Result of FASTA (omim) for
pFN21AE2157
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2157, 330 aa
1>>>pF1KE2157 330 - 330 aa - 330 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5919+/-0.000338; mu= 15.8676+/- 0.021
mean_var=92.5664+/-18.117, 0's: 0 Z-trim(118.2): 159 B-trim: 652 in 2/52
Lambda= 0.133305
statistics sampled from 30671 (30865) to 30671 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.362), width: 16
Scan time: 6.830
The best scores are: opt bits E(85289)
NP_002104 (OMIM: 134371,235400,603075) complement ( 330) 2371 465.7 5.9e-131
XP_011507759 (OMIM: 134371,235400,603075) PREDICTE ( 265) 1769 349.9 3.5e-96
NP_000177 (OMIM: 126700,134370,235400,609814,61069 (1231) 1468 292.6 3e-78
NP_005657 (OMIM: 600889) complement factor H-relat ( 270) 1201 240.6 2.8e-63
XP_011507760 (OMIM: 600889) PREDICTED: complement ( 266) 1169 234.5 1.9e-61
NP_110414 (OMIM: 608593,614809) complement factor ( 569) 1133 227.8 4.1e-59
XP_011507761 (OMIM: 600889) PREDICTED: complement ( 250) 1081 217.5 2.3e-56
NP_066303 (OMIM: 235400,603075,605336) complement ( 330) 1058 213.2 6.1e-55
XP_011508322 (OMIM: 608593,614809) PREDICTED: comp ( 572) 1054 212.6 1.6e-54
NP_006675 (OMIM: 605337) complement factor H-relat ( 331) 949 192.3 1.2e-48
XP_016855603 (OMIM: 605337) PREDICTED: complement ( 387) 934 189.4 1e-47
XP_006711192 (OMIM: 605337) PREDICTED: complement ( 570) 934 189.6 1.4e-47
NP_001188480 (OMIM: 605337) complement factor H-re ( 577) 934 189.6 1.4e-47
NP_001188479 (OMIM: 605337) complement factor H-re ( 578) 934 189.6 1.4e-47
XP_016855602 (OMIM: 605337) PREDICTED: complement ( 458) 799 163.5 7.7e-40
XP_016855601 (OMIM: 605337) PREDICTED: complement ( 468) 799 163.5 7.8e-40
XP_016855600 (OMIM: 605337) PREDICTED: complement ( 519) 799 163.6 8.4e-40
XP_005245170 (OMIM: 600889) PREDICTED: complement ( 205) 775 158.6 1e-38
XP_016856598 (OMIM: 600889) PREDICTED: complement ( 211) 760 155.7 7.8e-38
XP_011507762 (OMIM: 600889) PREDICTED: complement ( 201) 758 155.3 9.8e-38
NP_001299601 (OMIM: 600889) complement factor H-re ( 146) 681 140.4 2.2e-33
XP_016855599 (OMIM: 605337) PREDICTED: complement ( 519) 674 139.5 1.4e-32
XP_011507586 (OMIM: 134580,613235) PREDICTED: coag ( 675) 638 132.7 2.1e-30
XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 634 131.9 3.5e-30
NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 634 131.9 3.6e-30
XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 634 131.9 3.7e-30
NP_001160096 (OMIM: 235400,603075,605336) compleme ( 269) 598 124.7 2.2e-28
XP_016856597 (OMIM: 126700,134370,235400,609814,61 ( 446) 440 94.5 4.6e-19
NP_001014975 (OMIM: 126700,134370,235400,609814,61 ( 449) 440 94.5 4.6e-19
NP_000033 (OMIM: 138700) beta-2-glycoprotein 1 pre ( 345) 389 84.6 3.4e-16
XP_011507508 (OMIM: 120650,240500,610927,614699) P ( 969) 320 71.7 7.2e-12
NP_001006659 (OMIM: 120650,240500,610927,614699) c (1092) 320 71.7 7.9e-12
XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 316 71.2 2.2e-11
XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 316 71.4 3.2e-11
XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 316 71.4 3.2e-11
NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 316 71.4 3.2e-11
XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 316 71.4 3.3e-11
XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 316 71.4 3.3e-11
XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 316 71.4 3.3e-11
NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 316 71.4 3.3e-11
XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 316 71.4 3.3e-11
NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 316 71.4 3.3e-11
