Result of FASTA (omim) for
pFN21AE2092
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2092, 782 aa
1>>>pF1KE2092 782 - 782 aa - 782 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 17.1056+/-0.00066; mu= -32.9818+/- 0.041
mean_var=1060.2178+/-225.638, 0's: 0 Z-trim(122.4): 687 B-trim: 2114 in 1/58
Lambda= 0.039389
statistics sampled from 39682 (40544) to 39682 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.475), width: 16
Scan time: 15.800
The best scores are: opt bits E(85289)
NP_277021 (OMIM: 176873) cyclin-dependent kinase 1 ( 782) 5169 310.3 2.1e-83
NP_076916 (OMIM: 116951) cyclin-dependent kinase 1 ( 780) 5077 305.0 7.8e-82
NP_277024 (OMIM: 176873) cyclin-dependent kinase 1 ( 748) 4935 296.9 2e-79
XP_016858415 (OMIM: 176873) PREDICTED: cyclin-depe ( 781) 4844 291.8 7.6e-78
NP_001300911 (OMIM: 116951) cyclin-dependent kinas ( 779) 4787 288.6 7.1e-77
NP_001278274 (OMIM: 176873) cyclin-dependent kinas ( 772) 4428 268.1 9.8e-71
NP_277071 (OMIM: 116951) cyclin-dependent kinase 1 ( 770) 4350 263.7 2.1e-69
XP_006711128 (OMIM: 176873) PREDICTED: cyclin-depe ( 785) 4343 263.3 2.8e-69
NP_001300825 (OMIM: 116951) cyclin-dependent kinas ( 783) 4283 259.9 3e-68
XP_016858414 (OMIM: 176873) PREDICTED: cyclin-depe ( 791) 4178 254.0 1.9e-66
NP_277025 (OMIM: 176873) cyclin-dependent kinase 1 ( 565) 3725 228.1 8.4e-59
XP_011540795 (OMIM: 176873) PREDICTED: cyclin-depe ( 794) 3666 224.9 1.1e-57
NP_001778 (OMIM: 176873) cyclin-dependent kinase 1 ( 795) 3666 224.9 1.1e-57
XP_011540794 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3665 224.8 1.1e-57
XP_011540792 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3665 224.8 1.1e-57
XP_011540793 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3665 224.8 1.1e-57
XP_016858416 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 3662 224.6 1.2e-57
XP_011540796 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 3662 224.6 1.2e-57
XP_011540797 (OMIM: 176873) PREDICTED: cyclin-depe ( 760) 3657 224.3 1.5e-57
XP_016858417 (OMIM: 176873) PREDICTED: cyclin-depe ( 761) 3657 224.3 1.5e-57
XP_011540798 (OMIM: 176873) PREDICTED: cyclin-depe ( 578) 3473 213.7 1.8e-54
NP_277022 (OMIM: 176873) cyclin-dependent kinase 1 ( 526) 3445 212.1 4.9e-54
NP_443714 (OMIM: 603464) cyclin-dependent kinase 1 ( 360) 1224 85.7 3.8e-16
XP_006721371 (OMIM: 603464) PREDICTED: cyclin-depe ( 354) 1177 83.0 2.4e-15
XP_006721373 (OMIM: 603464) PREDICTED: cyclin-depe ( 343) 1167 82.5 3.5e-15
XP_016879296 (OMIM: 603464) PREDICTED: cyclin-depe ( 337) 1128 80.2 1.6e-14
XP_016879297 (OMIM: 603464) PREDICTED: cyclin-depe ( 289) 1031 74.6 6.5e-13
NP_001153839 (OMIM: 603464) cyclin-dependent kinas ( 289) 1031 74.6 6.5e-13
NP_001092003 (OMIM: 603464) cyclin-dependent kinas ( 283) 984 72.0 4.1e-12
XP_016879298 (OMIM: 603464) PREDICTED: cyclin-depe ( 283) 984 72.0 4.1e-12
NP_443713 (OMIM: 603464) cyclin-dependent kinase 1 ( 272) 974 71.4 5.9e-12
XP_016879299 (OMIM: 603464) PREDICTED: cyclin-depe ( 272) 974 71.4 5.9e-12
NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 912 67.9 7.3e-11
NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 905 67.5 9.5e-11
XP_005270360 (OMIM: 116940) PREDICTED: cyclin-depe ( 297) 834 63.5 1.6e-09
NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 834 63.5 1.6e-09
NP_001307847 (OMIM: 116940) cyclin-dependent kinas ( 297) 834 63.5 1.6e-09
NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 827 63.1 2.3e-09
XP_011521719 (OMIM: 603464) PREDICTED: cyclin-depe ( 261) 812 62.2 3.4e-09
NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 814 62.4 3.8e-09
NP_004926 (OMIM: 123831,616342) cyclin-dependent-l ( 292) 809 62.0 4.1e-09
XP_011521710 (OMIM: 603464) PREDICTED: cyclin-depe ( 369) 812 62.3 4.3e-09
XP_011521709 (OMIM: 603464) PREDICTED: cyclin-depe ( 375) 812 62.3 4.3e-09
XP_011521708 (OMIM: 603464) PREDICTED: cyclin-depe ( 386) 812 62.3 4.4e-09
XP_011521707 (OMIM: 603464) PREDICTED: cyclin-depe ( 392) 812 62.3 4.5e-09
XP_016874894 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 808 62.3 6.3e-09
NP_002586 (OMIM: 603440) cyclin-dependent kinase 1 ( 523) 808 62.3 6.3e-09
XP_016874895 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 808 62.3 6.3e-09
XP_011542230 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 804 62.0 7.2e-09
XP_011542229 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 804 62.0 7.2e-09
>>NP_277021 (OMIM: 176873) cyclin-dependent kinase 11B i (782 aa)
initn: 5169 init1: 5169 opt: 5169 Z-score: 1618.4 bits: 310.3 E(85289): 2.1e-83
Smith-Waterman score: 5169; 100.0% identity (100.0% similar) in 782 aa overlap (1-782:1-782)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
730 740 750 760 770 780
pF1KE2 KF
::
NP_277 KF
>>NP_076916 (OMIM: 116951) cyclin-dependent kinase 11A i (780 aa)
