Result of FASTA (omim) for
pFN21AE2486
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2486, 2223 aa
1>>>pF1KE2486 2223 - 2223 aa - 2223 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.2524+/-0.000382; mu= 3.7242+/- 0.024
mean_var=272.4159+/-55.497, 0's: 0 Z-trim(122.1): 293 B-trim: 0 in 0/59
Lambda= 0.077707
statistics sampled from 39349 (39654) to 39349 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.744), E-opt: 0.2 (0.465), width: 16
Scan time: 18.660
The best scores are: opt bits E(85289)
NP_066919 (OMIM: 608230) voltage-dependent T-type (2223) 15174 1716.0 0
NP_001003406 (OMIM: 608230) voltage-dependent T-ty (2188) 11521 1306.5 0
XP_016884525 (OMIM: 608230) PREDICTED: voltage-dep (1605) 10552 1197.8 0
XP_016884524 (OMIM: 608230) PREDICTED: voltage-dep (1606) 10540 1196.4 0
XP_016884526 (OMIM: 608230) PREDICTED: voltage-dep (1593) 7674 875.1 0
NP_001243253 (OMIM: 604065,616795) voltage-depende (2314) 4827 556.1 1.8e-156
NP_938200 (OMIM: 604065,616795) voltage-dependent (2266) 4778 550.6 8e-155
NP_001243263 (OMIM: 604065,616795) voltage-depende (2194) 4749 547.3 7.4e-154
NP_938192 (OMIM: 604065,616795) voltage-dependent (2273) 4749 547.3 7.6e-154
NP_938194 (OMIM: 604065,616795) voltage-dependent (2321) 4745 546.9 1.1e-153
NP_938191 (OMIM: 604065,616795) voltage-dependent (2366) 4745 546.9 1.1e-153
NP_001243257 (OMIM: 604065,616795) voltage-depende (2259) 4476 516.7 1.2e-144
NP_001005407 (OMIM: 607904,611942,617027) voltage- (2347) 3641 423.1 1.9e-116
XP_006721028 (OMIM: 607904,611942,617027) PREDICTE (2336) 3622 421.0 8.4e-116
XP_006721027 (OMIM: 607904,611942,617027) PREDICTE (2342) 3616 420.3 1.3e-115
NP_066921 (OMIM: 607904,611942,617027) voltage-dep (2353) 3616 420.3 1.3e-115
NP_938202 (OMIM: 604065,616795) voltage-dependent (2243) 3463 403.1 1.9e-110
NP_001243256 (OMIM: 604065,616795) voltage-depende (2277) 3456 402.3 3.3e-110
NP_938190 (OMIM: 604065,616795) voltage-dependent (2171) 3434 399.9 1.7e-109
NP_938201 (OMIM: 604065,616795) voltage-dependent (2250) 3434 399.9 1.8e-109
NP_938193 (OMIM: 604065,616795) voltage-dependent (2298) 3430 399.4 2.5e-109
NP_938406 (OMIM: 604065,616795) voltage-dependent (2343) 3430 399.4 2.5e-109
NP_001243262 (OMIM: 604065,616795) voltage-depende (2205) 3228 376.8 1.6e-102
NP_938198 (OMIM: 604065,616795) voltage-dependent (2284) 3228 376.8 1.6e-102
NP_938199 (OMIM: 604065,616795) voltage-dependent (2332) 3228 376.8 1.7e-102
NP_061496 (OMIM: 604065,616795) voltage-dependent (2377) 3228 376.8 1.7e-102
NP_001243254 (OMIM: 604065,616795) voltage-depende (2291) 3223 376.2 2.4e-102
NP_001243290 (OMIM: 604065,616795) voltage-depende (2246) 2805 329.4 3e-88
NP_001243288 (OMIM: 604065,616795) voltage-depende (2257) 2805 329.4 3e-88
NP_001243259 (OMIM: 604065,616795) voltage-depende (2239) 2804 329.2 3.3e-88
NP_001243289 (OMIM: 604065,616795) voltage-depende (2248) 2804 329.3 3.3e-88
NP_001243258 (OMIM: 604065,616795) voltage-depende (2250) 2804 329.3 3.3e-88
NP_001243255 (OMIM: 604065,616795) voltage-depende (2287) 2804 329.3 3.3e-88
XP_011521029 (OMIM: 607904,611942,617027) PREDICTE (1283) 2147 255.4 3.1e-66
XP_006721031 (OMIM: 607904,611942,617027) PREDICTE (1612) 2147 255.5 3.7e-66
XP_006721030 (OMIM: 607904,611942,617027) PREDICTE (1618) 2147 255.5 3.7e-66
XP_011521026 (OMIM: 607904,611942,617027) PREDICTE (2176) 1998 238.9 5.1e-61
XP_016879308 (OMIM: 607904,611942,617027) PREDICTE (2345) 1998 238.9 5.4e-61
XP_006721026 (OMIM: 607904,611942,617027) PREDICTE (2358) 1998 238.9 5.4e-61
XP_005255709 (OMIM: 607904,611942,617027) PREDICTE (2347) 1996 238.7 6.3e-61
XP_016879310 (OMIM: 607904,611942,617027) PREDICTE (1691) 1949 233.3 1.9e-59
XP_016879309 (OMIM: 607904,611942,617027) PREDICTE (1691) 1949 233.3 1.9e-59
XP_006722224 (OMIM: 604065,616795) PREDICTED: volt (2244) 1913 229.4 3.8e-58
NP_938196 (OMIM: 604065,616795) voltage-dependent (2261) 1913 229.4 3.9e-58
NP_938197 (OMIM: 604065,616795) voltage-dependent (2306) 1913 229.4 3.9e-58
XP_006722223 (OMIM: 604065,616795) PREDICTED: volt (2268) 1908 228.8 5.7e-58
NP_001243260 (OMIM: 604065,616795) voltage-depende (2232) 1771 213.4 2.4e-53
NP_001243261 (OMIM: 604065,616795) voltage-depende (2227) 1489 181.8 7.8e-44
XP_016861142 (OMIM: 604385,615548,615552) PREDICTE (1259) 1151 143.8 1.3e-32
XP_011531623 (OMIM: 604385,615548,615552) PREDICTE (1570) 1151 143.8 1.5e-32
>>NP_066919 (OMIM: 608230) voltage-dependent T-type calc (2223 aa)
initn: 15174 init1: 15174 opt: 15174 Z-score: 9199.4 bits: 1716.0 E(85289): 0
Smith-Waterman score: 15174; 100.0% identity (100.0% similar) in 2223 aa overlap (1-2223:1-2223)
10 20 30 40 50 60
pF1KE2 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 AADEGPPRAAPLHTPHAHHVHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_066 AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
2170 2180 2190 2200 2210 2220
pF1KE2 RKR
:::
NP_066 RKR
>>NP_001003406 (OMIM: 608230) voltage-dependent T-type c (2188 aa)
initn: 11508 init1: 11508 opt: 11521 Z-score: 6986.2 bits: 1306.5 E(85289): 0
Smith-Waterman score: 14827; 98.3% identity (98.4% similar) in 2223 aa overlap (1-2223:1-2188)
10 20 30 40 50 60
pF1KE2 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ
::::::: .:::::::::::::::::
NP_001 AKEPRHY-----------------------------------QLCPQHSPLDATPHTLVQ
490 500
550 560 570 580 590 600
pF1KE2 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE2 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE
570 580 590 600 610 620
670 680 690 700 710 720
pF1KE2 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV
630 640 650 660 670 680
730 740 750 760 770 780
pF1KE2 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG
690 700 710 720 730 740
790 800 810 820 830 840
pF1KE2 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL
750 760 770 780 790 800
850 860 870 880 890 900
pF1KE2 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE2 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KE2 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KE2 AADEGPPRAAPLHTPHAHHVHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KE2 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KE2 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KE2 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KE2 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KE2 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KE2 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KE2 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KE2 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL
1470 1480 1490 1500 1510 1520
1570 1580 1590 1600 1610 1620
pF1KE2 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG
1530 1540 1550 1560 1570 1580
1630 1640 1650 1660 1670 1680
pF1KE2 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW
1590 1600 1610 1620 1630 1640
1690 1700 1710 1720 1730 1740
pF1KE2 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA
1650 1660 1670 1680 1690 1700
1750 1760 1770 1780 1790 1800
pF1KE2 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN
1710 1720 1730 1740 1750 1760
1810 1820 1830 1840 1850 1860
pF1KE2 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS
1770 1780 1790 1800 1810 1820
1870 1880 1890 1900 1910 1920
pF1KE2 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN
1830 1840 1850 1860 1870 1880
1930 1940 1950 1960 1970 1980
pF1KE2 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT
1890 1900 1910 1920 1930 1940
1990 2000 2010 2020 2030 2040
pF1KE2 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD
1950 1960 1970 1980 1990 2000
2050 2060 2070 2080 2090 2100
pF1KE2 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH
2010 2020 2030 2040 2050 2060
2110 2120 2130 2140 2150 2160
pF1KE2 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA
2070 2080 2090 2100 2110 2120
2170 2180 2190 2200 2210 2220
pF1KE2 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
2130 2140 2150 2160 2170 2180
pF1KE2 RKR
:::
NP_001 RKR
>>XP_016884525 (OMIM: 608230) PREDICTED: voltage-depende (1605 aa)
initn: 10552 init1: 10552 opt: 10552 Z-score: 6401.1 bits: 1197.8 E(85289): 0
Smith-Waterman score: 10552; 99.0% identity (99.3% similar) in 1580 aa overlap (644-2223:26-1605)
620 630 640 650 660 670
pF1KE2 QADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILE
:: :. . ::. . ::::::::::
XP_016 MGQWGDGGMVRTPTCQGHTARVGVQRGSTAALWPDRVSIPHPNAPQPEELTNILE
10 20 30 40 50
680 690 700 710 720 730
pF1KE2 ICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTF
60 70 80 90 100 110
740 750 760 770 780 790
pF1KE2 RLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTD
120 130 140 150 160 170
800 810 820 830 840 850
pF1KE2 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVL
180 190 200 210 220 230
