Result of FASTA (omim) for
pFN21AE2012
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2012, 557 aa
1>>>pF1KE2012 557 - 557 aa - 557 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.6816+/-0.00036; mu= -5.3064+/- 0.023
mean_var=291.4245+/-61.220, 0's: 0 Z-trim(123.0): 363 B-trim: 91 in 1/54
Lambda= 0.075130
statistics sampled from 41687 (42061) to 41687 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.493), width: 16
Scan time: 10.970
The best scores are: opt bits E(85289)
NP_002850 (OMIM: 602505) paxillin isoform 1 [Homo ( 557) 3929 439.2 1.6e-122
XP_016875231 (OMIM: 602505) PREDICTED: paxillin is ( 563) 3901 436.2 1.3e-121
XP_016875232 (OMIM: 602505) PREDICTED: paxillin is ( 424) 3031 341.8 2.6e-93
NP_079433 (OMIM: 602505) paxillin isoform 4 [Homo ( 424) 3031 341.8 2.6e-93
XP_016875226 (OMIM: 602505) PREDICTED: paxillin is ( 700) 2148 246.2 2.5e-64
XP_016875222 (OMIM: 602505) PREDICTED: paxillin is ( 940) 2145 246.0 4e-64
XP_016875224 (OMIM: 602505) PREDICTED: paxillin is ( 858) 2135 244.9 7.8e-64
XP_016875218 (OMIM: 602505) PREDICTED: paxillin is (1087) 2120 243.3 2.9e-63
XP_005253974 (OMIM: 602505) PREDICTED: paxillin is ( 403) 2105 241.4 4.1e-63
NP_001230685 (OMIM: 602505) paxillin isoform 3 [Ho ( 605) 2105 241.5 5.6e-63
XP_016875228 (OMIM: 602505) PREDICTED: paxillin is ( 611) 2105 241.5 5.7e-63
XP_016875227 (OMIM: 602505) PREDICTED: paxillin is ( 645) 2105 241.6 5.9e-63
XP_016875230 (OMIM: 602505) PREDICTED: paxillin is ( 589) 2104 241.4 5.9e-63
NP_001074324 (OMIM: 602505) paxillin isoform 2 [Ho ( 591) 2104 241.4 5.9e-63
XP_016875229 (OMIM: 602505) PREDICTED: paxillin is ( 597) 2104 241.4 6e-63
XP_016875225 (OMIM: 602505) PREDICTED: paxillin is ( 748) 2105 241.6 6.7e-63
XP_016875223 (OMIM: 602505) PREDICTED: paxillin is ( 888) 2105 241.6 7.6e-63
XP_011536925 (OMIM: 602505) PREDICTED: paxillin is ( 996) 2105 241.7 8.4e-63
XP_006719599 (OMIM: 602505) PREDICTED: paxillin is ( 996) 2105 241.7 8.4e-63
XP_011536924 (OMIM: 602505) PREDICTED: paxillin is ( 996) 2105 241.7 8.4e-63
XP_006719598 (OMIM: 602505) PREDICTED: paxillin is ( 996) 2105 241.7 8.4e-63
XP_006719597 (OMIM: 602505) PREDICTED: paxillin is ( 996) 2105 241.7 8.4e-63
XP_016875220 (OMIM: 602505) PREDICTED: paxillin is ( 996) 2105 241.7 8.4e-63
XP_016875217 (OMIM: 602505) PREDICTED: paxillin is (1127) 2105 241.7 9.3e-63
XP_006719595 (OMIM: 602505) PREDICTED: paxillin is (1129) 2105 241.7 9.3e-63
XP_016875216 (OMIM: 602505) PREDICTED: paxillin is (1130) 2105 241.7 9.3e-63
XP_016875215 (OMIM: 602505) PREDICTED: paxillin is (1135) 2105 241.7 9.3e-63
XP_016875221 (OMIM: 602505) PREDICTED: paxillin is ( 961) 1805 209.1 5e-53
XP_016875219 (OMIM: 602505) PREDICTED: paxillin is (1057) 1805 209.2 5.4e-53
NP_004802 (OMIM: 605390) leupaxin isoform 2 [Homo ( 386) 1529 179.0 2.4e-44
NP_001137467 (OMIM: 605390) leupaxin isoform 1 [Ho ( 391) 1529 179.0 2.5e-44
NP_001294880 (OMIM: 605390) leupaxin isoform 3 [Ho ( 366) 1509 176.8 1e-43
XP_011543690 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 1509 176.8 1e-43
XP_011543693 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 1509 176.8 1e-43
XP_011543692 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 1509 176.8 1e-43
XP_006718813 (OMIM: 605390) PREDICTED: leupaxin is ( 290) 1469 172.4 1.8e-42
NP_001158191 (OMIM: 602353) transforming growth fa ( 444) 1374 162.2 3.1e-39
NP_057011 (OMIM: 602353) transforming growth facto ( 444) 1374 162.2 3.1e-39
NP_001035919 (OMIM: 602353) transforming growth fa ( 461) 1374 162.2 3.2e-39
XP_011543696 (OMIM: 605390) PREDICTED: leupaxin is ( 249) 724 91.6 3.2e-18
XP_011543695 (OMIM: 605390) PREDICTED: leupaxin is ( 254) 724 91.6 3.2e-18
