Result of FASTA (omim) for
pFN21AE2517
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2517, 441 aa
1>>>pF1KE2517 441 - 441 aa - 441 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2396+/-0.000422; mu= 13.2176+/- 0.026
mean_var=115.6735+/-24.335, 0's: 0 Z-trim(113.7): 170 B-trim: 327 in 1/54
Lambda= 0.119250
statistics sampled from 22903 (23104) to 22903 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.271), width: 16
Scan time: 8.150
The best scores are: opt bits E(85289)
NP_003788 (OMIM: 605984) polycomb protein EED isof ( 441) 3073 540.2 4.1e-153
XP_016874001 (OMIM: 605984) PREDICTED: polycomb pr ( 403) 2777 489.2 8.3e-138
XP_011543633 (OMIM: 605984) PREDICTED: polycomb pr ( 415) 2224 394.1 3.7e-109
XP_011543632 (OMIM: 605984) PREDICTED: polycomb pr ( 428) 2224 394.1 3.8e-109
NP_001294936 (OMIM: 605984) polycomb protein EED i ( 466) 2224 394.1 4e-109
XP_016874002 (OMIM: 605984) PREDICTED: polycomb pr ( 323) 1655 296.1 9e-80
NP_001317263 (OMIM: 605984) polycomb protein EED i ( 361) 1655 296.1 9.7e-80
NP_004362 (OMIM: 601924,616414) coatomer subunit a (1224) 188 44.2 0.0023
NP_001091868 (OMIM: 601924,616414) coatomer subuni (1233) 188 44.2 0.0023
NP_001186706 (OMIM: 614784,615973) POC1 centriolar ( 436) 181 42.6 0.0024
NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 181 42.6 0.0026
NP_942593 (OMIM: 610767,611081) autophagy-related ( 444) 177 41.9 0.004
XP_005246143 (OMIM: 610767,611081) PREDICTED: auto ( 463) 177 41.9 0.0041
XP_005246141 (OMIM: 610767,611081) PREDICTED: auto ( 480) 177 42.0 0.0042
NP_001177196 (OMIM: 610767,611081) autophagy-relat ( 491) 177 42.0 0.0043
NP_001177195 (OMIM: 610767,611081) autophagy-relat ( 523) 177 42.0 0.0045
XP_006712671 (OMIM: 610767,611081) PREDICTED: auto ( 540) 177 42.0 0.0046
NP_060444 (OMIM: 610767,611081) autophagy-related ( 588) 177 42.0 0.0049
NP_110430 (OMIM: 610767,611081) autophagy-related ( 607) 177 42.0 0.005
XP_005246139 (OMIM: 610767,611081) PREDICTED: auto ( 624) 177 42.1 0.0051
XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 172 40.9 0.0057
NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 172 41.0 0.0062
NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 172 41.0 0.0063
NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 172 41.0 0.0068
NP_001269469 (OMIM: 604596) CMT1A duplicated regio ( 714) 174 41.6 0.0081
XP_016879510 (OMIM: 611679) PREDICTED: F-box/WD re ( 724) 174 41.6 0.0082
XP_011521928 (OMIM: 611679) PREDICTED: F-box/WD re ( 745) 174 41.6 0.0084
NP_006373 (OMIM: 604596) CMT1A duplicated region t ( 752) 174 41.6 0.0084
XP_016879509 (OMIM: 611679) PREDICTED: F-box/WD re ( 856) 174 41.7 0.0093
XP_011521927 (OMIM: 611679) PREDICTED: F-box/WD re ( 856) 174 41.7 0.0093
>>NP_003788 (OMIM: 605984) polycomb protein EED isoform (441 aa)
initn: 3073 init1: 3073 opt: 3073 Z-score: 2869.8 bits: 540.2 E(85289): 4.1e-153
Smith-Waterman score: 3073; 100.0% identity (100.0% similar) in 441 aa overlap (1-441:1-441)
10 20 30 40 50 60
pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
370 380 390 400 410 420
430 440
pF1KE2 DSSILIAVCDDASIWRWDRLR
:::::::::::::::::::::
NP_003 DSSILIAVCDDASIWRWDRLR
430 440
>>XP_016874001 (OMIM: 605984) PREDICTED: polycomb protei (403 aa)
initn: 2777 init1: 2777 opt: 2777 Z-score: 2595.1 bits: 489.2 E(85289): 8.3e-138
Smith-Waterman score: 2777; 100.0% identity (100.0% similar) in 399 aa overlap (1-399:1-399)
10 20 30 40 50 60
pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
:::::::::::::::::::::::::::::::::::::::
XP_016 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKANRDH
370 380 390 400
430 440
pF1KE2 DSSILIAVCDDASIWRWDRLR
>>XP_011543633 (OMIM: 605984) PREDICTED: polycomb protei (415 aa)
initn: 2223 init1: 2223 opt: 2224 Z-score: 2080.8 bits: 394.1 E(85289): 3.7e-109
Smith-Waterman score: 2552; 93.8% identity (93.8% similar) in 400 aa overlap (1-375:1-400)
10 20 30 40 50 60
pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
