Result of FASTA (omim) for
pFN21AE2619
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2619, 456 aa
1>>>pF1KE2619 456 - 456 aa - 456 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0993+/-0.000479; mu= 12.3601+/- 0.030
mean_var=68.0131+/-13.991, 0's: 0 Z-trim(108.2): 209 B-trim: 33 in 1/51
Lambda= 0.155517
statistics sampled from 16095 (16307) to 16095 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.544), E-opt: 0.2 (0.191), width: 16
Scan time: 7.540
The best scores are: opt bits E(85289)
NP_002594 (OMIM: 171885) high affinity cAMP-specif ( 456) 3058 695.8 6e-200
XP_011515842 (OMIM: 171885) PREDICTED: high affini ( 456) 3058 695.8 6e-200
NP_001229247 (OMIM: 171885) high affinity cAMP-spe ( 482) 2930 667.1 2.8e-191
XP_016869027 (OMIM: 171885) PREDICTED: high affini ( 448) 2925 666.0 5.7e-191
XP_011534057 (OMIM: 604645) PREDICTED: cAMP-specif ( 489) 1851 425.0 2.1e-118
NP_061818 (OMIM: 604645) cAMP-specific 3',5'-cycli ( 450) 1846 423.9 4.3e-118
XP_005266988 (OMIM: 604645) PREDICTED: cAMP-specif ( 502) 1806 414.9 2.4e-115
XP_016866230 (OMIM: 604645) PREDICTED: cAMP-specif ( 343) 1546 356.6 6.1e-98
NP_001092289 (OMIM: 600128) cAMP-specific 3',5'-cy ( 606) 740 175.8 2.9e-43
XP_011526358 (OMIM: 600128) PREDICTED: cAMP-specif ( 606) 740 175.8 2.9e-43
NP_001092288 (OMIM: 600128) cAMP-specific 3',5'-cy ( 680) 740 175.8 3.2e-43
NP_001317101 (OMIM: 600128) cAMP-specific 3',5'-cy ( 712) 740 175.8 3.3e-43
NP_000914 (OMIM: 600128) cAMP-specific 3',5'-cycli ( 712) 740 175.8 3.3e-43
XP_005270981 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 738 175.3 3.4e-43
XP_005270982 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 738 175.3 3.4e-43
XP_016856935 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 738 175.3 3.4e-43
XP_011539868 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 738 175.3 3.4e-43
XP_006710743 (OMIM: 600127) PREDICTED: cAMP-specif ( 531) 738 175.3 3.4e-43
XP_016865060 (OMIM: 600129,606799,614613) PREDICTE ( 553) 738 175.3 3.6e-43
XP_016865059 (OMIM: 600129,606799,614613) PREDICTE ( 553) 738 175.3 3.6e-43
NP_001032416 (OMIM: 600127) cAMP-specific 3',5'-cy ( 564) 738 175.3 3.6e-43
NP_001184151 (OMIM: 600129,606799,614613) cAMP-spe ( 585) 738 175.3 3.8e-43
XP_016856934 (OMIM: 600127) PREDICTED: cAMP-specif ( 597) 738 175.3 3.8e-43
NP_001284369 (OMIM: 600127) cAMP-specific 3',5'-cy ( 644) 738 175.3 4.1e-43
NP_001284370 (OMIM: 600127) cAMP-specific 3',5'-cy ( 661) 738 175.3 4.2e-43
XP_011541779 (OMIM: 600129,606799,614613) PREDICTE ( 662) 738 175.3 4.2e-43
XP_005248595 (OMIM: 600129,606799,614613) PREDICTE ( 673) 738 175.3 4.3e-43
NP_006194 (OMIM: 600129,606799,614613) cAMP-specif ( 673) 738 175.3 4.3e-43
NP_001184149 (OMIM: 600129,606799,614613) cAMP-spe ( 679) 738 175.3 4.3e-43
NP_001184148 (OMIM: 600129,606799,614613) cAMP-spe ( 687) 738 175.3 4.4e-43
XP_016865058 (OMIM: 600129,606799,614613) PREDICTE ( 699) 738 175.3 4.5e-43
XP_005248594 (OMIM: 600129,606799,614613) PREDICTE ( 699) 738 175.3 4.5e-43
NP_001032417 (OMIM: 600127) cAMP-specific 3',5'-cy ( 721) 738 175.3 4.6e-43
NP_001032418 (OMIM: 600127) cAMP-specific 3',5'-cy ( 736) 738 175.3 4.7e-43
NP_002591 (OMIM: 600127) cAMP-specific 3',5'-cycli ( 736) 738 175.3 4.7e-43
XP_016865057 (OMIM: 600129,606799,614613) PREDICTE ( 738) 738 175.3 4.7e-43
XP_016865056 (OMIM: 600129,606799,614613) PREDICTE ( 743) 738 175.4 4.7e-43
NP_001184147 (OMIM: 600129,606799,614613) cAMP-spe ( 745) 738 175.4 4.7e-43
XP_011541775 (OMIM: 600129,606799,614613) PREDICTE ( 748) 738 175.4 4.8e-43
XP_016865055 (OMIM: 600129,606799,614613) PREDICTE ( 748) 738 175.4 4.8e-43
XP_011541773 (OMIM: 600129,606799,614613) PREDICTE ( 748) 738 175.4 4.8e-43
NP_001159371 (OMIM: 600129,606799,614613) cAMP-spe ( 748) 738 175.4 4.8e-43
