Result of FASTA (omim) for
pFN21AE2482
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2482, 468 aa
1>>>pF1KE2482 468 - 468 aa - 468 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7485+/-0.000395; mu= 11.5014+/- 0.025
mean_var=109.4188+/-22.420, 0's: 0 Z-trim(115.1): 409 B-trim: 19 in 1/49
Lambda= 0.122611
statistics sampled from 25005 (25417) to 25005 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.298), width: 16
Scan time: 8.090
The best scores are: opt bits E(85289)
NP_599024 (OMIM: 600825) nuclear receptor ROR-alph ( 468) 3180 573.5 4.4e-163
NP_002934 (OMIM: 600825) nuclear receptor ROR-alph ( 548) 3129 564.5 2.6e-160
XP_016877955 (OMIM: 600825) PREDICTED: nuclear rec ( 460) 3124 563.5 4.2e-160
NP_599022 (OMIM: 600825) nuclear receptor ROR-alph ( 556) 3124 563.6 4.9e-160
XP_011520176 (OMIM: 600825) PREDICTED: nuclear rec ( 525) 3120 562.9 7.6e-160
XP_011520179 (OMIM: 600825) PREDICTED: nuclear rec ( 467) 3119 562.7 7.8e-160
XP_005254641 (OMIM: 600825) PREDICTED: nuclear rec ( 477) 3113 561.6 1.7e-159
XP_011520177 (OMIM: 600825) PREDICTED: nuclear rec ( 504) 3113 561.6 1.7e-159
NP_599023 (OMIM: 600825) nuclear receptor ROR-alph ( 523) 3113 561.6 1.8e-159
XP_016877956 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 2590 469.0 9.8e-132
XP_011520180 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 2590 469.0 9.8e-132
XP_011520181 (OMIM: 600825) PREDICTED: nuclear rec ( 376) 2524 457.4 3.1e-128
NP_008845 (OMIM: 601972) nuclear receptor ROR-beta ( 459) 1971 359.6 1e-98
NP_001001523 (OMIM: 602943,616622) nuclear recepto ( 497) 950 179.0 2.6e-44
NP_005051 (OMIM: 602943,616622) nuclear receptor R ( 518) 950 179.0 2.7e-44
XP_006711547 (OMIM: 602943,616622) PREDICTED: nucl ( 651) 950 179.1 3.2e-44
NP_068370 (OMIM: 602408) nuclear receptor subfamil ( 614) 438 88.5 5.6e-17
XP_006713514 (OMIM: 602304) PREDICTED: nuclear rec ( 448) 428 86.6 1.5e-16
NP_001138897 (OMIM: 602304) nuclear receptor subfa ( 504) 428 86.7 1.6e-16
NP_005117 (OMIM: 602304) nuclear receptor subfamil ( 579) 428 86.7 1.8e-16
XP_005251928 (OMIM: 184757,612964,612965,613957) P ( 461) 419 85.1 4.6e-16
NP_004950 (OMIM: 184757,612964,612965,613957) ster ( 461) 419 85.1 4.6e-16
XP_011516757 (OMIM: 184757,612964,612965,613957) P ( 461) 419 85.1 4.6e-16
NP_001277195 (OMIM: 180220,615524) retinoic acid r ( 399) 417 84.7 5.2e-16
NP_001277206 (OMIM: 180220,615524) retinoic acid r ( 402) 417 84.7 5.2e-16
NP_001277229 (OMIM: 180220,615524) retinoic acid r ( 405) 417 84.7 5.2e-16
NP_000956 (OMIM: 180220,615524) retinoic acid rece ( 448) 417 84.7 5.7e-16
NP_001277145 (OMIM: 180220,615524) retinoic acid r ( 455) 417 84.7 5.8e-16
NP_001230659 (OMIM: 180190) retinoic acid receptor ( 382) 415 84.3 6.4e-16
NP_001036193 (OMIM: 180190) retinoic acid receptor ( 443) 415 84.3 7.2e-16
NP_000957 (OMIM: 180190) retinoic acid receptor ga ( 454) 415 84.3 7.4e-16
XP_011523398 (OMIM: 180240,612376) PREDICTED: reti ( 404) 407 82.9 1.8e-15
NP_001019980 (OMIM: 180240,612376) retinoic acid r ( 457) 407 82.9 2e-15
XP_005257610 (OMIM: 180240,612376) PREDICTED: reti ( 462) 407 82.9 2e-15
NP_000955 (OMIM: 180240,612376) retinoic acid rece ( 462) 407 82.9 2e-15
XP_011523397 (OMIM: 180240,612376) PREDICTED: reti ( 462) 407 82.9 2e-15
NP_001138773 (OMIM: 180240,612376) retinoic acid r ( 462) 407 82.9 2e-15
XP_005257611 (OMIM: 180240,612376) PREDICTED: reti ( 462) 407 82.9 2e-15
XP_005257609 (OMIM: 180240,612376) PREDICTED: reti ( 478) 407 82.9 2e-15
NP_001027458 (OMIM: 601529) nuclear receptor subfa ( 467) 399 81.5 5.4e-15
NP_001120834 (OMIM: 601529) nuclear receptor subfa ( 483) 399 81.5 5.5e-15
NP_001278850 (OMIM: 180245) retinoic acid receptor ( 365) 397 81.1 5.6e-15
XP_011537019 (OMIM: 601529) PREDICTED: nuclear rec ( 507) 399 81.5 5.7e-15
XP_011537018 (OMIM: 601529) PREDICTED: nuclear rec ( 521) 399 81.6 5.9e-15
XP_006719647 (OMIM: 601529) PREDICTED: nuclear rec ( 557) 399 81.6 6.2e-15
NP_001278849 (OMIM: 180245) retinoic acid receptor ( 435) 397 81.2 6.5e-15
XP_005269190 (OMIM: 601529) PREDICTED: nuclear rec ( 598) 399 81.6 6.6e-15
NP_003288 (OMIM: 601529) nuclear receptor subfamil ( 603) 399 81.6 6.6e-15
NP_002948 (OMIM: 180245) retinoic acid receptor RX ( 462) 397 81.2 6.8e-15
XP_011532146 (OMIM: 125853,601487,601665,604367,60 ( 250) 389 79.6 1.1e-14
>>NP_599024 (OMIM: 600825) nuclear receptor ROR-alpha is (468 aa)
initn: 3180 init1: 3180 opt: 3180 Z-score: 3048.8 bits: 573.5 E(85289): 4.4e-163
Smith-Waterman score: 3180; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468)
10 20 30 40 50 60
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS
