Result of FASTA (omim) for
pFN21AE2481
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2481, 472 aa
1>>>pF1KE2481 472 - 472 aa - 472 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6424+/-0.000344; mu= -1.6400+/- 0.022
mean_var=210.3542+/-43.109, 0's: 0 Z-trim(121.9): 29 B-trim: 356 in 1/54
Lambda= 0.088430
statistics sampled from 39265 (39294) to 39265 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.461), width: 16
Scan time: 11.460
The best scores are: opt bits E(85289)
NP_996783 (OMIM: 603183,604805) reticulon-2 isofor ( 472) 3097 407.5 4.2e-113
NP_005610 (OMIM: 603183,604805) reticulon-2 isofor ( 545) 1850 248.4 3.7e-65
NP_996784 (OMIM: 603183,604805) reticulon-2 isofor ( 205) 1249 171.5 1.9e-42
NP_066959 (OMIM: 600865) reticulon-1 isoform A [Ho ( 776) 695 101.1 1.1e-20
NP_997403 (OMIM: 604475) reticulon-4 isoform D [Ho ( 392) 676 98.6 3.4e-20
XP_016877067 (OMIM: 600865) PREDICTED: reticulon-1 ( 193) 647 94.7 2.4e-19
NP_996734 (OMIM: 600865) reticulon-1 isoform C [Ho ( 208) 640 93.8 4.8e-19
NP_722550 (OMIM: 604475) reticulon-4 isoform B [Ho ( 373) 631 92.8 1.7e-18
NP_001308790 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18
NP_001308791 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18
NP_001308833 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18
NP_001308792 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18
NP_997404 (OMIM: 604475) reticulon-4 isoform E [Ho ( 986) 626 92.4 6.2e-18
XP_016860007 (OMIM: 604475) PREDICTED: reticulon-4 ( 986) 626 92.4 6.2e-18
NP_001308789 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18
XP_005264491 (OMIM: 604475) PREDICTED: reticulon-4 ( 986) 626 92.4 6.2e-18
XP_016860008 (OMIM: 604475) PREDICTED: reticulon-4 ( 986) 626 92.4 6.2e-18
NP_001308788 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18
NP_065393 (OMIM: 604475) reticulon-4 isoform A [Ho (1192) 626 92.4 7.3e-18
NP_008939 (OMIM: 604475) reticulon-4 isoform C [Ho ( 199) 606 89.5 9.3e-18
NP_958832 (OMIM: 604249) reticulon-3 isoform c [Ho ( 255) 563 84.0 5.1e-16
NP_006045 (OMIM: 604249) reticulon-3 isoform a [Ho ( 236) 558 83.4 7.5e-16
NP_001252519 (OMIM: 604249) reticulon-3 isoform f ( 920) 569 85.1 9e-16
NP_958831 (OMIM: 604249) reticulon-3 isoform b [Ho (1013) 569 85.1 9.8e-16
NP_001252518 (OMIM: 604249) reticulon-3 isoform e (1032) 569 85.1 1e-15
XP_011543033 (OMIM: 604249) PREDICTED: reticulon-3 ( 260) 469 72.1 2.1e-12
NP_958833 (OMIM: 604249) reticulon-3 isoform d [Ho ( 241) 464 71.4 3.1e-12
XP_011543032 (OMIM: 604249) PREDICTED: reticulon-3 (1037) 475 73.1 4.1e-12
NP_001252520 (OMIM: 604249) reticulon-3 isoform g ( 214) 217 39.9 0.0086
>>NP_996783 (OMIM: 603183,604805) reticulon-2 isoform B (472 aa)
initn: 3097 init1: 3097 opt: 3097 Z-score: 2151.6 bits: 407.5 E(85289): 4.2e-113
Smith-Waterman score: 3097; 100.0% identity (100.0% similar) in 472 aa overlap (1-472:1-472)
10 20 30 40 50 60
pF1KE2 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 FSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 QITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPL
370 380 390 400 410 420
430 440 450 460 470
pF1KE2 LYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
430 440 450 460 470
>>NP_005610 (OMIM: 603183,604805) reticulon-2 isoform A (545 aa)
initn: 1849 init1: 1849 opt: 1850 Z-score: 1290.8 bits: 248.4 E(85289): 3.7e-65
Smith-Waterman score: 2699; 85.5% identity (85.5% similar) in 504 aa overlap (1-431:1-504)
10 20 30 40 50 60
pF1KE2 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE
190 200 210 220 230 240
250 260 270
pF1KE2 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLL-----------------------------
:::::::::::::::::::::::::::::::
NP_005 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLW
250 260 270 280 290 300
280
pF1KE2 --------------------------------------------VADLLYWKDTRTSGVV
