FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2216, 219 aa 1>>>pF1KE2216 219 - 219 aa - 219 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.4629+/-0.000297; mu= 18.2516+/- 0.019 mean_var=56.0406+/-11.304, 0's: 0 Z-trim(117.5): 18 B-trim: 0 in 0/52 Lambda= 0.171326 statistics sampled from 29535 (29554) to 29535 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.347), width: 16 Scan time: 6.870 The best scores are: opt bits E(85289) XP_011534961 (OMIM: 604441) PREDICTED: cell death ( 219) 1454 366.8 1.5e-101 XP_016876710 (OMIM: 604441) PREDICTED: cell death ( 219) 1454 366.8 1.5e-101 NP_055245 (OMIM: 604441) cell death activator CIDE ( 219) 1454 366.8 1.5e-101 NP_001305736 (OMIM: 604441) cell death activator C ( 219) 1454 366.8 1.5e-101 NP_001308071 (OMIM: 612120,615238) cell death acti ( 238) 545 142.2 7e-34 NP_071377 (OMIM: 612120,615238) cell death activat ( 238) 545 142.2 7e-34 NP_001186481 (OMIM: 612120,615238) cell death acti ( 238) 545 142.2 7e-34 NP_001186552 (OMIM: 612120,615238) cell death acti ( 251) 545 142.2 7.3e-34 NP_001270 (OMIM: 604440) cell death activator CIDE ( 219) 507 132.8 4.4e-31 NP_001305312 (OMIM: 604440) cell death activator C ( 253) 506 132.6 5.8e-31 NP_001186480 (OMIM: 612120,615238) cell death acti ( 248) 435 115.0 1.1e-25 NP_001308073 (OMIM: 612120,615238) cell death acti ( 164) 433 114.4 1.1e-25 NP_001308072 (OMIM: 612120,615238) cell death acti ( 164) 433 114.4 1.1e-25 NP_998731 (OMIM: 601882) DNA fragmentation factor ( 268) 144 43.1 0.00052 NP_004392 (OMIM: 601882) DNA fragmentation factor ( 331) 144 43.2 0.00062 >>XP_011534961 (OMIM: 604441) PREDICTED: cell death acti (219 aa) initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101 Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219) 10 20 30 40 50 60 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR 130 140 150 160 170 180 190 200 210 pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY ::::::::::::::::::::::::::::::::::::::: XP_011 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY 190 200 210 >>XP_016876710 (OMIM: 604441) PREDICTED: cell death acti (219 aa) initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101 Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219) 10 20 30 40 50 60 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR 130 140 150 160 170 180 190 200 210 pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY ::::::::::::::::::::::::::::::::::::::: XP_016 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY 190 200 210 >>NP_055245 (OMIM: 604441) cell death activator CIDE-B [ (219 aa) initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101 Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219) 10 20 30 40 50 60 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR 130 140 150 160 170 180 190 200 210 pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY ::::::::::::::::::::::::::::::::::::::: NP_055 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY 190 200 210 >>NP_001305736 (OMIM: 604441) cell death activator CIDE- (219 aa) initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101 Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219) 10 20 30 40 50 60 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR 130 140 150 160 170 180 190 200 210 pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY ::::::::::::::::::::::::::::::::::::::: NP_001 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY 190 200 210 >>NP_001308071 (OMIM: 612120,615238) cell death activato (238 aa) initn: 532 init1: 261 opt: 545 Z-score: 729.3 bits: 142.2 E(85289): 7e-34 Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:5-228) 10 20 30 40 50 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFRVCDHKRTIRKGLT :. :: : :..: : :: .: ... : : :. :: :: :..:::. NP_001 MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCRVSTADRSVRKGIM 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 AATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPT : . ..:: :. .::.: . . ::::::::.:..:..:: : :: .::::.::.:.: NP_001 AYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 RSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLG . :. ..: .. :.:: :::.:: ::.:..: :::::::: ::.: :.. : NP_001 SEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCG 120 130 140 150 160 170 180 190 200 210 pF1KE2 PKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRLHSY :....: .::. .:. ::.::: : :.. ....:. : ::. : NP_001 AKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ 180 190 200 210 220 230 >>NP_071377 (OMIM: 612120,615238) cell death activator C (238 aa) initn: 532 init1: 261 opt: 545 Z-score: 729.3 bits: 142.2 E(85289): 7e-34 Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:5-228) 10 20 30 40 50 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFRVCDHKRTIRKGLT :. :: : :..: : :: .: ... : : :. :: :: :..:::. NP_071 MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCRVSTADRSVRKGIM 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 AATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPT : . ..:: :. .::.: . . ::::::::.:..:..:: : :: .::::.::.:.: NP_071 AYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 RSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLG . :. ..: .. :.:: :::.:: ::.:..: :::::::: ::.: :.. : NP_071 SEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCG 120 130 140 150 160 170 180 190 200 210 pF1KE2 PKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRLHSY :....: .::. .:. ::.::: : :.. ....:. : ::. : NP_071 AKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ 180 190 200 210 220 230 >>NP_001186481 (OMIM: 612120,615238) cell death activato (238 aa) initn: 532 init1: 261 opt: 545 Z-score: 729.3 bits: 142.2 E(85289): 7e-34 Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:5-228) 10 20 30 40 50 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFRVCDHKRTIRKGLT :. :: : :..: : :: .: ... : : :. :: :: :..:::. NP_001 MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCRVSTADRSVRKGIM 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 AATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPT : . ..:: :. .::.: . . ::::::::.:..:..:: : :: .::::.::.:.: NP_001 AYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 RSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLG . :. ..: .. :.:: :::.:: ::.:..: :::::::: ::.: :.. : NP_001 SEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCG 120 130 140 150 160 170 180 190 200 210 pF1KE2 PKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRLHSY :....: .::. .:. ::.::: : :.. ....:. : ::. : NP_001 AKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ 180 190 200 210 220 230 >>NP_001186552 (OMIM: 612120,615238) cell death activato (251 aa) initn: 532 init1: 261 opt: 545 Z-score: 729.0 bits: 142.2 E(85289): 7.3e-34 Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:18-241) 10 20 30 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFR :. :: : :..: : :: .: ... : : :. :: : NP_001 MRNMESNAVQLTRMEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCR 10 20 30 40 50 40 50 60 70 80 90 pF1KE2 VCDHKRTIRKGLTAATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTC : :..:::. : . ..:: :. .::.: . . ::::::::.:..:..:: : :: NP_001 VSTADRSVRKGIMAYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTV 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE2 LMVLQSGQSWSPTRSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFY .::::.::.:.: . :. ..: .. :.:: :::.:: ::.:..: :::::::: NP_001 FMVLQKGQKWQPPSEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFY 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE2 GLYSMSCDFQGLGPKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRL ::.: :.. : :....: .::. .:. ::.::: : :.. ....:. : ::. NP_001 DTYSLSYDLHCCGAKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKA 180 190 200 210 220 230 pF1KE2 HSY : NP_001 SSLIPTCLKILQ 240 250 >>NP_001270 (OMIM: 604440) cell death activator CIDE-A i (219 aa) initn: 353 init1: 187 opt: 507 Z-score: 679.0 bits: 132.8 E(85289): 4.4e-31 Smith-Waterman score: 507; 41.2% identity (71.1% similar) in 211 aa overlap (12-216:11-216) 10 20 30 40 50 60 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL :.: .. ..:. : ..: : ::::: .: :. :.:. :.. :::. NP_001 MEAARDYAGALIRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELI 10 20 30 40 50 70 80 90 100 110 pF1KE2 AKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYG .:.:..:.. .:..:::::::::.::.:.::: : :.: .:.:..::.: : . : . . NP_001 SKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 LGRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELL : . . ::: :::.:. ::.:..: ::::::.: .::.: :.. : : .:: :: NP_001 -----PPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLL 120 130 140 150 160 170 180 190 200 210 pF1KE2 RWTSTLLQGLGHMLLGISSTLRHAVEGAEQW-----QQKGRLHSY :. : : :..:. ... . .... :. : :::. NP_001 RFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG 180 190 200 210 >>NP_001305312 (OMIM: 604440) cell death activator CIDE- (253 aa) initn: 353 init1: 187 opt: 506 Z-score: 676.8 bits: 132.6 E(85289): 5.8e-31 Smith-Waterman score: 506; 40.7% identity (70.6% similar) in 214 aa overlap (9-216:42-250) 10 20 30 pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPF :.. : .. ..:. : ..: : ::: NP_001 NHNGSWAREGPRLGPSWKRGLWSPRGGPNRPAEPSRPLTFMGSQTKRVLFTPLMHPARPF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE2 RVCDHKRTIRKGLTAATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDT :: .: :. :.:. :.. :::..:.:..:.. .:..:::::::::.::.:.::: : :.: NP_001 RVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNT 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE2 CLMVLQSGQSWSPTRSGVLSYGLGRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFY .:.:..::.: : . : . . : . . ::: :::.:. ::.:..: ::::::.: NP_001 HFMILEKGQKWMPGSQHVPTCS-----PPKRSGIARVTFDLYRLNPKDFIGCLNVKATMY 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 GLYSMSCDFQGLGPKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQW-----QQ .::.: :.. : : .:: :::. : : :..:. ... . .... :. : NP_001 EMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQA 190 200 210 220 230 240 pF1KE2 KGRLHSY :::. NP_001 KGRFTCG 250 219 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:24:00 2016 done: Sun Nov 6 12:24:01 2016 Total Scan time: 6.870 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]