Result of FASTA (ccds) for
pFN21AE2197
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2197, 378 aa
1>>>pF1KE2197 378 - 378 aa - 378 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4243+/-0.000815; mu= 16.1773+/- 0.049
mean_var=67.6175+/-13.630, 0's: 0 Z-trim(106.6): 22 B-trim: 10 in 1/49
Lambda= 0.155971
statistics sampled from 9068 (9082) to 9068 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.279), width: 16
Scan time: 2.610
The best scores are: opt bits E(32554)
CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 ( 378) 2606 595.3 2.9e-170
CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 ( 378) 2565 586.1 1.7e-167
CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 ( 407) 1329 308.0 9.7e-84
CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 ( 291) 823 194.0 1.4e-49
CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 ( 241) 716 169.9 2.1e-42
CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 ( 284) 601 144.1 1.5e-34
CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 ( 239) 429 105.3 5.7e-23
>>CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 (378 aa)
initn: 2606 init1: 2606 opt: 2606 Z-score: 3170.3 bits: 595.3 E(32554): 2.9e-170
Smith-Waterman score: 2606; 99.7% identity (100.0% similar) in 378 aa overlap (1-378:1-378)
10 20 30 40 50 60
pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
:::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
CCDS58 CDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
310 320 330 340 350 360
370
pF1KE2 YRVWIQCKYCKPLLSSTS
::::::::::::::::::
CCDS58 YRVWIQCKYCKPLLSSTS
370
>>CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 (378 aa)
initn: 2565 init1: 2565 opt: 2565 Z-score: 3120.4 bits: 586.1 E(32554): 1.7e-167
Smith-Waterman score: 2565; 98.7% identity (99.2% similar) in 378 aa overlap (1-378:1-378)
10 20 30 40 50 60
pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
:::::::::::.::::::::::::: ::::::::::::::::::::::::::::::::::
CCDS45 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
::: :::::::::::::::::::::::::::::: :::::::::::::::::::::::::
CCDS45 SEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
CCDS45 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
310 320 330 340 350 360
370
pF1KE2 YRVWIQCKYCKPLLSSTS
::::::::::::::::::
CCDS45 YRVWIQCKYCKPLLSSTS
370
>>CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 (407 aa)
initn: 1318 init1: 795 opt: 1329 Z-score: 1616.8 bits: 308.0 E(32554): 9.7e-84
Smith-Waterman score: 1329; 55.4% identity (78.4% similar) in 361 aa overlap (20-373:31-390)
10 20 30 40
pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAA
.:::.:.:::.::.:: ::...::.:. ::
CCDS22 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ
:..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ...
CCDS22 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 NHLK----DWFLENKSEVCECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ
. : .: . :. . . . : . :..: . :: : : ...: :. ..
CCDS22 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE
130 140 150 160 170
170 180 190 200 210 220
pF1KE2 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV
: . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.:::
CCDS22 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL
...: : ..:::::::.::. :: : : ::.:.:.::::.: ::.:: ..::::.::
CCDS22 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 KPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV
:::::.:.::::::: .:::::::.::: ::::::::::.::::. :. ..: :.:..
CCDS22 KPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEK
300 310 320 330 340 350
350 360 370
pF1KE2 QNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
:::::::::::: ::. :.::::: :. :::
CCDS22 QNLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSNMVSTLLSQD
360 370 380 390 400
>>CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 (291 aa)
initn: 803 init1: 393 opt: 823 Z-score: 1003.7 bits: 194.0 E(32554): 1.4e-49
Smith-Waterman score: 823; 49.2% identity (74.4% similar) in 258 aa overlap (20-270:31-287)
10 20 30 40
pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAA
.:::.:.:::.::.:: ::...::.:. ::
CCDS82 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ
:..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ...
CCDS82 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 NHLK----DWFLENKSEVCECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ
. : .: . :. . . . : . :..: . :: : : ...: :. ..
CCDS82 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE
130 140 150 160 170
170 180 190 200 210 220
pF1KE2 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV
: . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.:::
CCDS82 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL
...: : ..:::::::.::. :: : : ::.:.:.::::.: ::.
