Result of FASTA (omim) for
pFN21AE2367
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2367, 2145 aa
1>>>pF1KE2367 2145 - 2145 aa - 2145 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.1842+/-0.000483; mu= -2.5185+/- 0.030
mean_var=348.5963+/-76.488, 0's: 0 Z-trim(118.1): 151 B-trim: 1252 in 2/57
Lambda= 0.068693
statistics sampled from 30614 (30802) to 30614 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.361), width: 16
Scan time: 23.540
The best scores are: opt bits E(85289)
NP_443728 (OMIM: 611318) mediator of RNA polymeras (2145) 14389 1442.2 0
XP_011510692 (OMIM: 611318) PREDICTED: mediator of (2145) 14389 1442.2 0
XP_006713550 (OMIM: 611318) PREDICTED: mediator of (2180) 9995 1006.7 0
XP_016861170 (OMIM: 611318) PREDICTED: mediator of (1309) 8807 888.8 0
XP_016861167 (OMIM: 611318) PREDICTED: mediator of (2150) 8476 856.2 0
XP_016861168 (OMIM: 611318) PREDICTED: mediator of (2107) 8434 852.0 0
XP_016861165 (OMIM: 611318) PREDICTED: mediator of (2197) 8434 852.0 0
XP_016861166 (OMIM: 611318) PREDICTED: mediator of (2196) 8417 850.3 0
XP_011510696 (OMIM: 611318) PREDICTED: mediator of (1946) 8340 842.7 0
XP_016861169 (OMIM: 611318) PREDICTED: mediator of (2103) 8017 810.7 0
XP_011510701 (OMIM: 611318) PREDICTED: mediator of (1223) 4409 452.9 1e-125
NP_005111 (OMIM: 300188,300895,305450,309520) medi (2177) 2175 231.7 6.9e-59
XP_011537078 (OMIM: 147920,602113) PREDICTED: hist (5525) 392 55.3 2.2e-05
XP_006719679 (OMIM: 147920,602113) PREDICTED: hist (5536) 392 55.3 2.2e-05
NP_003473 (OMIM: 147920,602113) histone-lysine N-m (5537) 392 55.3 2.2e-05
XP_005269219 (OMIM: 147920,602113) PREDICTED: hist (5537) 392 55.3 2.2e-05
XP_006719677 (OMIM: 147920,602113) PREDICTED: hist (5540) 392 55.3 2.2e-05
XP_011537076 (OMIM: 147920,602113) PREDICTED: hist (5549) 392 55.3 2.2e-05
XP_011537075 (OMIM: 147920,602113) PREDICTED: hist (5552) 392 55.3 2.2e-05
XP_011537074 (OMIM: 147920,602113) PREDICTED: hist (5553) 392 55.3 2.2e-05
XP_011537073 (OMIM: 147920,602113) PREDICTED: hist (5555) 392 55.3 2.2e-05
XP_011537072 (OMIM: 147920,602113) PREDICTED: hist (5556) 392 55.3 2.2e-05
>>NP_443728 (OMIM: 611318) mediator of RNA polymerase II (2145 aa)
initn: 14389 init1: 14389 opt: 14389 Z-score: 7720.1 bits: 1442.2 E(85289): 0
Smith-Waterman score: 14389; 100.0% identity (100.0% similar) in 2145 aa overlap (1-2145:1-2145)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQAR
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPV
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 LMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLP
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 SVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQP
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140
pF1KE2 LFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
:::::::::::::::::::::::::::::::::::::::::::::
NP_443 LFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
2110 2120 2130 2140
>>XP_011510692 (OMIM: 611318) PREDICTED: mediator of RNA (2145 aa)
initn: 14389 init1: 14389 opt: 14389 Z-score: 7720.1 bits: 1442.2 E(85289): 0
Smith-Waterman score: 14389; 100.0% identity (100.0% similar) in 2145 aa overlap (1-2145:1-2145)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQAR
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPV
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 LMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLP
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 SVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQP
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140
pF1KE2 LFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
2110 2120 2130 2140
>>XP_006713550 (OMIM: 611318) PREDICTED: mediator of RNA (2180 aa)
initn: 9992 init1: 9992 opt: 9995 Z-score: 5366.5 bits: 1006.7 E(85289): 0
Smith-Waterman score: 14292; 98.4% identity (98.4% similar) in 2177 aa overlap (4-2145:4-2180)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKME----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSI
610 620 630 640 650 660
660 670 680
pF1KE2 -------------------------------IFSPMPGESCENANTSLGRRMSVNCEKLV
:::::::::::::::::::::::::::::
XP_006 MAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE2 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE2 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE2 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE2 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE2 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE2 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KE2 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KE2 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KE2 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450 1460