860 870 880 890 900 910
pF1KE2 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH
240 250 260 270 280 290
920 930 940 950 960 970
pF1KE2 LDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS
300 310 320 330 340 350
980 990 1000 1010 1020 1030
pF1KE2 YYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLH
360 370 380 390 400 410
1040 1050 1060 1070 1080 1090
pF1KE2 TPHAHHVHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHED
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHED
420 430 440 450 460 470
1100 1110 1120 1130 1140 1150
pF1KE2 CNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLF
480 490 500 510 520 530
1160 1170 1180 1190 1200 1210
pF1KE2 SPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTA
540 550 560 570 580 590
1220 1230 1240 1250 1260 1270
pF1KE2 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV
600 610 620 630 640 650
1280 1290 1300 1310 1320 1330
pF1KE2 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY
660 670 680 690 700 710
1340 1350 1360 1370 1380 1390
pF1KE2 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV
720 730 740 750 760 770
1400 1410 1420 1430 1440 1450
pF1KE2 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKR
780 790 800 810 820 830
1460 1470 1480 1490 1500 1510
pF1KE2 LRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPT
840 850 860 870 880 890
1520 1530 1540 1550 1560 1570
pF1KE2 SLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEI
900 910 920 930 940 950
1580 1590 1600 1610 1620 1630
pF1KE2 NAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIY
960 970 980 990 1000 1010
1640 1650 1660 1670 1680 1690
pF1KE2 AALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH
1020 1030 1040 1050 1060 1070
1700 1710 1720 1730 1740 1750
pF1KE2 DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE
1080 1090 1100 1110 1120 1130
1760 1770 1780 1790 1800 1810
pF1KE2 MAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDS
1140 1150 1160 1170 1180 1190
1820 1830 1840 1850 1860 1870
pF1KE2 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
1200 1210 1220 1230 1240 1250
1880 1890 1900 1910 1920 1930
pF1KE2 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
1260 1270 1280 1290 1300 1310
1940 1950 1960 1970 1980 1990
pF1KE2 RSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGS
1320 1330 1340 1350 1360 1370
2000 2010 2020 2030 2040 2050
pF1KE2 WASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPAP
1380 1390 1400 1410 1420 1430
2060 2070 2080 2090 2100 2110
pF1KE2 GPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGG
1440 1450 1460 1470 1480 1490
2120 2130 2140 2150 2160 2170
pF1KE2 AGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHG
1500 1510 1520 1530 1540 1550
2180 2190 2200 2210 2220
pF1KE2 LARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
1560 1570 1580 1590 1600
>>XP_016884524 (OMIM: 608230) PREDICTED: voltage-depende (1606 aa)
initn: 8708 init1: 8640 opt: 10540 Z-score: 6393.8 bits: 1196.4 E(85289): 0
Smith-Waterman score: 10540; 98.9% identity (99.2% similar) in 1581 aa overlap (644-2223:26-1606)
620 630 640 650 660 670
pF1KE2 QADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILE
:: :. . ::. . ::::::::::
XP_016 MGQWGDGGMVRTPTCQGHTARVGVQRGSTAALWPDRVSIPHPNAPQPEELTNILE
10 20 30 40 50
680 690 700 710 720 730
pF1KE2 ICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTF
60 70 80 90 100 110
740 750 760 770 780 790
pF1KE2 RLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTD
120 130 140 150 160 170
800 810 820 830 840 850
pF1KE2 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVL
180 190 200 210 220 230
860 870 880 890 900 910
pF1KE2 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH
240 250 260 270 280 290
920 930 940 950 960 970
pF1KE2 LDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS
300 310 320 330 340 350
980 990 1000 1010 1020 1030
pF1KE2 YYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLH
360 370 380 390 400 410
1040 1050 1060 1070 1080 1090
pF1KE2 TPHAHHVHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHED
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHED
420 430 440 450 460 470
1100 1110 1120 1130 1140 1150
pF1KE2 CNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLF
480 490 500 510 520 530
1160 1170 1180 1190 1200 1210
pF1KE2 SPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTA
540 550 560 570 580 590
1220 1230 1240 1250 1260 1270
pF1KE2 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV
600 610 620 630 640 650
1280 1290 1300 1310 1320 1330
pF1KE2 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY
660 670 680 690 700 710
1340 1350 1360 1370 1380 1390
pF1KE2 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV
720 730 740 750 760 770
1400 1410 1420 1430 1440 1450
pF1KE2 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKR
780 790 800 810 820 830
1460 1470 1480 1490 1500 1510
pF1KE2 LRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPT
840 850 860 870 880 890
1520 1530 1540 1550 1560 1570
pF1KE2 SLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEI
900 910 920 930 940 950
1580 1590 1600 1610 1620 1630
pF1KE2 NAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIY
960 970 980 990 1000 1010
1640 1650 1660 1670 1680 1690
pF1KE2 AALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH
1020 1030 1040 1050 1060 1070
1700 1710 1720 1730 1740 1750
pF1KE2 DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE
1080 1090 1100 1110 1120 1130
1760 1770 1780 1790 1800 1810
pF1KE2 MAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDS
1140 1150 1160 1170 1180 1190
1820 1830 1840 1850 1860 1870
pF1KE2 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
1200 1210 1220 1230 1240 1250
1880 1890 1900 1910 1920 1930
pF1KE2 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
1260 1270 1280 1290 1300 1310
1940 1950 1960 1970 1980 1990
pF1KE2 RSWLKHDSSQA-PPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQG
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSWLKHDSSQAAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQG
1320 1330 1340 1350 1360 1370
2000 2010 2020 2030 2040 2050
pF1KE2 SWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPA
1380 1390 1400 1410 1420 1430
2060 2070 2080 2090 2100 2110
pF1KE2 PGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRG
1440 1450 1460 1470 1480 1490
2120 2130 2140 2150 2160 2170
pF1KE2 GAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAH
1500 1510 1520 1530 1540 1550
2180 2190 2200 2210 2220
pF1KE2 GLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
1560 1570 1580 1590 1600
>>XP_016884526 (OMIM: 608230) PREDICTED: voltage-depende (1593 aa)
initn: 9547 init1: 7631 opt: 7674 Z-score: 4657.4 bits: 875.1 E(85289): 0
Smith-Waterman score: 10422; 98.1% identity (98.4% similar) in 1581 aa overlap (644-2223:26-1593)
620 630 640 650 660 670
pF1KE2 QADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILE
:: :. . ::. . ::::::::::
XP_016 MGQWGDGGMVRTPTCQGHTARVGVQRGSTAALWPDRVSIPHPNAPQPEELTNILE
10 20 30 40 50
680 690 700 710 720 730
pF1KE2 ICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTF
60 70 80 90 100 110
740 750 760 770 780 790
pF1KE2 RLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTD
120 130 140 150 160 170
800 810 820 830 840 850
pF1KE2 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVL
180 190 200 210 220 230
860 870 880 890 900 910
pF1KE2 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH
240 250 260 270 280 290
920 930 940 950 960 970
pF1KE2 LDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS
300 310 320 330 340 350
980 990 1000 1010 1020 1030
pF1KE2 YYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLH
360 370 380 390 400 410
1040 1050 1060 1070 1080 1090
pF1KE2 TPHAHHVHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHED
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHED
420 430 440 450 460 470
1100 1110 1120 1130 1140 1150
pF1KE2 CNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLF
480 490 500 510 520 530
1160 1170 1180 1190 1200 1210
pF1KE2 SPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTA
540 550 560 570 580 590
1220 1230 1240 1250 1260 1270
pF1KE2 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV
600 610 620 630 640 650
1280 1290 1300 1310 1320 1330
pF1KE2 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY
660 670 680 690 700 710
1340 1350 1360 1370 1380 1390
pF1KE2 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV
720 730 740 750 760 770
1400 1410 1420 1430 1440 1450
pF1KE2 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKR
780 790 800 810 820 830
1460 1470 1480 1490 1500 1510
pF1KE2 LRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPT
840 850 860 870 880 890
1520 1530 1540 1550 1560 1570
