.2 1.4e-09
XP_006719939 (OMIM: 609129,614567) PREDICTED: prot ( 930) 779 65.9 1.5e-09
NP_001245298 (OMIM: 609129,614567) protein diaphan (1112) 779 66.0 1.7e-09
NP_001245297 (OMIM: 609129,614567) protein diaphan (1123) 779 66.0 1.7e-09
NP_001245296 (OMIM: 609129,614567) protein diaphan (1147) 779 66.0 1.7e-09
NP_001245295 (OMIM: 609129,614567) protein diaphan (1182) 779 66.0 1.8e-09
NP_001035982 (OMIM: 609129,614567) protein diaphan (1193) 779 66.0 1.8e-09
NP_055807 (OMIM: 606626) disheveled-associated act (1078) 700 60.9 5.3e-08
XP_005267488 (OMIM: 606626) PREDICTED: disheveled- (1078) 700 60.9 5.3e-08
XP_005267487 (OMIM: 606626) PREDICTED: disheveled- (1078) 700 60.9 5.3e-08
XP_006715109 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08
XP_006715105 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08
XP_006715108 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08
XP_006715106 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08
XP_016866119 (OMIM: 606627) PREDICTED: disheveled- (1100) 699 60.9 5.6e-08
XP_006715102 (OMIM: 606627) PREDICTED: disheveled- (1176) 699 60.9 5.9e-08
NP_056160 (OMIM: 606627) disheveled-associated act (1067) 673 59.2 1.7e-07
NP_001188356 (OMIM: 606627) disheveled-associated (1068) 665 58.7 2.4e-07
XP_006715103 (OMIM: 606627) PREDICTED: disheveled- (1167) 665 58.8 2.6e-07
NP_001245299 (OMIM: 609129,614567) protein diaphan ( 691) 603 54.6 2.8e-06
XP_011508837 (OMIM: 616285) PREDICTED: formin-like (1048) 511 49.0 0.00021
XP_011508836 (OMIM: 616285) PREDICTED: formin-like (1076) 511 49.0 0.00021
XP_005246322 (OMIM: 616285) PREDICTED: formin-like (1084) 511 49.0 0.00021
XP_005246320 (OMIM: 616285) PREDICTED: formin-like (1087) 511 49.0 0.00021
XP_011508835 (OMIM: 616285) PREDICTED: formin-like (1091) 511 49.0 0.00021
NP_443137 (OMIM: 616285) formin-like protein 2 [Ho (1092) 511 49.0 0.00021
XP_011508834 (OMIM: 616285) PREDICTED: formin-like (1093) 511 49.0 0.00021
XP_011508833 (OMIM: 616285) PREDICTED: formin-like (1094) 511 49.0 0.00021
XP_011508832 (OMIM: 616285) PREDICTED: formin-like (1099) 511 49.0 0.00021
NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome ( 498) 463 45.6 0.001
XP_016857330 (OMIM: 606373,616193) PREDICTED: form (1102) 472 46.5 0.0012
XP_016857329 (OMIM: 606373,616193) PREDICTED: form (1102) 472 46.5 0.0012
XP_016857328 (OMIM: 606373,616193) PREDICTED: form (1159) 472 46.6 0.0012
XP_011542539 (OMIM: 606373,616193) PREDICTED: form (1360) 472 46.6 0.0014
XP_016857327 (OMIM: 606373,616193) PREDICTED: form (1384) 472 46.6 0.0014
XP_016857326 (OMIM: 606373,616193) PREDICTED: form (1417) 472 46.7 0.0014
>>NP_071934 (OMIM: 610982,613237,614455) inverted formin (1249 aa)
initn: 8320 init1: 8320 opt: 8320 Z-score: 2868.3 bits: 542.9 E(87258): 5.1e-153
Smith-Waterman score: 8320; 100.0% identity (100.0% similar) in 1249 aa overlap (1-1249:1-1249)
10 20 30 40 50 60
pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE2 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ
1210 1220 1230 1240
>>XP_005268061 (OMIM: 610982,613237,614455) PREDICTED: i (1281 aa)
initn: 8320 init1: 8320 opt: 8320 Z-score: 2868.2 bits: 542.9 E(87258): 5.2e-153
Smith-Waterman score: 8320; 100.0% identity (100.0% similar) in 1249 aa overlap (1-1249:33-1281)
10 20 30
pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANL
::::::::::::::::::::::::::::::