pF1KE2 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
1450 1460 1470 1480 1490 1500
1470 1480 1490 1500 1510 1520
pF1KE2 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
1510 1520 1530 1540 1550 1560
1530 1540 1550 1560 1570 1580
pF1KE2 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
1570 1580 1590 1600 1610 1620
1590 1600 1610 1620 1630 1640
pF1KE2 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
1630 1640 1650 1660 1670 1680
1650 1660 1670 1680 1690 1700
pF1KE2 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
1690 1700 1710 1720 1730 1740
1710 1720 1730 1740 1750 1760
pF1KE2 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
1750 1760 1770 1780 1790 1800
1770 1780 1790 1800 1810 1820
pF1KE2 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
1810 1820 1830 1840 1850 1860
1830 1840 1850 1860 1870 1880
pF1KE2 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
1870 1880 1890 1900 1910 1920
1890 1900 1910 1920 1930 1940
pF1KE2 LQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYG
1930 1940 1950 1960 1970 1980
1950 1960 1970 1980 1990 2000
pF1KE2 TQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQ
1990 2000 2010 2020 2030 2040
2010 2020 2030 2040 2050 2060
pF1KE2 PLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQM
2050 2060 2070 2080 2090 2100
2070 2080 2090 2100 2110 2120
pF1KE2 QQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQK
2110 2120 2130 2140 2150 2160
2130 2140
pF1KE2 QLSSNQPQQGVTPYGHPSHF
::::::::::::::::::::
XP_006 QLSSNQPQQGVTPYGHPSHF
2170 2180
>>XP_016861170 (OMIM: 611318) PREDICTED: mediator of RNA (1309 aa)
initn: 8807 init1: 8807 opt: 8807 Z-score: 4733.3 bits: 888.8 E(85289): 0
Smith-Waterman score: 8807; 100.0% identity (100.0% similar) in 1309 aa overlap (837-2145:1-1309)
810 820 830 840 850 860
pF1KE2 NNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLL
::::::::::::::::::::::::::::::
XP_016 MEPALNINGLIDFAIQLLNELSVVEAELLL
10 20 30
870 880 890 900 910 920
pF1KE2 KSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPER
40 50 60 70 80 90
930 940 950 960 970 980
pF1KE2 CILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENP
100 110 120 130 140 150
990 1000 1010 1020 1030 1040
pF1KE2 SARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLS
160 170 180 190 200 210
1050 1060 1070 1080 1090 1100
pF1KE2 SEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHV
220 230 240 250 260 270
1110 1120 1130 1140 1150 1160
pF1KE2 ALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAA
280 290 300 310 320 330
1170 1180 1190 1200 1210 1220
pF1KE2 AHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPK
340 350 360 370 380 390
1230 1240 1250 1260 1270 1280
pF1KE2 SCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQK
400 410 420 430 440 450
1290 1300 1310 1320 1330 1340
pF1KE2 LLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSV
460 470 480 490 500 510
1350 1360 1370 1380 1390 1400
pF1KE2 AEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSS
520 530 540 550 560 570
1410 1420 1430 1440 1450 1460
pF1KE2 ERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQP
580 590 600 610 620 630
1470 1480 1490 1500 1510 1520
pF1KE2 FLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLV
640 650 660 670 680 690
1530 1540 1550 1560 1570 1580
pF1KE2 GGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSN
700 710 720 730 740 750
1590 1600 1610 1620 1630 1640
pF1KE2 ASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDT
760 770 780 790 800 810
1650 1660 1670 1680 1690 1700
pF1KE2 KGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQ
820 830 840 850 860 870
1710 1720 1730 1740 1750 1760
pF1KE2 HHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEK
880 890 900 910 920 930
1770 1780 1790 1800 1810 1820
pF1KE2 KTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFF
940 950 960 970 980 990
1830 1840 1850 1860 1870 1880
pF1KE2 LQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLL
1000 1010 1020 1030 1040 1050
1890 1900 1910 1920 1930 1940
pF1KE2 QQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGT
1060 1070 1080 1090 1100 1110
1950 1960 1970 1980 1990 2000
pF1KE2 QMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQP
1120 1130 1140 1150 1160 1170
2010 2020 2030 2040 2050 2060
pF1KE2 LTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQ
1180 1190 1200 1210 1220 1230
2070 2080 2090 2100 2110 2120
pF1KE2 QPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQ
1240 1250 1260 1270 1280 1290
2130 2140
pF1KE2 LSSNQPQQGVTPYGHPSHF
:::::::::::::::::::
XP_016 LSSNQPQQGVTPYGHPSHF
1300
>>XP_016861167 (OMIM: 611318) PREDICTED: mediator of RNA (2150 aa)
initn: 8456 init1: 8345 opt: 8476 Z-score: 4553.1 bits: 856.2 E(85289): 0
