FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2685, 456 aa 1>>>pF1KE2685 456 - 456 aa - 456 aa Library: /omim/omim.rfq.tfa 62035967 residues in 87258 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.2398+/-0.000405; mu= -17.1567+/- 0.025 mean_var=527.2845+/-109.120, 0's: 0 Z-trim(124.9): 59 B-trim: 488 in 1/59 Lambda= 0.055854 statistics sampled from 48095 (48166) to 48095 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.813), E-opt: 0.2 (0.552), width: 16 Scan time: 10.310 The best scores are: opt bits E(87258) NP_006031 (OMIM: 604059) heparan sulfate glucosami ( 456) 3155 268.4 2.8e-71 NP_006033 (OMIM: 604057) heparan sulfate glucosami ( 406) 1436 129.9 1.3e-29 NP_006032 (OMIM: 604058) heparan sulfate glucosami ( 390) 1433 129.6 1.5e-29 NP_006034 (OMIM: 604056) heparan sulfate glucosami ( 367) 1431 129.4 1.6e-29 XP_011522416 (OMIM: 604057) PREDICTED: heparan sul ( 207) 1114 103.7 5.1e-22 XP_016880968 (OMIM: 604058) PREDICTED: heparan sul ( 203) 1111 103.4 5.9e-22 XP_011533890 (OMIM: 609407) PREDICTED: heparan sul ( 346) 840 81.8 3.3e-15 XP_016865963 (OMIM: 609407) PREDICTED: heparan sul ( 346) 840 81.8 3.3e-15 XP_016865960 (OMIM: 609407) PREDICTED: heparan sul ( 346) 840 81.8 3.3e-15 XP_016865959 (OMIM: 609407) PREDICTED: heparan sul ( 346) 840 81.8 3.3e-15 XP_016865962 (OMIM: 609407) PREDICTED: heparan sul ( 346) 840 81.8 3.3e-15 NP_705840 (OMIM: 609407) heparan sulfate glucosami ( 346) 840 81.8 3.3e-15 XP_006715442 (OMIM: 609407) PREDICTED: heparan sul ( 346) 840 81.8 3.3e-15 XP_016865961 (OMIM: 609407) PREDICTED: heparan sul ( 346) 840 81.8 3.3e-15 NP_005105 (OMIM: 603244) heparan sulfate glucosami ( 307) 789 77.6 5.2e-14 XP_011512215 (OMIM: 603244) PREDICTED: heparan sul ( 307) 789 77.6 5.2e-14 XP_016864331 (OMIM: 603950) PREDICTED: bifunctiona ( 493) 419 48.0 7e-05 XP_006714479 (OMIM: 603950) PREDICTED: bifunctiona ( 873) 419 48.2 0.00011 NP_004775 (OMIM: 603950) bifunctional heparan sulf ( 873) 419 48.2 0.00011 XP_016864035 (OMIM: 615039) PREDICTED: bifunctiona ( 493) 407 47.0 0.00014 XP_016864034 (OMIM: 615039) PREDICTED: bifunctiona ( 493) 407 47.0 0.00014 NP_072091 (OMIM: 615039) bifunctional heparan sulf ( 872) 407 47.2 0.00021 XP_016864332 (OMIM: 603950) PREDICTED: bifunctiona ( 484) 395 46.1 0.00026 XP_016872346 (OMIM: 603268) PREDICTED: bifunctiona ( 406) 392 45.8 0.00027 XP_016864330 (OMIM: 603950) PREDICTED: bifunctiona ( 519) 395 46.1 0.00028 XP_016864333 (OMIM: 603950) PREDICTED: bifunctiona ( 519) 395 46.1 0.00028 XP_005270313 (OMIM: 603268) PREDICTED: bifunctiona ( 509) 392 45.8 0.00032 XP_016864329 (OMIM: 603950) PREDICTED: bifunctiona ( 899) 395 46.3 0.00042 XP_016864328 (OMIM: 603950) PREDICTED: bifunctiona ( 899) 395 46.3 0.00042 NP_003626 (OMIM: 603268) bifunctional heparan sulf ( 883) 392 46.0 0.00048 XP_011538612 (OMIM: 603268) PREDICTED: bifunctiona ( 883) 392 46.0 0.00048 XP_016864922 (OMIM: 600853,616116) PREDICTED: bifu ( 553) 375 44.5 0.00089 XP_016864920 (OMIM: 600853,616116) PREDICTED: bifu ( 882) 375 44.7 0.0013 XP_016864918 (OMIM: 600853,616116) PREDICTED: bifu ( 882) 375 44.7 0.0013 XP_016864917 (OMIM: 600853,616116) PREDICTED: bifu ( 882) 375 44.7 0.0013 NP_001534 (OMIM: 600853,616116) bifunctional hepar ( 882) 375 44.7 0.0013 XP_006714846 (OMIM: 600853,616116) PREDICTED: bifu ( 882) 375 44.7 0.0013 XP_016864919 (OMIM: 600853,616116) PREDICTED: bifu ( 882) 375 44.7 0.0013 XP_005268499 (OMIM: 600853,616116) PREDICTED: bifu ( 471) 348 42.3 0.0036 XP_016864921 (OMIM: 600853,616116) PREDICTED: bifu ( 566) 348 42.3 0.0041 XP_011535940 (OMIM: 600853,616116) PREDICTED: bifu ( 566) 348 42.3 0.0041 XP_005268491 (OMIM: 600853,616116) PREDICTED: bifu ( 895) 348 42.5 0.0057 XP_005268492 (OMIM: 600853,616116) PREDICTED: bifu ( 895) 348 42.5 0.0057 XP_005268493 (OMIM: 600853,616116) PREDICTED: bifu ( 895) 348 42.5 0.0057 XP_016864916 (OMIM: 600853,616116) PREDICTED: bifu ( 895) 348 42.5 0.0057 XP_005268490 (OMIM: 600853,616116) PREDICTED: bifu ( 895) 348 42.5 0.0057 XP_005268494 (OMIM: 600853,616116) PREDICTED: bifu ( 895) 348 42.5 0.0057 XP_006714845 (OMIM: 600853,616116) PREDICTED: bifu ( 895) 348 42.5 0.0057 XP_016880969 (OMIM: 604057) PREDICTED: heparan sul ( 231) 329 40.5 0.0061 XP_011544303 (OMIM: 604056) PREDICTED: heparan sul ( 204) 326 40.2 0.0065 >>NP_006031 (OMIM: 604059) heparan sulfate glucosamine 3 (456 aa) initn: 3155 init1: 3155 opt: 3155 Z-score: 1400.8 bits: 268.4 E(87258): 2.8e-71 Smith-Waterman score: 3155; 99.8% identity (100.0% similar) in 456 aa overlap (1-456:1-456) 10 20 30 40 50 60 pF1KE2 MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PGTDGWGLPSGGGGARDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_006 PGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 IVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI 370 380 390 400 410 420 430 440 450 pF1KE2 DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK :::::::::::::::::::::::::::::::::::: NP_006 DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK 430 440 450 >>NP_006033 (OMIM: 604057) heparan sulfate glucosamine 3 (406 aa) initn: 1456 init1: 1412 opt: 1436 Z-score: 652.8 bits: 129.9 E(87258): 1.3e-29 Smith-Waterman score: 1455; 64.2% identity (80.4% similar) in 352 aa overlap (122-450:59-405) 100 110 120 130 140 pF1KE2 GAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWGLPSGG---GGARD--AWLRTPLAP : . : :.:: :: :. .: : : NP_006 LCSLLTSLYVFYCLAERCQTLSGPVVGLSGGGEEAGAPGGGVLAGGPRELAVW---PAAA 30 40 50 60 70 80 150 160 170 180 190 pF1KE2 SEMITAQSALPE---------REAQESSTTDEDLAGRRAANGSSERGGAVS-TP------ .. : ::. :. : .. .:. : .. :.: :..:. .: NP_006 QRKRLLQ--LPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLAL 90 100 110 120 130 140 200 210 220 230 240 pF1KE2 --DYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKGLEWYRNVM : : :.::::.:::::::::::::: .::::::::::.:::::::.:.::: :::..: NP_006 LLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLM 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE2 PKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKPEI :.::::::::::::::::: ::: :: .:.:: :::::::.:::::::::::::::.:.: NP_006 PRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDI 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE2 PTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEM :::: :.::::: ::::.:::::.::::: :::.::..::. :.::::::::: :::::. NP_006 PTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGEL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE2 AKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRL ..:::::::::..:.:::::::::::::::: : :: :.::::.::::::.:: .:..:: NP_006 GRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRL 330 340 350 360 370 380 430 440 450 pF1KE2 RKFYKPFNLMFYQMTGQDFQWEQEEGDK :.::.:::: ::::::.:: :. NP_006 REFYRPFNLKFYQMTGHDFGWDG 390 400 >>NP_006032 (OMIM: 604058) heparan sulfate glucosamine 3 (390 aa) initn: 1548 init1: 1412 opt: 1433 Z-score: 651.8 bits: 129.6 E(87258): 1.5e-29 Smith-Waterman score: 1469; 55.4% identity (70.6% similar) in 442 aa overlap (10-450:20-390) 10 20 30 40 50 pF1KE2 MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCY : ::::: ::.:. :.: ..:: NP_006 MGQRLSGGRSCLDVPGRLLPQPPPPP-------------PPVRR-----KLALLFAMLCV 10 20 30 40 60 70 80 90 100 pF1KE2 SLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPP-LDNASHG : . : :. : : .:: ::. :. :: : .: : NP_006 WLY---------MFLYSCAGSCAAAP------GLL----LLGSGSRAAHDPPALATAPDG 50 60 70 80 110 120 130 140 150 160 pF1KE2 EPPEPPEQPAAPGTDGWGLPSGGGGARDAWLRTPLAPSEMITAQSALPEREAQESSTTDE ::. : . :: :. :::: .. .. .: ::... : . NP_006 TPPRLPFR--AP-------PA-----------TPLASGKEMAEGAASPEEQSPEVPDSPS 90 100 110 120 170 180 190 200 210 220 pF1KE2 DLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVE ... ...:: :.::::.:::::::::::::: .::::::::::.: NP_006 PISSFFSGSGS--------------KQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAE 130 140 150 160 230 240 250 260 270 280 pF1KE2 PHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRN ::::::.:.::: :::..::.::::::::::::::::: ::: :: .:.:: :::::::. NP_006 PHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRD 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE2 PVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPL :::::::::::::::.:.::::: :.::::: ::::.:::::.::::: :::.::..::. NP_006 PVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPI 230 240 250 260 270 280 350 360 370 380 390 400 pF1KE2 SQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCL :.::::::::: :::::...:::::::::..:.:::::::::::::::: : :: :.:: NP_006 RQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCL 290 300 310 320 330 340 410 420 430 440 450 pF1KE2 GKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK ::.::::::.:: .:..:::.::.:::: ::::::.:: :. NP_006 GKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWD 350 360 370 380 390 >>NP_006034 (OMIM: 604056) heparan sulfate glucosamine 3 (367 aa) initn: 1543 init1: 1427 opt: 1431 Z-score: 651.2 bits: 129.4 E(87258): 1.6e-29 Smith-Waterman score: 1451; 56.9% identity (72.4% similar) in 427 aa overlap (29-450:10-367) 10 20 30 40 50 pF1KE2 MARWPAPPPPPPPPPPLAAPPPPGASAKGPP----ARKLLFMCTLSLSVTYLCYSLLGGS ::: ::.::: ::::: ::::::.: NP_006 MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCC 10 20 30 40 60 70 80 90 100 110 pF1KE2 GSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEP-P .: : . :: .: : .:: . :... .: : : NP_006 DDL----------GRS----------RLLGAPRCLRGPSAG-GQKLLQKSRPCDPSGPTP 50 60 70 80 120 130 140 150 160 170 pF1KE2 EQPAAPGTDGWGLPSGGGGARDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRR .:.::. ::. .:.: : : NP_006 SEPSAPS----------------------APA------AAVP--------------APR- 90 180 190 200 210 220 230 pF1KE2 AANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDR .::.. : .: : :.::::::.:::::::::.:: :::::::::.:.::::::: NP_006 -LSGSNHSG----SPKLGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDR 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE2 NYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAI :: .::.:::..::.::..:::.:::::::::.:::.:: .:..: :::::::::::::: NP_006 NYGRGLDWYRSLMPRTLESQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAI 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE2 SDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFV :::::::::::.::::: :.:.::::::.:.::.:::::.:.::::.:::::::.:: :: NP_006 SDYTQTLSKKPDIPTFEGLSFRNRTLGLVDVSWNAIRIGMYVLHLESWLQYFPLAQIHFV 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE2 SGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGR ::::::.::::::..::::::.:: .:.:::::::::::::::: :.: :::::::::: NP_006 SGERLITDPAGEMGRVQDFLGIKRFITDKHFYFNKTKGFPCLKKTESSLLPRCLGKSKGR 280 290 300 310 320 330 420 430 440 450 pF1KE2 THPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK :: .:::.:: .::.::.:.:. ::. .::::.:: NP_006 THVQIDPEVIDQLREFYRPYNIKFYETVGQDFRWE 340 350 360 >>XP_011522416 (OMIM: 604057) PREDICTED: heparan sulfate (207 aa) initn: 1111 init1: 1111 opt: 1114 Z-score: 516.5 bits: 103.7 E(87258): 5.1e-22 Smith-Waterman score: 1114; 77.1% identity (92.7% similar) in 205 aa overlap (246-450:2-206) 220 230 240 250 260 270 pF1KE2 AIRVHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIH ..::.::::::::::::::::: ::: :: XP_011 MDLMPRTLDGQITMEKTPSYFVTREAPARIS 10 20 30 280 290 300 310 320 330 pF1KE2 SMAKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGI .:.:: :::::::.:::::::::::::::.:.::::: :.::::: ::::.:::::.::: XP_011 AMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGI 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE2 YALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFP :: :::.::..::. :.::::::::: :::::...:::::::::..:.:::::::::::: XP_011 YAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFP 100 110 120 130 140 150 400 410 420 430 440 450 pF1KE2 CLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGD :::: : :: :.::::.::::::.:: .:..:::.::.:::: ::::::.:: :. XP_011 CLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG 160 170 180 190 200 pF1KE2 K >>XP_016880968 (OMIM: 604058) PREDICTED: heparan sulfate (203 aa) initn: 1111 init1: 1111 opt: 1111 Z-score: 515.3 bits: 103.4 E(87258): 5.9e-22 Smith-Waterman score: 1111; 77.8% identity (92.6% similar) in 203 aa overlap (248-450:1-203) 220 230 240 250 260 270 pF1KE2 RVHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSM ::.::::::::::::::::: ::: :: .: XP_016 MPRTLDGQITMEKTPSYFVTREAPARISAM 10 20 30 280 290 300 310 320 330 pF1KE2 AKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYA .:: :::::::.:::::::::::::::.:.::::: :.::::: ::::.:::::.::::: XP_016 SKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYA 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE2 LHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCL :::.::..::. :.::::::::: :::::...:::::::::..:.:::::::::::::: XP_016 KHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCL 100 110 120 130 140 150 400 410 420 430 440 450 pF1KE2 KKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK :: : :: :.::::.::::::.:: .:..:::.::.:::: ::::::.:: :. XP_016 KKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWD 160 170 180 190 200 >>XP_011533890 (OMIM: 609407) PREDICTED: heparan sulfate (346 aa) initn: 847 init1: 289 opt: 840 Z-score: 394.2 bits: 81.8 E(87258): 3.3e-15 Smith-Waterman score: 840; 44.2% identity (70.3% similar) in 317 aa overlap (143-449:39-345) 120 130 140 150 160 pF1KE2 EPPEQPAAPGTDGWGLPSGGGGARDAWLRTPLAPSEM----ITAQSALPEREAQESSTTD :. : : .:. .: : : . XP_011 LRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRALQFKRGLL 10 20 30 40 50 60 170 180 190 200 210 220 pF1KE2 EDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGV ... : .:.:.:. : : ..::.:.::::.::::::::: . .:: : .. XP_011 HEF---RKGNASKEQ---VRLHDL-VQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQ 70 80 90 100 110 120 230 240 250 260 270 280 pF1KE2 EPHFFD--RNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVV : :::: .:: ::.::::. :: . :::.::.:.::.:.:.:.::..: ..:::... XP_011 EIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLII 130 140 150 160 170 180 290 300 310 320 330 340 pF1KE2 VRNPVTRAISDYTQTLS----KKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLEN ::.:.:::::::::.: :. :: ::. : ......:.: .::. ::: XP_011 VREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCE-VNTKYKAVRTSIYTKHLER 190 200 210 220 230 240 350 360 370 380 390 400 pF1KE2 WLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPED ::.:::. :. :.:.:::..: :. :. ::.: ... ..::: :.:: ::. . XP_011 WLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLR--FN 250 260 270 280 290 410 420 430 440 450 pF1KE2 SSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK .::. :::: ::..::.:: .::::..::: :::.::. ..: XP_011 IIFNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP 300 310 320 330 340 >>XP_016865963 (OMIM: 609407) PREDICTED: heparan sulfate (346 aa) initn: 847 init1: 289 opt: 840 Z-score: 394.2 bits: 81.8 E(87258): 3.3e-15 Smith-Waterman score: 840; 44.2% identity (70.3% similar) in 317 aa overlap (143-449:39-345) 120 130 140 150 160 pF1KE2 EPPEQPAAPGTDGWGLPSGGGGARDAWLRTPLAPSEM----ITAQSALPEREAQESSTTD :. : : .:. .: : : . XP_016 LRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRALQFKRGLL 10 20 30 40 50 60 170 180 190 200 210 220 pF1KE2 EDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGV ... : .:.:.:. : : ..::.:.::::.::::::::: . .:: : .. XP_016 HEF---RKGNASKEQ---VRLHDL-VQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQ 70 80 90 100 110 120 230 240 250 260 270 280 pF1KE2 EPHFFD--RNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVV : :::: .:: ::.::::. :: . :::.::.:.::.:.:.:.::..: ..:::... XP_016 EIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLII 130 140 150 160 170 180 290 300 310 320 330 340 pF1KE2 VRNPVTRAISDYTQTLS----KKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLEN ::.:.:::::::::.: :. :: ::. : ......:.: .::. ::: XP_016 VREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCE-VNTKYKAVRTSIYTKHLER 190 200 210 220 230 240 350 360 370 380 