Result of FASTA (omim) for
pFN21AE2528
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2528, 449 aa
1>>>pF1KE2528 449 - 449 aa - 449 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9492+/-0.00032; mu= 20.0629+/- 0.020
mean_var=65.0512+/-13.117, 0's: 0 Z-trim(115.9): 160 B-trim: 177 in 2/50
Lambda= 0.159018
statistics sampled from 26536 (26702) to 26536 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.313), width: 16
Scan time: 6.430
The best scores are: opt bits E(85289)
NP_000162 (OMIM: 138491,149400) glycine receptor s ( 449) 3026 702.8 4.7e-202
NP_001139512 (OMIM: 138491,149400) glycine recepto ( 457) 3000 696.8 3e-200
XP_016864838 (OMIM: 138491,149400) PREDICTED: glyc ( 465) 2907 675.5 8e-194
NP_001036008 (OMIM: 600421) glycine receptor subun ( 449) 2523 587.4 2.6e-167
NP_001278929 (OMIM: 138491,149400) glycine recepto ( 366) 2478 577.0 2.8e-164
NP_006520 (OMIM: 600421) glycine receptor subunit ( 464) 2387 556.2 6.5e-158
XP_016884916 (OMIM: 305990) PREDICTED: glycine rec ( 452) 2337 544.7 1.8e-154
NP_001112358 (OMIM: 305990) glycine receptor subun ( 452) 2337 544.7 1.8e-154
NP_002054 (OMIM: 305990) glycine receptor subunit ( 452) 2331 543.4 4.7e-154
NP_001112357 (OMIM: 305990) glycine receptor subun ( 452) 2331 543.4 4.7e-154
XP_011543798 (OMIM: 305990) PREDICTED: glycine rec ( 436) 2328 542.7 7.3e-154
XP_006724550 (OMIM: 305990) PREDICTED: glycine rec ( 436) 2328 542.7 7.3e-154
XP_011543797 (OMIM: 305990) PREDICTED: glycine rec ( 436) 2328 542.7 7.3e-154
XP_016864119 (OMIM: 600421) PREDICTED: glycine rec ( 424) 2299 536.0 7.2e-152
XP_016884918 (OMIM: 305990) PREDICTED: glycine rec ( 363) 2008 469.2 8e-132
NP_001165413 (OMIM: 305990) glycine receptor subun ( 363) 2008 469.2 8e-132
XP_016884917 (OMIM: 305990) PREDICTED: glycine rec ( 363) 2008 469.2 8e-132
XP_011530569 (OMIM: 600421) PREDICTED: glycine rec ( 313) 1825 427.2 3.1e-119
XP_011530570 (OMIM: 600421) PREDICTED: glycine rec ( 269) 1277 301.4 1.9e-81
NP_000815 (OMIM: 138492,614619) glycine receptor s ( 497) 1170 277.0 7.6e-74
NP_001159532 (OMIM: 138492,614619) glycine recepto ( 497) 1170 277.0 7.6e-74
XP_016863523 (OMIM: 138492,614619) PREDICTED: glyc ( 399) 991 235.9 1.5e-61
XP_016863524 (OMIM: 138492,614619) PREDICTED: glyc ( 303) 987 234.9 2.2e-61
NP_001159533 (OMIM: 138492,614619) glycine recepto ( 303) 987 234.9 2.2e-61
XP_016863472 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 983 234.1 5.8e-61
NP_000798 (OMIM: 103780,137140) gamma-aminobutyric ( 451) 983 234.1 5.8e-61
XP_016863471 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 983 234.1 5.8e-61
NP_001107647 (OMIM: 103780,137140) gamma-aminobuty ( 451) 983 234.1 5.8e-61
NP_001121115 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59
NP_000797 (OMIM: 137160,611136,615744) gamma-amino ( 456) 954 227.5 5.9e-59
NP_001121117 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59
NP_001121116 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59
NP_001121120 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59
NP_000804 (OMIM: 600232) gamma-aminobutyric acid r ( 474) 943 224.9 3.5e-58
NP_068711 (OMIM: 600232) gamma-aminobutyric acid r ( 512) 940 224.3 6e-58
NP_068712 (OMIM: 137192,612269,617113) gamma-amino ( 473) 938 223.8 7.7e-58
XP_006720522 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 936 223.3 1e-57
XP_005268315 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 936 223.3 1e-57
NP_000801 (OMIM: 137142) gamma-aminobutyric acid r ( 462) 936 223.3 1e-57
NP_001158509 (OMIM: 137142) gamma-aminobutyric aci ( 462) 936 223.3 1e-57
NP_000805 (OMIM: 137192,612269,617113) gamma-amino ( 473) 935 223.1 1.2e-57
NP_000803 (OMIM: 137190,617153) gamma-aminobutyric ( 474) 935 223.1 1.2e-57
NP_055026 (OMIM: 602729) gamma-aminobutyric acid r ( 440) 927 221.3 4.2e-57
NP_000806 (OMIM: 137163,613060) gamma-aminobutyric ( 452) 927 221.3 4.3e-57
XP_011539496 (OMIM: 137163,613060) PREDICTED: gamm ( 465) 927 221.3 4.4e-57
XP_016856425 (OMIM: 137163,613060) PREDICTED: gamm ( 687) 927 221.4 6e-57