XP_016874068 (OMIM: 605390) PREDICTED: leupaxin is ( 283) 717 90.9 5.9e-18
XP_011537492 (OMIM: 605906,609452) PREDICTED: LIM ( 680) 613 79.9 3e-14
XP_005269521 (OMIM: 605906,609452) PREDICTED: LIM ( 727) 613 79.9 3.1e-14
NP_009009 (OMIM: 605906,609452) LIM domain-binding ( 727) 613 79.9 3.1e-14
XP_011537488 (OMIM: 605906,609452) PREDICTED: LIM ( 795) 613 79.9 3.4e-14
XP_011537495 (OMIM: 605906,609452) PREDICTED: LIM ( 463) 601 78.4 5.4e-14
XP_016871096 (OMIM: 605906,609452) PREDICTED: LIM ( 463) 601 78.4 5.4e-14
XP_011537493 (OMIM: 605906,609452) PREDICTED: LIM ( 633) 601 78.5 6.9e-14
XP_011537491 (OMIM: 605906,609452) PREDICTED: LIM ( 696) 601 78.6 7.4e-14
>>NP_002850 (OMIM: 602505) paxillin isoform 1 [Homo sapi (557 aa)
initn: 3929 init1: 3929 opt: 3929 Z-score: 2320.6 bits: 439.2 E(85289): 1.6e-122
Smith-Waterman score: 3929; 99.8% identity (100.0% similar) in 557 aa overlap (1-557:1-557)
10 20 30 40 50 60
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 YGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 EMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPPKPGSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPPKPGSQL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 FHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 FEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFK
490 500 510 520 530 540
550
pF1KE2 EQNDKPYCQNCFLKLFC
:::::::::::::::::
NP_002 EQNDKPYCQNCFLKLFC
550
>>XP_016875231 (OMIM: 602505) PREDICTED: paxillin isofor (563 aa)
initn: 3901 init1: 3901 opt: 3901 Z-score: 2304.1 bits: 436.2 E(85289): 1.3e-121
Smith-Waterman score: 3901; 99.8% identity (100.0% similar) in 553 aa overlap (5-557:11-563)
10 20 30 40 50
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTLREAKTADALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 SEALNGTILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 SEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQ
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 EEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE2 FFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTP
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 FVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQL
490 500 510 520 530 540
540 550
pF1KE2 NKGTFKEQNDKPYCQNCFLKLFC
:::::::::::::::::::::::
XP_016 NKGTFKEQNDKPYCQNCFLKLFC
550 560
>>XP_016875232 (OMIM: 602505) PREDICTED: paxillin isofor (424 aa)
initn: 3031 init1: 3031 opt: 3031 Z-score: 1796.3 bits: 341.8 E(85289): 2.6e-93
Smith-Waterman score: 3031; 100.0% identity (100.0% similar) in 424 aa overlap (134-557:1-424)
110 120 130 140 150 160
pF1KE2 VGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFP
::::::::::::::::::::::::::::::
XP_016 MSTSLGSNLSELDRLLLELNAVQHNPPGFP
10 20 30
170 180 190 200 210 220
pF1KE2 ADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDE
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 LESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGK
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTW
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 HPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWH
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 PEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHP
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 ECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPE
340 350 360 370 380 390
530 540 550
pF1KE2 HFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
::::::::::::::::::::::::::::::::::
XP_016 HFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
400 410 420
>>NP_079433 (OMIM: 602505) paxillin isoform 4 [Homo sapi (424 aa)