::::::::::::::::
NP_005 TAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVV
310 320 330 340 350 360
290 300 310 320 330 340
pF1KE2 FTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVD
370 380 390 400 410 420
350 360 370 380 390 400
pF1KE2 LTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTL
430 440 450 460 470 480
410 420 430 440 450 460
pF1KE2 LILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGS
::::::::::::::::::::::::
NP_005 LILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGS
490 500 510 520 530 540
>>NP_996784 (OMIM: 603183,604805) reticulon-2 isoform C (205 aa)
initn: 1249 init1: 1249 opt: 1249 Z-score: 883.0 bits: 171.5 E(85289): 1.9e-42
Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 201 aa overlap (272-472:5-205)
250 260 270 280 290 300
pF1KE2 QWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHF
::::::::::::::::::::::::::::::
NP_996 MGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHF
10 20 30
310 320 330 340 350 360
pF1KE2 SIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 SIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQ
40 50 60 70 80 90
370 380 390 400 410 420
pF1KE2 ITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 ITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLL
100 110 120 130 140 150
430 440 450 460 470
pF1KE2 YRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 YRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
160 170 180 190 200
>>NP_066959 (OMIM: 600865) reticulon-1 isoform A [Homo s (776 aa)
initn: 723 init1: 640 opt: 695 Z-score: 492.1 bits: 101.1 E(85289): 1.1e-20
Smith-Waterman score: 714; 36.6% identity (63.1% similar) in 407 aa overlap (83-453:381-770)
60 70 80 90 100
pF1KE2 SQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRS----VSEPRDQHPQPSL-GD
: ::. ..:: . : :.. . . ::
NP_066 ISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGD
360 370 380 390 400 410
110 120 130 140 150
pF1KE2 S-LESI---PSLSQSPEP------GRRGDPDTAPPSERPL-----EDLRLRLDHLGWVAR
: .: . : ... : :. : : .: : :. . .:: .
NP_066 SEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIE-
420 430 440 450 460
160 170 180 190 200
pF1KE2 GTGSGEDSSTSSSTPL--EDEEPQEPN-----RLETG-EAGEELDLRLRLAQPSS----P
: . ::.: .: .: :..:. : ::: .: :. : ::.:.: :
NP_066 ---SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYP
470 480 490 500 510 520
210 220 230 240 250
pF1KE2 EVLT---PQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCL
. :.: ::.:. . :: : . ....:. . : . :: :
NP_066 STEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP------
530 540 550 560 570 580
260 270 280 290 300 310
pF1KE2 DSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLC
: : . . . :::::.: . .:.:: .... :. : .::.:::.:.::: :
NP_066 -----LLFLNKQKAI--DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALS
590 600 610 620 630
320 330 340 350 360 370
pF1KE2 GTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHF
.:::.:.:..:::::.. : ..::.:::....::..:: .. . . : :. .::..
NP_066 ATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRL
640 650 660 670 680 690
380 390 400 410 420 430
pF1KE2 FLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLV
:::.:::::::.:.:...::.:::.:::::::...:...::.:..: .::::::::.:::
NP_066 FLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLV
700 710 720 730 740 750
440 450 460 470
pF1KE2 TNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
.... . :::.:::::
NP_066 RTHINAVVAKIQAKIPGAKRHAE
760 770
>>NP_997403 (OMIM: 604475) reticulon-4 isoform D [Homo s (392 aa)
initn: 652 init1: 606 opt: 676 Z-score: 483.6 bits: 98.6 E(85289): 3.4e-20
Smith-Waterman score: 679; 35.5% identity (62.2% similar) in 394 aa overlap (81-453:12-386)
60 70 80 90 100
pF1KE2 TTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQG----RSVSEPRDQHPQP---
:. :::: . : ::.:.. .