initn: 4322 init1: 4322 opt: 5077 Z-score: 1590.2 bits: 305.0 E(85289): 7.8e-82
Smith-Waterman score: 5077; 98.6% identity (99.2% similar) in 782 aa overlap (1-782:1-780)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_076 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::.::::::::::: ::.::::::::
NP_076 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
130 140 150 160 170
190 200 210 220 230 240
pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_076 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_076 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
:::::::::::::::::::::::::::.:::::::::::.::::::::::::::::.:::
NP_076 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
720 730 740 750 760 770
pF1KE2 KF
::
NP_076 KF
780
>>NP_277024 (OMIM: 176873) cyclin-dependent kinase 11B i (748 aa)
initn: 4935 init1: 4935 opt: 4935 Z-score: 1546.8 bits: 296.9 E(85289): 2e-79
Smith-Waterman score: 4935; 99.6% identity (100.0% similar) in 748 aa overlap (35-782:1-748)
10 20 30 40 50 60
pF1KE2 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRN
...:::::::::::::::::::::::::::
NP_277 MSQSDDRDSKRDSLEEGELRDHRMEITIRN
10 20 30
70 80 90 100 110 120
pF1KE2 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 DRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 DRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNI
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 VTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 VTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNW
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 ILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 ILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 AVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 AVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFS
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPT
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 WPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 WPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
700 710 720 730 740
>>XP_016858415 (OMIM: 176873) PREDICTED: cyclin-dependen (781 aa)
initn: 4113 init1: 4113 opt: 4844 Z-score: 1518.6 bits: 291.8 E(85289): 7.6e-78
Smith-Waterman score: 5040; 97.6% identity (97.6% similar) in 791 aa overlap (1-782:1-781)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_016 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKR----------K
70 80 90 100 110
130 140 150 160 170
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL
::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE2 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE2 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE2 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE2 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR
660 670 680 690 700 710
720 730 740 750 760 770
pF1KE2 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA
720 730 740 750 760 770
780
pF1KE2 SAAGPGFSLKF
:::::::::::
XP_016 SAAGPGFSLKF
780
>>NP_001300911 (OMIM: 116951) cyclin-dependent kinase 11 (779 aa)
initn: 4081 init1: 4081 opt: 4787 Z-score: 1501.1 bits: 288.6 E(85289): 7.1e-77
Smith-Waterman score: 4956; 96.3% identity (96.8% similar) in 791 aa overlap (1-782:1-779)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::.::::::::::: :
NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K
70 80 90 100 110
130 140 150 160 170
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL
::::: :::::::::::::::::::::::::::::::::::::: ::::::
NP_001 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL
120 130 140 150 160
180 190 200 210 220 230
pF1KE2 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE2 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE2 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE2 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
NP_001 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPK
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE2 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE2 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE2 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_001 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYR
530 540 550 560 570 580
600 610 620 630 640 650
pF1KE2 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG
::::::::::::::::::::::::::::::::::::.:::::::::::.:::::::::::
NP_001 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPG
590 600 610 620 630 640
660 670 680 690 700 710
pF1KE2 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR
650 660 670 680 690 700
720 730 740 750 760 770
pF1KE2 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA
710 720 730 740 750 760
780
pF1KE2 SAAGPGFSLKF
:::::::::::
NP_001 SAAGPGFSLKF
770
>>NP_001278274 (OMIM: 176873) cyclin-dependent kinase 11 (772 aa)