250 260 270 280 290 300
310 320 330
pF1KE2 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK
::::::::::::::::::::::: ::::::::::::
XP_011 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED
::::::::::::::::::::::::::::::::::::::::
XP_011 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKEYKTQRNSQEHRGWN
370 380 390 400 410
400 410 420 430 440
pF1KE2 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
>>XP_011543632 (OMIM: 605984) PREDICTED: polycomb protei (428 aa)
initn: 2223 init1: 2223 opt: 2224 Z-score: 2080.6 bits: 394.1 E(85289): 3.8e-109
Smith-Waterman score: 2717; 94.1% identity (94.1% similar) in 424 aa overlap (1-399:1-424)
10 20 30 40 50 60
pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
250 260 270 280 290 300
310 320 330
pF1KE2 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK
::::::::::::::::::::::: ::::::::::::
XP_011 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED
370 380 390 400 410 420
400 410 420 430 440
pF1KE2 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
::::
XP_011 PHKANRDH
>>NP_001294936 (OMIM: 605984) polycomb protein EED isofo (466 aa)
initn: 2223 init1: 2223 opt: 2224 Z-score: 2080.1 bits: 394.1 E(85289): 4e-109
Smith-Waterman score: 3013; 94.6% identity (94.6% similar) in 466 aa overlap (1-441:1-466)
10 20 30 40 50 60
pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
250 260 270 280 290 300
310 320 330
pF1KE2 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK
::::::::::::::::::::::: ::::::::::::
NP_001 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED
370 380 390 400 410 420
400 410 420 430 440
pF1KE2 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
430 440 450 460
>>XP_016874002 (OMIM: 605984) PREDICTED: polycomb protei (323 aa)
initn: 1677 init1: 1655 opt: 1655 Z-score: 1553.2 bits: 296.1 E(85289): 9e-80
Smith-Waterman score: 2044; 79.9% identity (79.9% similar) in 399 aa overlap (1-399:1-319)
10 20 30 40 50 60
pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
::
XP_016 SA----------------------------------------------------------
310 320 330 340 350 360
pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
::::::::::::::::::::::::::::::::::::::
XP_016 ----------------------SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
250 260 270 280
370 380 390 400 410 420
pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
:::::::::::::::::::::::::::::::::::::::
XP_016 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKANRDH
290 300 310 320
430 440
pF1KE2 DSSILIAVCDDASIWRWDRLR
>>NP_001317263 (OMIM: 605984) polycomb protein EED isofo (361 aa)
initn: 1655 init1: 1655 opt: 1655 Z-score: 1552.5 bits: 296.1 E(85289): 9.7e-80
Smith-Waterman score: 2340; 81.9% identity (81.9% similar) in 441 aa overlap (1-441:1-361)
10 20 30 40 50 60
pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
::
NP_001 SA----------------------------------------------------------
310 320 330 340 350 360
pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
::::::::::::::::::::::::::::::::::::::
NP_001 ----------------------SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
250 260 270 280
370 380 390 400 410 420
pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
290 300 310 320 330 340
430 440
pF1KE2 DSSILIAVCDDASIWRWDRLR
:::::::::::::::::::::
NP_001 DSSILIAVCDDASIWRWDRLR
350 360
>>NP_004362 (OMIM: 601924,616414) coatomer subunit alpha (1224 aa)
initn: 116 init1: 67 opt: 188 Z-score: 181.4 bits: 44.2 E(85289): 0.0023
Smith-Waterman score: 206; 22.1% identity (50.3% similar) in 308 aa overlap (155-425:58-355)
130 140 150 160 170 180
pF1KE2 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK
: . ..::.. .:. :.. : .:.
NP_004 LHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLF
30 40 50 60 70 80
190 200 210 220 230 240
pF1KE2 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY
.:: . : :: . : .::.: :...:.:: :. : : .. :: :. :..