XP_011526360 (OMIM: 600128) PREDICTED: cAMP-specif ( 481) 735 174.6 5e-43
XP_011541771 (OMIM: 600129,606799,614613) PREDICTE ( 797) 738 175.4 5.1e-43
XP_016865054 (OMIM: 600129,606799,614613) PREDICTE ( 797) 738 175.4 5.1e-43
XP_011541772 (OMIM: 600129,606799,614613) PREDICTE ( 797) 738 175.4 5.1e-43
NP_001098101 (OMIM: 600129,606799,614613) cAMP-spe ( 809) 738 175.4 5.1e-43
NP_001284371 (OMIM: 600127) cAMP-specific 3',5'-cy ( 503) 727 172.9 1.8e-42
NP_001184150 (OMIM: 600129,606799,614613) cAMP-spe ( 507) 722 171.7 4e-42
NP_001184152 (OMIM: 600129,606799,614613) cAMP-spe ( 518) 722 171.7 4e-42
>>NP_002594 (OMIM: 171885) high affinity cAMP-specific 3 (456 aa)
initn: 3058 init1: 3058 opt: 3058 Z-score: 3710.6 bits: 695.8 E(85289): 6e-200
Smith-Waterman score: 3058; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456)
10 20 30 40 50 60
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL
370 380 390 400 410 420
430 440 450
pF1KE2 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
::::::::::::::::::::::::::::::::::::
NP_002 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
430 440 450
>>XP_011515842 (OMIM: 171885) PREDICTED: high affinity c (456 aa)
initn: 3058 init1: 3058 opt: 3058 Z-score: 3710.6 bits: 695.8 E(85289): 6e-200
Smith-Waterman score: 3058; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456)
10 20 30 40 50 60
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL
370 380 390 400 410 420
430 440 450
pF1KE2 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
::::::::::::::::::::::::::::::::::::
XP_011 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
430 440 450
>>NP_001229247 (OMIM: 171885) high affinity cAMP-specifi (482 aa)
initn: 2930 init1: 2930 opt: 2930 Z-score: 3555.0 bits: 667.1 E(85289): 2.8e-191
Smith-Waterman score: 2930; 99.8% identity (100.0% similar) in 438 aa overlap (19-456:45-482)
10 20 30 40
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSR
:.::::::::::::::::::::::::::::
NP_001 PVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSR
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE2 AGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLN
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE2 ILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE2 RRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDL
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE2 DHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQI
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE2 GALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSK
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE2 QWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNT
380 390 400 410 420 430
410 420 430 440 450
pF1KE2 RLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
440 450 460 470 480
>>XP_016869027 (OMIM: 171885) PREDICTED: high affinity c (448 aa)
initn: 2925 init1: 2925 opt: 2925 Z-score: 3549.5 bits: 666.0 E(85289): 5.7e-191
Smith-Waterman score: 2925; 99.8% identity (100.0% similar) in 437 aa overlap (20-456:12-448)
10 20 30 40 50 60
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
.::::::::::::::::::::::::::::::::::::::::
XP_016 MWMEHQLFQGCQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL
360 370 380 390 400 410
430 440 450
pF1KE2 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
::::::::::::::::::::::::::::::::::::
XP_016 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
420 430 440
>>XP_011534057 (OMIM: 604645) PREDICTED: cAMP-specific 3 (489 aa)
initn: 1834 init1: 1764 opt: 1851 Z-score: 2246.6 bits: 425.0 E(85289): 2.1e-118
Smith-Waterman score: 1851; 61.9% identity (86.5% similar) in 423 aa overlap (20-441:46-468)
10 20 30 40
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRA
:: : : ... ::.: . ::::.:.:...
