Result of FASTA (omim) for
pFN21AE2270
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2270, 146 aa
1>>>pF1KE2270 146 - 146 aa - 146 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9748+/-0.000259; mu= 14.7737+/- 0.016
mean_var=66.1457+/-13.134, 0's: 0 Z-trim(120.7): 24 B-trim: 0 in 0/51
Lambda= 0.157697
statistics sampled from 36303 (36327) to 36303 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.791), E-opt: 0.2 (0.426), width: 16
Scan time: 5.550
The best scores are: opt bits E(85289)
NP_001275543 (OMIM: 105150,604312,611953) cystatin ( 146) 982 230.9 5.8e-61
NP_000090 (OMIM: 105150,604312,611953) cystatin-C ( 146) 982 230.9 5.8e-61
NP_001313 (OMIM: 123856) cystatin-SA precursor [Ho ( 141) 542 130.7 7.7e-31
NP_001890 (OMIM: 123857) cystatin-S precursor [Hom ( 141) 529 127.8 6e-30
NP_001889 (OMIM: 123855) cystatin-SN precursor [Ho ( 141) 523 126.4 1.5e-29
NP_001891 (OMIM: 123858) cystatin-D precursor [Hom ( 142) 488 118.5 3.9e-27
NP_001314 (OMIM: 601891) cystatin-M precursor [Hom ( 149) 282 71.6 5.2e-13
NP_001268659 (OMIM: 608683) cystatin-8 precursor [ ( 142) 260 66.6 1.6e-11
NP_005483 (OMIM: 608683) cystatin-8 precursor [Hom ( 142) 260 66.6 1.6e-11
NP_003641 (OMIM: 603253) cystatin-F precursor [Hom ( 145) 254 65.2 4.2e-11
NP_570612 (OMIM: 609731) cystatin-11 isoform 1 pre ( 138) 228 59.3 2.4e-09
NP_542177 (OMIM: 616536) cystatin-9-like precursor ( 147) 194 51.6 5.4e-07
NP_001159923 (OMIM: 228960,612358) kininogen-1 iso ( 391) 172 46.9 3.8e-05
NP_000884 (OMIM: 228960,612358) kininogen-1 isofor ( 427) 172 46.9 4e-05
NP_001095886 (OMIM: 228960,612358) kininogen-1 iso ( 644) 172 47.0 5.6e-05
>>NP_001275543 (OMIM: 105150,604312,611953) cystatin-C p (146 aa)
initn: 982 init1: 982 opt: 982 Z-score: 1215.4 bits: 230.9 E(85289): 5.8e-61
Smith-Waterman score: 982; 100.0% identity (100.0% similar) in 146 aa overlap (1-146:1-146)
10 20 30 40 50 60
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK
70 80 90 100 110 120
130 140
pF1KE2 AFCSFQIYAVPWQGTMTLSKSTCQDA
::::::::::::::::::::::::::
NP_001 AFCSFQIYAVPWQGTMTLSKSTCQDA
130 140
>>NP_000090 (OMIM: 105150,604312,611953) cystatin-C prec (146 aa)
initn: 982 init1: 982 opt: 982 Z-score: 1215.4 bits: 230.9 E(85289): 5.8e-61
Smith-Waterman score: 982; 100.0% identity (100.0% similar) in 146 aa overlap (1-146:1-146)
10 20 30 40 50 60
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK
70 80 90 100 110 120
130 140
pF1KE2 AFCSFQIYAVPWQGTMTLSKSTCQDA
::::::::::::::::::::::::::
NP_000 AFCSFQIYAVPWQGTMTLSKSTCQDA
130 140
>>NP_001313 (OMIM: 123856) cystatin-SA precursor [Homo s (141 aa)
initn: 584 init1: 490 opt: 542 Z-score: 674.6 bits: 130.7 E(85289): 7.7e-31
Smith-Waterman score: 542; 56.5% identity (79.6% similar) in 147 aa overlap (1-146:1-141)
10 20 30 40 50
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLV-GGPMDASVEEEGVRRALDFAVGE
:: :: . ::::: ::::: :: . :.. :: .::....: :.::: :...:
NP_001 MAWPLCTLLLLLATQAVALAWSPQ------EEDRIIEGGIYDADLNDERVQRALHFVISE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 YNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR
::::..: :. : :.:.:::.:::.:::::.:.:.::: :::.:::::.: ::.::.:..