pF1KE2 SLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEI
900 910 920 930 940 950
1580 1590 1600 1610 1620 1630
pF1KE2 NAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIY
960 970 980 990 1000 1010
1640 1650 1660 1670 1680 1690
pF1KE2 AALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH
1020 1030 1040 1050 1060 1070
1700 1710 1720 1730 1740 1750
pF1KE2 DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE
1080 1090 1100 1110 1120 1130
1760 1770 1780 1790 1800 1810
pF1KE2 MAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDS
::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 MAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQ-------------DS
1140 1150 1160 1170 1180
1820 1830 1840 1850 1860 1870
pF1KE2 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
1190 1200 1210 1220 1230 1240
1880 1890 1900 1910 1920 1930
pF1KE2 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
1250 1260 1270 1280 1290 1300
1940 1950 1960 1970 1980 1990
pF1KE2 RSWLKHDSSQA-PPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQG
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSWLKHDSSQAAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQG
1310 1320 1330 1340 1350 1360
2000 2010 2020 2030 2040 2050
pF1KE2 SWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPA
1370 1380 1390 1400 1410 1420
2060 2070 2080 2090 2100 2110
pF1KE2 PGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRG
1430 1440 1450 1460 1470 1480
2120 2130 2140 2150 2160 2170
pF1KE2 GAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAH
1490 1500 1510 1520 1530 1540
2180 2190 2200 2210 2220
pF1KE2 GLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
1550 1560 1570 1580 1590
>>NP_001243253 (OMIM: 604065,616795) voltage-dependent T (2314 aa)
initn: 6347 init1: 3044 opt: 4827 Z-score: 2930.2 bits: 556.1 E(85289): 1.8e-156
Smith-Waterman score: 6824; 53.0% identity (68.8% similar) in 2343 aa overlap (73-2193:75-2314)
50 60 70 80 90 100
pF1KE2 DGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPC
.. ::::::: .::::::::::::::..::
NP_001 DSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPC
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 DDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGM
.:. : :.::.:::.:::::: :::.:::.::::::::::::::::::::::::::.:::
NP_001 EDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 VEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFI
.::::::::...::.:::::::::.::::::::::::.::::::::::::::::::::::
NP_001 LEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 FGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHE
:::.::::::::::::::: :::.. .: : ::: :..:: ::::: .::. .:.
NP_001 FGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRS
230 240 250 260 270 280
290 300 310 320 330
pF1KE2 IPPLKEQGR---ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN
.: :. .: : : :. : .. :.. :::::.::. : .: :: :::::
NP_001 VPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQYYTNCSAGEHNPFKGAIN
290 300 310 320 330
340 350 360 370 380 390
pF1KE2 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
:::::::::.:::::::::::.:::.::::::::::::::::::::::::::::::::::
NP_001 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 QFSETKQREHRLMLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRR------
::::::::: .:: ::: :.::. ::.::..:::.::::...:. .::::: ::
NP_001 QFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSR
400 410 420 430 440 450
460 470 480 490
pF1KE2 ALGLYQALQSRRQALGPEAPAPAKPGPHAKE-----------PRHYHGKTKGQGD-----
: :. .: : :: . :.. .... .:.: :.:
NP_001 AAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPR
460 470 480 490 500 510
500 510 520
pF1KE2 -----EGRHL-GSRHCQTLHGPASP---GNDHSGREL--------C----------PQHS
. : :::. . : :..: : .: : : : .:
NP_001 ASPEIQDRDANGSRRLM-LPPPSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRS
520 530 540 550 560 570
530 540 550
pF1KE2 PLDAT----------PHTLVQPIPATL----------ASDPA------------------
: .:. : . ..: : :: .: :
NP_001 PSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKL
580 590 600 610 620 630
560 570 580 590
pF1KE2 ----SCPCCQHEDGRRPSGLGSTDSGQEGSGSG---SSAG-GEDE-ADGDGARS------
: :: . . : ..::: : : . :: :: : :: . :
NP_001 LETQSTGACQS-SCKISSPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVY
640 650 660 670 680 690
600 610 620 630 640 650
pF1KE2 --SEDGASSELGKEEEEEEQADGAVWLCGDV---WRETRAKLRGIVDSKYFNRGIMMAIL
..:. :.: . ..... : ..: :: .: :::::::.::::.:::
NP_001 EFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAIL
700 710 720 730 740 750
660 670 680 690 700 710
pF1KE2 VNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSII
:::.:::::.::::::::: ::: :.::::.:::::.::: ..: : :..:::::::..:
NP_001 VNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 VIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLML
:.::.:::::: :::::::::::.::::::::.:::.::::::::::::::::::::::
NP_001 VVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLML
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 FIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM
:::::::::::.:::::. . : :::.:::::::::::::::::::::::::: ::::::
NP_001 FIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM
880 890 900 910 920 930
840 850 860 870 880
pF1KE2 ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEG-----DANRSYS------DEDQ
:::: ::.:::.::::::::::::::::::::::::: ::. . : : .
NP_001 ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQG
940 950 960 970 980 990
890 900 910 920 930
pF1KE2 SSSNIEEF--DKLQEGLDSSGDPKLCP--IPMTPNGHLDPSL--PLGGHLGPAGAAGPAP
...: : : .. .::..:: : : . . . .: :: :: : :: :
NP_001 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT----AATPMS
1000 1010 1020 1030 1040
940 950 960 970 980 990
pF1KE2 RLSLQPDPMLVALG--SRKSSVMSLGR--MSYDQRSLSSSRSSYYGPWGRSAAWASRRSS
. . ::: ::..: . .. .....: :.::: ..::. ...:.:::::
NP_001 LPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS
1050 1060 1070 1080 1090 1100
1000 1010 1020 1030 1040
pF1KE2 WNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHVHHGP
::: :.. ::.:..::::.: : .. : ...: ::.: . :
NP_001 RNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH--------
1110 1120 1130 1140 1150
1050 1060 1070 1080 1090 1100
pF1KE2 HLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKD
.:: .: . ..: :: . . . : : :. : : : :.::::. :
NP_001 -------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLA
1160 1170 1180 1190 1200
1110 1120 1130 1140 1150 1160
pF1KE2 VFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLC
. : :.: ..: . . ::: : . : : :..::.:.: :..:::.::
NP_001 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLC
1210 1220 1230 1240 1250 1260
1170 1180 1190 1200 1210 1220
pF1KE2 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV
. ::.::.::.:::..:::::::::.:::.:. :.::::::.:::::::.:..:::.::
NP_001 HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKV
1270 1280 1290 1300 1310 1320
1230 1240 1250 1260 1270 1280
pF1KE2 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL
:.:: ::::::::::::::::.::..:.:::.::..: .:.::::.:::::::::::::
NP_001 VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPL
1330 1340 1350 1360 1370 1380
1290 1300 1310 1320 1330 1340
pF1KE2 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI
:::::: :::::::::.::::::::::.:::::::::::::::::::::. : : :::::
NP_001 RVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNI
1390 1400 1410 1420 1430 1440
1350 1360 1370 1380 1390 1400
pF1KE2 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
::.::: :.::::.:::::::::::::::::::::::::.:::.:::::.:::::. ::
NP_001 TNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH
1450 1460 1470 1480 1490 1500
1410 1420 1430 1440 1450 1460
pF1KE2 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRK
:::::::::::::::.::::::::::::::::::::::: ::::::::::::::::::::
NP_001 NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRK
1510 1520 1530 1540 1550 1560
1470 1480 1490 1500 1510 1520
pF1KE2 AQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCN
:: :::. : . :::.: .:::::::.::: .: ::::::..:::.:: :. ::: ::
NP_001 AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICN
1570 1580 1590 1600 1610 1620
1530 1540 1550 1560 1570 1580
pF1KE2 YMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTI
:.::..::::.:.::::::.::::.::::::::::::::.:::::::::.::.:::::::
NP_001 YIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI
1630 1640 1650 1660 1670 1680
1590 1600 1610 1620 1630 1640
pF1KE2 IRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK
:::::::::::::::::::.:::::::::.:::::::::::::::::::.:::::::::
NP_001 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD
1690 1700 1710 1720 1730 1740
1650 1660 1670 1680 1690 1700
pF1KE2 LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQ
: :.. .::::..:::::.::::::::::.:::::::::::::::::: . : .: ...