XP_005 SQGSVRSSPGQGPEWVGRGGRKVLRIWLGKMSVKEGAQRKWAALKEKLGPQDSDPTEANL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE2 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE2 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE2 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE2 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE2 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE2 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE2 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ
1210 1220 1230 1240 1250 1260
1240
pF1KE2 EEVPPDSDDNKTKKLCVIQ
:::::::::::::::::::
XP_005 EEVPPDSDDNKTKKLCVIQ
1270 1280
>>XP_016877084 (OMIM: 610982,613237,614455) PREDICTED: i (1281 aa)
initn: 8320 init1: 8320 opt: 8320 Z-score: 2868.2 bits: 542.9 E(87258): 5.2e-153
Smith-Waterman score: 8320; 100.0% identity (100.0% similar) in 1249 aa overlap (1-1249:33-1281)
10 20 30
pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANL
::::::::::::::::::::::::::::::
XP_016 SQGSVRSSPGQGPEWVGRGGRKVLRIWLGKMSVKEGAQRKWAALKEKLGPQDSDPTEANL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE2 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE2 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE2 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE2 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE2 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE2 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE2 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ
1210 1220 1230 1240 1250 1260
1240
pF1KE2 EEVPPDSDDNKTKKLCVIQ
:::::::::::::::::::
XP_016 EEVPPDSDDNKTKKLCVIQ
1270 1280
>>NP_001026884 (OMIM: 610982,613237,614455) inverted for (1240 aa)
initn: 8195 init1: 8195 opt: 8200 Z-score: 2827.4 bits: 535.3 E(87258): 9.8e-151
Smith-Waterman score: 8200; 99.8% identity (99.8% similar) in 1235 aa overlap (1-1235:1-1235)
10 20 30 40 50 60
pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE2 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ
::::::::::::::::::::::::::::::: . :
NP_001 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEGLRPRPKAK
1210 1220 1230 1240
>>XP_005268062 (OMIM: 610982,613237,614455) PREDICTED: i (1272 aa)
initn: 8195 init1: 8195 opt: 8200 Z-score: 2827.2 bits: 535.3 E(87258): 9.9e-151
Smith-Waterman score: 8200; 99.8% identity (99.8% similar) in 1235 aa overlap (1-1235:33-1267)
10 20 30
pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANL
::::::::::::::::::::::::::::::
XP_005 SQGSVRSSPGQGPEWVGRGGRKVLRIWLGKMSVKEGAQRKWAALKEKLGPQDSDPTEANL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE2 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE2 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE2 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE2 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE2 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE2 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE2 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ
1210 1220 1230 1240 1250 1260
1240
pF1KE2 EEVPPDSDDNKTKKLCVIQ
: . :
XP_005 EGLRPRPKAK
1270
>>NP_116103 (OMIM: 610982,613237,614455) inverted formin (234 aa)
initn: 1503 init1: 1503 opt: 1503 Z-score: 547.1 bits: 111.0 E(87258): 1e-23
Smith-Waterman score: 1503; 100.0% identity (100.0% similar) in 234 aa overlap (1-234:1-234)
10 20 30 40 50 60
pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLR
190 200 210 220 230
250 260 270 280 290 300
pF1KE2 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
>>XP_011535875 (OMIM: 124900,602121,616632) PREDICTED: p (1250 aa)
initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11
Smith-Waterman score: 1285; 28.2% identity (56.8% similar) in 1091 aa overlap (73-1034:165-1236)
50 60 70 80 90 100
pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT
:: ::. : :: . .: :. .
