Result of FASTA (omim) for
pFN21AE2293
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2293, 206 aa
1>>>pF1KE2293 206 - 206 aa - 206 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0499+/-0.000335; mu= 15.3802+/- 0.021
mean_var=69.3614+/-13.824, 0's: 0 Z-trim(115.9): 83 B-trim: 0 in 0/55
Lambda= 0.153998
statistics sampled from 26590 (26673) to 26590 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.313), width: 16
Scan time: 6.490
The best scores are: opt bits E(85289)
NP_001998 (OMIM: 164980) fibroblast growth factor ( 206) 1352 308.9 3.8e-84
XP_005273904 (OMIM: 164980) PREDICTED: fibroblast ( 118) 755 176.0 2.1e-44
NP_066276 (OMIM: 134921) fibroblast growth factor ( 208) 644 151.6 8.6e-37
NP_004455 (OMIM: 165190,190330) fibroblast growth ( 268) 397 96.8 3.5e-20
XP_016874485 (OMIM: 134921) PREDICTED: fibroblast ( 153) 376 91.9 5.7e-19
XP_016874484 (OMIM: 134921) PREDICTED: fibroblast ( 195) 376 92.0 6.9e-19
NP_001997 (OMIM: 134920) fibroblast growth factor ( 288) 358 88.1 1.5e-17
NP_062825 (OMIM: 605558,615721) fibroblast growth ( 211) 347 85.6 6.4e-17
NP_002001 (OMIM: 600921,612961) fibroblast growth ( 208) 346 85.4 7.3e-17
NP_003859 (OMIM: 300827,309630) fibroblast growth ( 207) 329 81.6 1e-15
NP_065688 (OMIM: 605831) fibroblast growth factor ( 170) 320 79.5 3.4e-15
NP_001308873 (OMIM: 601515,609307) fibroblast grow ( 184) 303 75.8 5e-14
NP_001308865 (OMIM: 601515,609307) fibroblast grow ( 184) 303 75.8 5e-14
NP_001308861 (OMIM: 601515,609307) fibroblast grow ( 184) 303 75.8 5e-14
NP_001308870 (OMIM: 601515,609307) fibroblast grow ( 185) 303 75.8 5e-14
NP_001308862 (OMIM: 601515,609307) fibroblast grow ( 187) 303 75.8 5.1e-14
NP_001308869 (OMIM: 601515,609307) fibroblast grow ( 187) 303 75.8 5.1e-14
NP_001308867 (OMIM: 601515,609307) fibroblast grow ( 187) 303 75.8 5.1e-14
NP_001308876 (OMIM: 601515,609307) fibroblast grow ( 200) 303 75.8 5.4e-14
NP_001308877 (OMIM: 601515,609307) fibroblast grow ( 213) 303 75.8 5.6e-14
NP_001308874 (OMIM: 601515,609307) fibroblast grow ( 213) 303 75.8 5.6e-14
NP_004106 (OMIM: 601515,609307) fibroblast growth ( 247) 303 75.9 6.3e-14
NP_787125 (OMIM: 601515,609307) fibroblast growth ( 252) 303 75.9 6.4e-14
NP_004103 (OMIM: 601514) fibroblast growth factor ( 225) 293 73.6 2.7e-13
NP_002000 (OMIM: 148180) fibroblast growth factor ( 194) 286 72.0 7.2e-13
NP_001132970 (OMIM: 300070) fibroblast growth fact ( 199) 283 71.4 1.2e-12
NP_001290389 (OMIM: 601514) fibroblast growth fact ( 166) 282 71.1 1.2e-12
NP_378668 (OMIM: 300070) fibroblast growth factor ( 192) 280 70.7 1.8e-12
NP_001132974 (OMIM: 300070) fibroblast growth fact ( 226) 280 70.7 2e-12
NP_001132973 (OMIM: 300070) fibroblast growth fact ( 226) 280 70.7 2e-12
NP_004105 (OMIM: 300070) fibroblast growth factor ( 245) 280 70.8 2.2e-12
XP_005262456 (OMIM: 300070) PREDICTED: fibroblast ( 255) 280 70.8 2.2e-12
NP_001132972 (OMIM: 300070) fibroblast growth fact ( 255) 280 70.8 2.2e-12
XP_006713601 (OMIM: 601513,617166) PREDICTED: fibr ( 178) 278 70.2 2.3e-12
NP_004104 (OMIM: 601513,617166) fibroblast growth ( 181) 278 70.2 2.3e-12