initn: 3031 init1: 3031 opt: 3031 Z-score: 1796.3 bits: 341.8 E(85289): 2.6e-93
Smith-Waterman score: 3031; 100.0% identity (100.0% similar) in 424 aa overlap (134-557:1-424)
110 120 130 140 150 160
pF1KE2 VGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFP
::::::::::::::::::::::::::::::
NP_079 MSTSLGSNLSELDRLLLELNAVQHNPPGFP
10 20 30
170 180 190 200 210 220
pF1KE2 ADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDE
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 LESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGK
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTW
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 HPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 HPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWH
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 PEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHP
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 ECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPE
340 350 360 370 380 390
530 540 550
pF1KE2 HFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
::::::::::::::::::::::::::::::::::
NP_079 HFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
400 410 420
>>XP_016875226 (OMIM: 602505) PREDICTED: paxillin isofor (700 aa)
initn: 3887 init1: 2103 opt: 2148 Z-score: 1275.9 bits: 246.2 E(85289): 2.5e-64
Smith-Waterman score: 2941; 76.7% identity (76.7% similar) in 589 aa overlap (106-557:112-700)
80 90 100 110 120 130
pF1KE2 FIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMS
::::::::::::::::::::::::::::::
XP_016 FIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMS
90 100 110 120 130 140
140 150 160 170 180 190
pF1KE2 TSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAG
150 160 170 180 190 200
200 210 220 230 240 250
pF1KE2 PLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQT
210 220 230 240 250 260
260 270
pF1KE2 RISASSATRELDELMASLSDFK--------------------------------------
::::::::::::::::::::::
XP_016 RISASSATRELDELMASLSDFKVVFPPGSPIPLRRTISVLASPSVPLLQHRTDAAASSSS
270 280 290 300 310 320
pF1KE2 ------------------------------------------------------------
XP_016 PLPSLLASSPLGPSAYTCGSSGVQSAGEEPHDEGVQGPALPIPAPHTMRSVGCQTDEDPL
330 340 350 360 370 380
280 290
pF1KE2 ---------------------------------------FMAQGKTGSSSPPGGPPKPGS
:::::::::::::::::::::
XP_016 FPPMQIQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGGFMAQGKTGSSSPPGGPPKPGS
390 400 410 420 430 440
300 310 320 330 340 350
pF1KE2 QLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIG
450 460 470 480 490 500
360 370 380 390 400 410
pF1KE2 SRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGP
510 520 530 540 550 560
420 430 440 450 460 470
pF1KE2 EGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNG
570 580 590 600 610 620
480 490 500 510 520 530
pF1KE2 SFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGT
630 640 650 660 670 680
540 550
pF1KE2 FKEQNDKPYCQNCFLKLFC
:::::::::::::::::::
XP_016 FKEQNDKPYCQNCFLKLFC
690 700
>--
initn: 676 init1: 676 opt: 676 Z-score: 413.6 bits: 86.7 E(85289): 2.7e-16
Smith-Waterman score: 676; 99.0% identity (100.0% similar) in 101 aa overlap (5-105:11-111)
10 20 30 40 50
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTLREAKTADALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 SEALNGTILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
::::::::::::::::::.::::::::::::::::::::::::::::::::
XP_016 SEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
XP_016 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
130 140 150 160 170 180
>>XP_016875222 (OMIM: 602505) PREDICTED: paxillin isofor (940 aa)
initn: 2667 init1: 2105 opt: 2145 Z-score: 1272.3 bits: 246.0 E(85289): 4e-64