XP_011 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE
140 150 160 170 180 190
110 120 130 140 150
pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG
. :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .::
XP_011 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED
200 210 220 230 240 250
160 170 180 190 200 210
pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ
. .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :..
XP_011 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV
.:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .::
XP_011 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV
320 330 340 350 360 370
280 290 300 310 320 330
pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E
: :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. .
XP_011 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK
380 390 400 410 420 430
340 350 360
pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ
: ....... :.. . . : : : :.......:.
XP_011 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL
440 450 460 470 480 490
370 380 390 400 410
pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP
. : :. .: : ..:.. .: . .. :..: : .. :
XP_011 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP
500 510 520 530 540 550
420 430 440
pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L
.. ..: .:: :: ::: ::.:. ::::::::: :
XP_011 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL
560 570 580 590 600 610
450 460 470
pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP
:. : . : : ::::::: :. :. :: :::: ::
XP_011 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP
620 630 640 650 660 670
480 490 500 510 520 530
pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV
:::: .::::::::: : ::::::: :: : : ::::: : : :: . ::
XP_011 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP-
680 690 700 710 720
540 550 560 570 580
pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS
:.: .: . ... : ..... ::.:: ::.. .. .:....
XP_011 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE
730 740 750 760 770 780
590 600 610 620 630 640
pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI
: : :... :: : : .: ..:. ::. ::.: . ::.:
XP_011 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI
790 800 810 820 830 840
650 660 670 680 690 700
pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH
:: .:. .:. .: . . . ....:.: .:: .... : . .: :: ...
XP_011 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ
850 860 870 880 890 900
710 720 730 740 750 760
pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR
: ... ..: . :.. .:. . .. ..:. : :::: : :... . .. :
XP_011 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL
910 920 930 940 950 960
770 780 790 800 810 820
pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE
.::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .:
XP_011 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA
970 980 990 1000 1010 1020
830 840 850 860 870
pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR
. .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. .
XP_011 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN
1030 1040 1050 1060 1070 1080
880 890 900 910 920 930
pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA
: . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: :
XP_011 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM
1090 1100 1110 1120 1130 1140
940 950 960 970 980 990
pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG
:. .::.:.:.. : : . .. .. .:. :.:.:: ...: .: : ::
XP_011 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKRG
1150 1160 1170 1180 1190
1000 1010 1020 1030 1040 1050
pF1KE2 DTDGGSKAA-SMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAV
... ::. .. :.: . . :. :. .. . :
XP_011 PRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVGRAS
1200 1210 1220 1230 1240 1250
1060 1070 1080 1090 1100 1110
pF1KE2 TPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKP
>>NP_001300936 (OMIM: 124900,602121,616632) protein diap (1250 aa)
initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11
Smith-Waterman score: 1280; 28.5% identity (57.0% similar) in 1051 aa overlap (73-995:187-1221)
50 60 70 80 90 100
pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT
:: ::. : :: . .: :. .
NP_001 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE
160 170 180 190 200 210
110 120 130 140 150
pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG
. :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .::
NP_001 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED
220 230 240 250 260 270
160 170 180 190 200 210
pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ
. .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :..
NP_001 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH
280 290 300 310 320 330
220 230 240 250 260 270
pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV
.:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .::
NP_001 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV
340 350 360 370 380 390
280 290 300 310 320 330
pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E
: :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. .
NP_001 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK
400 410 420 430 440 450
340 350 360
pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ
: ....... :.. . . : : : :.......:.
NP_001 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL
460 470 480 490 500 510
370 380 390 400 410
pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP
. : :. .: : ..:.. .: . .. :..: : .. :
NP_001 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP
520 530 540 550 560 570
420 430 440
pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L
.. ..: .:: :: ::: ::.:. ::::::::: :
NP_001 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL
580 590 600 610 620 630
450 460 470
pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP
:. : . : : ::::::: :. :. :: :::: ::
NP_001 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP
640 650 660 670 680 690
480 490 500 510 520 530
pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV
:::: .::::::::: : ::::::: :: : : ::::: : : :: . ::
NP_001 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP-
700 710 720 730 740
540 550 560 570 580
pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS
:.: .: . ... : ..... ::.:: ::.. .. .:....