initn: 4377 init1: 4377 opt: 4428 Z-score: 1390.9 bits: 268.1 E(85289): 9.8e-71
Smith-Waterman score: 5068; 98.7% identity (98.7% similar) in 782 aa overlap (1-782:1-772)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKR----------K
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
720 730 740 750 760 770
pF1KE2 KF
::
NP_001 KF
>>NP_277071 (OMIM: 116951) cyclin-dependent kinase 11A i (770 aa)
initn: 4333 init1: 4333 opt: 4350 Z-score: 1367.0 bits: 263.7 E(85289): 2.1e-69
Smith-Waterman score: 4984; 97.4% identity (98.0% similar) in 782 aa overlap (1-782:1-770)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_277 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::.::::::::::: :
NP_277 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
120 130 140 150 160
190 200 210 220 230 240
pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_277 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_277 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
:::::::::::::::::::::::::::.:::::::::::.::::::::::::::::.:::
NP_277 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
710 720 730 740 750 760
pF1KE2 KF
::
NP_277 KF
770
>>XP_006711128 (OMIM: 176873) PREDICTED: cyclin-dependen (785 aa)
initn: 3470 init1: 3470 opt: 4343 Z-score: 1364.7 bits: 263.3 E(85289): 2.8e-69
Smith-Waterman score: 5028; 97.0% identity (97.1% similar) in 795 aa overlap (1-782:1-785)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_006 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKR----------K
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
180 190 200 210 220 230
250 260 270 280
pF1KE2 ERFELGDGRKP-------------VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG
::::::::::: .:::::::::::::::::::::::::::::::::::
XP_006 ERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE2 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE2 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK
480 490 500 510 520 530
530 540 550 560 570 580
pF1KE2 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT
540 550 560 570 580 590
590 600 610 620 630 640
pF1KE2 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK
600 610 620 630 640 650
650 660 670 680 690 700
pF1KE2 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH
660 670 680 690 700 710
710 720 730 740 750 760
pF1KE2 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT
720 730 740 750 760 770
770 780
pF1KE2 NQGASAAGPGFSLKF
:::::::::::::::
XP_006 NQGASAAGPGFSLKF
780
>>NP_001300825 (OMIM: 116951) cyclin-dependent kinase 11 (783 aa)
initn: 3438 init1: 3438 opt: 4283 Z-score: 1346.3 bits: 259.9 E(85289): 3e-68
Smith-Waterman score: 4944; 95.7% identity (96.4% similar) in 795 aa overlap (1-782:1-783)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::.::::::::::: :
NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
120 130 140 150 160
190 200 210 220 230 240
pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
170 180 190 200 210 220
250 260 270 280
pF1KE2 ERFELGDGRKP-------------VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG
::::::::::: .:::::::::::::::::::::::::::::::::::
NP_001 ERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE2 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE2 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_001 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE2 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE2 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE2 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE2 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK
:::::::::::::::::::::::::::::::::::::::.:::::::::::.:::::::
NP_001 QWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEK
590 600 610 620 630 640
650 660 670 680 690 700
pF1KE2 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH
650 660 670 680 690 700
710 720 730 740 750 760
pF1KE2 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT
710 720 730 740 750 760
770 780
pF1KE2 NQGASAAGPGFSLKF
:::::::::::::::
NP_001 NQGASAAGPGFSLKF
770 780
>>XP_016858414 (OMIM: 176873) PREDICTED: cyclin-dependen (791 aa)
initn: 4113 init1: 4113 opt: 4178 Z-score: 1314.0 bits: 254.0 E(85289): 1.9e-66
Smith-Waterman score: 5141; 98.9% identity (98.9% similar) in 791 aa overlap (1-782:1-791)
10 20 30 40 50 60
pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
70 80 90 100 110 120
130 140 150 160 170
pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL
::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE2 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA
730 740 750 760 770 780
780
pF1KE2 SAAGPGFSLKF
:::::::::::
XP_016 SAAGPGFSLKF
790
782 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:48:41 2016 done: Sun Nov 6 05:48:44 2016
Total Scan time: 15.800 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]