Result of FASTA (omim) for
pFN21AE2239
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2239, 433 aa
1>>>pF1KE2239 433 - 433 aa - 433 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7624+/-0.000451; mu= 1.9912+/- 0.028
mean_var=210.3746+/-41.907, 0's: 0 Z-trim(117.0): 53 B-trim: 342 in 1/59
Lambda= 0.088426
statistics sampled from 28501 (28554) to 28501 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.335), width: 16
Scan time: 7.700
The best scores are: opt bits E(85289)
NP_114172 (OMIM: 123836) G2/mitotic-specific cycli ( 433) 2834 374.4 3.1e-103
NP_004692 (OMIM: 602755) G2/mitotic-specific cycli ( 398) 1311 180.1 8.9e-45
NP_001228 (OMIM: 123835) cyclin-A2 [Homo sapiens] ( 432) 618 91.7 3.9e-18
NP_149020 (OMIM: 300456) G2/mitotic-specific cycli (1395) 603 90.2 3.6e-17
XP_016885407 (OMIM: 300456) PREDICTED: G2/mitotic- (1395) 603 90.2 3.6e-17
XP_016885406 (OMIM: 300456) PREDICTED: G2/mitotic- (1396) 597 89.4 6.2e-17
XP_011533597 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 584 87.4 7.7e-17
NP_001104516 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 584 87.4 7.7e-17
XP_011533596 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 584 87.4 7.7e-17
NP_001104517 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 584 87.4 7.7e-17
XP_011533598 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 584 87.4 7.7e-17
NP_001104515 (OMIM: 604036) cyclin-A1 isoform b [H ( 464) 584 87.4 8.3e-17
NP_003905 (OMIM: 604036) cyclin-A1 isoform a [Homo ( 465) 584 87.4 8.3e-17
XP_016885404 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 589 88.4 1.3e-16
XP_016885402 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 589 88.4 1.3e-16
XP_016885403 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 589 88.4 1.3e-16
XP_016885405 (OMIM: 300456) PREDICTED: G2/mitotic- (1403) 587 88.2 1.5e-16
NP_391990 (OMIM: 300456) G2/mitotic-specific cycli ( 291) 414 65.6 2e-10
NP_066970 (OMIM: 607752,615872) cyclin-O [Homo sap ( 350) 317 53.3 1.2e-06
XP_011515668 (OMIM: 603775) PREDICTED: G1/S-specif ( 288) 299 50.9 5.1e-06
NP_001309191 (OMIM: 123837) G1/S-specific cyclin-E ( 395) 300 51.1 5.9e-06
XP_011525742 (OMIM: 123837) PREDICTED: G1/S-specif ( 407) 300 51.1 6.1e-06
NP_001229 (OMIM: 123837) G1/S-specific cyclin-E1 i ( 410) 300 51.1 6.1e-06
XP_016869447 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 299 51.0 6.6e-06
XP_016869446 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 299 51.0 6.6e-06
NP_477097 (OMIM: 603775) G1/S-specific cyclin-E2 [ ( 404) 299 51.0 6.6e-06
XP_016869448 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 299 51.0 6.6e-06
NP_001309188 (OMIM: 123837) G1/S-specific cyclin-E ( 365) 289 49.7 1.5e-05
NP_001751 (OMIM: 123834) G1/S-specific cyclin-D3 i ( 292) 284 49.0 1.9e-05
NP_444284 (OMIM: 168461,193300,254500) G1/S-specif ( 295) 284 49.0 1.9e-05
NP_001752 (OMIM: 600227) cyclin-F isoform 1 [Homo ( 786) 286 49.6 3.5e-05
NP_001310467 (OMIM: 600227) cyclin-F isoform 2 [Ho ( 478) 281 48.8 3.7e-05
XP_016879311 (OMIM: 600227) PREDICTED: cyclin-F is ( 867) 286 49.6 3.8e-05
NP_001750 (OMIM: 123833,615938) G1/S-specific cycl ( 289) 244 43.9 0.00066
XP_011513273 (OMIM: 123834) PREDICTED: G1/S-specif ( 276) 232 42.3 0.0018
>>NP_114172 (OMIM: 123836) G2/mitotic-specific cyclin-B1 (433 aa)
initn: 2834 init1: 2834 opt: 2834 Z-score: 1974.4 bits: 374.4 E(85289): 3.1e-103
Smith-Waterman score: 2834; 100.0% identity (100.0% similar) in 433 aa overlap (1-433:1-433)
10 20 30 40 50 60
pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS
370 380 390 400 410 420
430
pF1KE2 ALVQDLAKAVAKV
:::::::::::::
NP_114 ALVQDLAKAVAKV
430
>>NP_004692 (OMIM: 602755) G2/mitotic-specific cyclin-B2 (398 aa)
initn: 1228 init1: 1198 opt: 1311 Z-score: 924.9 bits: 180.1 E(85289): 8.9e-45
Smith-Waterman score: 1311; 52.7% identity (77.2% similar) in 395 aa overlap (40-427:6-391)
10 20 30 40 50 60
pF1KE2 KINAENKAKINMAGAKRVPTAPAATSKPGLRPRTA--LGDIGNKVSEQLQAKMPMKKEAK
:: .. : .: . :. ...... ... .