390 400 pF1KE2 WLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPED ::.:::. :. :.:.:::..: :. :. ::.: ... ..::: :.:: ::. . XP_016 WLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLR--FN 250 260 270 280 290 410 420 430 440 450 pF1KE2 SSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK .::. :::: ::..::.:: .::::..::: :::.::. ..: XP_016 IIFNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP 300 310 320 330 340 >>XP_016865960 (OMIM: 609407) PREDICTED: heparan sulfate (346 aa) initn: 847 init1: 289 opt: 840 Z-score: 394.2 bits: 81.8 E(87258): 3.3e-15 Smith-Waterman score: 840; 44.2% identity (70.3% similar) in 317 aa overlap (143-449:39-345) 120 130 140 150 160 pF1KE2 EPPEQPAAPGTDGWGLPSGGGGARDAWLRTPLAPSEM----ITAQSALPEREAQESSTTD :. : : .:. .: : : . XP_016 LRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRALQFKRGLL 10 20 30 40 50 60 170 180 190 200 210 220 pF1KE2 EDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGV ... : .:.:.:. : : ..::.:.::::.::::::::: . .:: : .. XP_016 HEF---RKGNASKEQ---VRLHDL-VQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQ 70 80 90 100 110 120 230 240 250 260 270 280 pF1KE2 EPHFFD--RNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVV : :::: .:: ::.::::. :: . :::.::.:.::.:.:.:.::..: ..:::... XP_016 EIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLII 130 140 150 160 170 180 290 300 310 320 330 340 pF1KE2 VRNPVTRAISDYTQTLS----KKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLEN ::.:.:::::::::.: :. :: ::. : ......:.: .::. ::: XP_016 VREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCE-VNTKYKAVRTSIYTKHLER 190 200 210 220 230 240 350 360 370 380 390 400 pF1KE2 WLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPED ::.:::. :. :.:.:::..: :. :. ::.: ... ..::: :.:: ::. . XP_016 WLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLR--FN 250 260 270 280 290 410 420 430 440 450 pF1KE2 SSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK .::. :::: ::..::.:: .::::..::: :::.::. ..: XP_016 IIFNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP 300 310 320 330 340 >>XP_016865959 (OMIM: 609407) PREDICTED: heparan sulfate (346 aa) initn: 847 init1: 289 opt: 840 Z-score: 394.2 bits: 81.8 E(87258): 3.3e-15 Smith-Waterman score: 840; 44.2% identity (70.3% similar) in 317 aa overlap (143-449:39-345) 120 130 140 150 160 pF1KE2 EPPEQPAAPGTDGWGLPSGGGGARDAWLRTPLAPSEM----ITAQSALPEREAQESSTTD :. : : .:. .: : : . XP_016 LRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRALQFKRGLL 10 20 30 40 50 60 170 180 190 200 210 220 pF1KE2 EDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGV ... : .:.:.:. : : ..::.:.::::.::::::::: . .:: : .. XP_016 HEF---RKGNASKEQ---VRLHDL-VQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQ 70 80 90 100 110 120 230 240 250 260 270 280 pF1KE2 EPHFFD--RNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVV : :::: .:: ::.::::. :: . :::.::.:.::.:.:.:.::..: ..:::... XP_016 EIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLII 130 140 150 160 170 180 290 300 310 320 330 340 pF1KE2 VRNPVTRAISDYTQTLS----KKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLEN ::.:.:::::::::.: :. :: ::. : ......:.: .::. ::: XP_016 VREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCE-VNTKYKAVRTSIYTKHLER 190 200 210 220 230 240 350 360 370 380 390 400 pF1KE2 WLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPED ::.:::. :. :.:.:::..: :. :. ::.: ... ..::: :.:: ::. . XP_016 WLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLR--FN 250 260 270 280 290 410 420 430 440 450 pF1KE2 SSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK .::. :::: ::..::.:: .::::..::: :::.::. ..: XP_016 IIFNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP 300 310 320 330 340 456 residues in 1 query sequences 62035967 residues in 87258 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Jun 2 11:47:28 2017 done: Fri Jun 2 11:47:30 2017 Total Scan time: 10.310 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]