NP_001243632 (OMIM: 137161) gamma-aminobutyric aci ( 462) 920 219.7 1.3e-56
NP_002033 (OMIM: 137161) gamma-aminobutyric acid r ( 479) 920 219.7 1.4e-56
NP_775807 (OMIM: 137166) gamma-aminobutyric acid r ( 465) 910 217.4 6.5e-56
NP_000807 (OMIM: 137164,607681,611277) gamma-amino ( 467) 905 216.2 1.5e-55
>>NP_000162 (OMIM: 138491,149400) glycine receptor subun (449 aa)
initn: 3026 init1: 3026 opt: 3026 Z-score: 3748.5 bits: 702.8 E(85289): 4.7e-202
Smith-Waterman score: 3026; 100.0% identity (100.0% similar) in 449 aa overlap (1-449:1-449)
10 20 30 40 50 60
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKEDEAGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKEDEAGEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 RFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISR
370 380 390 400 410 420
430 440
pF1KE2 IGFPMAFLIFNMFYWIIYKIVRREDVHNQ
:::::::::::::::::::::::::::::
NP_000 IGFPMAFLIFNMFYWIIYKIVRREDVHNQ
430 440
>>NP_001139512 (OMIM: 138491,149400) glycine receptor su (457 aa)
initn: 2371 init1: 2371 opt: 3000 Z-score: 3716.2 bits: 696.8 E(85289): 3e-200
Smith-Waterman score: 3000; 98.2% identity (98.2% similar) in 457 aa overlap (1-449:1-457)
10 20 30 40 50 60
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
250 260 270 280 290 300
310 320 330 340 350
pF1KE2 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHK-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 -EDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
370 380 390 400 410 420
420 430 440
pF1KE2 KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
:::::::::::::::::::::::::::::::::::::
NP_001 KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
430 440 450
>>XP_016864838 (OMIM: 138491,149400) PREDICTED: glycine (465 aa)
initn: 2907 init1: 2907 opt: 2907 Z-score: 3600.8 bits: 675.5 E(85289): 8e-194
Smith-Waterman score: 2907; 99.1% identity (99.8% similar) in 435 aa overlap (15-449:31-465)
10 20 30 40
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDK
. ..::::::::::::::::::::::::::
XP_016 MGIQPNLEPTLIKGNLYQHEKEPSLTFCSPLFLLSLAASKEAEAARSAPKPMSPSDFLDK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 LMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 EYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 ACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLR
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE2 YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 ITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLR
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE2 FRRKRRHHKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRRKRRHHKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEM
370 380 390 400 410 420
410 420 430 440
pF1KE2 RKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
430 440 450 460
>>NP_001036008 (OMIM: 600421) glycine receptor subunit a (449 aa)
initn: 2454 init1: 2111 opt: 2523 Z-score: 3124.9 bits: 587.4 E(85289): 2.6e-167
Smith-Waterman score: 2523; 83.9% identity (94.8% similar) in 441 aa overlap (9-449:14-447)
10 20 30 40 50
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDAR
.:.::. ...::.:.::...::: :::::::::::::::::::::
NP_001 MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDAR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDP
::::::::::::.::::::::::::::::::::::::::.::::::::.:::::::::::
NP_001 IRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 SMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPM
:::::::::::::::::::.:::.::::::::: .:::::::::.::::.::::::::::
NP_001 SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPM
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 DVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKF
::::::::::::::::::::::::... ::::.:::::::.:::::::::::::::::::
NP_001 DVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 TCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQS
::::.:::::::::::::::::::::::::::.:::::::::::::.:::::::::::::
NP_001 TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::.. :.:
NP_001 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKN-KDD