Smith-Waterman score: 14011; 97.0% identity (97.0% similar) in 2177 aa overlap (4-2145:4-2150)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKME----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSI
610 620 630 640 650 660
660 670 680
pF1KE2 -------------------------------IFSPMPGESCENANTSLGRRMSVNCEKLV
:::::::::::::::::::::::::::::
XP_016 MAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE2 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE2 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE2 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE2 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE2 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE2 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KE2 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KE2 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KE2 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450 1460
pF1KE2 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
1450 1460 1470 1480 1490 1500
1470 1480 1490 1500 1510 1520
pF1KE2 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
1510 1520 1530 1540 1550 1560
1530 1540 1550 1560 1570 1580
pF1KE2 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
1570 1580 1590 1600 1610 1620
1590 1600 1610 1620 1630 1640
pF1KE2 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
1630 1640 1650 1660 1670 1680
1650 1660 1670 1680 1690 1700
pF1KE2 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
1690 1700 1710 1720 1730 1740
1710 1720 1730 1740 1750 1760
pF1KE2 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
1750 1760 1770 1780 1790 1800
1770 1780 1790 1800 1810 1820
pF1KE2 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
1810 1820 1830 1840 1850 1860
1830 1840 1850 1860 1870 1880
pF1KE2 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
1870 1880 1890 1900 1910 1920
1890 1900 1910 1920 1930 1940
pF1KE2 LQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYG
:::::::::::::::::::: ::::::::::
XP_016 LQQQQQQRLLRQAQTRPFQQ------------------------------TMPQGYTMYG
1930 1940 1950
1950 1960 1970 1980 1990 2000
pF1KE2 TQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQ
1960 1970 1980 1990 2000 2010
2010 2020 2030 2040 2050 2060
pF1KE2 PLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQM
2020 2030 2040 2050 2060 2070
2070 2080 2090 2100 2110 2120
pF1KE2 QQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQK
2080 2090 2100 2110 2120 2130
2130 2140
pF1KE2 QLSSNQPQQGVTPYGHPSHF
::::::::::::::::::::
XP_016 QLSSNQPQQGVTPYGHPSHF
2140 2150
>>XP_016861168 (OMIM: 611318) PREDICTED: mediator of RNA (2107 aa)
initn: 10300 init1: 8337 opt: 8434 Z-score: 4530.7 bits: 852.0 E(85289): 0
Smith-Waterman score: 13451; 93.5% identity (93.5% similar) in 2197 aa overlap (1-2145:1-2107)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
:::::::::::::::::::::::::::::::::::::::
XP_016 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQ---------------------
250 260 270
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
XP_016 ------------------------------------------------------------
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ---------TVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
460 470 480 490 500 510
610 620 630 640 650
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKME----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSI
520 530 540 550 560 570
660 670 680
pF1KE2 -------------------------------IFSPMPGESCENANTSLGRRMSVNCEKLV
:::::::::::::::::::::::::::::
XP_016 MAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLV
580 590 600 610 620 630
690 700 710 720 730 740
pF1KE2 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
640 650 660 670 680 690
750 760 770 780 790 800
pF1KE2 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
700 710 720 730 740 750
810 820 830 840 850 860
pF1KE2 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
760 770 780 790 800 810
870 880 890 900 910 920
pF1KE2 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
820 830 840 850 860 870
930 940 950 960 970 980
pF1KE2 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KE2 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KE2 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
1000 1010 1020 1030 1040 1050
1110 1120 1130 1140 1150 1160
pF1KE2 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
1060 1070 1080 1090 1100 1110
1170 1180 1190 1200 1210 1220
pF1KE2 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
1120 1130 1140 1150 1160 1170
1230 1240 1250 1260 1270 1280
pF1KE2 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
1180 1190 1200 1210 1220 1230
1290 1300 1310 1320 1330 1340
pF1KE2 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
1240 1250 1260 1270 1280 1290
1350 1360 1370 1380 1390 1400
pF1KE2 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
1300 1310 1320 1330 1340 1350