370 380 390 400 410 420
430 440 450 460
pF1KE2 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
430 440 450 460
>>NP_002934 (OMIM: 600825) nuclear receptor ROR-alpha is (548 aa)
initn: 3127 init1: 3127 opt: 3129 Z-score: 2999.1 bits: 564.5 E(85289): 2.6e-160
Smith-Waterman score: 3129; 98.9% identity (99.6% similar) in 466 aa overlap (4-468:83-548)
10 20 30
pF1KE2 MMYFVIAAM-KAQIEIIPCKICGDKSSGIHYGV
:.. :. :::::::::::::::::::::::
NP_002 LSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGIHYGV
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 ITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGH
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE2 TPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPT
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE2 VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE2 PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE2 KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY
480 490 500 510 520 530
460
pF1KE2 KELFTSEFEPAMQIDG
::::::::::::::::
NP_002 KELFTSEFEPAMQIDG
540
>>XP_016877955 (OMIM: 600825) PREDICTED: nuclear recepto (460 aa)
initn: 3124 init1: 3124 opt: 3124 Z-score: 2995.4 bits: 563.5 E(85289): 4.2e-160
Smith-Waterman score: 3124; 99.8% identity (100.0% similar) in 460 aa overlap (9-468:1-460)
10 20 30 40 50 60
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC
:.::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS
360 370 380 390 400 410
430 440 450 460
pF1KE2 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
420 430 440 450 460
>>NP_599022 (OMIM: 600825) nuclear receptor ROR-alpha is (556 aa)
initn: 3124 init1: 3124 opt: 3124 Z-score: 2994.2 bits: 563.6 E(85289): 4.9e-160
Smith-Waterman score: 3124; 99.8% identity (100.0% similar) in 460 aa overlap (9-468:97-556)
10 20 30
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGC
:.::::::::::::::::::::::::::::
NP_599 FVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGC
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE2 KGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 KGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQR
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE2 DSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 DSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSK
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 ADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 ADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAEL
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE2 EHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 EHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQY
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE2 VVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 VVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKS
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE2 LGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE2 QHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 QHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTS
490 500 510 520 530 540
460
pF1KE2 EFEPAMQIDG
::::::::::
NP_599 EFEPAMQIDG
550
>>XP_011520176 (OMIM: 600825) PREDICTED: nuclear recepto (525 aa)
initn: 3120 init1: 3120 opt: 3120 Z-score: 2990.7 bits: 562.9 E(85289): 7.6e-160
Smith-Waterman score: 3120; 99.6% identity (99.6% similar) in 461 aa overlap (8-468:65-525)
10 20 30
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEG
: :::::::::::::::::::::::::::
XP_011 VGLRASCPTEWGQKVVRGAFRGALRAEKRPAATAQIEIIPCKICGDKSSGIHYGVITCEG
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE2 CKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQ
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE2 RDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGS
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE2 KADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAE
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE2 LEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQ
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE2 YVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFK
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE2 SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLA
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE2 LQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFT
460 470 480 490 500 510
460
pF1KE2 SEFEPAMQIDG
:::::::::::
XP_011 SEFEPAMQIDG
520
>>XP_011520179 (OMIM: 600825) PREDICTED: nuclear recepto (467 aa)
initn: 3117 init1: 3117 opt: 3119 Z-score: 2990.5 bits: 562.7 E(85289): 7.8e-160
Smith-Waterman score: 3119; 98.5% identity (98.9% similar) in 467 aa overlap (2-468:1-467)