310 320 330 340 350
360 370 380 390 400 410
pF1KE2 EAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKI
:. :.::.:.:::::: :::::::.. :: :. . : :::.::::.::.:::::
NP_001 EVRESRFSFTAYGMGP-CLQAKDGMTPKGPNHPVQVMP-----KSPDEMRKVFIDRAKKI
360 370 380 390 400 410
420 430 440
pF1KE2 DKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
: ::: ::.::::::.:::.::::.:.::.:.:
NP_001 DTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
420 430 440
>>NP_001278929 (OMIM: 138491,149400) glycine receptor su (366 aa)
initn: 2478 init1: 2478 opt: 2478 Z-score: 3070.3 bits: 577.0 E(85289): 2.8e-164
Smith-Waterman score: 2478; 100.0% identity (100.0% similar) in 366 aa overlap (84-449:1-366)
60 70 80 90 100 110
pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL
::::::::::::::::::::::::::::::
NP_001 MDYRVNIFLRQQWNDPRLAYNEYPDDSLDL
10 20 30
120 130 140 150 160 170
pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHK
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE2 EDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAK
280 290 300 310 320 330
420 430 440
pF1KE2 KIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
::::::::::::::::::::::::::::::::::::
NP_001 KIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
340 350 360
>>NP_006520 (OMIM: 600421) glycine receptor subunit alph (464 aa)
initn: 2457 init1: 2136 opt: 2387 Z-score: 2956.0 bits: 556.2 E(85289): 6.5e-158
Smith-Waterman score: 2494; 81.3% identity (91.9% similar) in 455 aa overlap (9-449:14-462)
10 20 30 40 50
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDAR
.:.::. ...::.:.::...::: :::::::::::::::::::::
NP_006 MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDAR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDP
::::::::::::.::::::::::::::::::::::::::.::::::::.:::::::::::
NP_006 IRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 SMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPM
:::::::::::::::::::.:::.::::::::: .:::::::::.::::.::::::::::
NP_006 SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPM
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 DVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKF
::::::::::::::::::::::::... ::::.:::::::.:::::::::::::::::::
NP_006 DVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 TCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQS
::::.:::::::::::::::::::::::::::.:::::::::::::.:::::::::::::
NP_006 TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKE-
::::::::::::::::::::::::::::::::::::::::::::::::::::::... :
NP_006 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEA
310 320 330 340 350 360
360 370 380 390 400
pF1KE2 -------------DEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSP
::. :.::.:.:::::: :::::::.. :: :. . : :::
NP_006 FALEKFYRFSDMDDEVRESRFSFTAYGMGP-CLQAKDGMTPKGPNHPVQVMP-----KSP
370 380 390 400 410
410 420 430 440
pF1KE2 EEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
.::::.::.:::::: ::: ::.::::::.:::.::::.:.::.:.:
NP_006 DEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
420 430 440 450 460
>>XP_016884916 (OMIM: 305990) PREDICTED: glycine recepto (452 aa)
initn: 2236 init1: 1988 opt: 2337 Z-score: 2894.2 bits: 544.7 E(85289): 1.8e-154
Smith-Waterman score: 2337; 79.9% identity (91.5% similar) in 437 aa overlap (18-449:22-452)
10 20 30 40 50
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD
: : :. .. ::. .: .:::::::::::::::::
XP_016 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL
::::::::::::::.:::::::::::::::::::::::::::::: ::::.:::::::::
XP_016 ARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF
:::::::::::::::::::::.::..::::::::::.::.::::::.::::.::::::::
XP_016 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG
::::::: ::::::::::::::::: .: ::::.:::::::::::::.: :::::::::
XP_016 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT
::::::..::::::::::::::::::::::::::.:::::::::::::.:::::::::::
XP_016 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH
::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::..