1410 1420 1430 1440 1450 1460
pF1KE2 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
1360 1370 1380 1390 1400 1410
1470 1480 1490 1500 1510 1520
pF1KE2 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
1420 1430 1440 1450 1460 1470
1530 1540 1550 1560 1570 1580
pF1KE2 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
1480 1490 1500 1510 1520 1530
1590 1600 1610 1620 1630 1640
pF1KE2 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
1540 1550 1560 1570 1580 1590
1650 1660 1670 1680 1690 1700
pF1KE2 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
1600 1610 1620 1630 1640 1650
1710 1720 1730 1740 1750 1760
pF1KE2 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
1660 1670 1680 1690 1700 1710
1770 1780 1790 1800 1810 1820
pF1KE2 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
1720 1730 1740 1750 1760 1770
1830 1840 1850 1860 1870 1880
pF1KE2 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
1780 1790 1800 1810 1820 1830
1890 1900 1910 1920
pF1KE2 LQQQQQQRLLRQAQTRPFQQ-----------------GQPGDQAALFAAQARPSPQLPQY
:::::::::::::::::::: :::::::::::::::::::::::
XP_016 LQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQY
1840 1850 1860 1870 1880 1890
1930 1940 1950 1960 1970 1980
pF1KE2 PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQI
1900 1910 1920 1930 1940 1950
1990 2000 2010 2020 2030 2040
pF1KE2 QQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDP
1960 1970 1980 1990 2000 2010
2050 2060 2070 2080 2090 2100
pF1KE2 MRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQ
2020 2030 2040 2050 2060 2070
2110 2120 2130 2140
pF1KE2 QTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
:::::::::::::::::::::::::::::::::::::
XP_016 QTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
2080 2090 2100
>>XP_016861165 (OMIM: 611318) PREDICTED: mediator of RNA (2197 aa)
initn: 8448 init1: 8337 opt: 8434 Z-score: 4530.4 bits: 852.0 E(85289): 0
Smith-Waterman score: 14248; 97.6% identity (97.6% similar) in 2194 aa overlap (4-2145:4-2197)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKME----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSI
610 620 630 640 650 660
660 670 680
pF1KE2 -------------------------------IFSPMPGESCENANTSLGRRMSVNCEKLV
:::::::::::::::::::::::::::::
XP_016 MAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE2 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE2 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE2 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE2 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE2 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE2 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KE2 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KE2 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KE2 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450 1460
pF1KE2 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
1450 1460 1470 1480 1490 1500
1470 1480 1490 1500 1510 1520
pF1KE2 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
1510 1520 1530 1540 1550 1560
1530 1540 1550 1560 1570 1580
pF1KE2 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
1570 1580 1590 1600 1610 1620
1590 1600 1610 1620 1630 1640
pF1KE2 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
1630 1640 1650 1660 1670 1680
1650 1660 1670 1680 1690 1700
pF1KE2 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
1690 1700 1710 1720 1730 1740
1710 1720 1730 1740 1750 1760
pF1KE2 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
1750 1760 1770 1780 1790 1800
1770 1780 1790 1800 1810 1820
pF1KE2 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
1810 1820 1830 1840 1850 1860
1830 1840 1850 1860 1870 1880
pF1KE2 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
1870 1880 1890 1900 1910 1920
1890 1900 1910 1920
pF1KE2 LQQQQQQRLLRQAQTRPFQQ-----------------GQPGDQAALFAAQARPSPQLPQY
:::::::::::::::::::: :::::::::::::::::::::::
XP_016 LQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQY
1930 1940 1950 1960 1970 1980
1930 1940 1950 1960 1970 1980
pF1KE2 PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQI
1990 2000 2010 2020 2030 2040
1990 2000 2010 2020 2030 2040
pF1KE2 QQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDP
2050 2060 2070 2080 2090 2100
2050 2060 2070 2080 2090 2100
pF1KE2 MRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQ
2110 2120 2130 2140 2150 2160
2110 2120 2130 2140
pF1KE2 QTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
:::::::::::::::::::::::::::::::::::::
XP_016 QTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
2170 2180 2190
>>XP_016861166 (OMIM: 611318) PREDICTED: mediator of RNA (2196 aa)
initn: 10899 init1: 6393 opt: 8417 Z-score: 4521.3 bits: 850.3 E(85289): 0
