Result of FASTA (omim) for
pFN21AE2452
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2452, 529 aa
1>>>pF1KE2452 529 - 529 aa - 529 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5485+/-0.0003; mu= 13.1909+/- 0.019
mean_var=91.8232+/-18.300, 0's: 0 Z-trim(119.2): 173 B-trim: 0 in 0/51
Lambda= 0.133844
statistics sampled from 32881 (33066) to 32881 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.388), width: 16
Scan time: 10.720
The best scores are: opt bits E(85289)
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 3658 716.2 6.2e-206
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 3658 716.2 6.2e-206
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 3658 716.2 6.2e-206
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 2986 586.4 7e-167
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 2539 500.0 5e-141
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 2539 500.0 5e-141
XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 2258 445.7 9.8e-125
XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 2258 445.7 9.8e-125
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1919 380.4 8.7e-105
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1841 365.3 2.5e-100
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 1720 341.9 2.4e-93
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1654 329.2 2e-89
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1639 326.3 1.3e-88
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1522 303.7 8.4e-82
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1423 284.6 4.5e-76
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1397 279.6 1.5e-74
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 1370 274.4 6.4e-73
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1318 264.3 5.9e-70
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 1314 263.5 1.1e-69
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1289 258.7 3e-68
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1289 258.7 3e-68
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1285 257.9 5.4e-68
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1283 257.5 6.2e-68
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 1281 257.1 7.9e-68
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1281 257.1 8e-68
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 1281 257.1 8.1e-68
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 1281 257.1 8.1e-68
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 1281 257.2 8.7e-68
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1278 256.6 1.2e-67
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1278 256.6 1.2e-67
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1232 247.7 6.2e-65
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1176 236.9 9.6e-62
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1176 236.9 9.6e-62
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 1119 225.9 2.2e-58
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 1113 224.7 4.9e-58
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 1113 224.7 5e-58
NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451) 1076 217.6 6.6e-56
XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451) 1076 217.6 6.6e-56
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 989 200.8 7.5e-51
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 971 197.3 8.8e-50
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 965 196.1 1.6e-49
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 917 186.8 8.7e-47
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 907 184.9 3.9e-46
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 903 184.1 6.9e-46
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 903 184.1 6.9e-46
XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 903 184.1 7.3e-46
XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441) 903 184.2 7.3e-46
XP_016877370 (OMIM: 118505,612052) PREDICTED: neur ( 245) 851 174.0 4.6e-43
XP_005254199 (OMIM: 118505,612052) PREDICTED: neur ( 243) 850 173.8 5.2e-43
XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 746 153.8 7.6e-37
>>XP_011542690 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa)
initn: 3658 init1: 3658 opt: 3658 Z-score: 3818.2 bits: 716.2 E(85289): 6.2e-206
Smith-Waterman score: 3658; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529)
10 20 30 40 50 60
pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
430 440 450 460 470 480
490 500 510 520
pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
490 500 510 520
>>XP_006716345 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa)
initn: 3658 init1: 3658 opt: 3658 Z-score: 3818.2 bits: 716.2 E(85289): 6.2e-206
Smith-Waterman score: 3658; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529)
10 20 30 40 50 60
pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
430 440 450 460 470 480
490 500 510 520
pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
490 500 510 520
>>NP_000733 (OMIM: 118502,610353) neuronal acetylcholine (529 aa)
initn: 3658 init1: 3658 opt: 3658 Z-score: 3818.2 bits: 716.2 E(85289): 6.2e-206
Smith-Waterman score: 3658; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529)
10 20 30 40 50 60
pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
430 440 450 460 470 480
490 500 510 520
pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
490 500 510 520
>>NP_001269384 (OMIM: 118502,610353) neuronal acetylchol (514 aa)
initn: 2983 init1: 2983 opt: 2986 Z-score: 3117.1 bits: 586.4 E(85289): 7e-167
Smith-Waterman score: 3530; 97.2% identity (97.2% similar) in 529 aa overlap (1-529:1-514)
10 20 30 40 50 60
pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
::::::::::::::::::::::: ::::::::::::::::::::::
NP_001 RLFKHLFRGYNRWARPVPNTSDV---------------DEKNQMMTTNVWLKQEWSDYKL
70 80 90 100
130 140 150 160 170 180
pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
410 420 430 440 450 460
490 500 510 520
pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
470 480 490 500 510
>>XP_005273454 (OMIM: 118502,610353) PREDICTED: neuronal (370 aa)
initn: 2539 init1: 2539 opt: 2539 Z-score: 2652.8 bits: 500.0 E(85289): 5e-141
Smith-Waterman score: 2539; 100.0% identity (100.0% similar) in 370 aa overlap (160-529:1-370)
130 140 150 160 170 180
pF1KE2 ITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTF
::::::::::::::::::::::::::::::
XP_005 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTF
10 20 30
190 200 210 220 230 240
pF1KE2 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE2 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE2 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE2 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE2 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV
280 290 300 310 320 330