XP_011 FSSLQAKSRKANIYSPDSLLQSPHPSSLLIKRCGEILFENPDQNAKCVCMLGDIRLRGQT
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE2 GFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNI
: ..:::::.:.::::...: . . ....::::::::...::..:: . :..
XP_011 GVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHL
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE2 LDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLR
::.:: :::. :: ::: :.::::::::::::::::.: :::. ::::..:.:::. :.
XP_011 LDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLH
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE2 RFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLD
:::::.:::::::::::::::::::::::::::::::::. .:: ::.:.:.:::.::.:
XP_011 RFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVD
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE2 HPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIG
::::::::::::::.::.::.: ::::::::::..:.:::: :..::: : :..: :.:
XP_011 HPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLG
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE2 ALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQ
.:::::::.::::.:. ...:: :: :::.. ::..::.:::::::::::: ::.:::
XP_011 SLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQ
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE2 WSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFS-NT
:::.: :::..::..:.:..: .::::... .:: .::::::.:.::::: :::.:. :.
XP_011 WSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNS
380 390 400 410 420 430
410 420 430 440 450
pF1KE2 RLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
::..::::.. :::.::.: .: :. ....
XP_011 TLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
440 450 460 470 480
>>NP_061818 (OMIM: 604645) cAMP-specific 3',5'-cyclic ph (450 aa)
initn: 1810 init1: 1740 opt: 1846 Z-score: 2241.1 bits: 423.9 E(85289): 4.3e-118
Smith-Waterman score: 1846; 61.7% identity (86.5% similar) in 423 aa overlap (20-441:7-429)
10 20 30 40 50 60
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
.: : : ... ::.: . ::::.:.:...: ..:::::.:
NP_061 MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYP
10 20 30 40
70 80 90 100 110 120
pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
.::::...: . . ....::::::::...::..:: . :..::.:: :::.
NP_061 FIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARH
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
:: ::: :.::::::::::::::::.: :::. ::::..:.:::. :.:::::.:::::
NP_061 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYH
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
::::::::::::::::::::::::::::. .:: ::.:.:.:::.::.::::::::::::
NP_061 SQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
:::.::.::.: ::::::::::..:.:::: :..::: : :..: :.:.:::::::.::
NP_061 TNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQ
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
::.:. ...:: :: :::.. ::..::.:::::::::::: ::.::::::.: :::..
NP_061 NEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYR
290 300 310 320 330 340
370 380 390 400 410
pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFS-NTRLSQTMLGHVG
::..:.:..: .::::... .:: .::::::.:.::::: :::.:. :. ::..::::..
NP_061 QGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLA
350 360 370 380 390 400
420 430 440 450
pF1KE2 LNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
:::.::.: .: :. ....
NP_061 HNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
410 420 430 440 450
>>XP_005266988 (OMIM: 604645) PREDICTED: cAMP-specific 3 (502 aa)
initn: 1784 init1: 1714 opt: 1806 Z-score: 2191.8 bits: 414.9 E(85289): 2.4e-115
Smith-Waterman score: 1806; 60.8% identity (85.4% similar) in 424 aa overlap (19-441:63-481)
10 20 30 40
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSR
.:.:: . :. : . ::.:.:..