XP_016 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR
..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..:
XP_016 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR
360 370 380 390 400 410
420 430 440
pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
::.:: ::: .::.::::::.:::: :::.:.::::..
XP_016 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
420 430 440 450
>>NP_001112358 (OMIM: 305990) glycine receptor subunit a (452 aa)
initn: 2236 init1: 1988 opt: 2337 Z-score: 2894.2 bits: 544.7 E(85289): 1.8e-154
Smith-Waterman score: 2337; 79.9% identity (91.5% similar) in 437 aa overlap (18-449:22-452)
10 20 30 40 50
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD
: : :. .. ::. .: .:::::::::::::::::
NP_001 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL
::::::::::::::.:::::::::::::::::::::::::::::: ::::.:::::::::
NP_001 ARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF
:::::::::::::::::::::.::..::::::::::.::.::::::.::::.::::::::
NP_001 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG
::::::: ::::::::::::::::: .: ::::.:::::::::::::.: :::::::::
NP_001 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT
::::::..::::::::::::::::::::::::::.:::::::::::::.:::::::::::
NP_001 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH
::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::..
NP_001 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR
..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..:
NP_001 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR
360 370 380 390 400 410
420 430 440
pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
::.:: ::: .::.::::::.:::: :::.:.::::..
NP_001 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
420 430 440 450
>>NP_002054 (OMIM: 305990) glycine receptor subunit alph (452 aa)
initn: 2230 init1: 1982 opt: 2331 Z-score: 2886.8 bits: 543.4 E(85289): 4.7e-154
Smith-Waterman score: 2331; 79.4% identity (91.5% similar) in 437 aa overlap (18-449:22-452)
10 20 30 40 50
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD
: : :. .. ::. .: .:::::::::::::::::
NP_002 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL
::::::::::::::.::::::::::..:::::::::::::::::: ::::.:::::::::
NP_002 ARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF
:::::::::::::::::::::.::..::::::::::.::.::::::.::::.::::::::
NP_002 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG
::::::: ::::::::::::::::: .: ::::.:::::::::::::.: :::::::::
NP_002 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT
::::::..::::::::::::::::::::::::::.:::::::::::::.:::::::::::
NP_002 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH
::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::..
NP_002 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR
..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..:
NP_002 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR
360 370 380 390 400 410
420 430 440
pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
::.:: ::: .::.::::::.:::: :::.:.::::..
NP_002 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
420 430 440 450
>>NP_001112357 (OMIM: 305990) glycine receptor subunit a (452 aa)
initn: 2230 init1: 1982 opt: 2331 Z-score: 2886.8 bits: 543.4 E(85289): 4.7e-154
Smith-Waterman score: 2331; 79.4% identity (91.5% similar) in 437 aa overlap (18-449:22-452)
10 20 30 40 50
pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD
: : :. .. ::. .: .:::::::::::::::::
NP_001 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL
::::::::::::::.::::::::::..:::::::::::::::::: ::::.:::::::::
NP_001 ARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF
:::::::::::::::::::::.::..::::::::::.::.::::::.::::.::::::::
NP_001 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG
::::::: ::::::::::::::::: .: ::::.:::::::::::::.: :::::::::
NP_001 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT
::::::..::::::::::::::::::::::::::.:::::::::::::.:::::::::::
NP_001 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH
::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::..
NP_001 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR
..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..:
NP_001 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR
360 370 380 390 400 410
420 430 440
pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
::.:: ::: .::.::::::.:::: :::.:.::::..
NP_001 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
420 430 440 450
449 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:28:02 2016 done: Tue Nov 8 03:28:03 2016
Total Scan time: 6.430 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]