490 500 510 520
pF1KE2 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
::::::::::::::::::::::::::::::::::::::::
XP_005 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
340 350 360 370
>>XP_016868492 (OMIM: 118502,610353) PREDICTED: neuronal (370 aa)
initn: 2539 init1: 2539 opt: 2539 Z-score: 2652.8 bits: 500.0 E(85289): 5e-141
Smith-Waterman score: 2539; 100.0% identity (100.0% similar) in 370 aa overlap (160-529:1-370)
130 140 150 160 170 180
pF1KE2 ITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTF
::::::::::::::::::::::::::::::
XP_016 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTF
10 20 30
190 200 210 220 230 240
pF1KE2 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE2 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE2 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE2 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE2 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV
280 290 300 310 320 330
490 500 510 520
pF1KE2 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
::::::::::::::::::::::::::::::::::::::::
XP_016 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
340 350 360 370
>>XP_016868493 (OMIM: 118502,610353) PREDICTED: neuronal (331 aa)
initn: 2258 init1: 2258 opt: 2258 Z-score: 2360.4 bits: 445.7 E(85289): 9.8e-125
Smith-Waterman score: 2258; 100.0% identity (100.0% similar) in 331 aa overlap (199-529:1-331)
170 180 190 200 210 220
pF1KE2 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES
::::::::::::::::::::::::::::::
XP_016 MKFGSWTYDKAKIDLEQMEQTVDLKDYWES
10 20 30
230 240 250 260 270 280
pF1KE2 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE2 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE2 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE2 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE2 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM
280 290 300 310 320 330
pF1KE2 I
:
XP_016 I
>>XP_011542691 (OMIM: 118502,610353) PREDICTED: neuronal (331 aa)
initn: 2258 init1: 2258 opt: 2258 Z-score: 2360.4 bits: 445.7 E(85289): 9.8e-125
Smith-Waterman score: 2258; 100.0% identity (100.0% similar) in 331 aa overlap (199-529:1-331)
170 180 190 200 210 220
pF1KE2 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES
::::::::::::::::::::::::::::::
XP_011 MKFGSWTYDKAKIDLEQMEQTVDLKDYWES
10 20 30
230 240 250 260 270 280
pF1KE2 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE2 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE2 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE2 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE2 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM
280 290 300 310 320 330
pF1KE2 I
:
XP_011 I
>>NP_000735 (OMIM: 118504,188890,600513) neuronal acetyl (627 aa)
initn: 2271 init1: 1898 opt: 1919 Z-score: 2002.2 bits: 380.4 E(85289): 8.7e-105
Smith-Waterman score: 1919; 75.1% identity (86.3% similar) in 386 aa overlap (25-406:4-380)
10 20 30 40 50
pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTET--
:: : : : :: :.: ...::.::
NP_000 MELGGPGAPRLLP-----PLLLLLGTGLLRASSHVETRA
10 20 30
60 70 80 90 100 110
pF1KE2 --EDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS
:.::.:.:: :::.:.::: : ::::.:::::::::::::::::::::::::.::::
NP_000 HAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWH
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE2 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPP
::::::.:.:. :.::.:.:::.:: :::::::::::.:::::.:::::: : :.:.::
NP_000 DYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPP
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE2 AIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNA
::::::::::::::::::::: ::::::::::::::: .:.. :: :.::::::.::.:
NP_000 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDA
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE2 TGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEK
.::::..::.::::::::.::::::::::::::::::::::::::::::::::::.::::
NP_000 VGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE2 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE2 PSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVV
: ::::: ::: ..: ::: :::.:: . :. .: :.: . :
NP_000 PRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCR----RLIESMHKMASAPRFWPEPEG
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE2 VEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYI
NP_000 EPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCR
400 410 420 430 440 450
>--
initn: 480 init1: 387 opt: 387 Z-score: 403.5 bits: 84.6 E(85289): 9.8e-16
Smith-Waterman score: 387; 78.6% identity (94.3% similar) in 70 aa overlap (460-529:558-627)
430 440 450 460 470 480
pF1KE2 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV
: ::: . .:.:::.::::::..::.: ::
NP_000 PCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSV
530 540 550 560 570 580
490 500 510 520
pF1KE2 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
:::::::::::::::::.:::::.:::.::::::.:::::
NP_000 KEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
590 600 610 620
>>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine (505 aa)
initn: 1864 init1: 1602 opt: 1841 Z-score: 1922.3 bits: 365.3 E(85289): 2.5e-100
Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (33-526:14-501)
10 20 30 40 50 60
pF1KE2 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL
::: : : :.: .:.: ::
NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL
10 20 30
70 80 90 100 110 120
pF1KE2 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW
:..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.:
NP_000 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS
::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.:::
NP_000 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS
:.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : ..
NP_000 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS
::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.:::::
NP_000 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM
::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.::::
NP_000 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR
: ::. ..:. .:: ..:.:: . : : : ::.. : :..
NP_000 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK
340 350 360 370 380
430 440 450 460 470
pF1KE2 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL
:. : .:.. : : ..:. ...:.:. . : ::....:.
NP_000 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI
390 400 410 420 430 440
480 490 500 510 520
pF1KE2 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..:
NP_000 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
450 460 470 480 490 500
529 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:15:18 2016 done: Sat Nov 5 04:15:19 2016
Total Scan time: 10.720 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]