XP_005 GCQQGPLPWDLPEMIRMVKLVWKSKSELQATKQRGIL--DNEDALRSFP---GDIRLRGQ
40 50 60 70 80
50 60 70 80 90 100
pF1KE2 AGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLN
.: ..:::::.:.::::...: . . ....::::::::...::..:: . :.
XP_005 TGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLH
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE2 ILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKL
.::.:: :::. :: ::: :.::::::::::::::::.: :::. ::::..:.:::. :
XP_005 LLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTL
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE2 RRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDL
.:::::.:::::::::::::::::::::::::::::::::. .:: ::.:.:.:::.::.
XP_005 HRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDV
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE2 DHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQI
:::::::::::::::.::.::.: ::::::::::..:.:::: :..::: : :..: :.
XP_005 DHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQL
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE2 GALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSK
:.:::::::.::::.:. ...:: :: :::.. ::..::.:::::::::::: ::.::
XP_005 GSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSK
330 340 350 360 370 380
350 360 370 380 390 400
pF1KE2 QWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFS-N
::::.: :::..::..:.:..: .::::... .:: .::::::.:.::::: :::.:. :
XP_005 QWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGN
390 400 410 420 430 440
410 420 430 440 450
pF1KE2 TRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
. ::..::::.. :::.::.: .: :. ....
XP_005 STLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
450 460 470 480 490 500
>>XP_016866230 (OMIM: 604645) PREDICTED: cAMP-specific 3 (343 aa)
initn: 1529 init1: 1459 opt: 1546 Z-score: 1879.4 bits: 356.6 E(85289): 6.1e-98
Smith-Waterman score: 1546; 67.4% identity (89.4% similar) in 322 aa overlap (121-441:1-322)
100 110 120 130 140 150
pF1KE2 YLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFH
:: ::: :.::::::::::::::::.: :
XP_016 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCH
10 20 30
160 170 180 190 200 210
pF1KE2 LFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANS
::. ::::..:.:::. :.:::::.:::::::::::::::::::::::::::::::::.
XP_016 LFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASF
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE2 VTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES
.:: ::.:.:.:::.::.:::::::::::::::.::.::.: ::::::::::..:.::::
XP_016 LTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRES
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE2 GLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQM
:..::: : :..: :.:.:::::::.::::.:. ...:: :: :::.. ::..::.
XP_016 RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQI
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE2 ALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGF
:::::::::::: ::.::::::.: :::..::..:.:..: .::::... .:: .:::::
XP_016 ALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGF
220 230 240 250 260 270
400 410 420 430 440
pF1KE2 MTYLVEPLFTEWARFS-NTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLL
:.:.::::: :::.:. :. ::..::::.. :::.::.: .: :. ....
XP_016 MSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAG
280 290 300 310 320 330
450
pF1KE2 PQENRLS
XP_016 QGTESEEQEGDSP
340
>>NP_001092289 (OMIM: 600128) cAMP-specific 3',5'-cyclic (606 aa)
initn: 581 init1: 289 opt: 740 Z-score: 897.8 bits: 175.8 E(85289): 2.9e-43
Smith-Waterman score: 740; 30.7% identity (62.4% similar) in 449 aa overlap (5-439:107-541)
10 20 30
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTA
: ::: . : . : ... .:..
NP_001 QGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLE----TLQTRHSVGEMASNKFK
80 90 100 110 120 130
40 50 60 70 80
pF1KE2 LYI-RMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEV-SVSARN----IRRLLSF
. : : . ::.: . . :. ..: .:.:.:. .:.:.. . :. ..
NP_001 RILNRELTHLSETSRSGNQVSEYISRTFLD-----QQTEVELPKVTAEEAPQPMSRISGL
140 150 160 170 180
90 100 110 120 130 140
pF1KE2 QRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLT
. .:. . ..:. ... :. . :: :: ...:..:.: .:... :...