NP_001868 (OMIM: 120650,240500,610927,614699) comp (1033) 292 66.3 3.2e-10
XP_016857076 (OMIM: 615827) PREDICTED: sushi domai ( 490) 250 58.0 4.9e-08
NP_060452 (OMIM: 615827) sushi domain-containing p ( 490) 250 58.0 4.9e-08
XP_016857077 (OMIM: 615827) PREDICTED: sushi domai ( 490) 250 58.0 4.9e-08
XP_016857073 (OMIM: 615827) PREDICTED: sushi domai ( 562) 250 58.0 5.4e-08
XP_006711471 (OMIM: 615827) PREDICTED: sushi domai ( 492) 242 56.4 1.4e-07
XP_005273226 (OMIM: 615827) PREDICTED: sushi domai ( 492) 242 56.4 1.4e-07
XP_011507987 (OMIM: 615827) PREDICTED: sushi domai ( 492) 242 56.4 1.4e-07
>>NP_002104 (OMIM: 134371,235400,603075) complement fact (330 aa)
initn: 2371 init1: 2371 opt: 2371 Z-score: 2472.1 bits: 465.7 E(85289): 5.9e-131
Smith-Waterman score: 2371; 100.0% identity (100.0% similar) in 330 aa overlap (1-330:1-330)
10 20 30 40 50 60
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
250 260 270 280 290 300
310 320 330
pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
::::::::::::::::::::::::::::::
NP_002 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
310 320 330
>>XP_011507759 (OMIM: 134371,235400,603075) PREDICTED: c (265 aa)
initn: 1871 init1: 1769 opt: 1769 Z-score: 1847.7 bits: 349.9 E(85289): 3.5e-96
Smith-Waterman score: 1769; 100.0% identity (100.0% similar) in 245 aa overlap (86-330:21-265)
60 70 80 90 100 110
pF1KE2 EYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN
::::::::::::::::::::::::::::::
XP_011 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN
10 20 30 40 50
120 130 140 150 160 170
pF1KE2 TGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE2 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE2 QCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGES
180 190 200 210 220 230
300 310 320 330
pF1KE2 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
:::::::::::::::::::::::::::::::::::
XP_011 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
240 250 260
>>NP_000177 (OMIM: 126700,134370,235400,609814,610698) c (1231 aa)
initn: 1323 init1: 1323 opt: 1468 Z-score: 1525.9 bits: 292.6 E(85289): 3e-78
Smith-Waterman score: 1469; 68.8% identity (80.1% similar) in 311 aa overlap (26-330:935-1231)
10 20 30 40 50
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGI---LYDEEKYKPFSQVPTGEVFY
:.:.::. . : .: ::
NP_000 FRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQY--------GEEVT
910 920 930 940 950
60 70 80 90 100
pF1KE2 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRL-CF-FPFVENGHSESSGQ-THLEGDT
:.: .: . .. : : :: :.:.. :. .: ::. . . .. :.
NP_000 YKCFEGFGIDGPAI---AKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQ
960 970 980 990 1000 1010
110 120 130 140 150 160
pF1KE2 VQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSG
: : : :.. .. .:..:.. :. : :: :::::::::::::.:.::::::::::
NP_000 VTYTCATYYKM-DGASNVTCINSRWTGRPTCR--DTSCVNPPTVQNAYIVSRQMSKYPSG
1020 1030 1040 1050 1060 1070
170 180 190 200 210 220
pF1KE2 ERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAP
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAP
1080 1090 1100 1110 1120 1130
230 240 250 260 270 280
pF1KE2 ASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLY
1140 1150 1160 1170 1180 1190
290 300 310 320 330
pF1KE2 LRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
:::::.::::::::::::::::::::::::::::::::::
NP_000 SRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
1200 1210 1220 1230
>--
initn: 828 init1: 451 opt: 590 Z-score: 613.3 bits: 123.7 E(85289): 2e-27
Smith-Waterman score: 590; 29.3% identity (58.9% similar) in 321 aa overlap (23-330:325-626)
10 20 30 40 50
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFY
::.: :.:: :: :. .:. : .:. .