NP_001 LECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQ-ESTCYNTV-
1750 1760 1770 1780 1790 1800
1710 1720 1730 1740 1750 1760
pF1KE2 FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPR
.::.:::::::::::::.:::.:::::::..:::::.:.::..::::::: . :.: :.
NP_001 -ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPH
1810 1820 1830 1840 1850 1860
1770 1780 1790 1800 1810
pF1KE2 LPTGSPGA-PG-RGPGGAGGG--GDTEGGLCRRCYS------PAQENLWLDSVSLIIKDS
: ::: :: .:: . . : . . : : :....:. :..::.:. :
NP_001 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTISLLIQGS
1870 1880 1890 1900 1910 1920
1820 1830 1840 1850 1860 1870
pF1KE2 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
:: :: ..:.:.: :.: . :: :. : :.:
NP_001 LEWELKLMDELAG--------PGG--------------QPSAFP-----SAPSLGGSD--
1930 1940 1950
1880 1890 1900 1910 1920 1930
pF1KE2 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
: . :: :. . : : .: : :. ....:. .:.
NP_001 --------PQMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGPL
1960 1970 1980 1990 2000
1940 1950 1960 1970 1980
pF1KE2 --RSW-LKHDSSQAPPSPFS-PDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIA
:.: : . .: . : : : .: .: .: . : :... ::.::.
NP_001 GHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTIPKLP
2010 2020 2030 2040 2050
1990 2000 2010 2020 2030
pF1KE2 LQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLEDS
: ::: .. : :::. ::: ..:: . . .:
NP_001 PPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQS
2060 2070 2080 2090 2100 2110
2040 2050 2060 2070
pF1KE2 LTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL-------RG-------
: ... :. . :::: :::. . . : .: : : :
NP_001 STQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGG
2120 2130 2140 2150 2160 2170
2080 2090 2100 2110
pF1KE2 -------RGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEGR
: : . ...:. :: :: . : . : : . :::.
NP_001 QEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNL---
2180 2190 2200 2210 2220
2120 2130 2140 2150 2160
pF1KE2 GGAGGGGAGSEHSETLSSLSLTSLFCPPP---P--PPAPGLTPARKFSSTSSLAAPGRPH
:: :: ::. .. :: :.: . :: : ::.::. :. :..: :
NP_001 GGQPLGGPGSRPKKKLSPPSIT--IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL
2230 2240 2250 2260 2270 2280
2170 2180 2190 2200 2210 2220
pF1KE2 AAALAHGLARSPSWAADR------SKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
:.. ..: ::: : :.:: :
NP_001 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
2290 2300 2310
pF1KE2 RKR
>>NP_938200 (OMIM: 604065,616795) voltage-dependent T-ty (2266 aa)
initn: 6347 init1: 3044 opt: 4778 Z-score: 2900.6 bits: 550.6 E(85289): 8e-155
Smith-Waterman score: 6746; 53.2% identity (69.7% similar) in 2278 aa overlap (73-2193:75-2266)
50 60 70 80 90 100
pF1KE2 DGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPC
.. ::::::: .::::::::::::::..::
NP_938 DSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPC
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 DDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGM
.:. : :.::.:::.:::::: :::.:::.::::::::::::::::::::::::::.:::
NP_938 EDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 VEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFI
.::::::::...::.:::::::::.::::::::::::.::::::::::::::::::::::
NP_938 LEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 FGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHE
:::.::::::::::::::: :::.. .: : ::: :..:: ::::: .::. .:.
NP_938 FGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRS
230 240 250 260 270 280
290 300 310 320 330
pF1KE2 IPPLKEQGR---ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN
.: :. .: : : :. : .. :.. :::::.::. : .: :: :::::
NP_938 VPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQYYTNCSAGEHNPFKGAIN
290 300 310 320 330
340 350 360 370 380 390
pF1KE2 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
:::::::::.:::::::::::.:::.::::::::::::::::::::::::::::::::::
NP_938 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 QFSETKQREHRLMLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRR------
::::::::: .:: ::: :.::. ::.::..:::.::::...:. .::::: ::
NP_938 QFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSR
400 410 420 430 440 450
460 470 480 490
pF1KE2 ALGLYQALQSRRQALGPEAPAPAKPGPHAKE-----------PRHYHGKTKGQGD-----
: :. .: : :: . :.. .... .:.: :.:
NP_938 AAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPR
460 470 480 490 500 510
500 510 520
pF1KE2 -----EGRHL-GSRHCQTLHGPASP---GNDHSGREL--------C----------PQHS
. : :::. . : :..: : .: : : : .:
NP_938 ASPEIQDRDANGSRRLM-LPPPSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRS
520 530 540 550 560 570
530 540 550
pF1KE2 PLDAT----------PHTLVQPIPATL----------ASDPA------------------
: .:. : . ..: : :: .: :
NP_938 PSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKL
580 590 600 610 620 630
560 570 580 590
pF1KE2 ----SCPCCQHEDGRRPSGLGSTDSGQEGSGSG---SSAG-GEDE-ADGDGARS------
: :: . . : ..::: : : . :: :: : :: . :
NP_938 LETQSTGACQS-SCKISSPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVY
640 650 660 670 680 690
600 610 620 630 640 650
pF1KE2 --SEDGASSELGKEEEEEEQADGAVWLCGDV---WRETRAKLRGIVDSKYFNRGIMMAIL
..:. :.: . ..... : ..: :: .: :::::::.::::.:::
NP_938 EFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAIL
700 710 720 730 740 750
660 670 680 690 700 710
pF1KE2 VNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSII
:::.:::::.::::::::: ::: :.::::.:::::.::: ..: : :..:::::::..:
NP_938 VNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 VIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLML
:.::.:::::: :::::::::::.::::::::.:::.::::::::::::::::::::::
NP_938 VVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLML
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 FIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM
:::::::::::.:::::. . : :::.:::::::::::::::::::::::::: ::::::
NP_938 FIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM
880 890 900 910 920 930
840 850 860 870 880
pF1KE2 ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEG-----DANRSYS------DEDQ
:::: ::.:::.::::::::::::::::::::::::: ::. . : : .