NP_001 HGLCHSASL--SSATVPRFGVQTDQEEQLAK-ELEDTNKWGLDVFKVAELSGNRPLTAII
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE2 FHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLA
: .:. . :.. :.. : .:.:.. ::.. :::..:::::.:. : : : :
NP_001 FSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALE
250 260 270 280 290 300
210 220 230 240 250 260
pF1KE2 NSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR
: .:: .:.:.: ::.:::::.. :::.:: :: .:...::::::: . ::.
NP_001 AVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQ
310 320 330 340 350 360
270 280 290 300 310 320
pF1KE2 ESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDR------GDLCLED
. .:..: ..: ... .. ..::::.:.. . :. ... .. : : :..
NP_001 AENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDN
370 380 390 400 410 420
330 340 350 360 370 380
pF1KE2 TRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHT
: ::: ..:::. :: . : .::.... :::.::: :.. : .::.::.::
NP_001 YSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHT
430 440 450 460 470 480
390 400 410 420 430 440
pF1KE2 ESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDA
:. . :.::. :...::. :: . . .: .: . :. : . .: :. :.
NP_001 ASVEKSQVGFIDYIAHPLWETWADLVHPD-AQDLLDTLEDNRE-WYQSKIPRSPSDLTNP
490 500 510 520 530 540
450
pF1KE2 AFELNSQLLPQENRLS
NP_001 ERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLD
550 560 570 580 590 600
>>XP_011526358 (OMIM: 600128) PREDICTED: cAMP-specific 3 (606 aa)
initn: 581 init1: 289 opt: 740 Z-score: 897.8 bits: 175.8 E(85289): 2.9e-43
Smith-Waterman score: 740; 30.7% identity (62.4% similar) in 449 aa overlap (5-439:107-541)
10 20 30
pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTA
: ::: . : . : ... .:..
XP_011 QGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLE----TLQTRHSVGEMASNKFK
80 90 100 110 120 130
40 50 60 70 80
pF1KE2 LYI-RMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEV-SVSARN----IRRLLSF
. : : . ::.: . . :. ..: .:.:.:. .:.:.. . :. ..
XP_011 RILNRELTHLSETSRSGNQVSEYISRTFLD-----QQTEVELPKVTAEEAPQPMSRISGL
140 150 160 170 180
90 100 110 120 130 140
pF1KE2 QRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLT
. .:. . ..:. ... :. . :: :: ...:..:.: .:... :...
XP_011 HGLCHSASL--SSATVPRFGVQTDQEEQLAK-ELEDTNKWGLDVFKVAELSGNRPLTAII
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE2 FHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLA
: .:. . :.. :.. : .:.:.. ::.. :::..:::::.:. : : : :
XP_011 FSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALE
250 260 270 280 290 300
210 220 230 240 250 260
pF1KE2 NSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR
: .:: .:.:.: ::.:::::.. :::.:: :: .:...::::::: . ::.
XP_011 AVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQ
310 320 330 340 350 360
270 280 290 300 310 320
pF1KE2 ESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDR------GDLCLED
. .:..: ..: ... .. ..::::.:.. . :. ... .. : : :..
XP_011 AENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDN
370 380 390 400 410 420
330 340 350 360 370 380
pF1KE2 TRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHT
: ::: ..:::. :: . : .::.... :::.::: :.. : .::.::.::
XP_011 YSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHT
430 440 450 460 470 480
390 400 410 420 430 440
pF1KE2 ESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDA
:. . :.::. :...::. :: . . .: .: . :. : . .: :. :.
XP_011 ASVEKSQVGFIDYIAHPLWETWADLVHPD-AQDLLDTLEDNRE-WYQSKIPRSPSDLTNP
490 500 510 520 530 540
450
pF1KE2 AFELNSQLLPQENRLS
XP_011 ERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLD
550 560 570 580 590 600
456 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:12:52 2016 done: Tue Nov 8 17:12:53 2016
Total Scan time: 7.540 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]