XP_005247284 (OMIM: 601513,617166) PREDICTED: fibr ( 207) 278 70.3 2.6e-12
NP_066360 (OMIM: 601513,617166) fibroblast growth ( 243) 278 70.3 2.9e-12
NP_004456 (OMIM: 149730,180920,602115) fibroblast ( 208) 270 68.5 8.9e-12
XP_005248321 (OMIM: 149730,180920,602115) PREDICTE ( 208) 270 68.5 8.9e-12
NP_001308875 (OMIM: 601515,609307) fibroblast grow ( 163) 265 67.3 1.6e-11
NP_001308864 (OMIM: 601515,609307) fibroblast grow ( 163) 265 67.3 1.6e-11
NP_001308872 (OMIM: 601515,609307) fibroblast grow ( 163) 265 67.3 1.6e-11
NP_001308871 (OMIM: 601515,609307) fibroblast grow ( 163) 265 67.3 1.6e-11
NP_001308863 (OMIM: 601515,609307) fibroblast grow ( 163) 265 67.3 1.6e-11
NP_001308878 (OMIM: 601515,609307) fibroblast grow ( 163) 265 67.3 1.6e-11
NP_001308860 (OMIM: 601515,609307) fibroblast grow ( 163) 265 67.3 1.6e-11
XP_016861368 (OMIM: 601513,617166) PREDICTED: fibr ( 157) 259 65.9 3.9e-11
NP_005238 (OMIM: 164950,610706) fibroblast growth ( 239) 261 66.5 4e-11
NP_001244136 (OMIM: 131220) fibroblast growth fact ( 155) 245 62.8 3.3e-10
NP_001244134 (OMIM: 131220) fibroblast growth fact ( 155) 245 62.8 3.3e-10
>>NP_001998 (OMIM: 164980) fibroblast growth factor 4 pr (206 aa)
initn: 1352 init1: 1352 opt: 1352 Z-score: 1631.7 bits: 308.9 E(85289): 3.8e-84
Smith-Waterman score: 1352; 100.0% identity (100.0% similar) in 206 aa overlap (1-206:1-206)
10 20 30 40 50 60
pF1KE2 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIA
130 140 150 160 170 180
190 200
pF1KE2 LSKNGKTKKGNRVSPTMKVTHFLPRL
::::::::::::::::::::::::::
NP_001 LSKNGKTKKGNRVSPTMKVTHFLPRL
190 200
>>XP_005273904 (OMIM: 164980) PREDICTED: fibroblast grow (118 aa)
initn: 755 init1: 755 opt: 755 Z-score: 918.2 bits: 176.0 E(85289): 2.1e-44
Smith-Waterman score: 755; 99.1% identity (100.0% similar) in 116 aa overlap (1-116:1-116)
10 20 30 40 50 60
pF1KE2 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSP
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_005 AAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDTLLHR
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 VERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIA
>>NP_066276 (OMIM: 134921) fibroblast growth factor 6 pr (208 aa)
initn: 621 init1: 621 opt: 644 Z-score: 781.5 bits: 151.6 E(85289): 8.6e-37
Smith-Waterman score: 647; 54.1% identity (72.9% similar) in 207 aa overlap (3-206:14-208)
10 20 30 40
pF1KE2 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAE--LERR-
: : .: :.:..:. : ..:. : :: . :. :
NP_066 MALGQKLFITMSRGAGRLQGTLWALVFLGILV------GMVVPS-PAGTRANNTLLDSRG
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 WESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGG
: .: :: .: .:.. . .:: ::.:::: ::::::::::::::.::::::.:
NP_066 WGTL--LSRSRAGLAGEIAGVNWESG---YLVGIKRQRRLYCNVGIGFHLQVLPDGRISG
60 70 80 90 100
110 120 130 140 150 160
pF1KE2 AHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNY
.: .. ::::.: :::::::.::: : .::::.:::.::..: : .:: :.: ::::::
NP_066 THEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNY
110 120 130 140 150 160
170 180 190 200
pF1KE2 NAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL
::::: : : .::::: :..:.:..::: : :::::::.