NP_997 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEE
10 20 30 40
110 120 130 140 150 160
pF1KE2 --SLGDSLESIPSLSQSPEPGRRGDP-DTAPPSERPLEDLRLRLDHLGWVARGTGSGEDS
. ..:: . : ..: : . : ::: . :: :. : . . ::
NP_997 EEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFG--NDFVPPAPRG-------
50 60 70 80 90
170 180 190 200 210 220
pF1KE2 STSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPS
:: : :.: . . . .. . .: : ...:. : . : : :
NP_997 ------PLPAAPPVAPERQPSWDPSP-VSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPP
100 110 120 130 140
230 240 250 260 270
pF1KE2 PSRSRDSNSGPEEPLLEEEEKQWGPLEREPV----RGQCLDSTDQLEFTV----EPRL--
: . : : ::. . :. ::. :.:. :.. :: .
NP_997 PPPA--SVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSS-GSVDETLFALPAASEPVIRS
150 160 170 180 190 200
280 290 300 310 320
pF1KE2 -LVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQ
:.:::::.: . .:::: . . :: : ::::::.:..:: :: :::.:.:. :.:
NP_997 SAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE2 AVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLA
:....: ..::.:::. ......: ... :.. ..: . .::..:::.:::::::.:
NP_997 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA
270 280 290 300 310 320
390 400 410 420 430 440
pF1KE2 LLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRA
.:....:.:::.:::::::::..:.::..:..:..::::::.:.::...... :::.:
NP_997 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA
330 340 350 360 370 380
450 460 470
pF1KE2 KIPGTGALASAAAAVSGSKAKAE
::::
NP_997 KIPGLKRKAE
390
>>XP_016877067 (OMIM: 600865) PREDICTED: reticulon-1 iso (193 aa)
initn: 640 init1: 640 opt: 647 Z-score: 468.3 bits: 94.7 E(85289): 2.4e-19
Smith-Waterman score: 647; 51.1% identity (84.9% similar) in 186 aa overlap (268-453:2-187)
240 250 260 270 280 290
pF1KE2 EEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLC
: : . :::::.: . .:.:: .... :.
XP_016 MPFLPAIDLLYWRDIKQTGIVFGSFLLLLFS
10 20 30
300 310 320 330 340 350
pF1KE2 LLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTER
: .::.:::.:.::: : .:::.:.:..:::::.. : ..::.:::....::..:: ..
XP_016 LTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQK
40 50 60 70 80 90
360 370 380 390 400 410
pF1KE2 LSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFT
. . : :. .::..:::.:::::::.:.:...::.:::.:::::::...:...::
XP_016 YTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFT
100 110 120 130 140 150
420 430 440 450 460 470
pF1KE2 IPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
.:..: .::::::::.::: .... . :::.:::::
XP_016 LPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
160 170 180 190
>>NP_996734 (OMIM: 600865) reticulon-1 isoform C [Homo s (208 aa)
initn: 640 init1: 640 opt: 640 Z-score: 463.0 bits: 93.8 E(85289): 4.8e-19
Smith-Waterman score: 640; 51.7% identity (86.1% similar) in 180 aa overlap (274-453:23-202)
250 260 270 280 290 300
pF1KE2 GPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSI
:::::.: . .:.:: .... :. : .::.
NP_996 MQATADSTKMDCVWSNWKSQAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSV
10 20 30 40 50
310 320 330 340 350 360
pF1KE2 VSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQIT
:::.:.::: : .:::.:.:..:::::.. : ..::.:::....::..:: .. . .
NP_996 VSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQ
60 70 80 90 100 110
370 380 390 400 410 420
pF1KE2 SRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYR
: :. .::..:::.:::::::.:.:...::.:::.:::::::...:...::.:..:
NP_996 FYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYV
120 130 140 150 160 170
430 440 450 460 470
pF1KE2 QHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
.::::::::.::: .... . :::.:::::
NP_996 KHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
180 190 200
>>NP_722550 (OMIM: 604475) reticulon-4 isoform B [Homo s (373 aa)
initn: 653 init1: 607 opt: 631 Z-score: 452.9 bits: 92.8 E(85289): 1.7e-18
Smith-Waterman score: 677; 34.7% identity (61.9% similar) in 383 aa overlap (81-453:12-367)
60 70 80 90 100
pF1KE2 TTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQG----RSVSEPRDQHPQP---
:. :::: . : ::.:.. .
