Result of FASTA (omim) for
pFN21AE2623
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2623, 227 aa
1>>>pF1KE2623 227 - 227 aa - 227 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3349+/-0.000449; mu= -3.2648+/- 0.028
mean_var=242.2868+/-48.685, 0's: 0 Z-trim(117.2): 25 B-trim: 0 in 0/56
Lambda= 0.082397
statistics sampled from 28891 (28913) to 28891 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.339), width: 16
Scan time: 5.020
The best scores are: opt bits E(85289)
NP_060282 (OMIM: 613748) MICOS complex subunit MIC ( 227) 1440 183.6 2.4e-46
NP_001304106 (OMIM: 613748) MICOS complex subunit ( 232) 1420 181.2 1.3e-45
NP_001304107 (OMIM: 613748) MICOS complex subunit ( 138) 757 102.2 4.5e-22
NP_115719 (OMIM: 615634) MICOS complex subunit MIC ( 235) 344 53.3 4.1e-07
XP_011511536 (OMIM: 615634) PREDICTED: MICOS compl ( 199) 342 53.0 4.2e-07
NP_001307539 (OMIM: 615634) MICOS complex subunit ( 236) 342 53.1 4.8e-07
>>NP_060282 (OMIM: 613748) MICOS complex subunit MIC19 i (227 aa)
initn: 1440 init1: 1440 opt: 1440 Z-score: 953.1 bits: 183.6 E(85289): 2.4e-46
Smith-Waterman score: 1440; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227)
10 20 30 40 50 60
pF1KE2 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 KHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESH
130 140 150 160 170 180
190 200 210 220
pF1KE2 PVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
:::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
190 200 210 220
>>NP_001304106 (OMIM: 613748) MICOS complex subunit MIC1 (232 aa)
initn: 1426 init1: 755 opt: 1420 Z-score: 940.1 bits: 181.2 E(85289): 1.3e-45
Smith-Waterman score: 1420; 97.8% identity (97.8% similar) in 232 aa overlap (1-227:1-232)
10 20 30 40 50 60
pF1KE2 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
70 80 90 100 110 120
130 140 150 160 170
pF1KE2 KHL-----ARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHLDIEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
130 140 150 160 170 180
180 190 200 210 220
pF1KE2 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
190 200 210 220 230
>>NP_001304107 (OMIM: 613748) MICOS complex subunit MIC1 (138 aa)
initn: 757 init1: 757 opt: 757 Z-score: 517.3 bits: 102.2 E(85289): 4.5e-22
Smith-Waterman score: 757; 98.4% identity (99.2% similar) in 125 aa overlap (1-125:1-125)
10 20 30 40 50 60
pF1KE2 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 KHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESH
::: .
NP_001 KHLIKVELLWVKPGVLTA
130
>>NP_115719 (OMIM: 615634) MICOS complex subunit MIC25 i (235 aa)
initn: 503 init1: 337 opt: 344 Z-score: 248.8 bits: 53.3 E(85289): 4.1e-07
Smith-Waterman score: 468; 37.7% identity (69.9% similar) in 236 aa overlap (1-220:1-234)
10 20 30 40 50
pF1KE2 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESS-----PSGSKSQRYSGAY
::.: :. :::.: .::.: . :..:.::::::..:::: : :..: .:
NP_115 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNL
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 GASVSDEELKRRVA----EELALEQAKKESEDQKRLKQAKELD---RERAAANEQLTRAI
: .. : : . . ..... :. :... : : .. ::: ::... ..:
NP_115 RAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKH-SKAS
70 80 90 100 110
110 120 130 140 150 160
pF1KE2 LR--ERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQ
: : :.::. :. .:::.:: .. :...:.:::::: :.:....:.:....::..
NP_115 LPTGEGSISHEEQ-KSVRLARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFH
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 KAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLE
.:: ..:. .: . .:::. :::.::.:::. :..: :: :. :..::. :..
NP_115 EAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG
180 190 200 210 220 230
pF1KE2 KGG
>>XP_011511536 (OMIM: 615634) PREDICTED: MICOS complex s (199 aa)
initn: 400 init1: 327 opt: 342 Z-score: 248.5 bits: 53.0 E(85289): 4.2e-07
Smith-Waterman score: 347; 37.1% identity (67.2% similar) in 186 aa overlap (37-220:28-198)
10 20 30 40 50 60
pF1KE2 TRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRV
:::. : : ::. : : .::
XP_011 MKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGS---SGGQQPSGMKEGVKRYE
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 AEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILR--ERICSEEERAKAKHLA
:. :. : .: :. . ::: ::... ..: : : :.::. ... :
XP_011 QEHAAI---------QDKLFQVAK--REREAATKH-SKASLPTGEGSISHEEQKSVRLQA
60 70 80 90 100
130 140 150 160 170 180
pF1KE2 RQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHPVCA
:.:: .. :...:.:::::: :.:....:.:....::...:: ..:. .: . .:::.
XP_011 RELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCS
110 120 130 140 150 160
190 200 210 220
pF1KE2 DLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
:::.::.:::. :..: :: :. :..::. :..
XP_011 GLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG
170 180 190
>>NP_001307539 (OMIM: 615634) MICOS complex subunit MIC2 (236 aa)
initn: 530 init1: 327 opt: 342 Z-score: 247.5 bits: 53.1 E(85289): 4.8e-07
Smith-Waterman score: 468; 36.9% identity (69.5% similar) in 236 aa overlap (1-220:1-235)
10 20 30 40 50
pF1KE2 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESS-----PSGSKSQRYSGAY
::.: :. :::.: .::.: . :..:.::::::..:::: : :..: .:
NP_001 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNL
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 GASVSDEELKRRVA----EELALEQAKKESEDQKRLKQAKELD---RERAAANEQLTRAI
: .. : : . . ..... :. :... : : .. ::: ::... ..:
NP_001 RAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKH-SKAS
70 80 90 100 110
110 120 130 140 150 160
pF1KE2 LR--ERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQ
: : :.::. ... ::.:: .. :...:.:::::: :.:....:.:....::..
NP_001 LPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFH
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 KAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLE
.:: ..:. .: . .:::. :::.::.:::. :..: :: :. :..::. :..
NP_001 EAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG
180 190 200 210 220 230
pF1KE2 KGG
227 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:16:11 2016 done: Tue Nov 8 17:16:11 2016
Total Scan time: 5.020 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]