Smith-Waterman score: 2145; 59.9% identity (74.1% similar) in 563 aa overlap (22-557:394-940)
10 20 30 40
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEET--P--YSYP-TGNHTYQEIAVP
:.. :: . : .. : .:. . :: . :
XP_016 PDTFNSRSPSVEGSLWAVGTESQGRDWRHLPTITSELSGAPRCHTVPCAGSTALQEPGEP
370 380 390 400 410 420
50 60 70 80 90 100
pF1KE2 --PPVPPPPSSEALNGTILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSV
::. : ::: .: .: : .. :.... . .. . :. ....
XP_016 QGPPASPSCPEEALAATWEQP---WASEVFGPERMPPSGAARSFQEVTEPAVVAVDRQAI
430 440 450 460 470 480
110 120 130 140 150
pF1KE2 GSPCSRVGEEEHVYS------FPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQ--
: . . ::: . :.. :. :. .: . .::....: . .. .
XP_016 -FPDTWTLTEEHGLQQERPRPEPGRLGSSSPA-SVTTEQLGAKMTERGSVARPTQGPETP
490 500 510 520 530
160 170 180 190 200 210
pF1KE2 HNPPGFP---ADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDV
..: : ..... .: :: :.. .:.: :. .. .: . . . .: :
XP_016 RSPEGTTEAATQDGKEQPELPCAMA--MGTPSTTERIS-TSGQIQGLEQRADGERCWAAG
540 550 560 570 580 590
220 230 240 250 260
pF1KE2 RP-----SVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDE
: : . :: .: : .. :. .:: :.:. . :.:.
XP_016 WPRDGGRSSPGGQDEGGGSWPLEEVVLLVS---ISS-----SVQEGEKYPHPCAARHRTP
600 610 620 630 640
270 280 290 300 310 320
pF1KE2 LMASLSDF----KFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVC
. : .. .:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSPDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVC
650 660 670 680 690 700
330 340 350 360 370 380
pF1KE2 GACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCY
710 720 730 740 750 760
390 400 410 420 430 440
pF1KE2 YCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGG
770 780 790 800 810 820
450 460 470 480 490 500
pF1KE2 CARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGC
830 840 850 860 870 880
510 520 530 540 550
pF1KE2 QKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
890 900 910 920 930 940
>--
initn: 1830 init1: 1798 opt: 1815 Z-score: 1079.0 bits: 210.2 E(85289): 2.3e-53
Smith-Waterman score: 1815; 92.1% identity (93.8% similar) in 305 aa overlap (5-296:11-315)
10 20 30 40 50
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTLREAKTADALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 SEALNGTILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 SEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
190 200 210 220 230 240
240 250 260 270 280
pF1KE2 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFK-------FMAQGKTGS-
::::::::::::::::::::::::::::::::::::::::::: . : : ..:
XP_016 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKTSSSTVALSAPGLSSSA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 -----SSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGK
: ::. :: :
XP_016 PSSYCSLPPSPPPMPSVFLPPTTIPSPRGQGHTPEFPCTEQSGRGLLPPVAPSWLDLAGL
310 320 330 340 350 360
>>XP_016875224 (OMIM: 602505) PREDICTED: paxillin isofor (858 aa)
initn: 2667 init1: 2105 opt: 2135 Z-score: 1267.0 bits: 244.9 E(85289): 7.8e-64
Smith-Waterman score: 2170; 58.1% identity (72.8% similar) in 592 aa overlap (1-557:272-858)
10 20 30
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETP
.:.: : :.:.....: .. :: .:
XP_016 TVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKTSSSTVALSAPGLSSSAP
250 260 270 280 290 300
40 50 60 70
pF1KE2 YSY---PTGNHTYQEIAVPPP-VPPP---------PSSEALNGTILDPL-DQWQP-SGSR
:: : . . . .:: .: : : .: . .: :. .: .:
XP_016 SSYCSLPPSPPPMPSVFLPPTTIPSPRGQGHTPEFPCTEQSGRGLLPPVAPSWLDLAGLG
310 320 330 340 350 360
80 90 100 110 120
pF1KE2 FIHQQPQSSSP-VYGSSAKTSSVSNPQDSVGSPC--SRVGEEEHVYSFPNK-----QKSA
. . .: :: : :: ... :. .: : :... . .. : :. .