Smith-Waterman score: 14236; 97.6% identity (97.6% similar) in 2195 aa overlap (3-2145:3-2196)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKME----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSI
610 620 630 640 650 660
660 670 680
pF1KE2 -------------------------------IFSPMPGESCENANTSLGRRMSVNCEKLV
:::::::::::::::::::::::::::::
XP_016 MAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE2 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE2 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_016 RCILAYLYDLYVSCSHLRSKFGDLFS-ACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
970 980 990 1000 1010
990 1000 1010 1020 1030 1040
pF1KE2 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
1020 1030 1040 1050 1060 1070
1050 1060 1070 1080 1090 1100
pF1KE2 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
1080 1090 1100 1110 1120 1130
1110 1120 1130 1140 1150 1160
pF1KE2 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
1140 1150 1160 1170 1180 1190
1170 1180 1190 1200 1210 1220
pF1KE2 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
1200 1210 1220 1230 1240 1250
1230 1240 1250 1260 1270 1280
pF1KE2 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
1260 1270 1280 1290 1300 1310
1290 1300 1310 1320 1330 1340
pF1KE2 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
1320 1330 1340 1350 1360 1370
1350 1360 1370 1380 1390 1400
pF1KE2 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
1380 1390 1400 1410 1420 1430
1410 1420 1430 1440 1450 1460
pF1KE2 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
1440 1450 1460 1470 1480 1490
1470 1480 1490 1500 1510 1520
pF1KE2 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
1500 1510 1520 1530 1540 1550
1530 1540 1550 1560 1570 1580
pF1KE2 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
1560 1570 1580 1590 1600 1610
1590 1600 1610 1620 1630 1640
pF1KE2 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
1620 1630 1640 1650 1660 1670
1650 1660 1670 1680 1690 1700
pF1KE2 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
1680 1690 1700 1710 1720 1730
1710 1720 1730 1740 1750 1760
pF1KE2 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
1740 1750 1760 1770 1780 1790
1770 1780 1790 1800 1810 1820
pF1KE2 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
1800 1810 1820 1830 1840 1850
1830 1840 1850 1860 1870 1880
pF1KE2 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
1860 1870 1880 1890 1900 1910
1890 1900 1910 1920
pF1KE2 LQQQQQQRLLRQAQTRPFQQ-----------------GQPGDQAALFAAQARPSPQLPQY
:::::::::::::::::::: :::::::::::::::::::::::
XP_016 LQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQY
1920 1930 1940 1950 1960 1970
1930 1940 1950 1960 1970 1980
pF1KE2 PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQI
1980 1990 2000 2010 2020 2030
1990 2000 2010 2020 2030 2040
pF1KE2 QQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDP
2040 2050 2060 2070 2080 2090
2050 2060 2070 2080 2090 2100
pF1KE2 MRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLFPRQGLQ
2100 2110 2120 2130 2140 2150
2110 2120 2130 2140
pF1KE2 QTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
:::::::::::::::::::::::::::::::::::::
XP_016 QTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
2160 2170 2180 2190
>>XP_011510696 (OMIM: 611318) PREDICTED: mediator of RNA (1946 aa)
initn: 8373 init1: 8337 opt: 8340 Z-score: 4480.8 bits: 842.7 E(85289): 0
Smith-Waterman score: 12637; 98.2% identity (98.2% similar) in 1937 aa overlap (4-1905:4-1940)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKME----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSI
610 620 630 640 650 660
660 670 680
pF1KE2 -------------------------------IFSPMPGESCENANTSLGRRMSVNCEKLV
:::::::::::::::::::::::::::::
XP_011 MAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQI
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE2 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPE
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE2 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIEN
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE2 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVL
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE2 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQH
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE2 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLA
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE2 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNP
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KE2 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KE2 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGS
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KE2 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSS
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450 1460