NP_066 NAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI
170 180 190 200
>>NP_004455 (OMIM: 165190,190330) fibroblast growth fact (268 aa)
initn: 417 init1: 305 opt: 397 Z-score: 483.4 bits: 96.8 E(85289): 3.5e-20
Smith-Waterman score: 397; 38.3% identity (64.3% similar) in 196 aa overlap (20-206:26-219)
10 20 30 40 50
pF1KE2 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALS
::: . : ::. : :. . . .. . :
NP_004 MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGS--SSRQSSSSAMSSSS
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 LARLPVAAQPKEAA-VQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRD
. :.:. .... ..... .. . .: ::: :::::::: :::...:.: .
NP_004 ASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANML
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 SLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYK
:.::. : .:.:.: :: : :.:::.::::..: :::.: :.: . :.::.: :
NP_004 SVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAI
120 130 140 150 160 170
180 190 200
pF1KE2 Y----PG--MFIALSKNGKTKKGN--RVSPTMKVTHFLPRL
. : ..::.: ::.:.: ::.: ::::::.
NP_004 HRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKK
180 190 200 210 220 230
NP_004 PPSPIKPKIPLSAPRKNTNSVKYRLKFRFG
240 250 260
>>XP_016874485 (OMIM: 134921) PREDICTED: fibroblast grow (153 aa)
initn: 353 init1: 353 opt: 376 Z-score: 461.6 bits: 91.9 E(85289): 5.7e-19
Smith-Waterman score: 379; 49.7% identity (69.8% similar) in 149 aa overlap (3-148:14-150)
10 20 30 40
pF1KE2 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAE--LERR-
: : .: :.:..:. : ..:. : :: . :. :
XP_016 MALGQKLFITMSRGAGRLQGTLWALVFLGILV------GMVVPS-PAGTRANNTLLDSRG
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 WESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGG
: .: :: .: .:.. . .:: ::.:::: ::::::::::::::.::::::.:
XP_016 WGTL--LSRSRAGLAGEIAGVNWESG---YLVGIKRQRRLYCNVGIGFHLQVLPDGRISG
60 70 80 90 100
110 120 130 140 150 160
pF1KE2 AHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNY
.: .. ::::.: :::::::.::: : .::::.:::.::..
XP_016 THEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATKGI
110 120 130 140 150
170 180 190 200
pF1KE2 NAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL
>>XP_016874484 (OMIM: 134921) PREDICTED: fibroblast grow (195 aa)
initn: 353 init1: 353 opt: 376 Z-score: 460.1 bits: 92.0 E(85289): 6.9e-19
Smith-Waterman score: 379; 49.7% identity (69.8% similar) in 149 aa overlap (3-148:14-150)
10 20 30 40
pF1KE2 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAE--LERR-
: : .: :.:..:. : ..:. : :: . :. :
XP_016 MALGQKLFITMSRGAGRLQGTLWALVFLGILV------GMVVPS-PAGTRANNTLLDSRG
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 WESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGG
: .: :: .: .:.. . .:: ::.:::: ::::::::::::::.::::::.:
XP_016 WGTL--LSRSRAGLAGEIAGVNWESG---YLVGIKRQRRLYCNVGIGFHLQVLPDGRISG
60 70 80 90 100
110 120 130 140 150 160
pF1KE2 AHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNY
.: .. ::::.: :::::::.::: : .::::.:::.::..
XP_016 THEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATLRTPGLQGHTSSHSCVQP
110 120 130 140 150 160
170 180 190 200
pF1KE2 NAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL
XP_016 RLRAPRPEFQFLANLPSSYSSYFGQRH
170 180 190
>>NP_001997 (OMIM: 134920) fibroblast growth factor 2 [H (288 aa)
initn: 256 init1: 256 opt: 358 Z-score: 436.1 bits: 88.1 E(85289): 1.5e-17
Smith-Waterman score: 358; 38.6% identity (64.7% similar) in 184 aa overlap (25-204:107-283)
10 20 30 40 50
pF1KE2 MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWE--SLVA
::: . . .:: .. :. : ...:
NP_001 SRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAA
80 90 100 110 120 130
60 70 80 90 100 110
pF1KE2 LSLARLPVAAQPKEAAVQSGAGDYLLG-IKRLRRLYCNVGIGFHLQALPDGRIGGAHADT
:.. :: : :... :.: . : .: .::::. : :: :. ::::. :.. .
NP_001 GSITTLP--ALPEDG----GSGAFPPGHFKDPKRLYCKNG-GFFLRIHPDGRVDGVREKS
140 150 160 170 180
120 130 140 150 160 170
pF1KE2 RDSL-LELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYE
. :.:. ::::::: :: . ..::. :.: .: :::: : : : ::::.:.
