Result of FASTA (omim) for
pFN21AE2299
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2299, 429 aa
1>>>pF1KE2299 429 - 429 aa - 429 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8754+/-0.000359; mu= 14.3871+/- 0.022
mean_var=72.3714+/-14.435, 0's: 0 Z-trim(114.9): 82 B-trim: 548 in 2/48
Lambda= 0.150762
statistics sampled from 24900 (24982) to 24900 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.293), width: 16
Scan time: 8.450
The best scores are: opt bits E(85289)
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 2890 637.8 1.6e-182
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 1052 238.0 3.4e-62
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 418 100.1 1.2e-20
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 398 95.7 1.4e-19
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 400 96.2 2e-19
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 400 96.2 2e-19
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 400 96.2 2e-19
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 398 95.8 2.4e-19
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 394 94.8 2.5e-19
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 394 94.9 3.9e-19
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 393 94.7 5.7e-19
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 392 94.5 5.9e-19
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 389 93.8 7.4e-19
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 389 93.8 7.4e-19
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 389 93.8 8.5e-19
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 389 93.8 8.5e-19
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 389 93.8 8.5e-19
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 389 93.8 8.5e-19
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 378 91.4 4.7e-18
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 371 89.9 1.3e-17
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 371 89.9 1.3e-17
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 343 83.7 5e-16
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 343 83.8 7.6e-16
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 332 81.4 4.2e-15
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 329 80.8 8.2e-15
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 323 79.5 2.1e-14
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 317 78.1 4.1e-14
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 296 73.6 1e-12
NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 277 69.5 1.9e-11
XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 277 69.5 1.9e-11
XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 277 69.5 2.1e-11
XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 277 69.5 2.4e-11
XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 259 65.5 2e-10
NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10
XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10
XP_006714648 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10
XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10
NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10
NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10
NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10
NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10
XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10
XP_011541610 (OMIM: 601918) PREDICTED: growth/diff ( 454) 259 65.6 3.1e-10
NP_005251 (OMIM: 601918) growth/differentiation fa ( 454) 259 65.6 3.1e-10
NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 250 63.6 1e-09
NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 250 63.6 1.1e-09
XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 250 63.6 1.1e-09
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 246 62.7 2e-09
NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 244 62.2 2.1e-09
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 238 61.0 5.7e-09
>>NP_057288 (OMIM: 605120,615506) growth/differentiation (429 aa)
initn: 2890 init1: 2890 opt: 2890 Z-score: 3397.9 bits: 637.8 E(85289): 1.6e-182
Smith-Waterman score: 2890; 100.0% identity (100.0% similar) in 429 aa overlap (1-429:1-429)
10 20 30 40 50 60
pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 NVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 EEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 EEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEG
370 380 390 400 410 420
pF1KE2 MSVAECGCR
:::::::::
NP_057 MSVAECGCR
>>NP_055297 (OMIM: 608748) bone morphogenetic protein 10 (424 aa)
initn: 821 init1: 540 opt: 1052 Z-score: 1237.5 bits: 238.0 E(85289): 3.4e-62
Smith-Waterman score: 1052; 42.1% identity (71.6% similar) in 437 aa overlap (4-429:2-424)
10 20 30 40 50
pF1KE2 MCPGALWVALPLLSLLAGSL-QGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHT-FNLKMF
:.: ..: : ::. : .:.:... .. . ... : . :. ... .
NP_055 MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPL----EEDMSLFGDVFSEQDGVDFNTL
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAI
:...: .::..:::: .:.::...:.::.::..:::....:... :..::.:::. :: .
NP_055 LQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 SITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDG
: .. . ..:. ::::.:::.::.. ::::::. : . ...:..::..
