Result of FASTA (omim) for
pFN21AE2180
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2180, 417 aa
1>>>pF1KE2180 417 - 417 aa - 417 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5824+/-0.000286; mu= 13.7021+/- 0.018
mean_var=130.9026+/-26.680, 0's: 0 Z-trim(122.0): 79 B-trim: 1971 in 1/53
Lambda= 0.112099
statistics sampled from 39278 (39373) to 39278 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.462), width: 16
Scan time: 8.830
The best scores are: opt bits E(85289)
NP_079492 (OMIM: 150400,224750,257980,606268) prot ( 417) 3013 498.0 1.8e-140
XP_011510231 (OMIM: 150400,224750,257980,606268) P ( 385) 2743 454.3 2.4e-127
NP_003385 (OMIM: 225300,601906,617073) protein Wnt ( 389) 1282 218.0 3.2e-56
XP_011510232 (OMIM: 150400,224750,257980,606268) P ( 299) 890 154.5 3.2e-37
XP_011537024 (OMIM: 225300,601906,617073) PREDICTE ( 267) 791 138.5 2e-32
XP_016875408 (OMIM: 225300,601906,617073) PREDICTE ( 267) 791 138.5 2e-32
NP_005421 (OMIM: 164820,615220,615221) proto-oncog ( 370) 741 130.5 6.8e-30
NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 726 128.1 3.5e-29
NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 710 125.5 2.1e-28
XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt ( 446) 710 125.6 2.5e-28
XP_011532393 (OMIM: 228930,276820,601570) PREDICTE ( 282) 693 122.6 1.2e-27
NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 693 122.7 1.4e-27
NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 683 121.1 4.3e-27
XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt ( 353) 683 121.1 4.4e-27
XP_011537026 (OMIM: 225300,601906,617073) PREDICTE ( 164) 579 104.0 2.9e-22
XP_016865315 (OMIM: 606360) PREDICTED: protein Wnt ( 255) 568 102.4 1.4e-21
NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 570 102.8 1.4e-21
NP_490645 (OMIM: 606360) protein Wnt-8a isoform 3 ( 351) 568 102.5 1.7e-21
NP_001287868 (OMIM: 606360) protein Wnt-8a isoform ( 369) 568 102.5 1.8e-21
NP_001287867 (OMIM: 606360) protein Wnt-8a isoform ( 386) 568 102.5 1.9e-21
XP_016865314 (OMIM: 606360) PREDICTED: protein Wnt ( 391) 568 102.6 1.9e-21
XP_016865313 (OMIM: 606360) PREDICTED: protein Wnt ( 408) 568 102.6 1.9e-21
XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt ( 295) 564 101.8 2.4e-21
NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 564 101.9 2.8e-21
XP_006713387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17
XP_011532391 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17
XP_011532390 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17
NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 471 86.8 9.4e-17
XP_011532387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17
XP_011532388 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17
XP_011532389 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17
XP_016862617 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17
NP_003383 (OMIM: 164975,180700) protein Wnt-5a iso ( 380) 471 86.9 9.7e-17
XP_016862616 (OMIM: 164975,180700) PREDICTED: prot ( 394) 471 86.9 9.9e-17
XP_011541927 (OMIM: 606360) PREDICTED: protein Wnt ( 337) 468 86.3 1.2e-16
NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 461 85.2 2.8e-16
NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 461 85.2 2.8e-16
NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 427 79.7 1.3e-14
XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt ( 363) 427 79.7 1.3e-14
XP_011539900 (OMIM: 158330,603490,611812) PREDICTE ( 296) 410 76.9 7.5e-14
NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 410 77.0 8.5e-14
XP_011539899 (OMIM: 158330,603490,611812) PREDICTE ( 373) 410 77.0 8.9e-14
XP_011543543 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 393 74.1 4.5e-13
XP_016873730 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 393 74.1 4.5e-13
NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 393 74.2 5.8e-13
XP_005274288 (OMIM: 603699) PREDICTED: protein Wnt ( 354) 393 74.2 5.8e-13
XP_011543540 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 393 74.2 5.9e-13
XP_011543541 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 393 74.2 5.9e-13
XP_011543542 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 393 74.2 5.9e-13
NP_001278809 (OMIM: 601968) protein Wnt-2b isoform ( 299) 391 73.8 6.4e-13
>>NP_079492 (OMIM: 150400,224750,257980,606268) protein (417 aa)
initn: 3013 init1: 3013 opt: 3013 Z-score: 2642.8 bits: 498.0 E(85289): 1.8e-140
Smith-Waterman score: 3013; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417)
10 20 30 40 50 60
pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR
310 320 330 340 350 360
370 380 390 400 410