NP_001 YNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQK
60 70 80 90 100 110
120 130 140
pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA
: .:::::: :::. :.: .: ::.:
NP_001 KQLCSFQIYEVPWEDRMSLVNSRCQEA
120 130 140
>>NP_001890 (OMIM: 123857) cystatin-S precursor [Homo sa (141 aa)
initn: 583 init1: 486 opt: 529 Z-score: 658.7 bits: 127.8 E(85289): 6e-30
Smith-Waterman score: 529; 55.8% identity (78.2% similar) in 147 aa overlap (1-146:1-141)
10 20 30 40 50
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLV-GGPMDASVEEEGVRRALDFAVGE
:: :: . :::.: :: ::: :: . :.. :: .::....: :.::: ::..:
NP_001 MARPLCTLLLLMATLAGALA------SSSKEENRIIPGGIYDADLNDEWVQRALHFAISE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 YNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR
::::..: :. : :::.:::.: .:::::.:::.::: :::.:::::.: ::.::.:..
NP_001 YNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQK
60 70 80 90 100 110
120 130 140
pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA
: .:::.:: :::. :.: .: ::.:
NP_001 KQLCSFEIYEVPWEDRMSLVNSRCQEA
120 130 140
>>NP_001889 (OMIM: 123855) cystatin-SN precursor [Homo s (141 aa)
initn: 573 init1: 473 opt: 523 Z-score: 651.3 bits: 126.4 E(85289): 1.5e-29
Smith-Waterman score: 523; 55.1% identity (78.9% similar) in 147 aa overlap (1-146:1-141)
10 20 30 40 50
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLV-GGPMDASVEEEGVRRALDFAVGE
:: : . ::::: :::::: :: . :.. :: ..:....: :.::: ::..:
NP_001 MAQYLSTLLLLLATLAVALAWSPK------EEDRIIPGGIYNADLNDEWVQRALHFAISE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 YNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR
::::..: :. : :.:.:::.: :.:::::.:::.::: :::.:::::.: ::.::.:..
NP_001 YNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQK
60 70 80 90 100 110
120 130 140
pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA
: .:::.:: :::.. .: :: ::..
NP_001 KQLCSFEIYEVPWENRRSLVKSRCQES
120 130 140
>>NP_001891 (OMIM: 123858) cystatin-D precursor [Homo sa (142 aa)
initn: 482 init1: 334 opt: 488 Z-score: 608.2 bits: 118.5 E(85289): 3.9e-27
Smith-Waterman score: 488; 51.0% identity (78.6% similar) in 145 aa overlap (1-144:1-140)
10 20 30 40 50 60
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY
: :...:::::. : ::.: ::. .. :.:: .......:. :::::..::
NP_001 MMWPMHTPLLLLTALMVAVA-----GSASAQSRTLAGGIHATDLNDKSVQCALDFAISEY
10 20 30 40 50
70 80 90 100 110
pF1KE2 NKASN-DMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR
::. : : :.:: :::. : .:::.::::...:..:::::::.:::::::::.:::.::.
NP_001 NKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKE
60 70 80 90 100 110
120 130 140
pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA
. :::::: :::. ... . :.
NP_001 EEFCSFQINEVPWEDKISILNYKCRKV
120 130 140
>>NP_001314 (OMIM: 601891) cystatin-M precursor [Homo sa (149 aa)
initn: 251 init1: 193 opt: 282 Z-score: 354.6 bits: 71.6 E(85289): 5.2e-13
Smith-Waterman score: 282; 36.4% identity (65.0% similar) in 143 aa overlap (8-143:7-146)
10 20 30 40 50
pF1KE2 MAGPLRAPLLL-LAILAVALAVSPA-AGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVG
:: : ::..: : . : : . : . :.:: : : .. :..: . ::.
