FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2410, 286 aa
  1>>>pF1KE2410 286 - 286 aa - 286 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4056+/-0.000309; mu= 14.9128+/- 0.019
 mean_var=72.6029+/-15.081, 0's: 0 Z-trim(117.1): 13  B-trim: 1696 in 1/52
 Lambda= 0.150521
 statistics sampled from 28874 (28887) to 28874 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.339), width:  16
 Scan time:  7.330

The best scores are:                                      opt bits E(85289)
NP_631917 (OMIM: 610603) alpha-ketoglutarate-depen ( 286) 2009 445.1 7.1e-125
NP_001138846 (OMIM: 610602) DNA oxidative demethyl ( 261)  377 90.7 3.2e-18
NP_001001655 (OMIM: 610602) DNA oxidative demethyl ( 261)  377 90.7 3.2e-18
NP_001138847 (OMIM: 610602) DNA oxidative demethyl ( 261)  377 90.7 3.2e-18
XP_005253892 (OMIM: 610602) PREDICTED: DNA oxidati ( 261)  377 90.7 3.2e-18


>>NP_631917 (OMIM: 610603) alpha-ketoglutarate-dependent  (286 aa)
 initn: 2009 init1: 2009 opt: 2009  Z-score: 2362.8  bits: 445.1 E(85289): 7.1e-125
Smith-Waterman score: 2009; 99.7% identity (100.0% similar) in 286 aa overlap (1-286:1-286)

               10        20        30        40        50        60
pF1KE2 MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 IREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 IREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 YRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGEYTYVERVKIPLD
       :::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
NP_631 YRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLD
              190       200       210       220       230       240

              250       260       270       280      
pF1KE2 HGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
       ::::::::::::::::::::::::::::::::::::::::::::::
NP_631 HGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
              250       260       270       280      

>>NP_001138846 (OMIM: 610602) DNA oxidative demethylase   (261 aa)
 initn: 339 init1: 163 opt: 377  Z-score: 448.1  bits: 90.7 E(85289): 3.2e-18
Smith-Waterman score: 377; 37.0% identity (60.9% similar) in 192 aa overlap (91-277:67-256)

               70        80        90       100       110       120
pF1KE2 QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG
                                     : :  .    ::: :...: ..: .   . 
NP_001 TRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGAL
         40        50        60        70        80        90      

                 130         140       150       160       170     
pF1KE2 IREDIT---YQQPRLTAWYGE--LPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNS
        : ..    .. ::  : ::.  : ::.: .:. :.: : :::. .....   ::.::: 
NP_001 ARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKP-WIPVLERIRDHVSGVTGQTFNF
        100       110       120       130        140       150     

         180       190       200       210       220       230     
pF1KE2 LLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGEYTYVERV
       .: : :..  : .  : :::  :.    :::.:::: : : .:.:   . ..    :  :
NP_001 VLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDS-RGKSPSRRVAVV
         160       170       180       190       200        210    

         240       250       260       270       280      
pF1KE2 KIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
       ..:: ::.::.:.  :.. : : .: . .   :::::::: .         
NP_001 RLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK    
          220       230       240       250       260     

>>NP_001001655 (OMIM: 610602) DNA oxidative demethylase   (261 aa)
 initn: 339 init1: 163 opt: 377  Z-score: 448.1  bits: 90.7 E(85289): 3.2e-18
Smith-Waterman score: 377; 37.0% identity (60.9% similar) in 192 aa overlap (91-277:67-256)

               70        80        90       100       110       120
pF1KE2 QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG
                                     : :  .    ::: :...: ..: .   . 
NP_001 TRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGAL
         40        50        60        70        80        90      

                 130         140       150       160       170     
pF1KE2 IREDIT---YQQPRLTAWYGE--LPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNS
        : ..    .. ::  : ::.  : ::.: .:. :.: : :::. .....   ::.::: 
NP_001 ARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKP-WIPVLERIRDHVSGVTGQTFNF
        100       110       120       130        140       150     

         180       190       200       210       220       230     
pF1KE2 LLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGEYTYVERV
       .: : :..  : .  : :::  :.    :::.:::: : : .:.:   . ..    :  :
NP_001 VLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDS-RGKSPSRRVAVV
         160       170       180       190       200        210    

         240       250       260       270       280      
pF1KE2 KIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
       ..:: ::.::.:.  :.. : : .: . .   :::::::: .         
NP_001 RLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK    
          220       230       240       250       260     

>>NP_001138847 (OMIM: 610602) DNA oxidative demethylase   (261 aa)
 initn: 339 init1: 163 opt: 377  Z-score: 448.1  bits: 90.7 E(85289): 3.2e-18
Smith-Waterman score: 377; 37.0% identity (60.9% similar) in 192 aa overlap (91-277:67-256)

               70        80        90       100       110       120
pF1KE2 QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG
                                     : :  .    ::: :...: ..: .   . 
NP_001 TRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGAL
         40        50        60        70        80        90      

                 130         140       150       160       170     
pF1KE2 IREDIT---YQQPRLTAWYGE--LPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNS
        : ..    .. ::  : ::.  : ::.: .:. :.: : :::. .....   ::.::: 
NP_001 ARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKP-WIPVLERIRDHVSGVTGQTFNF
        100       110       120       130        140       150     

         180       190       200       210       220       230     
pF1KE2 LLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGEYTYVERV
       .: : :..  : .  : :::  :.    :::.:::: : : .:.:   . ..    :  :
NP_001 VLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDS-RGKSPSRRVAVV
         160       170       180       190       200        210    

         240       250       260       270       280      
pF1KE2 KIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
       ..:: ::.::.:.  :.. : : .: . .   :::::::: .         
NP_001 RLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK    
          220       230       240       250       260     

>>XP_005253892 (OMIM: 610602) PREDICTED: DNA oxidative d  (261 aa)
 initn: 339 init1: 163 opt: 377  Z-score: 448.1  bits: 90.7 E(85289): 3.2e-18
Smith-Waterman score: 377; 37.0% identity (60.9% similar) in 192 aa overlap (91-277:67-256)

               70        80        90       100       110       120
pF1KE2 QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG
                                     : :  .    ::: :...: ..: .   . 
XP_005 TRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGAL
         40        50        60        70        80        90      

                 130         140       150       160       170     
pF1KE2 IREDIT---YQQPRLTAWYGE--LPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNS
        : ..    .. ::  : ::.  : ::.: .:. :.: : :::. .....   ::.::: 
XP_005 ARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKP-WIPVLERIRDHVSGVTGQTFNF
        100       110       120       130        140       150     

         180       190       200       210       220       230     
pF1KE2 LLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGEYTYVERV
       .: : :..  : .  : :::  :.    :::.:::: : : .:.:   . ..    :  :
XP_005 VLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDS-RGKSPSRRVAVV
         160       170       180       190       200        210    

         240       250       260       270       280      
pF1KE2 KIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
       ..:: ::.::.:.  :.. : : .: . .   :::::::: .         
XP_005 RLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK    
          220       230       240       250       260     




286 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 19:23:24 2016 done: Sat Nov  5 19:23:25 2016
 Total Scan time:  7.330 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]