pF1KE2 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
370 380 390 400 410
>>XP_011510231 (OMIM: 150400,224750,257980,606268) PREDI (385 aa)
initn: 2743 init1: 2743 opt: 2743 Z-score: 2407.3 bits: 454.3 E(85289): 2.4e-127
Smith-Waterman score: 2743; 100.0% identity (100.0% similar) in 380 aa overlap (38-417:6-385)
10 20 30 40 50 60
pF1KE2 PWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGL
::::::::::::::::::::::::::::::
XP_011 MTPPSRSAPNDILDLRLPPEPVLNANTVCLTLPGL
10 20 30
70 80 90 100 110 120
pF1KE2 SRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 RESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKG
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 LSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNN
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 RVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 GQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSA
280 290 300 310 320 330
370 380 390 400 410
pF1KE2 GSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
340 350 360 370 380
>>NP_003385 (OMIM: 225300,601906,617073) protein Wnt-10b (389 aa)
initn: 1791 init1: 664 opt: 1282 Z-score: 1130.2 bits: 218.0 E(85289): 3.2e-56
Smith-Waterman score: 1776; 60.4% identity (80.9% similar) in 404 aa overlap (14-417:5-389)
10 20 30 40 50 60
pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV
:.:.: :. . :.:: : . :. :.:: :.:: :: :.::::
NP_003 MLEEPRPRPPPSGLAGLLFLALCS----RALSNEILGLKLPGEPPLTANTV
10 20 30 40
70 80 90 100 110 120
pF1KE2 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES
:::: :::.::. .:.:.:::.:::.::..::.::::::.::::::::.:: ...:..:
NP_003 CLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD
:..::::::::.... ::::.:::..::.:::: .::: . :... .: :: :::.
NP_003 AILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKL--LQLQ
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA
::.:::.. :..: . ::: ::.::::::. :: :::.::.::::::: :::.:
NP_003 ALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQA
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI
:::.::::::::.: ::..:::::::::::::.::::...::::.::: :: :. :: .:
NP_003 RMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFI
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR
::::.: ..: ::: .. .:::::::::::::.: . : :: ::
NP_003 DTHNRNSGAFQPRLR-----------PRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGR
290 300 310 320 330
370 380 390 400 410
pF1KE2 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
:::.: :::::.:::::::.::::: :::::::::::.:.:.::..::::.:::
NP_003 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
340 350 360 370 380
>>XP_011510232 (OMIM: 150400,224750,257980,606268) PREDI (299 aa)
initn: 923 init1: 890 opt: 890 Z-score: 789.1 bits: 154.5 E(85289): 3.2e-37
Smith-Waterman score: 890; 100.0% identity (100.0% similar) in 126 aa overlap (1-126:1-126)
10 20 30 40 50 60
pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD
::::::
XP_011 PIFSRGSDGEHAAEVQVPRHVRQLPAQDVLAGDARVPHRGGAAAQPLPPRHAHPAAQPQR
130 140 150 160 170 180
>>XP_011537024 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa)
initn: 1321 init1: 664 opt: 791 Z-score: 703.3 bits: 138.5 E(85289): 2e-32
Smith-Waterman score: 1285; 62.1% identity (80.0% similar) in 280 aa overlap (138-417:3-267)
110 120 130 140 150 160
pF1KE2 SSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDE
::::.:::..::.:::: .::: . :..
XP_011 MLAAGVMHAVATACSLGKLVSCGCGWKGSGEQ
10 20 30
170 180 190 200 210 220
pF1KE2 EAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKD
. .: :: :::.::.:::.. :..: . ::: ::.::::::. :: :::.::.:
XP_011 DRLRAKL--LQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 FLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVG
:::::: :::.::::.::::::::.: ::..:::::::::::::.::::...::::.::
XP_011 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 ALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCE
: :: :. :: .: ::::.: ..: ::: . ..::::::::::::
XP_011 AALRERLGRAIFIDTHNRNSGAFQPRLR-----------PRRLS--GELVYFEKSPDFCE
160 170 180 190
350 360 370 380 390 400
pF1KE2 REPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEEC
:.: . : :: :: :::.: :::::.:::::::.::::: :::::::::::.:.:.::
XP_011 RDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDEC
200 210 220 230 240 250
410
pF1KE2 RITEWVSVCK
..::::.:::
XP_011 KVTEWVNVCK
260
>>XP_016875408 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa)
initn: 1321 init1: 664 opt: 791 Z-score: 703.3 bits: 138.5 E(85289): 2e-32
Smith-Waterman score: 1285; 62.1% identity (80.0% similar) in 280 aa overlap (138-417:3-267)
110 120 130 140 150 160
pF1KE2 SSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDE
::::.:::..::.:::: .::: . :..