CCDS82 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 KPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV
>>CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 (241 aa)
initn: 694 init1: 284 opt: 716 Z-score: 874.8 bits: 169.9 E(32554): 2.1e-42
Smith-Waterman score: 716; 47.9% identity (72.7% similar) in 238 aa overlap (40-270:1-237)
10 20 30 40 50 60
pF1KE2 PAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVD
..::.:. :::..::.::: :: :.::
CCDS82 MQWSKEEEAAARKKVKENSAVRVLLEEQVK
10 20 30
70 80 90 100 110 120
pF1KE2 YEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLK----DWFLENKSEVCE
:: .: :::. :::::.: :::::.::. ::::. : ... . : .: . :. . .
CCDS82 YEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSW-DHVKTSATN
40 50 60 70 80
130 140 150 160 170 180
pF1KE2 CRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQKISDLEICADEFPGSSATYR
. : . :..: . :: : : ...: :. ..: . . . ::::.::.:
CCDS82 RFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFR
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE2 ILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCD
:::::::.::.:::::.: .:.: :.:::::.: :.:::...: : ..:::::::.::
CCDS82 ILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCD
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE2 EEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLR
. :: : : ::.:.:.::::.: ::.
CCDS82 DGLPYPFPDGILDVILLVFVLSSIHPDRTLFI
210 220 230 240
>>CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 (284 aa)
initn: 711 init1: 516 opt: 601 Z-score: 733.9 bits: 144.1 E(32554): 1.5e-34
Smith-Waterman score: 607; 38.5% identity (56.2% similar) in 322 aa overlap (51-372:19-269)
30 40 50 60 70 80
pF1KE2 GSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWND
:.:..... : . :: : .:.: :.
CCDS43 MASLQRKGLQARILTSEEEEKLKRDQTL-VSDFKQQKLEQEAQKNWDL
10 20 30 40
90 100 110 120 130 140
pF1KE2 FYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQ
::: . ..::::::: :: :: .: ::. ::
CCDS43 FYKRNSTNFFKDRHWTTREFEEL----------------RS----CREFED---------
50 60 70
150 160 170 180 190 200
pF1KE2 HKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQ
::.. .::.:::::: .::.:.
CCDS43 ----------------------QKLT-----------------MLEAGCGVGNCLFPLLE
80 90
210 220 230 240 250 260
pF1KE2 TNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILI
.::..:.: :::: ::: :. : :: :: .: :: .. :: :.:...::
CCDS43 --EDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLI
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE2 FVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGT
:::::. ::::. ... . ..:::: ::.:::: :: :.:::: .. :. ::::: :::
CCDS43 FVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGT
160 170 180 190 200 210
330 340 350 360 370
pF1KE2 RVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
: ::::.. : :: .: :.: : : ::. . : . ::..: :. ::
CCDS43 RSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVV
220 230 240 250 260 270
CCDS43 LGLDPKS
280
>>CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 (239 aa)
initn: 429 init1: 429 opt: 429 Z-score: 525.9 bits: 105.3 E(32554): 5.7e-23
Smith-Waterman score: 429; 47.3% identity (68.0% similar) in 150 aa overlap (223-372:75-224)
200 210 220 230 240 250
pF1KE2 NTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKG
. : :: :: .: :: .. ::
CCDS77 WDLFYKRNSTNFFKDRHWTTREFEELRSCREQNPLYDTERCKVFQCDLTKDDLLDHVPPE
50 60 70 80 90 100
260 270 280 290 300 310
pF1KE2 SLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGN
:.:...:::::::. ::::. ... . ..:::: ::.:::: :: :.:::: .. :. :
CCDS77 SVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGEN
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE2 FYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKP
:::: :::: ::::.. : :: .: :.: : : ::. . : . ::..: :. ::
CCDS77 FYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKP
170 180 190 200 210 220
pF1KE2 LLSSTS
CCDS77 PKNPSPVVLGLDPKS
230
378 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:17:30 2016 done: Sun Nov 6 16:17:31 2016
Total Scan time: 2.610 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]