NP_938 ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQG
940 950 960 970 980 990
890 900 910 920 930
pF1KE2 SSSNIEEF--DKLQEGLDSSGDPKLCP--IPMTPNGHLDPSL--PLGGHLGPAGAAGPAP
...: : : .. .::..:: : : . . . .: :: :: : :: :
NP_938 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT----AATPMS
1000 1010 1020 1030 1040
940 950 960 970 980 990
pF1KE2 RLSLQPDPMLVALG--SRKSSVMSLGR--MSYDQRSLSSSRSSYYGPWGRSAAWASRRSS
. . ::: ::..: . .. .....: :.::: ..::. ...:.:::::
NP_938 LPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS
1050 1060 1070 1080 1090 1100
1000 1010 1020 1030 1040
pF1KE2 WNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHVHHGP
::: :.. ::.:..::::.: : .. : ...: ::.: . :
NP_938 RNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH--------
1110 1120 1130 1140 1150
1050 1060 1070 1080 1090 1100
pF1KE2 HLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKD
.:: .: . ..: :: . . . : : :. : : : :.::::. :
NP_938 -------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLA
1160 1170 1180 1190 1200
1110 1120 1130 1140 1150 1160
pF1KE2 VFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLC
. : :.: ..: . . ::: : . : : :..::.:.: :..:::.::
NP_938 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLC
1210 1220 1230 1240 1250 1260
1170 1180 1190 1200 1210 1220
pF1KE2 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV
. ::.::.::.:::..:::::::::.:::.:. :.::::::.:::::::.:..:::.::
NP_938 HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKV
1270 1280 1290 1300 1310 1320
1230 1240 1250 1260 1270 1280
pF1KE2 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL
:.:: ::::::::::::::::.::..:.:::.::..: .:.::::.:::::::::::::
NP_938 VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPL
1330 1340 1350 1360 1370 1380
1290 1300 1310 1320 1330 1340
pF1KE2 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI
:::::: :::::::::.::::::::::.:::::::::::::::::::::. : : :::::
NP_938 RVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNI
1390 1400 1410 1420 1430 1440
1350 1360 1370 1380 1390 1400
pF1KE2 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
::.::: :.::::.:::::::::::::::::::::::::.:::.:::::.:::::. ::
NP_938 TNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH
1450 1460 1470 1480 1490 1500
1410 1420 1430 1440 1450 1460
pF1KE2 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRK
:::::::::::::::.::::::::::::::::::::::: ::::::::::::::::::::
NP_938 NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRK
1510 1520 1530 1540 1550 1560
1470 1480 1490 1500 1510 1520
pF1KE2 AQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCN
:: :::. : . :::.: .:::::::.::: .: ::::::..:::.:: :. ::: ::
NP_938 AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICN
1570 1580 1590 1600 1610 1620
1530 1540 1550 1560 1570 1580
pF1KE2 YMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTI
:.::..::::.:.::::::.::::.::::::::::::::.:::::::::.::.:::::::
NP_938 YIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI
1630 1640 1650 1660 1670 1680
1590 1600 1610 1620 1630 1640
pF1KE2 IRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK
:::::::::::::::::::.:::::::::.:::::::::::::::::::.:::::::::
NP_938 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD
1690 1700 1710 1720 1730 1740
1650 1660 1670 1680 1690 1700
pF1KE2 LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQ
: :.. .::::..:::::.::::::::::.:::::::::::::::::: . : .: ...
NP_938 LECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQ-ESTCYNTV-
1750 1760 1770 1780 1790 1800
1710 1720 1730 1740 1750 1760
pF1KE2 FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPR
.::.:::::::::::::.:::.:::::::..:::::.:.::..::::::: . :.: :.
NP_938 -ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPH
1810 1820 1830 1840 1850 1860
1770 1780 1790 1800 1810 1820
pF1KE2 LPTGSPGA-PG-RGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDS-LEGELTI
: ::: :: .:: . . :.: .. . .. :. .. . . : : .
NP_938 SPLGSPFLWPGVEGPDSPDS--PKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLL
1870 1880 1890 1900 1910 1920
1830 1840 1850 1860 1870 1880
pF1KE2 IDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTAC
:: . . .: : :.: . ....: . .:.:.: . : .
NP_938 TVRKSG-VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQP-ADTSYI
1930 1940 1950 1960 1970 1980
1890 1900 1910 1920 1930 1940
pF1KE2 PPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHD
::. :.: : . . : . :: . : .. : . . ..
NP_938 LQLPKDAPHLLQPHSAPTWGTIPK----LPPPGRSPLAQRPLRRQAAIRTDSLD--VQGL
1990 2000 2010 2020 2030
1950 1960 1970 1980 1990 2000
pF1KE2 SSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSP
.:. . ..:.: :. . . :..: .. . . ::. . .:
NP_938 GSRE---DLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHS----KISKH------MTP
2040 2050 2060 2070 2080
2010 2020 2030 2040 2050
pF1KE2 RVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPA---PAPGPRA
. : : . . .: . .::. : : .: : ::. :.::
NP_938 PAPC------PGPEPNWGKGPPETRSSLELDTELSWISGD-----LLPPGGQEEPPSPRD
2090 2100 2110 2120 2130
2060 2070 2080 2090 2100 2110
pF1KE2 GLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGST-SPGCTHHDSMDPSDEEGRGGAGG
. . . : . : : .:: :: . : . : : . :::. ::
NP_938 LKKCYSVEAQSCQRRPTSWLD----EQRRHSIAVSCLDSGSQPHLGTDPSNL---GGQPL
2140 2150 2160 2170 2180
2120 2130 2140 2150 2160 2170
pF1KE2 GGAGSEHSETLSSLSLTSLFCPPP---P--PPAPGLTPARKFSSTSSLAAPGRPHAAALA
:: ::. .. :: :.: . :: : ::.::. :. :..: : :..
NP_938 GGPGSRPKKKLSPPSIT--IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPLASGPP
2190 2200 2210 2220 2230
2180 2190 2200 2210 2220
pF1KE2 HGLARSPSWAADR------SKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
..: ::: : :.:: :
NP_938 DSMAASPSPKKDVLSLSGLSSDPADLDP
2240 2250 2260
>>NP_001243263 (OMIM: 604065,616795) voltage-dependent T (2194 aa)
initn: 5248 init1: 1799 opt: 4749 Z-score: 2883.2 bits: 547.3 E(85289): 7.4e-154
Smith-Waterman score: 6691; 53.6% identity (68.8% similar) in 2285 aa overlap (73-2193:75-2194)
50 60 70 80 90 100
pF1KE2 DGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPC
.. ::::::: .::::::::::::::..::
NP_001 DSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPC
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 DDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGM
.:. : :.::.:::.:::::: :::.:::.::::::::::::::::::::::::::.:::
NP_001 EDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 VEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFI
.::::::::...::.:::::::::.::::::::::::.::::::::::::::::::::::
NP_001 LEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 FGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHE
:::.::::::::::::::: :::.. .: : ::: :..:: ::::: .::. .:.
NP_001 FGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRS
230 240 250 260 270 280
290 300 310 320 330
pF1KE2 IPPLKEQGR---ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN
.: :. .: : : :. : .. :.. :::::.::. : .: :: :::::
NP_001 VPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQYYTNCSAGEHNPFKGAIN
290 300 310 320 330
340 350 360 370 380 390
pF1KE2 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
:::::::::.:::::::::::.:::.::::::::::::::::::::::::::::::::::
NP_001 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 QFSETKQREHRLMLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRR------
::::::::: .:: ::: :.::. ::.::..:::.::::...:. .::::: ::
NP_001 QFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSR
400 410 420 430 440 450
460 470 480 490
pF1KE2 ALGLYQALQSRRQALGPEAPAPAKPGPHAKE-----------PRHYHGKTKGQGD-----
: :. .: : :: . :.. .... .:.: :.:
NP_001 AAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPR
460 470 480 490 500 510
500 510 520
pF1KE2 -----EGRHL-GSRHCQTLHGPASP---GNDHSGREL--------C----------PQHS
. : :::. . : :..: : .: : : : .:
NP_001 ASPEIQDRDANGSRRLM-LPPPSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRS
520 530 540 550 560 570
530 540 550
pF1KE2 PLDAT----------PHTLVQPIPATL----------ASDPA------------------
: .:. : . ..: : :: .: :
NP_001 PSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKL
580 590 600 610 620 630
560 570 580 590
pF1KE2 ----SCPCCQHEDGRRPSGLGSTDSGQEGSGSG---SSAG-GEDE-ADGDGARS------
: :: . . : ..::: : : . :: :: : :: . :
NP_001 LETQSTGACQS-SCKISSPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVY
640 650 660 670 680 690
600 610 620 630 640 650
pF1KE2 --SEDGASSELGKEEEEEEQADGAVWLCGDV---WRETRAKLRGIVDSKYFNRGIMMAIL
..:. :.: . ..... : ..: :: .: :::::::.::::.:::
NP_001 EFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAIL
700 710 720 730 740 750
660 670 680 690 700 710
pF1KE2 VNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSII
:::.:::::.::::::::: ::: :.::::.:::::.::: ..: : :..:::::::..:
NP_001 VNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 VIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLML
:.::.:::::: :::::::::::.::::::::.:::.::::::::::::::::::::::
NP_001 VVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLML
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 FIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM
:::::::::::.:::::. . : :::.:::::::::::::::::::::::::: ::::::
NP_001 FIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM
880 890 900 910 920 930
840 850 860 870 880
pF1KE2 ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEG-----DANRSYS------DEDQ
:::: ::.:::.::::::::::::::::::::::::: ::. . : : .
