Result of FASTA (omim) for
pFN21AE2535
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2535, 281 aa
1>>>pF1KE2535 281 - 281 aa - 281 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8795+/-0.000344; mu= 17.4946+/- 0.021
mean_var=62.7955+/-12.638, 0's: 0 Z-trim(113.4): 22 B-trim: 0 in 0/50
Lambda= 0.161849
statistics sampled from 22725 (22745) to 22725 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.267), width: 16
Scan time: 5.860
The best scores are: opt bits E(85289)
NP_619515 (OMIM: 602428) hyaluronan synthase 3 iso ( 281) 1873 445.8 4.1e-125
XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1634 390.2 4.4e-108
NP_005320 (OMIM: 602428) hyaluronan synthase 3 iso ( 553) 1634 390.2 4.4e-108
XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1634 390.2 4.4e-108
NP_001186209 (OMIM: 602428) hyaluronan synthase 3 ( 553) 1634 390.2 4.4e-108
NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Ho ( 552) 1041 251.8 2.1e-66
XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan ( 328) 361 92.8 8.9e-19
NP_001284365 (OMIM: 601463) hyaluronan synthase 1 ( 577) 361 93.0 1.4e-18
NP_001514 (OMIM: 601463) hyaluronan synthase 1 iso ( 578) 361 93.0 1.4e-18
>>NP_619515 (OMIM: 602428) hyaluronan synthase 3 isoform (281 aa)
initn: 1873 init1: 1873 opt: 1873 Z-score: 2367.1 bits: 445.8 E(85289): 4.1e-125
Smith-Waterman score: 1873; 100.0% identity (100.0% similar) in 281 aa overlap (1-281:1-281)
10 20 30 40 50 60
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
190 200 210 220 230 240
250 260 270 280
pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
:::::::::::::::::::::::::::::::::::::::::
NP_619 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
250 260 270 280
>>XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa)
initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108
Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246)
10 20 30 40 50 60
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
190 200 210 220 230 240
250 260 270 280
pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
::::::
XP_005 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE
250 260 270 280 290 300
>>NP_005320 (OMIM: 602428) hyaluronan synthase 3 isoform (553 aa)
initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108
Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246)
10 20 30 40 50 60
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
190 200 210 220 230 240
250 260 270 280
pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
::::::
NP_005 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE
250 260 270 280 290 300
>>XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa)
initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108
Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246)
10 20 30 40 50 60
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
190 200 210 220 230 240
250 260 270 280
pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
::::::
XP_011 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE
250 260 270 280 290 300
>>NP_001186209 (OMIM: 602428) hyaluronan synthase 3 isof (553 aa)
initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108
Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246)
10 20 30 40 50 60
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
190 200 210 220 230 240
250 260 270 280
pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
::::::
NP_001 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE
250 260 270 280 290 300
>>NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Homo s (552 aa)
initn: 764 init1: 483 opt: 1041 Z-score: 1313.0 bits: 251.8 E(85289): 2.1e-66
Smith-Waterman score: 1041; 61.8% identity (87.0% similar) in 238 aa overlap (9-246:10-243)
10 20 30 40 50
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQ
::..::.::....: :: :::..:::::.:...:.:::::::.:. ::.::
NP_005 MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 SLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVV
:::::::::.:... :. : .:::::::::::::::::::.:..:...: .:::
NP_005 SLFAFLEHRKMKKS---LETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVV
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 MVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVR
::.::: ..: ::.::: ::.: .... ..:..:::: : :::. : .:. ..: ..:
NP_005 MVIDGNSEDDLYMMDIFSEVMG-RDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 ASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVG
.. :::::::::::::::::.::: ::::.:::::::.:::: ..::..::::::.::
NP_005 SNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVG
180 190 200 210 220 230
240 250 260 270 280
pF1KE2 GVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
:::::::
NP_005 GVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFV
240 250 260 270 280 290
>>XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan synt (328 aa)
initn: 731 init1: 359 opt: 361 Z-score: 458.1 bits: 92.8 E(85289): 8.9e-19
Smith-Waterman score: 765; 50.8% identity (70.8% similar) in 250 aa overlap (10-246:21-268)
10 20 30 40
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYG
: : : ::: .:: . ::..: . . :.:::::
XP_011 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 AILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQ
:.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
XP_011 AFLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASAR
70 80 90 100 110
110 120 130 140 150 160
pF1KE2 RISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASL
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
XP_011 ALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAV
120 130 140 150 160 170
170 180 190 200 210
pF1KE2 QEGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDS
: : :. .::. :. :.:::::::::::::::::::::.:::::
XP_011 GAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDS
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 DTVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRH
:: ::: .:..:::.:::.::.:::::.
XP_011 DTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSY
240 250 260 270 280 290
>>NP_001284365 (OMIM: 601463) hyaluronan synthase 1 isof (577 aa)
initn: 731 init1: 359 opt: 361 Z-score: 454.6 bits: 93.0 E(85289): 1.4e-18
Smith-Waterman score: 765; 50.8% identity (70.8% similar) in 250 aa overlap (10-246:20-267)
10 20 30 40 50
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA
: : : ::: .:: . ::..: . . :.::::::
NP_001 MRQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR
.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
NP_001 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA
70 80 90 100 110
120 130 140 150 160
pF1KE2 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
NP_001 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG
120 130 140 150 160 170
170 180 190 200 210
pF1KE2 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD
: : :. .::. :. :.:::::::::::::::::::::.::::::
NP_001 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSD
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 TVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHV
: ::: .:..:::.:::.::.:::::.
NP_001 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF
240 250 260 270 280 290
>>NP_001514 (OMIM: 601463) hyaluronan synthase 1 isoform (578 aa)
initn: 731 init1: 359 opt: 361 Z-score: 454.6 bits: 93.0 E(85289): 1.4e-18
Smith-Waterman score: 765; 50.8% identity (70.8% similar) in 250 aa overlap (10-246:21-268)
10 20 30 40
pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYG
: : : ::: .:: . ::..: . . :.:::::
NP_001 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 AILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQ
:.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
NP_001 AFLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASAR
70 80 90 100 110
110 120 130 140 150 160
pF1KE2 RISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASL
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
NP_001 ALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAV
120 130 140 150 160 170
170 180 190 200 210
pF1KE2 QEGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDS
: : :. .::. :. :.:::::::::::::::::::::.:::::
NP_001 GAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDS
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 DTVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRH
:: ::: .:..:::.:::.::.:::::.
NP_001 DTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSY
240 250 260 270 280 290
281 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:35:10 2016 done: Tue Nov 8 03:35:11 2016
Total Scan time: 5.860 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]