XP_016 VMPDTFNSRSPSVEGSLWAVGTESQGRDWRHLPTITSELSGAPRCHTVPCAGSTALQEPG
370 380 390 400 410 420
130 140 150 160 170 180
pF1KE2 EP-----SPTVMSTSLGSNLSELDRLLLELNAVQHNPP-GFPADEANSSPPLPGALSPLY
:: ::. .:... . :. . .. :: : . . . : :..
XP_016 EPQGPPASPSCPEEALAATWEQ--PWASEVFGPERMPPSGAARSFQEVTEPAVVAVDRQA
430 440 450 460 470
190 200 210 220 230
pF1KE2 GVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRP---SVESLLDEL--ESSVPSPVPAIT
:.: . : . : : .:.:. . :: : . : ..:.: .. ..:: :. .
XP_016 IFPDTWT-LTEEHG-LQQERPRPEPGR-LGSSSPASVTTEQLGAKMTERGSVARPTQGPE
480 490 500 510 520 530
240 250 260 270 280 290
pF1KE2 VNQGEMSSPQRVTST-QQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPPK
. .. .. . .:. ..: .. . : . .. .::::::::::::::::::
XP_016 TPRSPEGTTEAATQDGKEQPELPCAMAMGTPSTTERISTSGQFMAQGKTGSSSPPGGPPK
540 550 560 570 580 590
300 310 320 330 340 350
pF1KE2 PGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQE
600 610 620 630 640 650
360 370 380 390 400 410
pF1KE2 EIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAF
660 670 680 690 700 710
420 430 440 450 460 470
pF1KE2 FGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPF
720 730 740 750 760 770
480 490 500 510 520 530
pF1KE2 VNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN
780 790 800 810 820 830
540 550
pF1KE2 KGTFKEQNDKPYCQNCFLKLFC
::::::::::::::::::::::
XP_016 KGTFKEQNDKPYCQNCFLKLFC
840 850
>--
initn: 1725 init1: 1725 opt: 1725 Z-score: 1026.8 bits: 200.4 E(85289): 1.9e-50
Smith-Waterman score: 1725; 99.6% identity (100.0% similar) in 261 aa overlap (5-265:11-271)
10 20 30 40 50
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTLREAKTADALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 SEALNGTILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 SEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPP
:::::::::::::::::::::::::::::::
XP_016 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKTSSSTVALSAPGLSSSA
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQ
XP_016 PSSYCSLPPSPPPMPSVFLPPTTIPSPRGQGHTPEFPCTEQSGRGLLPPVAPSWLDLAGL
310 320 330 340 350 360
>>XP_016875218 (OMIM: 602505) PREDICTED: paxillin isofor (1087 aa)
initn: 3887 init1: 2103 opt: 2120 Z-score: 1256.7 bits: 243.3 E(85289): 2.9e-63
Smith-Waterman score: 2121; 76.3% identity (84.0% similar) in 401 aa overlap (167-557:704-1087)
140 150 160 170 180 190
pF1KE2 SLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGAL--SPLYGVPETNSPLGGKA
:.:: :::. : ::: : . : ..
