Result of FASTA (omim) for
pFN21AE2281
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2281, 843 aa
1>>>pF1KE2281 843 - 843 aa - 843 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7934+/-0.000359; mu= 6.2364+/- 0.023
mean_var=230.6218+/-47.351, 0's: 0 Z-trim(121.5): 33 B-trim: 735 in 1/55
Lambda= 0.084455
statistics sampled from 38122 (38158) to 38122 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.447), width: 16
Scan time: 14.120
The best scores are: opt bits E(85289)
NP_064590 (OMIM: 611748) OTU domain-containing pro ( 843) 5792 719.2 2e-206
XP_016857340 (OMIM: 611748) PREDICTED: OTU domain- ( 714) 4933 614.4 5.6e-175
XP_016857339 (OMIM: 611748) PREDICTED: OTU domain- ( 764) 4890 609.2 2.2e-173
XP_011508086 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108
XP_011508087 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108
XP_011508085 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108
XP_011508084 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108
XP_011508089 (OMIM: 611748) PREDICTED: OTU domain- ( 773) 2830 358.2 8e-98
XP_011508088 (OMIM: 611748) PREDICTED: OTU domain- ( 773) 2830 358.2 8e-98
XP_011508090 (OMIM: 611748) PREDICTED: OTU domain- ( 773) 2830 358.2 8e-98
NP_570971 (OMIM: 612024) OTU domain-containing pro ( 926) 2156 276.2 4.8e-73
NP_001316836 (OMIM: 612024) OTU domain-containing ( 425) 1950 250.8 9.8e-66
XP_011534398 (OMIM: 191163,616744) PREDICTED: tumo ( 689) 344 55.3 1.1e-06
XP_005267176 (OMIM: 191163,616744) PREDICTED: tumo ( 790) 344 55.3 1.2e-06
NP_001257437 (OMIM: 191163,616744) tumor necrosis ( 790) 344 55.3 1.2e-06
NP_001257436 (OMIM: 191163,616744) tumor necrosis ( 790) 344 55.3 1.2e-06
XP_011534397 (OMIM: 191163,616744) PREDICTED: tumo ( 790) 344 55.3 1.2e-06
NP_006281 (OMIM: 191163,616744) tumor necrosis fac ( 790) 344 55.3 1.2e-06
XP_011538189 (OMIM: 611749) PREDICTED: ubiquitin t ( 248) 244 42.7 0.0024
XP_016871847 (OMIM: 611749) PREDICTED: ubiquitin t ( 382) 244 42.9 0.0034
NP_060050 (OMIM: 611749) ubiquitin thioesterase ZR ( 708) 244 43.1 0.0053
XP_016871846 (OMIM: 611749) PREDICTED: ubiquitin t ( 708) 244 43.1 0.0053
XP_005269983 (OMIM: 611749) PREDICTED: ubiquitin t ( 708) 244 43.1 0.0053
XP_005269982 (OMIM: 611749) PREDICTED: ubiquitin t ( 734) 244 43.1 0.0055
XP_006717970 (OMIM: 611749) PREDICTED: ubiquitin t ( 734) 244 43.1 0.0055
>>NP_064590 (OMIM: 611748) OTU domain-containing protein (843 aa)
initn: 5792 init1: 5792 opt: 5792 Z-score: 3827.1 bits: 719.2 E(85289): 2e-206
Smith-Waterman score: 5792; 100.0% identity (100.0% similar) in 843 aa overlap (1-843:1-843)
10 20 30 40 50 60
pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV
790 800 810 820 830 840
pF1KE2 HRF
:::
NP_064 HRF
>>XP_016857340 (OMIM: 611748) PREDICTED: OTU domain-cont (714 aa)
initn: 4933 init1: 4933 opt: 4933 Z-score: 3262.5 bits: 614.4 E(85289): 5.6e-175
Smith-Waterman score: 4933; 100.0% identity (100.0% similar) in 714 aa overlap (130-843:1-714)
100 110 120 130 140 150
pF1KE2 SHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQS
::::::::::::::::::::::::::::::
XP_016 MPICAFQLPDLTVYNEDFRSFIERDLIEQS
10 20 30
160 170 180 190 200 210
pF1KE2 MLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYA
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE2 LMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGAN
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE2 CGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLE
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE2 VPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGW
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE2 EWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPR
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE2 STPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKK
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE2 NMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAE
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE2 SVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERF
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE2 LAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIP
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE2 RPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGL
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE2 HRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFC
640 650 660 670 680 690
820 830 840
pF1KE2 SCCYREELRRREREPDGELLVHRF
::::::::::::::::::::::::
XP_016 SCCYREELRRREREPDGELLVHRF
700 710
>>XP_016857339 (OMIM: 611748) PREDICTED: OTU domain-cont (764 aa)
initn: 4890 init1: 4890 opt: 4890 Z-score: 3233.7 bits: 609.2 E(85289): 2.2e-173
Smith-Waterman score: 4890; 99.4% identity (99.9% similar) in 712 aa overlap (132-843:53-764)
110 120 130 140 150 160
pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML
. .:.:::::::::::::::::::::::::
XP_016 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
270 280 290 300 310 320
410 420 430 440 450 460
pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRST
330 340 350 360 370 380
470 480 490 500 510 520
pF1KE2 PESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNM
390 400 410 420 430 440
530 540 550 560 570 580
pF1KE2 GGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESV
450 460 470 480 490 500
590 600 610 620 630 640
pF1KE2 GNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLA
510 520 530 540 550 560
650 660 670 680 690 700
pF1KE2 EQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRP
570 580 590 600 610 620
710 720 730 740 750 760
pF1KE2 SGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHR
630 640 650 660 670 680
770 780 790 800 810 820
pF1KE2 GALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSC
690 700 710 720 730 740
830 840
pF1KE2 CYREELRRREREPDGELLVHRF
::::::::::::::::::::::
XP_016 CYREELRRREREPDGELLVHRF
750 760
>>XP_011508086 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa)
initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108
Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852)
10 20 30 40 50 60
pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
370 380 390 400 410 420
430 440 450 460 470
pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES
::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
790 800 810 820 830 840
840
pF1KE2 REPDGELLVHRF
::::::::::::
XP_011 REPDGELLVHRF
850
>>XP_011508087 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa)
initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108
Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852)
10 20 30 40 50 60
pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
370 380 390 400 410 420
430 440 450 460 470
pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES
::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
790 800 810 820 830 840
840
pF1KE2 REPDGELLVHRF
::::::::::::
XP_011 REPDGELLVHRF
850
>>XP_011508085 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa)
initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108
Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852)
10 20 30 40 50 60
pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
370 380 390 400 410 420
430 440 450 460 470
pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES
::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
790 800 810 820 830 840
840
pF1KE2 REPDGELLVHRF
::::::::::::
XP_011 REPDGELLVHRF
850
>>XP_011508084 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa)
initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108
Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852)
10 20 30 40 50 60
pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
370 380 390 400 410 420
430 440 450 460 470
pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES
::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE
790 800 810 820 830 840
840
pF1KE2 REPDGELLVHRF
::::::::::::
XP_011 REPDGELLVHRF
850
>>XP_011508089 (OMIM: 611748) PREDICTED: OTU domain-cont (773 aa)
initn: 4876 init1: 2815 opt: 2830 Z-score: 1877.2 bits: 358.2 E(85289): 8e-98
Smith-Waterman score: 4862; 98.2% identity (98.6% similar) in 721 aa overlap (132-843:53-773)
110 120 130 140 150 160
pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML
. .:.:::::::::::::::::::::::::
XP_011 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
270 280 290 300 310 320
410 420 430 440 450
pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTA
:::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_011 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTA
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE2 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT
390 400 410 420 430 440
520 530 540 550 560 570
pF1KE2 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV
450 460 470 480 490 500
580 590 600 610 620 630
pF1KE2 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL
510 520 530 540 550 560
640 650 660 670 680 690
pF1KE2 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY
570 580 590 600 610 620
700 710 720 730 740 750
pF1KE2 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG
630 640 650 660 670 680
760 770 780 790 800 810
pF1KE2 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH
690 700 710 720 730 740
820 830 840
pF1KE2 PETNNFCSCCYREELRRREREPDGELLVHRF
:::::::::::::::::::::::::::::::
XP_011 PETNNFCSCCYREELRRREREPDGELLVHRF
750 760 770
>>XP_011508088 (OMIM: 611748) PREDICTED: OTU domain-cont (773 aa)
initn: 4876 init1: 2815 opt: 2830 Z-score: 1877.2 bits: 358.2 E(85289): 8e-98
Smith-Waterman score: 4862; 98.2% identity (98.6% similar) in 721 aa overlap (132-843:53-773)
110 120 130 140 150 160
pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML
. .:.:::::::::::::::::::::::::
XP_011 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
270 280 290 300 310 320
410 420 430 440 450
pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTA
:::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_011 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTA
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE2 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT
390 400 410 420 430 440
520 530 540 550 560 570
pF1KE2 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV
450 460 470 480 490 500
580 590 600 610 620 630
pF1KE2 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL
510 520 530 540 550 560
640 650 660 670 680 690
pF1KE2 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY
570 580 590 600 610 620
700 710 720 730 740 750
pF1KE2 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG
630 640 650 660 670 680
760 770 780 790 800 810
pF1KE2 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH
690 700 710 720 730 740
820 830 840
pF1KE2 PETNNFCSCCYREELRRREREPDGELLVHRF
:::::::::::::::::::::::::::::::
XP_011 PETNNFCSCCYREELRRREREPDGELLVHRF
750 760 770
>>XP_011508090 (OMIM: 611748) PREDICTED: OTU domain-cont (773 aa)
initn: 4876 init1: 2815 opt: 2830 Z-score: 1877.2 bits: 358.2 E(85289): 8e-98
Smith-Waterman score: 4862; 98.2% identity (98.6% similar) in 721 aa overlap (132-843:53-773)
110 120 130 140 150 160
pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML
. .:.:::::::::::::::::::::::::
XP_011 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW
270 280 290 300 310 320
410 420 430 440 450
pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTA
:::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_011 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTA
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE2 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT
390 400 410 420 430 440
520 530 540 550 560 570
pF1KE2 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV
450 460 470 480 490 500
580 590 600 610 620 630
pF1KE2 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL
510 520 530 540 550 560
640 650 660 670 680 690
pF1KE2 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY
570 580 590 600 610 620
700 710 720 730 740 750
pF1KE2 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG
630 640 650 660 670 680
760 770 780 790 800 810
pF1KE2 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH
690 700 710 720 730 740
820 830 840
pF1KE2 PETNNFCSCCYREELRRREREPDGELLVHRF
:::::::::::::::::::::::::::::::
XP_011 PETNNFCSCCYREELRRREREPDGELLVHRF
750 760 770
843 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:13:12 2016 done: Sun Nov 6 06:13:14 2016
Total Scan time: 14.120 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]