NP_001 ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQG
940 950 960 970 980 990
890 900 910 920 930
pF1KE2 SSSNIEEF--DKLQEGLDSSGDPKLCP--IPMTPNGHLDPSL--PLGGHLGPAGAAGPAP
...: : : .. .::..:: : : . . . .: :: :: : :: :
NP_001 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT----AATPMS
1000 1010 1020 1030 1040
940 950 960 970 980 990
pF1KE2 RLSLQPDPMLVALG--SRKSSVMSLGR--MSYDQRSLSSSRSSYYGPWGRSAAWASRRSS
. . ::: ::..: . .. .....: :.::: ..::. ...:.:::::
NP_001 LPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS
1050 1060 1070 1080 1090 1100
1000 1010 1020 1030 1040
pF1KE2 WNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHVHHGP
::: :.. ::.:..::::.: : .. : ...: ::.: . :
NP_001 RNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH--------
1110 1120 1130 1140 1150
1050 1060 1070 1080 1090 1100
pF1KE2 HLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKD
.:: .: . ..: :: . . . : : :. : : : :.::::. :
NP_001 -------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLA
1160 1170 1180 1190 1200
1110 1120 1130 1140 1150 1160
pF1KE2 VFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLC
. : :.: ..: . . ::: : . : : :..::.:.: :..:::.::
NP_001 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLC
1210 1220 1230 1240 1250 1260
1170 1180 1190 1200 1210 1220
pF1KE2 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV
. ::.::.::.:::..:::::::::.:::.:. :.::::::.:::::::.:..:::.::
NP_001 HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKV
1270 1280 1290 1300 1310 1320
1230 1240 1250 1260 1270 1280
pF1KE2 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL
:.:: ::::::::::::::::.::..:.:::.::..: .:.::::.:::::::::::::
NP_001 VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPL
1330 1340 1350 1360 1370 1380
1290 1300 1310 1320 1330 1340
pF1KE2 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI
:::::: :::::::::.::::::::::.:::::::::::::::::::::. : : :::::
NP_001 RVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNI
1390 1400 1410 1420 1430 1440
1350 1360 1370 1380 1390 1400
pF1KE2 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
::.::: :.::::.:::::::::::::::::::::::::.:::.:::::.:::::. ::
NP_001 TNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH
1450 1460 1470 1480 1490 1500
1410 1420 1430 1440 1450 1460
pF1KE2 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-
:::::::::::::::.::::::::::::::::::::::: :::::::::::::::::::
NP_001 NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS
1510 1520 1530 1540 1550 1560
1470 1480 1490 1500 1510
pF1KE2 ------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLE
.:: :::. : . :::.: .:::::::.::: .: ::::::..:::.:: :.
NP_001 KEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD
1570 1580 1590 1600 1610 1620
1520 1530 1540 1550 1560 1570
pF1KE2 TALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAA
::: :::.::..::::.:.::::::.::::.::::::::::::::.:::::::::.::.
NP_001 EALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS
1630 1640 1650 1660 1670 1680
1580 1590 1600 1610 1620 1630
pF1KE2 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL
::::::::::::::::::::::::::.:::::::::.:::::::::::::::::::.:::
NP_001 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL
1690 1700 1710 1720 1730 1740
1640 1650 1660 1670 1680 1690
pF1KE2 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDER
:::::: : :.. .::::..:::::.::::::::::.:::::::::::::::::: . :
NP_001 GVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQ-ES
1750 1760 1770 1780 1790 1800
1700 1710 1720 1730 1740 1750
pF1KE2 SCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAH
.: ... .::.:::::::::::::.:::.:::::::..:::::.:.::..::::::: .
NP_001 TCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-K
1810 1820 1830 1840 1850 1860
1760 1770 1780 1790 1800 1810
pF1KE2 GLGPGPRLPTGSPGA-PG-RGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSL
:.: :. : ::: :: .:: ::
NP_001 TLSPQPHSPLGSPFLWPGVEGPD-----------------SP------------------
1870 1880 1890
1820 1830 1840 1850 1860 1870
pF1KE2 EGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSL
:. . . .: ::. : ::.: .::
NP_001 -------DSPKPGALH----PAA-----H-----------------ARSAS-----HFSL
1900 1910
1880 1890 1900 1910 1920 1930
pF1KE2 EDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV-
: :: : :: :. . : : .: : :. ....:. .:.
NP_001 EHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGPLG
1920 1930 1940 1950 1960
1940 1950 1960 1970 1980 1990
pF1KE2 -RSW-LKHDSSQAPPSPFS-PDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIAL
:.: : . .: . : : : .: .: .: . : :... ::.::.
NP_001 HRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTIPKLPP
1970 1980 1990 2000 2010
2000 2010 2020 2030 2040 2050
pF1KE2 QGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPA
: ::: .. : :::. :::. .. :: :: :. . ::.
NP_001 PG-----RSPLAQRPLRRQAAIRTDSLDV---QGLGSR----EDLLAEEE-------PPS
2020 2030 2040 2050
2060 2070 2080 2090 2100
pF1KE2 PAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGST-SPGCTHHDSMDPSDEE
: . : :. : . : : .:: :: . : . : : . :::.
NP_001 PRDLKKC-YSVEAQ---SCQRRPTSWLD----EQRRHSIAVSCLDSGSQPHLGTDPSNL-
2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 GRGGAGGGGAGSEHSETLSSLSLTSLFCPPP---P--PPAPGLTPARKFSSTSSLAAPGR
:: :: ::. .. :: :.: . :: : ::.::. :. :..:
NP_001 --GGQPLGGPGSRPKKKLSPPSIT--IDPPESQGPRTPPSPGICLRRRAPSSDS----KD
2110 2120 2130 2140 2150
2170 2180 2190 2200 2210
pF1KE2 PHAAALAHGLARSPSWAADR------SKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAA
: :.. ..: ::: : :.:: :
NP_001 PLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
2160 2170 2180 2190
2220
pF1KE2 SKRKR
>>NP_938192 (OMIM: 604065,616795) voltage-dependent T-ty (2273 aa)
initn: 5248 init1: 1799 opt: 4749 Z-score: 2883.0 bits: 547.3 E(85289): 7.6e-154
Smith-Waterman score: 6717; 53.0% identity (69.5% similar) in 2285 aa overlap (73-2193:75-2273)
50 60 70 80 90 100
pF1KE2 DGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPC
.. ::::::: .::::::::::::::..::
NP_938 DSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPC
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 DDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGM
.:. : :.::.:::.:::::: :::.:::.::::::::::::::::::::::::::.:::
NP_938 EDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 VEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFI
.::::::::...::.:::::::::.::::::::::::.::::::::::::::::::::::
NP_938 LEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 FGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHE
:::.::::::::::::::: :::.. .: : ::: :..:: ::::: .::. .:.
NP_938 FGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRS
230 240 250 260 270 280
290 300 310 320 330
pF1KE2 IPPLKEQGR---ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN
.: :. .: : : :. : .. :.. :::::.::. : .: :: :::::
NP_938 VPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQYYTNCSAGEHNPFKGAIN
290 300 310 320 330
340 350 360 370 380 390
pF1KE2 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
:::::::::.:::::::::::.:::.::::::::::::::::::::::::::::::::::
NP_938 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 QFSETKQREHRLMLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRR------
::::::::: .:: ::: :.::. ::.::..:::.::::...:. .::::: ::
NP_938 QFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSR
400 410 420 430 440 450
460 470 480 490
pF1KE2 ALGLYQALQSRRQALGPEAPAPAKPGPHAKE-----------PRHYHGKTKGQGD-----
: :. .: : :: . :.. .... .:.: :.:
NP_938 AAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPR
460 470 480 490 500 510
500 510 520
pF1KE2 -----EGRHL-GSRHCQTLHGPASP---GNDHSGREL--------C----------PQHS
. : :::. . : :..: : .: : : : .:
NP_938 ASPEIQDRDANGSRRLM-LPPPSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRS
520 530 540 550 560 570
530 540 550
pF1KE2 PLDAT----------PHTLVQPIPATL----------ASDPA------------------
: .:. : . ..: : :: .: :
NP_938 PSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKL
580 590 600 610 620 630
560 570 580 590
pF1KE2 ----SCPCCQHEDGRRPSGLGSTDSGQEGSGSG---SSAG-GEDE-ADGDGARS------
: :: . . : ..::: : : . :: :: : :: . :
NP_938 LETQSTGACQS-SCKISSPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVY
640 650 660 670 680 690
600 610 620 630 640 650
pF1KE2 --SEDGASSELGKEEEEEEQADGAVWLCGDV---WRETRAKLRGIVDSKYFNRGIMMAIL
..:. :.: . ..... : ..: :: .: :::::::.::::.:::
NP_938 EFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAIL
700 710 720 730 740 750
660 670 680 690 700 710
pF1KE2 VNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSII
:::.:::::.::::::::: ::: :.::::.:::::.::: ..: : :..:::::::..:
NP_938 VNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 VIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLML
:.::.:::::: :::::::::::.::::::::.:::.::::::::::::::::::::::
NP_938 VVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLML
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 FIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM
:::::::::::.:::::. . : :::.:::::::::::::::::::::::::: ::::::
NP_938 FIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM
880 890 900 910 920 930
840 850 860 870 880
pF1KE2 ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEG-----DANRSYS------DEDQ
:::: ::.:::.::::::::::::::::::::::::: ::. . : : .