NP_000 RNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYS
300 310 320 330 340 350
60 70 80 90 100 110
pF1KE2 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQI
: :. .: .:: :.: .: ::..::::. ::: :.::..:::.... :. ..: ....
NP_000 YYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDV
360 370 380 390 400 410
120 130 140 150 160 170
pF1KE2 ICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERV
:. :: : . .....:.: ::: :.: . : . ..:. : :.. : :..
NP_000 ACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKA
420 430 440 450 460 470
180 190 200 210 220
pF1KE2 RYECRSPYEMFGDEE----VMCLNGNWTEPPQCKDSTGKCGPPPPID---NGDITSFPLS
.:.:. : . .: : . : . .:. : : : : : .. ..:.: : :.
NP_000 KYQCKLGY-VTADGETSGSITCGKDGWSAQPTCIKS---CDIPVFMNARTKNDFTWFKLN
480 490 500 510 520
230 240 250 260 270 280
pF1KE2 VYAPASSVEYQCQNLYQLEGNKR---ITCRNGQWSEPPKCLHPCVISREI-MENYNIALR
....:.:.. :. . .. :.: . ::. : : . :: . . .. :
NP_000 -----DTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYE-----RECELPKIDVHLV
530 540 550 560 570
290 300 310 320 330
pF1KE2 WTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKL--EYPTCAKR
:. : ..:: .: :: :. . . . . :. : . : : ..
NP_000 PDRKKDQY-KVGEVLKFSCKPGFTIVGPNSV---QCYHFGLSPDLPICKEQVQSCGPPPE
580 590 600 610 620 630
NP_000 LLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIP
640 650 660 670 680 690
>--
initn: 391 init1: 169 opt: 273 Z-score: 283.8 bits: 62.7 E(85289): 4.5e-09
Smith-Waterman score: 275; 25.6% identity (56.4% similar) in 227 aa overlap (90-304:634-843)
60 70 80 90 100 110
pF1KE2 VSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGH-SESSGQTHLEGDTVQIICNTGY
: . ::. .:.. . . ....:. :: .
NP_000 VGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRF
610 620 630 640 650 660
120 130 140 150 160 170
pF1KE2 RLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPS--GERVRYEC
:... :.:.::. :.: : : ...: . : .... :.:. : :. :...:
NP_000 -LMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWA---QLSSPPYYYGDSVEFNC
670 680 690 700 710
180 190 200 210 220 230
pF1KE2 RSPYEMFGDEEVMCLNGNWTEPPQCK--DSTGKCGPPPPIDNGDITSFPLSV---YAPAS
. :.: . . :..: ::. ::: :. :: .: : :. . :
NP_000 SESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKS----SNLIILEEHLKNKKEFDHNS
720 730 740 750 760 770
240 250 260 270 280
pF1KE2 SVEYQCQNLYQLEGNKRITCRNGQWSEPPKC----LHPCVISREIMENYNIALRWTAKQK
...:.:.. :: . .: ::.:. .: .. : .: ...:..
NP_000 NIRYRCRGK---EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTT------
780 790 800 810 820
290 300 310 320 330
pF1KE2 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
: : ::.. .:...:
NP_000 LNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRS
830 840 850 860 870 880
>--
initn: 128 init1: 112 opt: 204 Z-score: 212.1 bits: 49.5 E(85289): 4.5e-05
Smith-Waterman score: 204; 34.5% identity (60.7% similar) in 84 aa overlap (186-266:849-931)
160 170 180 190 200 210
pF1KE2 AHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPID
::. : .: : : : .. :. :: :.
