Result of FASTA (omim) for
pFN21AE2588
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2588, 1143 aa
1>>>pF1KE2588 1143 - 1143 aa - 1143 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5529+/-0.000435; mu= 17.7267+/- 0.027
mean_var=174.9066+/-38.696, 0's: 0 Z-trim(115.6): 153 B-trim: 2993 in 2/54
Lambda= 0.096978
statistics sampled from 25886 (26097) to 25886 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.306), width: 16
Scan time: 11.660
The best scores are: opt bits E(85289)
NP_001239053 (OMIM: 607505) PAS domain-containing (1143) 7738 1096.5 0
XP_011509132 (OMIM: 607505) PREDICTED: PAS domain- (1330) 7573 1073.5 0
XP_011509130 (OMIM: 607505) PREDICTED: PAS domain- (1330) 7573 1073.5 0
NP_001239048 (OMIM: 607505) PAS domain-containing (1330) 7573 1073.5 0
XP_011509131 (OMIM: 607505) PREDICTED: PAS domain- (1330) 7573 1073.5 0
XP_011509128 (OMIM: 607505) PREDICTED: PAS domain- (1355) 7573 1073.5 0
NP_055963 (OMIM: 607505) PAS domain-containing ser (1323) 7526 1067.0 0
XP_016859124 (OMIM: 607505) PREDICTED: PAS domain- (1323) 7526 1067.0 0
NP_001239049 (OMIM: 607505) PAS domain-containing (1323) 7526 1067.0 0
XP_016859125 (OMIM: 607505) PREDICTED: PAS domain- (1323) 7526 1067.0 0
XP_016859123 (OMIM: 607505) PREDICTED: PAS domain- (1414) 7526 1067.0 0
XP_011509133 (OMIM: 607505) PREDICTED: PAS domain- (1144) 6234 886.1 0
XP_011509134 (OMIM: 607505) PREDICTED: PAS domain- (1137) 6187 879.5 0
XP_011509135 (OMIM: 607505) PREDICTED: PAS domain- (1114) 6126 871.0 0
XP_005247048 (OMIM: 607505) PREDICTED: PAS domain- (1107) 6079 864.4 0
NP_001239051 (OMIM: 607505) PAS domain-containing (1288) 5630 801.7 0
XP_011509136 (OMIM: 607505) PREDICTED: PAS domain- ( 944) 4652 664.7 7.5e-190
XP_011509137 (OMIM: 607505) PREDICTED: PAS domain- ( 873) 4494 642.5 3.2e-183
NP_003948 (OMIM: 609236) serine/threonine-protein ( 668) 218 44.1 0.0034
NP_001243558 (OMIM: 609236) serine/threonine-prote ( 674) 218 44.1 0.0034
XP_005253275 (OMIM: 609236) PREDICTED: serine/thre ( 720) 218 44.2 0.0035
NP_001243556 (OMIM: 609236) serine/threonine-prote ( 736) 218 44.2 0.0036
XP_006718437 (OMIM: 609236) PREDICTED: serine/thre ( 758) 218 44.2 0.0036
NP_002639 (OMIM: 164960) serine/threonine-protein ( 313) 212 42.9 0.0037
NP_001001852 (OMIM: 610580) serine/threonine-prote ( 326) 212 42.9 0.0038
XP_016874025 (OMIM: 609236) PREDICTED: serine/thre ( 858) 218 44.3 0.0039
XP_016874022 (OMIM: 609236) PREDICTED: serine/thre ( 880) 218 44.3 0.004
NP_115806 (OMIM: 609235) serine/threonine-protein ( 778) 217 44.1 0.0041
NP_001230115 (OMIM: 164960) serine/threonine-prote ( 404) 212 43.0 0.0044
>>NP_001239053 (OMIM: 607505) PAS domain-containing seri (1143 aa)
initn: 7738 init1: 7738 opt: 7738 Z-score: 5861.9 bits: 1096.5 E(85289): 0
Smith-Waterman score: 7738; 99.8% identity (99.9% similar) in 1143 aa overlap (1-1143:1-1143)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
:::
NP_001 FSL
>>XP_011509132 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa)
initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0
Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
::::::::::::::::::::::::::::::::::::::. .:
XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
>>XP_011509130 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa)
initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0
Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
::::::::::::::::::::::::::::::::::::::. .:
XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
>>NP_001239048 (OMIM: 607505) PAS domain-containing seri (1330 aa)
initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0
Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
::::::::::::::::::::::::::::::::::::::. .:
NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
NP_001 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
>>XP_011509131 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa)
initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0
Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
::::::::::::::::::::::::::::::::::::::. .:
XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
>>XP_011509128 (OMIM: 607505) PREDICTED: PAS domain-cont (1355 aa)
initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.3 bits: 1073.5 E(85289): 0
Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:26-1149)
10 20 30
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTA
:::::::::::::::::::::::::::::::::::
XP_011 MRPRAAPPPEQLLELEAWQLASLLPMEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 EPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 TDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 GYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSV
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 WMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHIT
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 DLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGY
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 RASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 YNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIR
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 KLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALG
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 REEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLER
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 MGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAG
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 LSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_011 LSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVS
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 SCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQT
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 SSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRE
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE2 SCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTP
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_011 SCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTP
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE2 VIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHS
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE2 QRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEY
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE2 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE2 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAG
1090 1100 1110 1120 1130 1140
1120 1130 1140
pF1KE2 QSRVSVNAGLGAWVRWLQRSVIHTRFSL
:::. .:
XP_011 QSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEY
1150 1160 1170 1180 1190 1200
>>NP_055963 (OMIM: 607505) PAS domain-containing serine/ (1323 aa)
initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0
Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_055 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
:::::::::::::::::::::::::::::::.
NP_055 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
NP_055 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE
1150 1160 1170 1180 1190 1200
>>XP_016859124 (OMIM: 607505) PREDICTED: PAS domain-cont (1323 aa)
initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0
Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_016 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
:::::::::::::::::::::::::::::::.
XP_016 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
XP_016 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE
1150 1160 1170 1180 1190 1200
>>NP_001239049 (OMIM: 607505) PAS domain-containing seri (1323 aa)
initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0
Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
:::::::::::::::::::::::::::::::.
NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
NP_001 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE
1150 1160 1170 1180 1190 1200
>>XP_016859125 (OMIM: 607505) PREDICTED: PAS domain-cont (1323 aa)
initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0
Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112)
10 20 30 40 50 60
pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_016 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR
:::::::::::::::::::::::::::::::.
XP_016 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF
1090 1100 1110 1120 1130 1140
pF1KE2 FSL
XP_016 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE
1150 1160 1170 1180 1190 1200
1143 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:41:19 2016 done: Tue Nov 8 16:41:21 2016
Total Scan time: 11.660 Total Display time: 0.420
Function used was FASTA [36.3.4 Apr, 2011]