XP_016 MLAAGVMHAVATACSLGKLVSCGCGWKGSGEQ
10 20 30
170 180 190 200 210 220
pF1KE2 EAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKD
. .: :: :::.::.:::.. :..: . ::: ::.::::::. :: :::.::.:
XP_016 DRLRAKL--LQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 FLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVG
:::::: :::.::::.::::::::.: ::..:::::::::::::.::::...::::.::
XP_016 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 ALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCE
: :: :. :: .: ::::.: ..: ::: . ..::::::::::::
XP_016 AALRERLGRAIFIDTHNRNSGAFQPRLR-----------PRRLS--GELVYFEKSPDFCE
160 170 180 190
350 360 370 380 390 400
pF1KE2 REPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEEC
:.: . : :: :: :::.: :::::.:::::::.::::: :::::::::::.:.:.::
XP_016 RDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDEC
200 210 220 230 240 250
410
pF1KE2 RITEWVSVCK
..::::.:::
XP_016 KVTEWVNVCK
260
>>NP_005421 (OMIM: 164820,615220,615221) proto-oncogene (370 aa)
initn: 1036 init1: 373 opt: 741 Z-score: 657.7 bits: 130.5 E(85289): 6.8e-30
Smith-Waterman score: 948; 38.4% identity (60.1% similar) in 404 aa overlap (23-416:10-369)
10 20 30 40 50
pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPND------ILDLRLPPEPV
:: .:: ::: : :. :... . .
NP_005 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLL
10 20 30 40
60 70 80 90 100 110
pF1KE2 LNANTVCLTL-PGL---SRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSL
..... :.: :.: ::.: .. ..: . :. :.: :..::. :::..:::: .
NP_005 TDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE2 ETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAF
. . . : .:: ::.:: .::..:::.:.:. .:. :....: :: :::
NP_005 PGPHLF---GKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRG-----
110 120 130 140 150
180 190 200 210 220 230
pF1KE2 RRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLD
:: : :.::::: .. ::. :...:.:
NP_005 --------------------------------PGGPD-WHWGGCSDNIDFGRLFGREFVD
160 170 180
240 250 260 270 280 290
pF1KE2 SREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALL
: : ::.. : ::::..:: .:. .::..::::: :::: ..:::. : .:.:: .:
NP_005 SGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVL
190 200 210 220 230 240
300 310 320 330 340 350
pF1KE2 RSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREP
:.:: :. . ::.... . : : : :: :::::::::.::
NP_005 RDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKP---PSPHDLVYFEKSPNFCTYSG
250 260 270 280 290 300
360 370 380 390 400 410
pF1KE2 RLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRIT
:: .:::.:: ::.:: . ::: .:::::: : .:::.: ::::: : :..: :
NP_005 RLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHT
310 320 330 340 350 360
pF1KE2 EWVSVCK
. . :
NP_005 RVLHECL
370
>>NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt-3 p (355 aa)
initn: 1037 init1: 374 opt: 726 Z-score: 644.8 bits: 128.1 E(85289): 3.5e-29
Smith-Waterman score: 985; 39.3% identity (64.0% similar) in 361 aa overlap (60-417:44-355)
30 40 50 60 70 80
pF1KE2 LLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGI
.: ..::: .:.. : . .. :. .:.
NP_110 LGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGV
20 30 40 50 60 70
90 100 110 120 130 140
pF1KE2 QIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNAC
...:.::::::: .::::.... ... .:..... :::::..:::.:::. ::. .:
NP_110 KLGIQECQHQFRGRRWNCTTID--DSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSC
80 90 100 110 120 130
150 160 170 180 190 200
pF1KE2 ALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSW
: : ::::. ..: : :: ..:
NP_110 AEGTSTICGCDSHHKG---------------------------P---------PG--EGW
140 150
210 220 230 240 250 260
pF1KE2 EWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSG
.::::: : :: :..: :.:: . : .. : :::..:: .....:. :::::: ::
NP_110 KWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSG
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 SCQLKTCWQVTPEFRTVGALLRSRFHRAT--LIRPHNRNGGQLEPGPAGAPSPAPGAPGP
::..:::: . :.::..: .:.... :. ... : .. : .: : : :
NP_110 SCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKP----P
220 230 240 250 260
330 340 350 360 370 380
pF1KE2 RRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQT
.: ::::.:.::.::: .:. : :: : :: .: : ::: .::::::: .