NP_004 MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVL
10 20 30
70 80 90 100 110 120
pF1KE2 PSATGKVIDK--KLPKPLE--KVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVD
..: . .. : . :::. :. ... . .: .::. :::.:.
NP_004 EEIGNRVTTRAAQVAKKAQNTKVPVQ-PTKTTNVNKQLKPTASVKPVQMEKLAPK-----
40 50 60 70 80
130 140 150 160 170 180
pF1KE2 TASPSPMETSGCAPAEEDLCQAFSDVILA-VNDVDAEDGADPNLCSEYVKDIYAYLRQLE
::.: ..: ::.:::::::..: ..:.: :: .:.:::.:::::: ::::::
NP_004 GPSPTPEDVS---MKEENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLE
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE2 EEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKK
:.. :..: ::...: :::::.::::::. ::::::::.:: :.:.:::.: . : .:
NP_004 VLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRK
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE2 MLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLP
:::::.::...:::::::. :.: ::...:::.::. :::.:: ::. :.: ::::::
NP_004 KLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLP
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE2 LHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWT
::::::::: ::::::::::::::::::..::::::. ::..::.: ::. :.: .:.:.
NP_004 LHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWN
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE2 PTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSAL
:.: .:::. .: ::::.::::: ::..::: ...:::::.:: ::: .:::::
NP_004 LKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKA
330 340 350 360 370 380
430
pF1KE2 VQDLAKAVAKV
:.:::
NP_004 VKDLASPLIGRS
390
>>NP_001228 (OMIM: 123835) cyclin-A2 [Homo sapiens] (432 aa)
initn: 538 init1: 380 opt: 618 Z-score: 446.6 bits: 91.7 E(85289): 3.9e-18
Smith-Waterman score: 618; 31.6% identity (62.4% similar) in 399 aa overlap (28-415:35-424)
10 20 30 40 50
pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQ
: : ...: : :. :: . :
NP_001 SAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSP
. : ... : : :... : :. :. . : : : : . .:.. .:.
NP_001 QR-PKTRRVAPLKDLPVNDEHVTVPPWKANSKQPA-FTIHVDEAEKEAQKKPAESQKIER
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 EPILV-DTASPSPMETSGCAPAEEDLCQAFS-----DVILAVNDVDAEDGADPNLCSEYV
: :. ..: : . .: . . .: :. ....: : .. : .:
NP_001 EDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIVLED---EKPVSVNEVPDYH
130 140 150 160 170
180 190 200 210 220 230
pF1KE2 KDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSII
.::..:::..: . . :. . ..:..:::::.::::.: ...: .::....:. :
NP_001 EDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 DRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKIL
:::... : . :::::..::..:::.::.::::...:...::.::::.:. .:: .:
NP_001 DRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVL
240 250 260 270 280 290
300 310 320 330 340
pF1KE2 RALNFGLGRPLPLHFLRRA---SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAA
..:.: :. : .:: . .. .. :: .:: .: ::...: : .... :: ::.
NP_001 KVLTFDLAAPTVNQFLTQYFLHQQPANCKVE--SLAMFLGELSLIDADPYLKYLPSVIAG
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 GAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYAT
.:: ::: . . : .: . .:: ::: : .. : .. . . : ......:: .
NP_001 AAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQH--AQQSIREKYKN
360 370 380 390 400 410
410 420 430
pF1KE2 SKHAKISTLPQLNSALVQDLAKAVAKV
::. .: :
NP_001 SKYHGVSLLNPPETLNL
420 430
>>NP_149020 (OMIM: 300456) G2/mitotic-specific cyclin-B3 (1395 aa)
initn: 580 init1: 542 opt: 603 Z-score: 429.2 bits: 90.2 E(85289): 3.6e-17
Smith-Waterman score: 640; 30.7% identity (62.4% similar) in 404 aa overlap (29-419:980-1376)
10 20 30 40 50
pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAA-TSKPGLRPRTALGDIGNKVSEQLQ
::: . ::: .. :..: :. ..: .