NP_000 NSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKI-PCSQPPQIE
820 830 840 850 860 870
220 230 240 250 260 270
pF1KE2 NGDITSFPLS--VYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLH-PCVISREI
.: :.: : :: .... : :.. ... ... :: :.:: ::.: ::
NP_000 HGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEI
880 890 900 910 920 930
280 290 300 310 320 330
pF1KE2 MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
NP_000 SHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFEN
940 950 960 970 980 990
>--
initn: 113 init1: 91 opt: 195 Z-score: 202.8 bits: 47.7 E(85289): 0.00015
Smith-Waterman score: 285; 29.5% identity (60.7% similar) in 183 aa overlap (93-265:153-324)
70 80 90 100 110
pF1KE2 SKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG-----QTHLEGDTVQIICNTG
:::. ::. . :. :..:...::.:
NP_000 EINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHF-GQAVRFVCNSG
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE2 YRLQNNENNISCVERG-WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE
:.....:. . : . : :: ::: .. :: .: ..... : .. . : .:: .:.
NP_000 YKIEGDEE-MHCSDDGFWSKEKPKC--VEISCKSPDVINGSPISQKII--YKENERFQYK
190 200 210 220 230
180 190 200 210 220 230
pF1KE2 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVE
: ::. ...: ...: :.:.... : : : ::: . :: . . .. .
NP_000 CNMGYEYSERGDAVCTESGWRPLPSCEEKS--CDNPY-IPNGDYS--PLRIKHRTGDEIT
240 250 260 270 280 290
240 250 260 270 280 290
pF1KE2 YQCQN-LYQLEGNKRITCRNGQWSEPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRT
:::.: .: .. : . : :.: :.:
NP_000 YQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGK
300 310 320 330 340 350
300 310 320 330
pF1KE2 GESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
NP_000 YYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKS
360 370 380 390 400 410
>>NP_005657 (OMIM: 600889) complement factor H-related p (270 aa)
initn: 1669 init1: 1008 opt: 1201 Z-score: 1257.2 bits: 240.6 E(85289): 2.8e-63
Smith-Waterman score: 1557; 70.9% identity (77.3% similar) in 330 aa overlap (1-330:1-270)
10 20 30 40 50 60
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_005 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
:::::::::::::::::::::::
NP_005 QNNENNISCVERGWSTPPKCRSTI------------------------------------
130 140
190 200 210 220 230 240
pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
:. :::::::::::::::: ::::::.::::::::::
NP_005 -----------------------SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL
150 160 170 180
250 260 270 280 290 300
pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .::::
NP_005 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC
190 200 210 220 230 240
310 320 330
pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
: ::. ..::..:. : .::: ::.: ..
NP_005 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK
250 260 270
>>XP_011507760 (OMIM: 600889) PREDICTED: complement fact (266 aa)
initn: 1639 init1: 978 opt: 1169 Z-score: 1224.0 bits: 234.5 E(85289): 1.9e-61
Smith-Waterman score: 1523; 70.0% identity (76.4% similar) in 330 aa overlap (1-330:1-266)
10 20 30 40 50 60
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_011 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
:::::::::::::::::::
XP_011 QNNENNISCVERGWSTPPK-----------------------------------------
130
190 200 210 220 230 240
pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
:. : :::::::::::::::: ::::::.::::::::::
XP_011 --FSAE--------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL
140 150 160 170
250 260 270 280 290 300
pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .::::
XP_011 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC
180 190 200 210 220 230
310 320 330
pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
: ::. ..::..:. : .::: ::.: ..
XP_011 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK
240 250 260
>>NP_110414 (OMIM: 608593,614809) complement factor H-re (569 aa)
initn: 1639 init1: 1031 opt: 1133 Z-score: 1182.2 bits: 227.8 E(85289): 4.1e-59
Smith-Waterman score: 1133; 51.7% identity (68.4% similar) in 329 aa overlap (1-327:1-322)
10 20 30 40 50 60
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
: :: :::::: .:.::::.:.::::::.::.::::: :.::::::::::::::::::::
NP_110 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
:::::::::::::::::::::::::.: ::::.:::::::: ::::::::::::::: :
NP_110 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
::::.::::::::::::: : : : : :. .. : : :. ... ::.
NP_110 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRKNL
130 140 150 160 170
190 200 210 220 230
pF1KE2 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN
:.. :.: . .:. : :: .. .::::: ..::.. . :. :::.:.