NP_938 ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQG
940 950 960 970 980 990
890 900 910 920 930
pF1KE2 SSSNIEEF--DKLQEGLDSSGDPKLCP--IPMTPNGHLDPSL--PLGGHLGPAGAAGPAP
...: : : .. .::..:: : : . . . .: :: :: : :: :
NP_938 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT----AATPMS
1000 1010 1020 1030 1040
940 950 960 970 980 990
pF1KE2 RLSLQPDPMLVALG--SRKSSVMSLGR--MSYDQRSLSSSRSSYYGPWGRSAAWASRRSS
. . ::: ::..: . .. .....: :.::: ..::. ...:.:::::
NP_938 LPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS
1050 1060 1070 1080 1090 1100
1000 1010 1020 1030 1040
pF1KE2 WNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHVHHGP
::: :.. ::.:..::::.: : .. : ...: ::.: . :
NP_938 RNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH--------
1110 1120 1130 1140 1150
1050 1060 1070 1080 1090 1100
pF1KE2 HLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKD
.:: .: . ..: :: . . . : : :. : : : :.::::. :
NP_938 -------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLA
1160 1170 1180 1190 1200
1110 1120 1130 1140 1150 1160
pF1KE2 VFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLC
. : :.: ..: . . ::: : . : : :..::.:.: :..:::.::
NP_938 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLC
1210 1220 1230 1240 1250 1260
1170 1180 1190 1200 1210 1220
pF1KE2 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV
. ::.::.::.:::..:::::::::.:::.:. :.::::::.:::::::.:..:::.::
NP_938 HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKV
1270 1280 1290 1300 1310 1320
1230 1240 1250 1260 1270 1280
pF1KE2 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL
:.:: ::::::::::::::::.::..:.:::.::..: .:.::::.:::::::::::::
NP_938 VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPL
1330 1340 1350 1360 1370 1380
1290 1300 1310 1320 1330 1340
pF1KE2 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI
:::::: :::::::::.::::::::::.:::::::::::::::::::::. : : :::::
NP_938 RVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNI
1390 1400 1410 1420 1430 1440
1350 1360 1370 1380 1390 1400
pF1KE2 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
::.::: :.::::.:::::::::::::::::::::::::.:::.:::::.:::::. ::
NP_938 TNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH
1450 1460 1470 1480 1490 1500
1410 1420 1430 1440 1450 1460
pF1KE2 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-
:::::::::::::::.::::::::::::::::::::::: :::::::::::::::::::
NP_938 NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS
1510 1520 1530 1540 1550 1560
1470 1480 1490 1500 1510
pF1KE2 ------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLE
.:: :::. : . :::.: .:::::::.::: .: ::::::..:::.:: :.
NP_938 KEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD
1570 1580 1590 1600 1610 1620
1520 1530 1540 1550 1560 1570
pF1KE2 TALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAA
::: :::.::..::::.:.::::::.::::.::::::::::::::.:::::::::.::.
NP_938 EALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS
1630 1640 1650 1660 1670 1680
1580 1590 1600 1610 1620 1630
pF1KE2 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL
::::::::::::::::::::::::::.:::::::::.:::::::::::::::::::.:::
NP_938 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL
1690 1700 1710 1720 1730 1740
1640 1650 1660 1670 1680 1690
pF1KE2 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDER
:::::: : :.. .::::..:::::.::::::::::.:::::::::::::::::: . :
NP_938 GVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQ-ES
1750 1760 1770 1780 1790 1800
1700 1710 1720 1730 1740 1750
pF1KE2 SCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAH
.: ... .::.:::::::::::::.:::.:::::::..:::::.:.::..::::::: .
NP_938 TCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-K
1810 1820 1830 1840 1850 1860
1760 1770 1780 1790 1800 1810
pF1KE2 GLGPGPRLPTGSPGA-PG-RGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDS-
:.: :. : ::: :: .:: . . :.: .. . .. :. .. . .
NP_938 TLSPQPHSPLGSPFLWPGVEGPDSPDS--PKPGALHPAAHARSASHFSLEHPTMQPHPTE
1870 1880 1890 1900 1910 1920
1820 1830 1840 1850 1860 1870
pF1KE2 LEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLS
: : . :: . . .: : :.: . ....: . .:.:.: .
NP_938 LPGPDLLTVRKSG-VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQP
1930 1940 1950 1960 1970 1980
1880 1890 1900 1910 1920 1930
pF1KE2 LEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV
: . ::. :.: : . . : . :: . : .. : . .
NP_938 -ADTSYILQLPKDAPHLLQPHSAPTWGTIPK----LPPPGRSPLAQRPLRRQAAIRTDSL
1990 2000 2010 2020 2030
1940 1950 1960 1970 1980 1990
pF1KE2 RSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGS
.. .:. . ..:.: :. . . :..: .. . . ::. .
NP_938 D--VQGLGSRE---DLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHS----KISKH--
2040 2050 2060 2070 2080
2000 2010 2020 2030 2040 2050
pF1KE2 WASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPA---
.: . : : . . .: . .::. : : .: : ::.
NP_938 ----MTPPAPC------PGPEPNWGKGPPETRSSLELDTELSWISGD-----LLPPGGQE
2090 2100 2110 2120 2130
2060 2070 2080 2090 2100
pF1KE2 PAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGST-SPGCTHHDSMDPSDEE
:.:: . . . : . : : .:: :: . : . : : . :::.
NP_938 EPPSPRDLKKCYSVEAQSCQRRPTSWLD----EQRRHSIAVSCLDSGSQPHLGTDPSNL-
2140 2150 2160 2170 2180
2110 2120 2130 2140 2150 2160
pF1KE2 GRGGAGGGGAGSEHSETLSSLSLTSLFCPPP---P--PPAPGLTPARKFSSTSSLAAPGR
:: :: ::. .. :: :.: . :: : ::.::. :. :..:
NP_938 --GGQPLGGPGSRPKKKLSPPSIT--IDPPESQGPRTPPSPGICLRRRAPSSDS----KD
2190 2200 2210 2220 2230
2170 2180 2190 2200 2210
pF1KE2 PHAAALAHGLARSPSWAADR------SKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAA
: :.. ..: ::: : :.:: :
NP_938 PLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
2240 2250 2260 2270
2220
pF1KE2 SKRKR
>>NP_938194 (OMIM: 604065,616795) voltage-dependent T-ty (2321 aa)
initn: 5248 init1: 1799 opt: 4745 Z-score: 2880.5 bits: 546.9 E(85289): 1.1e-153
Smith-Waterman score: 6795; 52.8% identity (68.6% similar) in 2350 aa overlap (73-2193:75-2321)
50 60 70 80 90 100
pF1KE2 DGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPC
.. ::::::: .::::::::::::::..::
NP_938 DSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPC
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 DDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGM
.:. : :.::.:::.:::::: :::.:::.::::::::::::::::::::::::::.:::
NP_938 EDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 VEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFI
.::::::::...::.:::::::::.::::::::::::.::::::::::::::::::::::
NP_938 LEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 FGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHE
:::.::::::::::::::: :::.. .: : ::: :..:: ::::: .::. .:.