NP_149 ALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGT-INEAFL
950 960 970 980 990 1000
60 70 80 90 100 110
pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEP--VPEPEPEP-----EPEPV
. . . ::. ::: .. : : :.. : : .:. : :: .
NP_149 FEDMITLNEKPT-TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESI
1010 1020 1030 1040 1050 1060
120 130 140 150 160
pF1KE2 KEEKLSPEPILVDTASPSPMETSGCAPAEED----LCQAFSDVILAVNDVDAEDGADPNL
: : : . : . :.:.: : . .. : .:.: ::..::..
NP_149 TE-KSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDID-EDSSDPSF
1070 1080 1090 1100 1110 1120
170 180 190 200 210 220
pF1KE2 CSEYVKDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYM
:.:.:..:... .::: . :. . :.:..:::::.::::.::..:.. .::.:.
NP_149 NPMYAKEIFSYMKE-REEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYL
1130 1140 1150 1160 1170 1180
230 240 250 260 270 280
pF1KE2 TVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQM
.:...: .... : :::.:.::..::.:.:: :.. ::... :..: . .. .:
NP_149 AVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSM
1190 1200 1210 1220 1230 1240
290 300 310 320 330 340
pF1KE2 EMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIA
:..:: .:. .. :. ::::: .. ..... ::..:. :.:. .: .:. :..:
NP_149 EINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLA
1250 1260 1270 1280 1290 1300
350 360 370 380 390 400
pF1KE2 AGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYA
:... ::: . : :.: :.:: .:. : :....: : ... . : .: ::.
NP_149 AASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLK--AVYYKYS
1310 1320 1330 1340 1350 1360
410 420 430
pF1KE2 TSKHAKISTLPQLNSALVQDLAKAVAKV
... .: :.
NP_149 HPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL
1370 1380 1390
>>XP_016885407 (OMIM: 300456) PREDICTED: G2/mitotic-spec (1395 aa)
initn: 580 init1: 542 opt: 603 Z-score: 429.2 bits: 90.2 E(85289): 3.6e-17
Smith-Waterman score: 640; 30.7% identity (62.4% similar) in 404 aa overlap (29-419:980-1376)
10 20 30 40 50
pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAA-TSKPGLRPRTALGDIGNKVSEQLQ
::: . ::: .. :..: :. ..: .
XP_016 ALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGT-INEAFL
950 960 970 980 990 1000
60 70 80 90 100 110
pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEP--VPEPEPEP-----EPEPV
. . . ::. ::: .. : : :.. : : .:. : :: .
XP_016 FEDMITLNEKPT-TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESI
1010 1020 1030 1040 1050 1060
120 130 140 150 160
pF1KE2 KEEKLSPEPILVDTASPSPMETSGCAPAEED----LCQAFSDVILAVNDVDAEDGADPNL
: : : . : . :.:.: : . .. : .:.: ::..::..
XP_016 TE-KSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDID-EDSSDPSF
1070 1080 1090 1100 1110 1120
170 180 190 200 210 220
pF1KE2 CSEYVKDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYM
:.:.:..:... .::: . :. . :.:..:::::.::::.::..:.. .::.:.
XP_016 NPMYAKEIFSYMKE-REEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYL
1130 1140 1150 1160 1170 1180
230 240 250 260 270 280
pF1KE2 TVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQM
.:...: .... : :::.:.::..::.:.:: :.. ::... :..: . .. .:
XP_016 AVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSM
1190 1200 1210 1220 1230 1240
290 300 310 320 330 340
pF1KE2 EMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIA
:..:: .:. .. :. ::::: .. ..... ::..:. :.:. .: .:. :..:
XP_016 EINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLA
1250 1260 1270 1280 1290 1300
350 360 370 380 390 400
pF1KE2 AGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYA
:... ::: . : :.: :.:: .:. : :....: : ... . : .: ::.
XP_016 AASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLK--AVYYKYS
1310 1320 1330 1340 1350 1360
410 420 430
pF1KE2 TSKHAKISTLPQLNSALVQDLAKAVAKV
... .: :.
XP_016 HPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL
1370 1380 1390
>>XP_016885406 (OMIM: 300456) PREDICTED: G2/mitotic-spec (1396 aa)
initn: 580 init1: 542 opt: 597 Z-score: 425.0 bits: 89.4 E(85289): 6.2e-17
Smith-Waterman score: 638; 31.1% identity (62.7% similar) in 405 aa overlap (29-419:980-1377)
10 20 30 40 50
pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAA-TSKPGLRPRTALGDIGNKVSEQLQ
::: . ::: .. :..: :. ..: .