NP_110 IRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV
. ..: :.: : .:.:. : :.. : : . .. . . : :.:
NP_110 NFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSVEVN
240 250 260 270 280 290
300 310 320 330
pF1KE2 CKRGYRLSSRSHTLRTTCWDGK-LEYPTCAKR
:. : . . . :: .: : : :
NP_110 CRNEYAMIGNNMI---TCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNS
300 310 320 330 340 350
>--
initn: 810 init1: 622 opt: 685 Z-score: 716.5 bits: 141.7 E(85289): 3.6e-33
Smith-Waterman score: 685; 40.2% identity (66.4% similar) in 229 aa overlap (100-327:345-568)
70 80 90 100 110 120
pF1KE2 ITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISC
::. ... .. :. .: ... :
NP_110 IWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS----VC
320 330 340 350 360 370
130 140 150 160 170 180
pF1KE2 VERGWSTPPKC-RSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEV
.. :. : .. . : :: . ::. .. .. : .::.: :. : . .:.
NP_110 INGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLLPEAKEI
380 390 400 410 420
190 200 210 220 230 240
pF1KE2 MCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR
.: .: : :.: .::. ::::: :.::: :::::::: :.:.: :.::..:.:.:.
NP_110 VCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVT
430 440 450 460 470 480
250 260 270 280 290 300
pF1KE2 ITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSS
.:::: ::::::.:: :::.:.: :.. :: :.: ::: .::...:: :: ..
NP_110 VTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMI
490 500 510 520 530 540
310 320 330
pF1KE2 RSHTLRTTCWDGKLEYPTCAKR
: .:. : .::.::: :
NP_110 SSPPFRAICQEGKFEYPICE
550 560
>>XP_011507761 (OMIM: 600889) PREDICTED: complement fact (250 aa)
initn: 1549 init1: 888 opt: 1081 Z-score: 1132.9 bits: 217.5 E(85289): 2.3e-56
Smith-Waterman score: 1437; 69.6% identity (76.4% similar) in 309 aa overlap (22-330:2-250)
10 20 30 40 50 60
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
:::::::::::::::::::::::::::::::::::::::
XP_011 MFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40
70 80 90 100 110 120
pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
::::::::::::::::::::::: :.:
XP_011 QNNENNISCVERGWSTPPKCRST-----------------------ISAE----------
110 120
190 200 210 220 230 240
pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
:::::::::::::::: ::::::.::::::::::
XP_011 --------------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL
130 140 150 160
250 260 270 280 290 300
pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .::::
XP_011 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC
170 180 190 200 210 220
310 320 330
pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
: ::. ..::..:. : .::: ::.: ..
XP_011 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK
230 240 250
>>NP_066303 (OMIM: 235400,603075,605336) complement fact (330 aa)
initn: 1236 init1: 561 opt: 1058 Z-score: 1107.4 bits: 213.2 E(85289): 6.1e-55
Smith-Waterman score: 1058; 40.9% identity (71.5% similar) in 330 aa overlap (1-327:1-329)
10 20 30 40 50 60
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
: ::..::: .: ..:.. :::: :.:: :. :. .:. : .:. . : :. .:
NP_066 MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
.:: :.: : ::..::::. ::: :.::..:::.... :. ..:..... :. :: :
NP_066 TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
. .....:.:.::: :.: . : . ..:. : :.. : : .....:.:. :
NP_066 PKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFI-SESSSIYILNKEIQYKCKPGY
130 140 150 160 170
190 200 210 220 230
pF1KE2 EMF-GDEE--VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC
:. . ::...:. : : .:. ::::::::.::: ::: :.::.: : :::::
NP_066 ATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQC
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 QNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAE
: :.:.:.. .:: ::.:::::.:.:::.:..: :.. :: :. . .: : .::.. :
NP_066 QPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIE
240 250 260 270 280 290
300 310 320 330
pF1KE2 FVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
:.:: :: .. .....: .: .::: :
NP_066 FMCKLGYNANTSILSFQAVCREGIVEYPRCE
300 310 320 330
>>XP_011508322 (OMIM: 608593,614809) PREDICTED: compleme (572 aa)
initn: 1560 init1: 952 opt: 1054 Z-score: 1100.0 bits: 212.6 E(85289): 1.6e-54
Smith-Waterman score: 1054; 50.5% identity (67.3% similar) in 309 aa overlap (21-327:24-325)
10 20 30 40 50
pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEY
:.::::::.::.::::: :.:::::::::::::::::
XP_011 MVKPLRQKRNQENVVFHRPCEAGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 NFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTG
::::::::::::::::::::::::::::.: ::::.:::::::: ::::::::::::::
XP_011 NFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 YRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECR
: :::::.::::::::::::: : : : : :. .. : : :. ... ::
XP_011 YSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCR
130 140 150 160 170
180 190 200 210 220 230
pF1KE2 SPYEMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQ
. :.. :.: . .:. : :: .. .::::: ..::.. . :. :::.