NP_001 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE
750 760 770 780 790 800
590 600 610 620 630 640
pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI
: : :... :: : : .: ..:. ::. ::.: . ::.:
NP_001 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI
810 820 830 840 850 860
650 660 670 680 690 700
pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH
:: .:. .:. .: . . . ....:.: .:: .... : . .: :: ...
NP_001 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ
870 880 890 900 910 920
710 720 730 740 750 760
pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR
: ... ..: . :.. .:. . .. ..:. : :::: : :... . .. :
NP_001 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL
930 940 950 960 970 980
770 780 790 800 810 820
pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE
.::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .:
NP_001 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA
990 1000 1010 1020 1030 1040
830 840 850 860 870
pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR
. .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. .
NP_001 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN
1050 1060 1070 1080 1090 1100
880 890 900 910 920 930
pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA
: . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: :
NP_001 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM
1110 1120 1130 1140 1150 1160
940 950 960 970 980 990
pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG
:. .::.:.:.. : : . .. .. .:. :.:.:: ...: .:. :
NP_001 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQ
1170 1180 1190 1200 1210 1220
1000 1010 1020 1030 1040 1050
pF1KE2 DTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAVT
:
NP_001 DNLLCPWEVEEEEETFKLPTGRPGVQSHLC
1230 1240 1250
>>XP_011535874 (OMIM: 124900,602121,616632) PREDICTED: p (1260 aa)
initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11
Smith-Waterman score: 1285; 28.2% identity (56.8% similar) in 1091 aa overlap (73-1034:175-1246)
50 60 70 80 90 100
pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT
:: ::. : :: . .: :. .
XP_011 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE
150 160 170 180 190 200
110 120 130 140 150
pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG
. :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .::
XP_011 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED
210 220 230 240 250 260
160 170 180 190 200 210
pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ
. .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :..
XP_011 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH
270 280 290 300 310 320
220 230 240 250 260 270
pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV
.:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .::
XP_011 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV
330 340 350 360 370 380
280 290 300 310 320 330
pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E
: :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. .
XP_011 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK
390 400 410 420 430 440
340 350 360
pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ
: ....... :.. . . : : : :.......:.
XP_011 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL
450 460 470 480 490 500
370 380 390 400 410
pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP
. : :. .: : ..:.. .: . .. :..: : .. :
XP_011 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP
510 520 530 540 550 560
420 430 440
pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L
.. ..: .:: :: ::: ::.:. ::::::::: :
XP_011 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL
570 580 590 600 610 620
450 460 470
pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP
:. : . : : ::::::: :. :. :: :::: ::
XP_011 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP
630 640 650 660 670 680
480 490 500 510 520 530
pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV
:::: .::::::::: : ::::::: :: : : ::::: : : :: . ::
XP_011 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP-
690 700 710 720 730
540 550 560 570 580
pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS
:.: .: . ... : ..... ::.:: ::.. .. .:....
XP_011 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE
740 750 760 770 780 790
590 600 610 620 630 640
pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI
: : :... :: : : .: ..:. ::. ::.: . ::.:
XP_011 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI
800 810 820 830 840 850
650 660 670 680 690 700
pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH
:: .:. .:. .: . . . ....:.: .:: .... : . .: :: ...
XP_011 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ
860 870 880 890 900 910
710 720 730 740 750 760
pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR
: ... ..: . :.. .:. . .. ..:. : :::: : :... . .. :
XP_011 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL
920 930 940 950 960 970
770 780 790 800 810 820
pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE
.::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .:
XP_011 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA
980 990 1000 1010 1020 1030
830 840 850 860 870
pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR
. .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. .