NP_055 SQPVSFN-GLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLES
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 TDAWDSATETKTF-LVSQDIQDEG--WETLEVSSAVKRWVRSDSTKSKNKLEVTVES-HR
:. : . . ::: .: . :::..:..:..:: .: : : ..::: .:: :
NP_055 KG--DNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGS--STHQLEVHIESKHD
180 190 200 210 220
240 250 260 270 280 290
pF1KE2 KGCDT----LDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKD
.. :. :.:.. ... :...:::.:.:: :: . :: ::::::: : .:. :
NP_055 EAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD-KERKEELNEMISHEQLPELDNLGLD
230 240 250 260 270 280
300 310 320 330 340
pF1KE2 G-STEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPK
. :. :: . . ... :: :: .:.: :..:..: : ..:..::::::::::
NP_055 SFSSGPGEEALLQ-MRSNIIYDST-ARIRRNA-KGNYCKRTPLYIDFKEIGWDSWIIAPP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE2 EYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDM
::::::.: : .:::. .:::::::.:.::::: :..::::::::: :::.:: :
NP_055 GYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK-
350 360 370 380 390 400
410 420
pF1KE2 GVPTLKYHYEGMSVAECGCR
:: : :..::::.:.:::::
NP_055 GVVTYKFKYEGMAVSECGCR
410 420
>>NP_001001557 (OMIM: 118100,601147,613094,613703,615360 (455 aa)
initn: 427 init1: 327 opt: 418 Z-score: 491.7 bits: 100.1 E(85289): 1.2e-20
Smith-Waterman score: 479; 31.3% identity (55.3% similar) in 387 aa overlap (76-429:85-455)
50 60 70 80 90 100
pF1KE2 GGLPEHTFNLKMFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYT-SDKSTTP
: :: : .::...: :. ..:
NP_001 PRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGIN
60 70 80 90 100 110
110 120 130 140 150
pF1KE2 ASNIVRSFSMEDAISIT--ATEDF---PFQKHILLFNISI-PRHEQITRAELRLYVSCQN
:: . : : . :.. . .:. :.... ::..:. .:... :::::. . .
NP_001 ASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPS
120 130 140 150 160 170
160 170 180 190 200
pF1KE2 ----------HVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETL--E
::. :. .. .:: : .. :. : : : .. . :. : :
NP_001 APWGPPAGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEV--FDVWQGLRHQPWKQLCLE
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE2 VSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISV---PPGSRNLPFFVVFSNDHSS
. .: : . :. ... . . . .: .. :: : : .:::. :
NP_001 LRAA---WGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERAL--LVVFT---RS
240 250 260 270 280
270 280 290 300 310 320
pF1KE2 GTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGA
:. :.::... :.. . .:: .. :.. : ::.:.: :
NP_001 QRKNLFAEMREQLGSA-EAAGPGAGAEGSWPPPSGA----PDARPWLPSPGRRRRRTAFA
290 300 310 320 330
330 340 350 360 370
pF1KE2 GSH-----------CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTK
. : :.: :.:::...:::.::::: :::::.:.: : ::: . . ::.
NP_001 SRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTN
340 350 360 370 380 390
380 390 400 410 420
pF1KE2 HAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR
:::.:::.. : .. .:::::::.:::.:: : : .. .:: : : ::::
NP_001 HAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYID-AGNNVVYKQYEDMVVESCGCR
400 410 420 430 440 450
>>XP_016866687 (OMIM: 112265) PREDICTED: bone morphogene (239 aa)
initn: 422 init1: 351 opt: 398 Z-score: 472.7 bits: 95.7 E(85289): 1.4e-19
Smith-Waterman score: 409; 33.3% identity (60.3% similar) in 237 aa overlap (199-428:29-238)
170 180 190 200 210 220
pF1KE2 SVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEV
: :: ..... . ..:: . .:.: .
XP_016 MEAERAQVLPTVRDADLFLLDTRKAQALDVGWLVFDITVTSNHWV----INPQNNLGL
10 20 30 40 50
230 240 250 260 270 280
pF1KE2 TVESHRKGCDTLDISVP-------PGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQE
. .. ..... : :.. ::.:.: : ... :: .
