Result of FASTA (omim) for
pFN21AE2285
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2285, 166 aa
1>>>pF1KE2285 166 - 166 aa - 166 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0958+/-0.000359; mu= 13.4653+/- 0.022
mean_var=64.1132+/-12.484, 0's: 0 Z-trim(113.2): 16 B-trim: 0 in 0/52
Lambda= 0.160177
statistics sampled from 22473 (22489) to 22473 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.264), width: 16
Scan time: 4.970
The best scores are: opt bits E(85289)
NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] ( 166) 1069 255.4 3.1e-68
NP_619579 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 884 212.7 2.3e-55
NP_068733 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 884 212.7 2.3e-55
XP_011534665 (OMIM: 601443,610687) PREDICTED: cofi ( 149) 799 193.0 1.7e-49
NP_001230574 (OMIM: 601443,610687) cofilin-2 isofo ( 149) 799 193.0 1.7e-49
NP_006861 (OMIM: 609114) destrin isoform a [Homo s ( 165) 780 188.6 3.9e-48
XP_011527444 (OMIM: 609114) PREDICTED: destrin iso ( 165) 780 188.6 3.9e-48
XP_011527445 (OMIM: 609114) PREDICTED: destrin iso ( 165) 780 188.6 3.9e-48
NP_001011546 (OMIM: 609114) destrin isoform b [Hom ( 148) 716 173.8 1e-43
XP_011527446 (OMIM: 609114) PREDICTED: destrin iso ( 148) 716 173.8 1e-43
NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Ho ( 350) 152 43.7 0.00035
NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1 ( 357) 152 43.7 0.00035
NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens ( 349) 134 39.5 0.0062
>>NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] (166 aa)
initn: 1069 init1: 1069 opt: 1069 Z-score: 1346.1 bits: 255.4 E(85289): 3.1e-68
Smith-Waterman score: 1069; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
130 140 150 160
>>NP_619579 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa)
initn: 884 init1: 884 opt: 884 Z-score: 1115.1 bits: 212.7 E(85289): 2.3e-55
Smith-Waterman score: 884; 80.7% identity (95.8% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
:::::.:.: ::::::::::::::: ::.::::::::::::.::..::.::.:.:::::.
NP_619 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
:.::.:::..:::.:: .::::::::::::::::::::::::::::::::::::::::::
NP_619 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::.:::::: :.: ...::: ::.:::::..:.:::::::
NP_619 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
130 140 150 160
>>NP_068733 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa)
initn: 884 init1: 884 opt: 884 Z-score: 1115.1 bits: 212.7 E(85289): 2.3e-55
Smith-Waterman score: 884; 80.7% identity (95.8% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
:::::.:.: ::::::::::::::: ::.::::::::::::.::..::.::.:.:::::.
NP_068 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
:.::.:::..:::.:: .::::::::::::::::::::::::::::::::::::::::::
NP_068 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::.:::::: :.: ...::: ::.:::::..:.:::::::
NP_068 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
130 140 150 160
>>XP_011534665 (OMIM: 601443,610687) PREDICTED: cofilin- (149 aa)
initn: 799 init1: 799 opt: 799 Z-score: 1009.6 bits: 193.0 E(85289): 1.7e-49
Smith-Waterman score: 799; 80.5% identity (96.0% similar) in 149 aa overlap (18-166:1-149)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
:::::::: ::.::::::::::::.::..::.::.:.:::::.
XP_011 MKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
:.::.:::..:::.:: .::::::::::::::::::::::::::::::::::::::::::
XP_011 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::.:::::: :.: ...::: ::.:::::..:.:::::::
XP_011 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
110 120 130 140
>>NP_001230574 (OMIM: 601443,610687) cofilin-2 isoform 2 (149 aa)
initn: 799 init1: 799 opt: 799 Z-score: 1009.6 bits: 193.0 E(85289): 1.7e-49
Smith-Waterman score: 799; 80.5% identity (96.0% similar) in 149 aa overlap (18-166:1-149)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
:::::::: ::.::::::::::::.::..::.::.:.:::::.