NP_001 MARSNLPLALGLALVAFCLLALPRDARARPQE--RMVGELRDLSPDDPQVQKAAQAAVA
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 EYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQP-----NLDNCPFHD
:: .::..:. : ....:..:.:::..::: .:.: : : ::. .: .::.
NP_001 SYNMGSNSIYYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTTCPLAA
60 70 80 90 100 110
120 130 140
pF1KE2 QPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
. ..: :.:.. .::::.. : : .:
NP_001 GAQ-QEKLRCDFEVLVVPWQNSSQLLKHNCVQM
120 130 140
>>NP_001268659 (OMIM: 608683) cystatin-8 precursor [Homo (142 aa)
initn: 239 init1: 239 opt: 260 Z-score: 327.9 bits: 66.6 E(85289): 1.6e-11
Smith-Waterman score: 260; 34.0% identity (66.0% similar) in 144 aa overlap (6-146:3-142)
10 20 30 40 50
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVG---GPMDASVEEEGVRRALDFAV
: : : .:.. ::. .: ..: : : :..:: . .:.. : ::.
NP_001 MPRCRWLSLILLTIPLAL--VARKDPKKNETGVLRKLKPVNAS--NANVKQCLWFAM
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 GEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHL
:::: :.: : ......:. :.. ..:..:::..:. : : . . : .... .:
NP_001 QEYNKESEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKL
60 70 80 90 100 110
120 130 140
pF1KE2 KRKAFCSFQIYAVPWQGTMTLSKSTCQDA
::: ::: . :.::.: .:. .. :.::
NP_001 KRKLSCSFLVGALPWNGEFTVMEKKCEDA
120 130 140
>>NP_005483 (OMIM: 608683) cystatin-8 precursor [Homo sa (142 aa)
initn: 239 init1: 239 opt: 260 Z-score: 327.9 bits: 66.6 E(85289): 1.6e-11
Smith-Waterman score: 260; 34.0% identity (66.0% similar) in 144 aa overlap (6-146:3-142)
10 20 30 40 50
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVG---GPMDASVEEEGVRRALDFAV
: : : .:.. ::. .: ..: : : :..:: . .:.. : ::.
NP_005 MPRCRWLSLILLTIPLAL--VARKDPKKNETGVLRKLKPVNAS--NANVKQCLWFAM
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 GEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHL
:::: :.: : ......:. :.. ..:..:::..:. : : . . : .... .:
NP_005 QEYNKESEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKL
60 70 80 90 100 110
120 130 140
pF1KE2 KRKAFCSFQIYAVPWQGTMTLSKSTCQDA
::: ::: . :.::.: .:. .. :.::
NP_005 KRKLSCSFLVGALPWNGEFTVMEKKCEDA
120 130 140
>>NP_003641 (OMIM: 603253) cystatin-F precursor [Homo sa (145 aa)
initn: 270 init1: 176 opt: 254 Z-score: 320.4 bits: 65.2 E(85289): 4.2e-11
Smith-Waterman score: 254; 35.6% identity (63.0% similar) in 135 aa overlap (5-132:1-133)
10 20 30 40 50
pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGK-----PPRLVGG-PMDASVEEEGVRRALD
.:: :::. :..: ..: :: :. : : .... :: .:
NP_003 MRAAGTLLAF--CCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAAR
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 FAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQP-NLDNCPFHD
..: ..:. .:::. . ...:: ::: :..:.:.::.::::: :.: ::.: :.
NP_003 YSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQT
60 70 80 90 100 110
120 130 140
pF1KE2 QPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
. ::. : ....:::
NP_003 NHTLKQTLSCYSEVWVVPWLQHFEVPVLRCH
120 130 140
146 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:36:59 2016 done: Mon Nov 7 01:37:00 2016
Total Scan time: 5.550 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]