XP_011 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN
1040 1050 1060 1070 1080 1090
880 890 900 910 920 930
pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA
: . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: :
XP_011 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM
1100 1110 1120 1130 1140 1150
940 950 960 970 980 990
pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG
:. .::.:.:.. : : . .. .. .:. :.:.:: ...: .: : ::
XP_011 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKRG
1160 1170 1180 1190 1200
1000 1010 1020 1030 1040 1050
pF1KE2 DTDGGSKAA-SMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAV
... ::. .. :.: . . :. :. .. . :
XP_011 PRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVGRAS
1210 1220 1230 1240 1250 1260
1060 1070 1080 1090 1100 1110
pF1KE2 TPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKP
>>NP_001073280 (OMIM: 124900,602121,616632) protein diap (1263 aa)
initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11
Smith-Waterman score: 1285; 28.2% identity (56.8% similar) in 1091 aa overlap (73-1034:178-1249)
50 60 70 80 90 100
pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT
:: ::. : :: . .: :. .
NP_001 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE
150 160 170 180 190 200
110 120 130 140 150
pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG
. :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .::
NP_001 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED
210 220 230 240 250 260
160 170 180 190 200 210
pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ
. .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :..
NP_001 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH
270 280 290 300 310 320
220 230 240 250 260 270
pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV
.:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .::
NP_001 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV
330 340 350 360 370 380
280 290 300 310 320 330
pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E
: :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. .
NP_001 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK
390 400 410 420 430 440
340 350 360
pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ
: ....... :.. . . : : : :.......:.
NP_001 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL
450 460 470 480 490 500
370 380 390 400 410
pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP
. : :. .: : ..:.. .: . .. :..: : .. :
NP_001 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP
510 520 530 540 550 560
420 430 440
pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L
.. ..: .:: :: ::: ::.:. ::::::::: :
NP_001 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL
570 580 590 600 610 620
450 460 470
pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP
:. : . : : ::::::: :. :. :: :::: ::
NP_001 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP
630 640 650 660 670 680
480 490 500 510 520 530
pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV
:::: .::::::::: : ::::::: :: : : ::::: : : :: . ::
NP_001 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP-
690 700 710 720 730 740
540 550 560 570 580
pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS
:.: .: . ... : ..... ::.:: ::.. .. .:....
NP_001 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE
750 760 770 780 790
590 600 610 620 630 640
pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI
: : :... :: : : .: ..:. ::. ::.: . ::.:
NP_001 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI
800 810 820 830 840 850
650 660 670 680 690 700
pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH
:: .:. .:. .: . . . ....:.: .:: .... : . .: :: ...
NP_001 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ
860 870 880 890 900 910
710 720 730 740 750 760
pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR
: ... ..: . :.. .:. . .. ..:. : :::: : :... . .. :
NP_001 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL
920 930 940 950 960 970
770 780 790 800 810 820
pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE
.::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .:
NP_001 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA
980 990 1000 1010 1020 1030
830 840 850 860 870
pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR
. .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. .
NP_001 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN
1040 1050 1060 1070 1080 1090
880 890 900 910 920 930
pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA
: . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: :
NP_001 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM
1100 1110 1120 1130 1140 1150
940 950 960 970 980 990
pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG
:. .::.:.:.. : : . .. .. .:. :.:.:: ...: .: : ::
NP_001 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKRG
1160 1170 1180 1190 1200
1000 1010 1020 1030 1040 1050
pF1KE2 DTDGGSKAA-SMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAV
... ::. .. :.: . . :. :. .. . :
NP_001 PRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVGRAS
1210 1220 1230 1240 1250 1260
1060 1070 1080 1090 1100 1110
pF1KE2 TPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKP
1249 residues in 1 query sequences
62035967 residues in 87258 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Jun 29 17:41:21 2017 done: Thu Jun 29 17:41:23 2017
Total Scan time: 17.050 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]