XP_016 QLCAETGDGRSINVKSAGLVGRQGPQSKQ-PFMVAF-------FKASEVLLRSV------
60 70 80 90 100
290 300 310 320 330 340
pF1KE2 SVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGW
. .: . . ..:: ..:.. ..:. . ....: :.: : :.:.:.::
XP_016 ---RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQA-----CKKHELYVSFRDLGW
110 120 130 140 150
350 360 370 380 390 400
pF1KE2 DSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPI
..:::::. : :. : : : ::: .. :.:::::::::: :: .: : ::.::::. :
XP_016 QDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAI
160 170 180 190 200 210
410 420
pF1KE2 SVLYKDDMGVPTLKYHYEGMSVAECGCR
:::: :: . :: .:..: : :::
XP_016 SVLYFDDSSNVILK-KYRNMVVRSCGCH
220 230
>>NP_000548 (OMIM: 112600,113100,200700,201250,228900,60 (501 aa)
initn: 375 init1: 326 opt: 400 Z-score: 469.9 bits: 96.2 E(85289): 2e-19
Smith-Waterman score: 444; 27.1% identity (55.7% similar) in 431 aa overlap (18-429:102-501)
10 20 30 40
pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLG-VPGG
:. . :: . .: . . .: : .:::
NP_000 ANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG
80 90 100 110 120 130
50 60 70 80 90 100
pF1KE2 GLPEHTFNL-KMFLENVKVDFLRSLNLSGVPSQDKTRVEPP-----QYMIDLYNRYTSDK
: .. .. . :: :.. : : . : .:: .::..:: : ::
NP_000 KAPPKAGSVPSSFL-------LKKAREPGPPREPKEPFRPPPITPHEYMLSLY-RTLSDA
140 150 160 170 180
110 120 130 140 150
pF1KE2 STTPASNIVR-SFSMEDAIS--ITATED--FPF-QKHILLFNISIPRHEQITRAELR-LY
. ... :. .. ..:. : .: : .:. .:.:: ... . :::: :
NP_000 DRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILR
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKR
. .. . :. : .. . . .. . :. . : .. :::....
NP_000 KKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVP-GLDGSGWEVFDI------
250 260 270 280 290
220 230 240 250 260
pF1KE2 WVRSDSTKSKNKLEVTVESHRKG--CDTLDISVPPGSRNL---PFFVVFSNDHSSGTKET
: . :.. .: . .:. ..: : .. ..:.. .:.::.
NP_000 WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFG----------
300 310 320 330 340
270 280 290 300 310 320
pF1KE2 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ
: . :... .: .: : . . . : . .. .. ..: : . ..:.
NP_000 RTKKRDLFFNE----IKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRP-SKNLKARCS
350 360 370 380 390 400
330 340 350 360 370 380
pF1KE2 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV
. .:.:::.:.:::.::::: ::::..:.: : ::: . . ::.::..:::.. : ..
NP_000 RKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPEST
410 420 430 440 450 460
390 400 410 420
pF1KE2 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR
.:::::.:::::.:. :. . . : .:: : : ::::
NP_000 PPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR
470 480 490 500
>>NP_001306067 (OMIM: 112600,113100,200700,201250,228900 (501 aa)
initn: 375 init1: 326 opt: 400 Z-score: 469.9 bits: 96.2 E(85289): 2e-19
Smith-Waterman score: 444; 27.1% identity (55.7% similar) in 431 aa overlap (18-429:102-501)
10 20 30 40
pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLG-VPGG
:. . :: . .: . . .: : .:::
NP_001 ANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG
80 90 100 110 120 130
50 60 70 80 90 100
pF1KE2 GLPEHTFNL-KMFLENVKVDFLRSLNLSGVPSQDKTRVEPP-----QYMIDLYNRYTSDK
: .. .. . :: :.. : : . : .:: .::..:: : ::
NP_001 KAPPKAGSVPSSFL-------LKKAREPGPPREPKEPFRPPPITPHEYMLSLY-RTLSDA
140 150 160 170 180
110 120 130 140 150
pF1KE2 STTPASNIVR-SFSMEDAIS--ITATED--FPF-QKHILLFNISIPRHEQITRAELR-LY
. ... :. .. ..:. : .: : .:. .:.:: ... . :::: :
NP_001 DRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILR
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKR
. .. . :. : .. . . .. . :. . : .. :::....
NP_001 KKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVP-GLDGSGWEVFDI------
250 260 270 280 290
220 230 240 250 260
pF1KE2 WVRSDSTKSKNKLEVTVESHRKG--CDTLDISVPPGSRNL---PFFVVFSNDHSSGTKET
: . :.. .: . .:. ..: : .. ..:.. .:.::.
NP_001 WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFG----------
300 310 320 330 340
270 280 290 300 310 320
pF1KE2 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ
: . :... .: .: : . . . : . .. .. ..: : . ..:.