NP_001 MKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
:.::.:::..:::.:: .::::::::::::::::::::::::::::::::::::::::::
NP_001 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::.:::::: :.: ...::: ::.:::::..:.:::::::
NP_001 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
110 120 130 140
>>NP_006861 (OMIM: 609114) destrin isoform a [Homo sapie (165 aa)
initn: 773 init1: 705 opt: 780 Z-score: 985.2 bits: 188.6 E(85289): 3.9e-48
Smith-Waterman score: 780; 71.1% identity (86.7% similar) in 166 aa overlap (1-166:1-165)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
::::: :.: : ..: :::::: :::::.:::::::.:::: ::: ::.:::::::::::
NP_006 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
: :. ::. :: :::.::::::::::..:::::.::.:.:..:::: ::::::::::::
NP_006 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::. ::::: ::: :... : .::::::: ....:: :.
NP_006 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV
130 140 150 160
>>XP_011527444 (OMIM: 609114) PREDICTED: destrin isoform (165 aa)
initn: 773 init1: 705 opt: 780 Z-score: 985.2 bits: 188.6 E(85289): 3.9e-48
Smith-Waterman score: 780; 71.1% identity (86.7% similar) in 166 aa overlap (1-166:1-165)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
::::: :.: : ..: :::::: :::::.:::::::.:::: ::: ::.:::::::::::
XP_011 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
: :. ::. :: :::.::::::::::..:::::.::.:.:..:::: ::::::::::::
XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::. ::::: ::: :... : .::::::: ....:: :.
XP_011 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV
130 140 150 160
>>XP_011527445 (OMIM: 609114) PREDICTED: destrin isoform (165 aa)
initn: 773 init1: 705 opt: 780 Z-score: 985.2 bits: 188.6 E(85289): 3.9e-48
Smith-Waterman score: 780; 71.1% identity (86.7% similar) in 166 aa overlap (1-166:1-165)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
::::: :.: : ..: :::::: :::::.:::::::.:::: ::: ::.:::::::::::
XP_011 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
: :. ::. :: :::.::::::::::..:::::.::.:.:..:::: ::::::::::::
XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::. ::::: ::: :... : .::::::: ....:: :.
XP_011 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV
130 140 150 160
>>NP_001011546 (OMIM: 609114) destrin isoform b [Homo sa (148 aa)
initn: 709 init1: 641 opt: 716 Z-score: 906.0 bits: 173.8 E(85289): 1e-43
Smith-Waterman score: 716; 72.5% identity (87.9% similar) in 149 aa overlap (18-166:1-148)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
::::: :::::.:::::::.:::: ::: ::.:::::::::::
NP_001 MKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
: :. ::. :: :::.::::::::::..:::::.::.:.:..:::: ::::::::::::
NP_001 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::. ::::: ::: :... : .::::::: ....:: :.
NP_001 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV
110 120 130 140
>>XP_011527446 (OMIM: 609114) PREDICTED: destrin isoform (148 aa)
initn: 709 init1: 641 opt: 716 Z-score: 906.0 bits: 173.8 E(85289): 1e-43
Smith-Waterman score: 716; 72.5% identity (87.9% similar) in 149 aa overlap (18-166:1-148)
10 20 30 40 50 60
pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
::::: :::::.:::::::.:::: ::: ::.:::::::::::
XP_011 MKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40
70 80 90 100 110 120
pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
: :. ::. :: :::.::::::::::..:::::.::.:.:..:::: ::::::::::::
XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
:::::::. ::::: ::: :... : .::::::: ....:: :.
XP_011 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV
110 120 130 140
166 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:56:11 2016 done: Mon Nov 7 00:56:12 2016
Total Scan time: 4.970 Total Display time: -0.040
Function used was FASTA [36.3.4 Apr, 2011]