10 20 30 40 50 60
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC
: : .. ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKFREGTAIAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS
360 370 380 390 400 410
430 440 450 460
pF1KE2 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
420 430 440 450 460
>>XP_005254641 (OMIM: 600825) PREDICTED: nuclear recepto (477 aa)
initn: 3113 init1: 3113 opt: 3113 Z-score: 2984.7 bits: 561.6 E(85289): 1.7e-159
Smith-Waterman score: 3113; 99.8% identity (100.0% similar) in 458 aa overlap (11-468:20-477)
10 20 30 40 50
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT
.::::::::::::::::::::::::::::::::::::::::
XP_005 MLTGSQSTFGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 YSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 QQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 PSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 TCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFME
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 LCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEF
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 GKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGI
370 380 390 400 410 420
420 430 440 450 460
pF1KE2 LTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
430 440 450 460 470
>>XP_011520177 (OMIM: 600825) PREDICTED: nuclear recepto (504 aa)
initn: 3113 init1: 3113 opt: 3113 Z-score: 2984.3 bits: 561.6 E(85289): 1.7e-159
Smith-Waterman score: 3113; 99.8% identity (100.0% similar) in 458 aa overlap (11-468:47-504)
10 20 30 40
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKG
.:::::::::::::::::::::::::::::
XP_011 TEAIRTTHAVLLKKPPGWKSGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKG
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE2 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE2 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE2 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE2 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE2 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE2 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH
380 390 400 410 420 430
410 420 430 440 450 460
pF1KE2 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF
440 450 460 470 480 490
pF1KE2 EPAMQIDG
::::::::
XP_011 EPAMQIDG
500
>>NP_599023 (OMIM: 600825) nuclear receptor ROR-alpha is (523 aa)
initn: 3113 init1: 3113 opt: 3113 Z-score: 2984.1 bits: 561.6 E(85289): 1.8e-159
Smith-Waterman score: 3113; 99.8% identity (100.0% similar) in 458 aa overlap (11-468:66-523)
10 20 30 40
pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKG
.:::::::::::::::::::::::::::::
NP_599 ARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKG
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE2 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE2 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE2 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE2 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE2 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE2 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH
400 410 420 430 440 450
410 420 430 440 450 460
pF1KE2 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF
460 470 480 490 500 510
pF1KE2 EPAMQIDG
::::::::
NP_599 EPAMQIDG
520
>>XP_016877956 (OMIM: 600825) PREDICTED: nuclear recepto (386 aa)
initn: 2590 init1: 2590 opt: 2590 Z-score: 2486.0 bits: 469.0 E(85289): 9.8e-132
Smith-Waterman score: 2590; 100.0% identity (100.0% similar) in 386 aa overlap (83-468:1-386)
60 70 80 90 100 110
pF1KE2 SCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQ
::::::::::::::::::::::::::::::
XP_016 MSRDAVKFGRMSKKQRDSLYAEVQKHRMQQ
10 20 30
120 130 140 150 160 170
pF1KE2 QQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQP
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 SPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLET
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 CQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMEL
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE2 CQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFG
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE2 KSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGIL
280 290 300 310 320 330
420 430 440 450 460
pF1KE2 TKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
340 350 360 370 380
468 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:45:25 2016 done: Mon Nov 7 20:45:26 2016
Total Scan time: 8.090 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]