XP_011 KNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYD
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 CQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESA
:. . ..: :.: : .:.:. : :.. : : . .. . . : :.
XP_011 CNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSV
240 250 260 270 280 290
300 310 320 330
pF1KE2 EFVCKRGYRLSSRSHTLRTTCWDGK-LEYPTCAKR
: :. : . . . :: .: : : :
XP_011 EVNCRNEYAMIGNNMI---TCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFN
300 310 320 330 340 350
XP_011 HNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDG
360 370 380 390 400 410
>--
initn: 810 init1: 622 opt: 685 Z-score: 716.5 bits: 141.7 E(85289): 3.6e-33
Smith-Waterman score: 685; 40.2% identity (66.4% similar) in 229 aa overlap (100-327:348-571)
70 80 90 100 110 120
pF1KE2 ITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISC
::. ... .. :. .: ... :
XP_011 IWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS----VC
320 330 340 350 360 370
130 140 150 160 170 180
pF1KE2 VERGWSTPPKC-RSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEV
.. :. : .. . : :: . ::. .. .. : .::.: :. : . .:.
XP_011 INGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLLPEAKEI
380 390 400 410 420 430
190 200 210 220 230 240
pF1KE2 MCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR
.: .: : :.: .::. ::::: :.::: :::::::: :.:.: :.::..:.:.:.
XP_011 VCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVT
440 450 460 470 480 490
250 260 270 280 290 300
pF1KE2 ITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSS
.:::: ::::::.:: :::.:.: :.. :: :.: ::: .::...:: :: ..
XP_011 VTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMI
500 510 520 530 540 550
310 320 330
pF1KE2 RSHTLRTTCWDGKLEYPTCAKR
: .:. : .::.::: :
XP_011 SSPPFRAICQEGKFEYPICE
560 570
>>NP_006675 (OMIM: 605337) complement factor H-related p (331 aa)
initn: 1085 init1: 505 opt: 949 Z-score: 994.1 bits: 192.3 E(85289): 1.2e-48
Smith-Waterman score: 949; 40.3% identity (66.9% similar) in 335 aa overlap (1-327:1-330)
10 20 30 40 50
pF1KE2 MWLLVSVILISRISSVGG-EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNF
: ::..::: .: ..: :. ::::.:.:: :: . . . . .:. . : :. ::
NP_006 MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 VSPSKSFWTRITCTEEGWSPTPKCLRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTG
:.:: :.: : ::..::::: ::: : .::: :.. .. . .: :. :
NP_006 VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 YRLQ--NNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE
: :. ..:.:.. :::. : : . : . :. .:.. : : .. . . ::
NP_006 YATADGNSSGSITCLQNGWSAQPICIKF---C-DMPVFENSRAKSNGM-RFKLHDTLDYE
130 140 150 160 170
180 190 200 210 220 230
pF1KE2 CRSPYEM-FGDEE--VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASS
: . ::. .:. ..: . .:.. : : .:. ::::::::.::: ::: :.::.: :
NP_006 CYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 VEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRT
::::::. :.:.:.. .:: ::.:::::.:.:::.:..: :.. :: :. . : : .:
NP_006 VEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKT
240 250 260 270 280 290
300 310 320 330
pF1KE2 GESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
:.. ::.:: :: .. .....: .: .::: :
NP_006 GDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE
300 310 320 330
330 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:09:23 2016 done: Mon Nov 7 01:09:25 2016
Total Scan time: 6.830 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]