NP_001 RTKKRDLFFNE----IKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRP-SKNLKARCS
350 360 370 380 390 400
330 340 350 360 370 380
pF1KE2 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV
. .:.:::.:.:::.::::: ::::..:.: : ::: . . ::.::..:::.. : ..
NP_001 RKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPEST
410 420 430 440 450 460
390 400 410 420
pF1KE2 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR
.:::::.:::::.:. :. . . : .:: : : ::::
NP_001 PPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR
470 480 490 500
>>XP_011527377 (OMIM: 112600,113100,200700,201250,228900 (501 aa)
initn: 375 init1: 326 opt: 400 Z-score: 469.9 bits: 96.2 E(85289): 2e-19
Smith-Waterman score: 444; 27.1% identity (55.7% similar) in 431 aa overlap (18-429:102-501)
10 20 30 40
pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLG-VPGG
:. . :: . .: . . .: : .:::
XP_011 ANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG
80 90 100 110 120 130
50 60 70 80 90 100
pF1KE2 GLPEHTFNL-KMFLENVKVDFLRSLNLSGVPSQDKTRVEPP-----QYMIDLYNRYTSDK
: .. .. . :: :.. : : . : .:: .::..:: : ::
XP_011 KAPPKAGSVPSSFL-------LKKAREPGPPREPKEPFRPPPITPHEYMLSLY-RTLSDA
140 150 160 170 180
110 120 130 140 150
pF1KE2 STTPASNIVR-SFSMEDAIS--ITATED--FPF-QKHILLFNISIPRHEQITRAELR-LY
. ... :. .. ..:. : .: : .:. .:.:: ... . :::: :
XP_011 DRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILR
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKR
. .. . :. : .. . . .. . :. . : .. :::....
XP_011 KKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVP-GLDGSGWEVFDI------
250 260 270 280 290
220 230 240 250 260
pF1KE2 WVRSDSTKSKNKLEVTVESHRKG--CDTLDISVPPGSRNL---PFFVVFSNDHSSGTKET
: . :.. .: . .:. ..: : .. ..:.. .:.::.
XP_011 WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFG----------
300 310 320 330 340
270 280 290 300 310 320
pF1KE2 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ
: . :... .: .: : . . . : . .. .. ..: : . ..:.
XP_011 RTKKRDLFFNE----IKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRP-SKNLKARCS
350 360 370 380 390 400
330 340 350 360 370 380
pF1KE2 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV
. .:.:::.:.:::.::::: ::::..:.: : ::: . . ::.::..:::.. : ..
XP_011 RKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPEST
410 420 430 440 450 460
390 400 410 420
pF1KE2 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR
.:::::.:::::.:. :. . . : .:: : : ::::
XP_011 PPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR
470 480 490 500
>>NP_066551 (OMIM: 112265) bone morphogenetic protein 5 (454 aa)
initn: 451 init1: 351 opt: 398 Z-score: 468.3 bits: 95.8 E(85289): 2.4e-19
Smith-Waterman score: 453; 31.0% identity (58.5% similar) in 316 aa overlap (124-428:168-453)
100 110 120 130 140
pF1KE2 NRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQK-HI--LLFNIS-IPRHEQITRAE
.:: :. : . :... ::. : .: ::
NP_066 QSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAE
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE2 LRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSS
.:.: . .:. .. .: . ::... :. .: . : :: .....
NP_066 FRIYKDRSNNRFENETIK--ISIYQIIKEYTNRDADLFLLDTRKAQAL-DVGWLVFDITV
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE2 AVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVP-------PGSRNLPFFVVFSNDHS
. ..:: . .:.: . . .. ..... : :.. ::.:.:
NP_066 TSNHWV----INPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQ-PFMVAF-----
260 270 280 290 300
270 280 290 300 310 320
pF1KE2 SGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAG
: ... :: . . .: . . ..:: ..:.. ..:. . ....:
NP_066 --FKASEVLLRSV---------RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQA-
310 320 330 340 350
330 340 350 360 370 380
pF1KE2 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHL
:.: : :.:.:.::..:::::. : :. : : : ::: .. :.::::::::::
NP_066 ----CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHL
360 370 380 390 400
390 400 410 420
pF1KE2 KFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR
:: .: : ::.::::. ::::: :: . :: .:..: : :::
NP_066 MFPDHVPKPCCAPTKLNAISVLYFDDSSNVILK-KYRNMVVRSCGCH
410 420 430 440 450
>>XP_011527625 (OMIM: 112261,112600,235200) PREDICTED: b (240 aa)
initn: 375 init1: 190 opt: 394 Z-score: 468.0 bits: 94.8 E(85289): 2.5e-19
Smith-Waterman score: 412; 31.5% identity (59.1% similar) in 276 aa overlap (157-429:2-240)
130 140 150 160 170 180
pF1KE2 PFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSAT
:. . . ... . ::... . : ..