NP_722 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEE
10 20 30 40
110 120 130 140 150 160
pF1KE2 --SLGDSLESIPSLSQSPEPGRRGDP-DTAPPSERPLEDLRLRLDHLGWVARGTGSGEDS
. ..:: . : ..: : . : ::: . :: :. : . . ::
NP_722 EEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFG--NDFVPPAPRG-------
50 60 70 80 90
170 180 190 200 210 220
pF1KE2 STSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPS
:: : :.: . . . .. . .: : ...:. : . : : :
NP_722 ------PLPAAPPVAPERQPSWDPSP-VSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPP
100 110 120 130 140
230 240 250 260 270 280
pF1KE2 PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKD
: : . . : : : :. .. . . . .:.:::::.:
NP_722 P---------PPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGS--VVVDLLYWRD
150 160 170 180 190
290 300 310 320 330 340
pF1KE2 TRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPF
. .:::: . . :: : ::::::.:..:: :: :::.:.:. :.::....: ..::
NP_722 IKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPF
200 210 220 230 240 250
350 360 370 380 390 400
pF1KE2 QAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGA
.:::. ......: ... :.. ..: . .::..:::.:::::::.:.:....:.:::
NP_722 RAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGA
260 270 280 290 300 310
410 420 430 440 450 460
pF1KE2 IFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASA
.:::::::::..:.::..:..:..::::::.:.::...... :::.:::::
NP_722 LFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE
320 330 340 350 360 370
470
pF1KE2 AAAVSGSKAKAE
>>NP_001308790 (OMIM: 604475) reticulon-4 isoform E [Hom (986 aa)
initn: 606 init1: 606 opt: 626 Z-score: 443.0 bits: 92.4 E(85289): 6.2e-18
Smith-Waterman score: 626; 40.1% identity (74.0% similar) in 269 aa overlap (189-453:712-980)
160 170 180 190 200 210
pF1KE2 DSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLT--PQLSP-GSGTPQ
:: :. ::. : .. ..: ::.: .
NP_001 EYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSK
690 700 710 720 730 740
220 230 240 250 260 270
pF1KE2 AGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVE-PRLLVAD
. :. : .... : ... . .. : . : . . :..: . :.:
NP_001 VLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVD
750 760 770 780 790 800
280 290 300 310 320 330
pF1KE2 LLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRG
::::.: . .:::: . . :: : ::::::.:..:: :: :::.:.:. :.::....
NP_001 LLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKS
810 820 830 840 850 860
340 350 360 370 380 390
pF1KE2 DGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYI
: ..::.:::. ......: ... :.. ..: . .::..:::.:::::::.:.:...
NP_001 DEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWV
870 880 890 900 910 920
400 410 420 430 440 450
pF1KE2 LTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGT
.:.:::.:::::::::..:.::..:..:..::::::.:.::...... :::.:::::
NP_001 FTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGL
930 940 950 960 970 980
460 470
pF1KE2 GALASAAAAVSGSKAKAE
NP_001 KRKAE
>>NP_001308791 (OMIM: 604475) reticulon-4 isoform E [Hom (986 aa)
initn: 606 init1: 606 opt: 626 Z-score: 443.0 bits: 92.4 E(85289): 6.2e-18
Smith-Waterman score: 626; 40.1% identity (74.0% similar) in 269 aa overlap (189-453:712-980)
160 170 180 190 200 210
pF1KE2 DSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLT--PQLSP-GSGTPQ
:: :. ::. : .. ..: ::.: .
NP_001 EYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSK
690 700 710 720 730 740
220 230 240 250 260 270
pF1KE2 AGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVE-PRLLVAD
. :. : .... : ... . .. : . : . . :..: . :.:
NP_001 VLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVD
750 760 770 780 790 800
280 290 300 310 320 330
pF1KE2 LLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRG
::::.: . .:::: . . :: : ::::::.:..:: :: :::.:.:. :.::....
NP_001 LLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKS
810 820 830 840 850 860
340 350 360 370 380 390
pF1KE2 DGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYI
: ..::.:::. ......: ... :.. ..: . .::..:::.:::::::.:.:...
NP_001 DEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWV
870 880 890 900 910 920
400 410 420 430 440 450
pF1KE2 LTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGT
.:.:::.:::::::::..:.::..:..:..::::::.:.::...... :::.:::::
NP_001 FTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGL
930 940 950 960 970 980
460 470
pF1KE2 GALASAAAAVSGSKAKAE
NP_001 KRKAE
472 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:42:43 2016 done: Mon Nov 7 20:42:45 2016
Total Scan time: 11.460 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]