NP_004 TLLGHLDYIRTTFFHHEYP-WILSASDDQTIRVWNWQSRTCVCVL---TGHNHYVMCAQF
90 100 110 120 130 140
250 260 270 280 290 300
pF1KE2 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF--PDFSTR
. ..: ..:.....: :.. : :.. . . ... :. : : ..
NP_004 HPTEDLVVSASLDQTVRVWDISGLR-----KKNLSPGAVESDVRGITGVDLFGTTDAVVK
150 160 170 180 190
310 320 330 340 350
pF1KE2 DIHRNYVDCVRWLG-----DLILSKSCENAIVCWKPGKMED-DIDKIKPSESNVT-----
. ... : : . ::.: . . . :. .. . ..: . .::.
NP_004 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH
200 210 220 230 240 250
360 370 380
pF1KE2 -----ILGRFDYSQCDIWYMR-------FSMD---FW-------QKMLALGNQVGKLYVW
::. . .. .: : : : :: ...: :.. : . :.
NP_004 PRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHD-GGMIVF
260 270 280 290 300 310
390 400 410 420 430 440
pF1KE2 DLEVEDPHKAKCTTLTHHKCGAAIRQTSF--SRDSSILIAVCDDASIWRWDRLR
:: : : : .. :. .:: .: :.: ...
NP_004 KLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAV
320 330 340 350 360 370
NP_004 LLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLI
380 390 400 410 420 430
>>NP_001091868 (OMIM: 601924,616414) coatomer subunit al (1233 aa)
initn: 116 init1: 67 opt: 188 Z-score: 181.4 bits: 44.2 E(85289): 0.0023
Smith-Waterman score: 206; 22.1% identity (50.3% similar) in 308 aa overlap (155-425:58-355)
130 140 150 160 170 180
pF1KE2 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK
: . ..::.. .:. :.. : .:.
NP_001 LHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLF
30 40 50 60 70 80
190 200 210 220 230 240
pF1KE2 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY
.:: . : :: . : .::.: :...:.:: :. : : .. :: :. :..
NP_001 TLLGHLDYIRTTFFHHEYP-WILSASDDQTIRVWNWQSRTCVCVL---TGHNHYVMCAQF
90 100 110 120 130 140
250 260 270 280 290 300
pF1KE2 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF--PDFSTR
. ..: ..:.....: :.. : :.. . . ... :. : : ..
NP_001 HPTEDLVVSASLDQTVRVWDISGLR-----KKNLSPGAVESDVRGITGVDLFGTTDAVVK
150 160 170 180 190
310 320 330 340 350
pF1KE2 DIHRNYVDCVRWLG-----DLILSKSCENAIVCWKPGKMED-DIDKIKPSESNVT-----
. ... : : . ::.: . . . :. .. . ..: . .::.
NP_001 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH
200 210 220 230 240 250
360 370 380
pF1KE2 -----ILGRFDYSQCDIWYMR-------FSMD---FW-------QKMLALGNQVGKLYVW
::. . .. .: : : : :: ...: :.. : . :.
NP_001 PRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHD-GGMIVF
260 270 280 290 300 310
390 400 410 420 430 440
pF1KE2 DLEVEDPHKAKCTTLTHHKCGAAIRQTSF--SRDSSILIAVCDDASIWRWDRLR
:: : : : .. :. .:: .: :.: ...
NP_001 KLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAV
320 330 340 350 360 370
NP_001 LLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLI
380 390 400 410 420 430
>>NP_001186706 (OMIM: 614784,615973) POC1 centriolar pro (436 aa)
initn: 166 init1: 82 opt: 181 Z-score: 180.9 bits: 42.6 E(85289): 0.0024
Smith-Waterman score: 181; 28.6% identity (61.6% similar) in 112 aa overlap (155-266:151-258)
130 140 150 160 170 180
pF1KE2 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK
: : : .: ::: ... . . . ..
NP_001 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY
:: :....: ..::: . : :...:.: .:.. .. :. ..:: :.....
NP_001 HYQVHSGGVNCISFHP-SGNYLITASSDGTLKILDLLEGRLIYT---LQGHTGPVFTVSF
190 200 210 220 230
250 260 270 280 290 300
pF1KE2 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI
. :: . : : : .. ::: :
NP_001 SKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEE
240 250 260 270 280 290
441 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 02:47:05 2016 done: Tue Nov 8 02:47:06 2016
Total Scan time: 8.150 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]