NP_938 FGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRS
230 240 250 260 270 280
290 300 310 320 330
pF1KE2 IPPLKEQGR---ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN
.: :. .: : : :. : .. :.. :::::.::. : .: :: :::::
NP_938 VPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQYYTNCSAGEHNPFKGAIN
290 300 310 320 330
340 350 360 370 380 390
pF1KE2 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
:::::::::.:::::::::::.:::.::::::::::::::::::::::::::::::::::
NP_938 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 QFSETKQREHRLMLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRR------
::::::::: .:: ::: :.::. ::.::..:::.::::...:. .::::: ::
NP_938 QFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSR
400 410 420 430 440 450
460 470 480 490
pF1KE2 ALGLYQALQSRRQALGPEAPAPAKPGPHAKE-----------PRHYHGKTKGQGD-----
: :. .: : :: . :.. .... .:.: :.:
NP_938 AAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPR
460 470 480 490 500 510
500 510 520
pF1KE2 -----EGRHL-GSRHCQTLHGPASP---GNDHSGREL--------C----------PQHS
. : :::. . : :..: : .: : : : .:
NP_938 ASPEIQDRDANGSRRLM-LPPPSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRS
520 530 540 550 560 570
530 540 550
pF1KE2 PLDAT----------PHTLVQPIPATL----------ASDPA------------------
: .:. : . ..: : :: .: :
NP_938 PSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKL
580 590 600 610 620 630
560 570 580 590
pF1KE2 ----SCPCCQHEDGRRPSGLGSTDSGQEGSGSG---SSAG-GEDE-ADGDGARS------
: :: . . : ..::: : : . :: :: : :: . :
NP_938 LETQSTGACQS-SCKISSPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVY
640 650 660 670 680 690
600 610 620 630 640 650
pF1KE2 --SEDGASSELGKEEEEEEQADGAVWLCGDV---WRETRAKLRGIVDSKYFNRGIMMAIL
..:. :.: . ..... : ..: :: .: :::::::.::::.:::
NP_938 EFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAIL
700 710 720 730 740 750
660 670 680 690 700 710
pF1KE2 VNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSII
:::.:::::.::::::::: ::: :.::::.:::::.::: ..: : :..:::::::..:
NP_938 VNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 VIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLML
:.::.:::::: :::::::::::.::::::::.:::.::::::::::::::::::::::
NP_938 VVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLML
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 FIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM
:::::::::::.:::::. . : :::.:::::::::::::::::::::::::: ::::::
NP_938 FIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM
880 890 900 910 920 930
840 850 860 870 880
pF1KE2 ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEG-----DANRSYS------DEDQ
:::: ::.:::.::::::::::::::::::::::::: ::. . : : .
NP_938 ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQG
940 950 960 970 980 990
890 900 910 920 930
pF1KE2 SSSNIEEF--DKLQEGLDSSGDPKLCP--IPMTPNGHLDPSL--PLGGHLGPAGAAGPAP
...: : : .. .::..:: : : . . . .: :: :: : :: :
NP_938 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT----AATPMS
1000 1010 1020 1030 1040
940 950 960 970 980 990
pF1KE2 RLSLQPDPMLVALG--SRKSSVMSLGR--MSYDQRSLSSSRSSYYGPWGRSAAWASRRSS
. . ::: ::..: . .. .....: :.::: ..::. ...:.:::::
NP_938 LPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS
1050 1060 1070 1080 1090 1100
1000 1010 1020 1030 1040
pF1KE2 WNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHVHHGP
::: :.. ::.:..::::.: : .. : ...: ::.: . :
NP_938 RNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH--------
1110 1120 1130 1140 1150
1050 1060 1070 1080 1090 1100
pF1KE2 HLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKD
.:: .: . ..: :: . . . : : :. : : : :.::::. :
NP_938 -------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLA
1160 1170 1180 1190 1200
1110 1120 1130 1140 1150 1160
pF1KE2 VFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLC
. : :.: ..: . . ::: : . : : :..::.:.: :..:::.::
NP_938 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLC
1210 1220 1230 1240 1250 1260
1170 1180 1190 1200 1210 1220
pF1KE2 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV
. ::.::.::.:::..:::::::::.:::.:. :.::::::.:::::::.:..:::.::
NP_938 HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKV
1270 1280 1290 1300 1310 1320
1230 1240 1250 1260 1270 1280
pF1KE2 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL
:.:: ::::::::::::::::.::..:.:::.::..: .:.::::.:::::::::::::
NP_938 VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPL
1330 1340 1350 1360 1370 1380
1290 1300 1310 1320 1330 1340
pF1KE2 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI
:::::: :::::::::.::::::::::.:::::::::::::::::::::. : : :::::
NP_938 RVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNI
1390 1400 1410 1420 1430 1440
1350 1360 1370 1380 1390 1400
pF1KE2 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
::.::: :.::::.:::::::::::::::::::::::::.:::.:::::.:::::. ::
NP_938 TNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH
1450 1460 1470 1480 1490 1500
1410 1420 1430 1440 1450 1460
pF1KE2 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-
:::::::::::::::.::::::::::::::::::::::: :::::::::::::::::::
NP_938 NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS
1510 1520 1530 1540 1550 1560
1470 1480 1490 1500 1510
pF1KE2 ------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLE
.:: :::. : . :::.: .:::::::.::: .: ::::::..:::.:: :.
NP_938 KEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD
1570 1580 1590 1600 1610 1620
1520 1530 1540 1550 1560 1570
pF1KE2 TALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAA
::: :::.::..::::.:.::::::.::::.::::::::::::::.:::::::::.::.
NP_938 EALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS
1630 1640 1650 1660 1670 1680
1580 1590 1600 1610 1620 1630
pF1KE2 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL
::::::::::::::::::::::::::.:::::::::.:::::::::::::::::::.:::
NP_938 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL
1690 1700 1710 1720 1730 1740
1640 1650 1660 1670 1680 1690
pF1KE2 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDER
:::::: : :.. .::::..:::::.::::::::::.:::::::::::::::::: . :
NP_938 GVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQ-ES
1750 1760 1770 1780 1790 1800
1700 1710 1720 1730 1740 1750
pF1KE2 SCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAH
.: ... .::.:::::::::::::.:::.:::::::..:::::.:.::..::::::: .
NP_938 TCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-K
1810 1820 1830 1840 1850 1860
1760 1770 1780 1790 1800
pF1KE2 GLGPGPRLPTGSPGA-PG-RGPGGAGGG--GDTEGGLCRRCYS------PAQENLWLDSV
:.: :. : ::: :: .:: . . : . . : : :....:. :..
NP_938 TLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTI
1870 1880 1890 1900 1910 1920
1810 1820 1830 1840 1850 1860
pF1KE2 SLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSI
::.:. ::: :: ..:.:.: :.: . :: :.
NP_938 SLLIQGSLEWELKLMDELAG--------PGG--------------QPSAFP-----SAPS
1930 1940 1950
1870 1880 1890 1900 1910 1920
pF1KE2 LLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEME
: :.: : . :: :. . : : .: : :. ....:.
NP_938 LGGSD----------PQMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHG
1960 1970 1980 1990 2000
1930 1940 1950 1960 1970 1980
pF1KE2 EIPFNPV--RSW-LKHDSSQAPPSPFS-PDASSPLLPMPAEFFHPAVSASQKGPEKGTGT
.:. :.: : . .: . : : : .: .: .: . : :...
NP_938 STAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTW
2010 2020 2030 2040 2050
1990 2000 2010 2020
pF1KE2 GTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSL
::.::. : ::: .. : :::. ::: ..:: .
NP_938 GTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARA
2060 2070 2080 2090 2100 2110
2030 2040 2050 2060 2070
pF1KE2 QTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL-------RG
. .: : ... :. . :::: :::. . . : .: : : :
NP_938 YSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISG
2120 2130 2140 2150 2160 2170
2080 2090 2100
pF1KE2 --------------RGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMD
: : . ...:. :: :: . : . : : . :
NP_938 DLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTD
2180 2190 2200 2210 2220 2230
2110 2120 2130 2140 2150
pF1KE2 PSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPP---P--PPAPGLTPARKFSSTSSL
::. :: :: ::. .. :: :.: . :: : ::.::. :. :..:
NP_938 PSNL---GGQPLGGPGSRPKKKLSPPSIT--IDPPESQGPRTPPSPGICLRRRAPSSDS-
2240 2250 2260 2270 2280
2160 2170 2180 2190 2200 2210
pF1KE2 AAPGRPHAAALAHGLARSPSWAADR------SKDPPGRAPLPMGLGPLAPPPQPLPGELE
: :.. ..: ::: : :.:: :
NP_938 ---KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
2290 2300 2310 2320
2220
pF1KE2 PGDAASKRKR
2223 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:54:20 2016 done: Mon Nov 7 20:54:23 2016
Total Scan time: 18.660 Total Display time: 1.610
Function used was FASTA [36.3.4 Apr, 2011]