NP_001 DPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYR
190 200 210 220 230 240
180 190 200
pF1KE2 SYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL
: :: . ..::...:. : :....: .:. :::
NP_001 SRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
250 260 270 280
>>NP_062825 (OMIM: 605558,615721) fibroblast growth fact (211 aa)
initn: 390 init1: 158 opt: 347 Z-score: 424.8 bits: 85.6 E(85289): 6.4e-17
Smith-Waterman score: 347; 41.7% identity (64.4% similar) in 163 aa overlap (57-205:33-193)
30 40 50 60 70
pF1KE2 GGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGD-------YLLG
: :. .. . :: .:. : .: :
NP_062 PLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHLHG
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE2 IKRLRRLYCNVGIGFHLQALPDGRIGGAHAD-TRDSLLELSPVERGVVSIFGVASRFFVA
: : :.::: .: :::: :::: . :.. : . ..::. : :.::: :: : ....
NP_062 ILRRRQLYCRTG--FHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLG
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE2 MSSKGKLYGSPFFTDECTFKEILLPNNYNAYES--YKYPG----MFIALSKNGKTKKGNR
:..::.:::: .:.:: :.: . : ::.: : ::. .:.::.:.: . : :
NP_062 MNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGAR
130 140 150 160 170 180
200
pF1KE2 VSPTMKVTHFLPRL
. .: ::::::
NP_062 SKRHQKFTHFLPRPVDPERVPELYKDLLMYT
190 200 210
>>NP_002001 (OMIM: 600921,612961) fibroblast growth fact (208 aa)
initn: 344 init1: 157 opt: 346 Z-score: 423.7 bits: 85.4 E(85289): 7.3e-17
Smith-Waterman score: 346; 40.5% identity (69.3% similar) in 163 aa overlap (50-205:32-190)
20 30 40 50 60 70
pF1KE2 LAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLG
:.. :.. ... :. :: . :.: :
NP_002 APLGEVGNYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTD--LDHLKG
10 20 30 40 50
80 90 100 110 120 130
pF1KE2 IKRLRRLYCNVGIGFHLQALPDGRIGGAHAD-TRDSLLELSPVERGVVSIFGVASRFFVA
: : :.::: . ::::. .:.: : :.. : .: ..::. . :.::: :: : ....
NP_002 ILRRRQLYCRT--GFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLG
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE2 MSSKGKLYGSPFFTDECTFKEILLPNNYNAYES--YKY--PG--MFIALSKNGKTKKGNR
:. ::.:::: .:.::.:.: . : ::.: : ::. : ...::.:.: ..:.:
NP_002 MNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTR
120 130 140 150 160 170
200
pF1KE2 VSPTMKVTHFLPRL
.. .: ::::::
NP_002 TKRHQKFTHFLPRPVDPDKVPELYKDILSQS
180 190 200
>>NP_003859 (OMIM: 300827,309630) fibroblast growth fact (207 aa)
initn: 350 init1: 148 opt: 329 Z-score: 403.3 bits: 81.6 E(85289): 1e-15
Smith-Waterman score: 333; 38.0% identity (64.9% similar) in 171 aa overlap (54-205:21-189)
30 40 50 60 70
pF1KE2 AGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPK---------EAAVQSGAG
::. .:.: .: :. .: :.
NP_003 MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSP
10 20 30 40 50
80 90 100 110 120 130
pF1KE2 -DY--LLGIKRLRRLYCNVGIGFHLQALPDGRIGGA-HADTRDSLLELSPVERGVVSIFG
:. : :: : :.::: .: :::. .:.: . :. : .: ..::. . :..:: :
NP_003 TDFAHLKGILRRRQLYCRTG--FHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRG
60 70 80 90 100
140 150 160 170 180
pF1KE2 VASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYES--YKYPG----MFIALSKN
: : ....:. .:.:::: .: ::.:.: . : ::.: : ::. ...::.:.
NP_003 VDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKD
110 120 130 140 150 160
190 200
pF1KE2 GKTKKGNRVSPTMKVTHFLPRL
:. ..: :.. .: ::::::
NP_003 GSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR
170 180 190 200
206 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:35:18 2016 done: Sun Nov 6 04:35:19 2016
Total Scan time: 6.490 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]