pF1KE2 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQ
1450 1460 1470 1480 1490 1500
1470 1480 1490 1500 1510 1520
pF1KE2 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNL
1510 1520 1530 1540 1550 1560
1530 1540 1550 1560 1570 1580
pF1KE2 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLS
1570 1580 1590 1600 1610 1620
1590 1600 1610 1620 1630 1640
pF1KE2 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLID
1630 1640 1650 1660 1670 1680
1650 1660 1670 1680 1690 1700
pF1KE2 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEE
1690 1700 1710 1720 1730 1740
1710 1720 1730 1740 1750 1760
pF1KE2 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEE
1750 1760 1770 1780 1790 1800
1770 1780 1790 1800 1810 1820
pF1KE2 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGF
1810 1820 1830 1840 1850 1860
1830 1840 1850 1860 1870 1880
pF1KE2 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKL
1870 1880 1890 1900 1910 1920
1890 1900 1910 1920 1930 1940
pF1KE2 LQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYG
::::::::::::::::::::
XP_011 LQQQQQQRLLRQAQTRPFQQKTVIHV
1930 1940
>>XP_016861169 (OMIM: 611318) PREDICTED: mediator of RNA (2103 aa)
initn: 12424 init1: 7923 opt: 8017 Z-score: 4307.3 bits: 810.7 E(85289): 0
Smith-Waterman score: 13810; 96.5% identity (96.5% similar) in 2162 aa overlap (1-2145:1-2103)
10 20 30 40 50 60
pF1KE2 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKME----
610 620 630 640 650
670 680 690 700 710 720
pF1KE2 MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS
:::::
XP_016 -------------------------------------------------------DESSS
660
730 740 750 760 770 780
pF1KE2 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
670 680 690 700 710 720
790 800 810 820 830 840
pF1KE2 PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
730 740 750 760 770 780
850 860 870 880 890 900
pF1KE2 LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
790 800 810 820 830 840
910 920 930 940 950 960
pF1KE2 TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KE2 IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
910 920 930 940 950 960
1030 1040 1050 1060 1070 1080
pF1KE2 GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
970 980 990 1000 1010 1020
1090 1100 1110 1120 1130 1140
pF1KE2 HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
1030 1040 1050 1060 1070 1080
1150 1160 1170 1180 1190 1200
pF1KE2 ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
1090 1100 1110 1120 1130 1140
1210 1220 1230 1240 1250 1260
pF1KE2 NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
1150 1160 1170 1180 1190 1200
1270 1280 1290 1300 1310 1320
pF1KE2 LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
1210 1220 1230 1240 1250 1260
1330 1340 1350 1360 1370 1380
pF1KE2 WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
1270 1280 1290 1300 1310 1320
1390 1400 1410 1420 1430 1440
pF1KE2 FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
1330 1340 1350 1360 1370 1380
1450 1460 1470 1480 1490 1500
pF1KE2 QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
1390 1400 1410 1420 1430 1440
1510 1520 1530 1540 1550 1560
pF1KE2 REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
1450 1460 1470 1480 1490 1500
1570 1580 1590 1600 1610 1620
pF1KE2 NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
1510 1520 1530 1540 1550 1560
1630 1640 1650 1660 1670 1680
pF1KE2 VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
1570 1580 1590 1600 1610 1620
1690 1700 1710 1720 1730 1740
pF1KE2 KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
1630 1640 1650 1660 1670 1680
1750 1760 1770 1780 1790 1800
pF1KE2 SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
1690 1700 1710 1720 1730 1740
1810 1820 1830 1840 1850 1860
pF1KE2 SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
1750 1760 1770 1780 1790 1800
1870 1880 1890 1900
pF1KE2 RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQ---------------
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDN
1810 1820 1830 1840 1850 1860
1910 1920 1930 1940 1950 1960
pF1KE2 --GQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVL
1870 1880 1890 1900 1910 1920
1970 1980 1990 2000 2010 2020
pF1KE2 SPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPL
1930 1940 1950 1960 1970 1980
2030 2040 2050 2060 2070 2080
pF1KE2 VGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSS
1990 2000 2010 2020 2030 2040
2090 2100 2110 2120 2130 2140
pF1KE2 QSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPS
2050 2060 2070 2080 2090 2100
pF1KE2 HF
::
XP_016 HF
2145 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:32:30 2016 done: Sun Nov 6 09:32:34 2016
Total Scan time: 23.540 Total Display time: 1.570
Function used was FASTA [36.3.4 Apr, 2011]