NP_110 TER----DLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEK
270 280 290 300 310 320
390 400 410
pF1KE2 RSERCHCRFHWCCFVVCEEC-RITEWVSVCK
:.:.::: :::::.: :.:: :: . : .::
NP_110 RKEKCHCIFHWCCYVSCQECIRIYD-VHTCK
330 340 350
>>NP_149122 (OMIM: 606359) protein Wnt-3a precursor [Hom (352 aa)
initn: 1014 init1: 369 opt: 710 Z-score: 630.9 bits: 125.5 E(85289): 2.1e-28
Smith-Waterman score: 969; 38.7% identity (61.6% similar) in 372 aa overlap (49-417:35-352)
20 30 40 50 60 70
pF1KE2 RPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRH
: .:.: : ..::: .:.. : .
NP_149 GYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPIL-----CASIPGLVPKQLRFCRNY
10 20 30 40 50
80 90 100 110 120 130
pF1KE2 PDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAA
.. :. .::.:.:.::::::: .::::.... ... .:..... :::::..:::.
NP_149 VEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVH--DSLAIFGPVLDKATRESAFVHAIAS
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE2 AGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPAL
:::. ::. .:: : :::.. ..:
NP_149 AGVAFAVTRSCAEGTAAICGCSSRHQG---------------------------------
120 130 140
200 210 220 230 240 250
pF1KE2 PTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENM
::: .:.::::: :. :: :..: :.:: . : .. : :::..::::. .:
NP_149 ---SPG--KGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHM
150 160 170 180 190
260 270 280 290 300 310
pF1KE2 RRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRAT--LIRPHNRNGGQLEP-GPA
. :::::: ::::..:::: :.::..: .:.... :. ... : .. : .: :
NP_149 HLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPR
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE2 GAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSM
. .: . ::::.: ::.::: .:. : :: : :: :: : ::: .
NP_149 YTYFKVP---------TERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLL
260 270 280 290 300 310
380 390 400 410
pF1KE2 CCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
::::::: . : :.:.: :::::.: :.:: . : .::
NP_149 CCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
320 330 340 350
>>XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt-3a (446 aa)
initn: 992 init1: 369 opt: 710 Z-score: 629.5 bits: 125.6 E(85289): 2.5e-28
Smith-Waterman score: 969; 38.7% identity (61.6% similar) in 372 aa overlap (49-417:35-352)
20 30 40 50 60 70
pF1KE2 RPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRH
: .:.: : ..::: .:.. : .
XP_011 GYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPIL-----CASIPGLVPKQLRFCRNY
10 20 30 40 50
80 90 100 110 120 130
pF1KE2 PDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAA
.. :. .::.:.:.::::::: .::::.... ... .:..... :::::..:::.
XP_011 VEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVH--DSLAIFGPVLDKATRESAFVHAIAS
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE2 AGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPAL
:::. ::. .:: : :::.. ..:
XP_011 AGVAFAVTRSCAEGTAAICGCSSRHQG---------------------------------
120 130 140
200 210 220 230 240 250
pF1KE2 PTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENM
::: .:.::::: :. :: :..: :.:: . : .. : :::..::::. .:
XP_011 ---SPG--KGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHM
150 160 170 180 190
260 270 280 290 300 310
pF1KE2 RRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRAT--LIRPHNRNGGQLEP-GPA
. :::::: ::::..:::: :.::..: .:.... :. ... : .. : .: :
XP_011 HLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPR
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE2 GAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSM
. .: . ::::.: ::.::: .:. : :: : :: :: : ::: .
XP_011 YTYFKVP---------TERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLL
260 270 280 290 300 310
380 390 400 410
pF1KE2 CCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
::::::: . : :.:.: :::::.: :.:: . : .::
XP_011 CCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCKPCHSWATGREGRRRWSTL
320 330 340 350 360 370
XP_011 GCGPRDGCLRTGHSGPCRSLAWIWSPGSQGHDLLEQLPRSGGLGQCSSLQNWTAVSGCLR
380 390 400 410 420 430
417 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:12:41 2016 done: Sun Nov 6 03:12:42 2016
Total Scan time: 8.830 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]