XP_016 ALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGT-INEAFL
950 960 970 980 990 1000
60 70 80 90 100 110
pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEP--VPEPEPEP-----EPEPV
. . . ::. ::: .. : : :.. : : .:. : :: .
XP_016 FEDMITLNEKPT-TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESI
1010 1020 1030 1040 1050 1060
120 130 140 150 160
pF1KE2 KEEKLSPEPILVDTASPSPMETSGCAPAEEDLC--QAFS---DVILAVNDVDAEDGADPN
: : : . : . :.:.: : . :: . . : .:.: ::..::.
XP_016 TE-KSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEQITPREDID-EDSSDPS
1070 1080 1090 1100 1110 1120
170 180 190 200 210 220
pF1KE2 LCSEYVKDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMY
. :.:.:..:... .::: . :. . :.:..:::::.::::.::..:.. .::.:
XP_016 FNPMYAKEIFSYMKE-REEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLY
1130 1140 1150 1160 1170 1180
230 240 250 260 270 280
pF1KE2 MTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQ
..:...: .... : :::.:.::..::.:.:: :.. ::... :..: . .. .
XP_016 LAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLS
1190 1200 1210 1220 1230 1240
290 300 310 320 330 340
pF1KE2 MEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQI
::..:: .:. .. :. ::::: .. ..... ::..:. :.:. .: .:. :..
XP_016 MEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKL
1250 1260 1270 1280 1290 1300
350 360 370 380 390 400
pF1KE2 AAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKY
::... ::: . : :.: :.:: .:. : :....: : ... . : .: ::
XP_016 AAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLK--AVYYKY
1310 1320 1330 1340 1350 1360
410 420 430
pF1KE2 ATSKHAKISTLPQLNSALVQDLAKAVAKV
. ... .: :.
XP_016 SHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL
1370 1380 1390
>>XP_011533597 (OMIM: 604036) PREDICTED: cyclin-A1 isofo (421 aa)
initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17
Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421)
140 150 160 170 180 190
pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK
:.: .::...:: :::. : .. . .
XP_011 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH
130 140 150 160 170 180
200 210 220 230 240
pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV
:. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::.
XP_011 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA
.::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: .
XP_011 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY
. : :. ..::::. ::..:. : .... :: :::.::::: ... : :: .
XP_011 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK
.:. ..: ...: : . . . ......:: .::. .: . :.:
XP_011 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ
370 380 390 400 410 420
430
pF1KE2 AVAKV
>>NP_001104516 (OMIM: 604036) cyclin-A1 isoform c [Homo (421 aa)
initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17
Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421)
140 150 160 170 180 190
pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK
:.: .::...:: :::. : .. . .
NP_001 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH
130 140 150 160 170 180
200 210 220 230 240
pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV
:. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::.
NP_001 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA
.::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: .
NP_001 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY
. : :. ..::::. ::..:. : .... :: :::.::::: ... : :: .
NP_001 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK
.:. ..: ...: : . . . ......:: .::. .: . :.:
NP_001 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ
370 380 390 400 410 420
430
pF1KE2 AVAKV
>>XP_011533596 (OMIM: 604036) PREDICTED: cyclin-A1 isofo (421 aa)
initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17
Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421)
140 150 160 170 180 190
pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK
:.: .::...:: :::. : .. . .
XP_011 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH
130 140 150 160 170 180
200 210 220 230 240
pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV
:. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::.
XP_011 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA
.::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: .
XP_011 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY
. : :. ..::::. ::..:. : .... :: :::.::::: ... : :: .
XP_011 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK
.:. ..: ...: : . . . ......:: .::. .: . :.:
XP_011 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ
370 380 390 400 410 420
430
pF1KE2 AVAKV
>>NP_001104517 (OMIM: 604036) cyclin-A1 isoform c [Homo (421 aa)
initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17
Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421)
140 150 160 170 180 190
pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK
:.: .::...:: :::. : .. . .
NP_001 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH
130 140 150 160 170 180
200 210 220 230 240
pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV
:. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::.
NP_001 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA
.::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: .
NP_001 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY
. : :. ..::::. ::..:. : .... :: :::.::::: ... : :: .
NP_001 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK
.:. ..: ...: : . . . ......:: .::. .: . :.:
NP_001 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ
370 380 390 400 410 420
430
pF1KE2 AVAKV
433 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 20:12:52 2016 done: Sun Nov 6 20:12:53 2016
Total Scan time: 7.700 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]