XP_011 MQDALGNNSSFHHRINIYEIIKPATANSKFP
10 20 30
190 200 210 220 230 240
pF1KE2 ETK---TFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDIS
:. : ::.:. . ::...:. :: ::. . .. .::. ...: . .
XP_011 VTRLLDTRLVNQNASR--WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVR
40 50 60 70 80
250 260 270 280 290 300
pF1KE2 VPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEED
. ::.: ...:: . ..: . : ...::. :. :...
XP_011 I---SRSL-----HQDEHSWS------QIRPL--------LVTFGHDGK---GHPLHKRE
90 100 110 120
310 320 330 340 350 360
pF1KE2 TDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFP
. :..:. : :.. : :.: :.::..::.:: :.:. :.: : ::
XP_011 --------KRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFP
130 140 150 160 170
370 380 390 400 410 420
pF1KE2 LADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSV
::: .. :.::::::::. . .:. :::::::.:: ::.:: :. .:: .:. : :
XP_011 LADHLNSTNHAIVQTLVN-SVNSKIPKACCVPTELSAISMLYLDENEKVVLK-NYQDMVV
180 190 200 210 220 230
pF1KE2 AECGCR
::::
XP_011 EGCGCR
240
>>NP_001191 (OMIM: 112261,112600,235200) bone morphogene (396 aa)
initn: 459 init1: 190 opt: 394 Z-score: 464.5 bits: 94.9 E(85289): 3.9e-19
Smith-Waterman score: 520; 31.7% identity (58.1% similar) in 382 aa overlap (67-429:55-396)
40 50 60 70 80 90
pF1KE2 AHSPLGVPGGGLPEHTFNLKMFLENVKVDFLRSLNLSGV---PSQDKTRVEPPQYMIDLY
:: :.. :. :. .. : :: ::.:::
NP_001 VPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPP-YMLDLY
30 40 50 60 70 80
100 110 120 130 140
pF1KE2 NRYTSDKSTTPA-----------SNIVRSFSMEDAISITATEDFPFQKHILLFNIS-IPR
:. : . .:: .: :::: :... . .. ..::.: ::
NP_001 RRH-SGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRR-FFFNLSSIPT
90 100 110 120 130 140
150 160 170 180 190
pF1KE2 HEQITRAELRLYV-SCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETK---TFLVSQDI
.: :: :::... . :. . . ... . ::... . : .. :. : ::.:.
NP_001 EEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNA
150 160 170 180 190 200
200 210 220 230 240 250
pF1KE2 QDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVF
. ::...:. :: ::. . .. .::. ...: . . . ::.:
NP_001 SR--WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRI---SRSL-----H
210 220 230 240 250
260 270 280 290 300 310
pF1KE2 SNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARR
...:: . ..: . : ...::. :. :... . :..
NP_001 QDEHSWS------QIRPL--------LVTFGHDGK---GHPLHKRE--------KRQAKH
260 270 280
320 330 340 350 360 370
pF1KE2 KRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQ
:. : :.. : :.: :.::..::.:: :.:. :.: : ::::: .. :.:::::
NP_001 KQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQ
290 300 310 320 330 340
380 390 400 410 420
pF1KE2 TLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR
:::. . .:. :::::::.:: ::.:: :. .:: .:. : : ::::
NP_001 TLVN-SVNSKIPKACCVPTELSAISMLYLDENEKVVLK-NYQDMVVEGCGCR
350 360 370 380 390
429 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 15:32:11 2016 done: Sun Nov 6 15:32:13 2016
Total Scan time: 8.450 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]