XP_016 PPGSPIPLRRTISVLASPSVPLLQHRTDAAASSSSPLPSLLASSPLGPSAYTCGSSGVQS
680 690 700 710 720 730
200 210 220 230 240 250
pF1KE2 GPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITV----NQGEMSSPQRVTS
. :.:. .: .: :.. .:.: .: .. . :... .
XP_016 AG---EEPHDEGVQG-----PAL---------PIPAPHTMRSVGCQTDEDPLFPPMQIQG
740 750 760 770
260 270 280 290 300
pF1KE2 TQQQT---RISASSATRELDELMASLSDFK-FMAQGKTGSSSPPGGPPKPGSQLDSMLGS
.:.. : :.. :. . . .: :::::::::::::::::::::::::::::
XP_016 LEQRADGERCWAAGWPRDGGRSSPGGQDEGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGS
780 790 800 810 820 830
310 320 330 340 350 360
pF1KE2 LQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERD
840 850 860 870 880 890
370 380 390 400 410 420
pF1KE2 GQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDG
900 910 920 930 940 950
430 440 450 460 470 480
pF1KE2 KAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQ
960 970 980 990 1000 1010
490 500 510 520 530 540
pF1KE2 PYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKP
1020 1030 1040 1050 1060 1070
550
pF1KE2 YCQNCFLKLFC
:::::::::::
XP_016 YCQNCFLKLFC
1080
>--
initn: 1822 init1: 1798 opt: 1815 Z-score: 1078.1 bits: 210.3 E(85289): 2.6e-53
Smith-Waterman score: 1815; 92.1% identity (93.8% similar) in 305 aa overlap (5-296:11-315)
10 20 30 40 50
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTLREAKTADALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 SEALNGTILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 SEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA
190 200 210 220 230 240
240 250 260 270 280
pF1KE2 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFK-------FMAQGKTGS-
::::::::::::::::::::::::::::::::::::::::::: . : : ..:
XP_016 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKTSSSTVALSAPGLSSSA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 -----SSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGK
: ::. :: :
XP_016 PSSYCSLPPSPPPMPSVFLPPTTIPSPRGQGHTPEFPCTEQSGRGLLPPVAPSWLDLAGL
310 320 330 340 350 360
>>XP_005253974 (OMIM: 602505) PREDICTED: paxillin isofor (403 aa)
initn: 2105 init1: 2105 opt: 2105 Z-score: 1254.2 bits: 241.4 E(85289): 4.1e-63
Smith-Waterman score: 2107; 75.2% identity (82.6% similar) in 408 aa overlap (160-557:13-403)
130 140 150 160 170 180
pF1KE2 SPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLYGVPETNSP
::.:. . ...: : . :... :
XP_005 MSAPSSTGPQYCPGLPS-RKEATPEGRPETCLLPSSPQAQRP
10 20 30 40
190 200 210 220 230 240
pF1KE2 LGGKAGPLTKEK------PKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMS
. : :. : :.:::. :. . :: .: : .. :. .:
XP_005 IQGLEQRADGERCWAAGWP-RDGGRS----SPGGQ---DEGGGSWPLEEVVLLVS---IS
50 60 70 80 90
250 260 270 280 290
pF1KE2 SPQRVTSTQQQTRISASSATRELDELMASLSDF----KFMAQGKTGSSSPPGGPPKPGSQ
: :.:. . :.:. . : .. .::::::::::::::::::::::
XP_005 S-----SVQEGEKYPHPCAARHRTPSLRSPDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQ
100 110 120 130 140
300 310 320 330 340 350
pF1KE2 LDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGS
150 160 170 180 190 200
360 370 380 390 400 410
pF1KE2 RNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPE
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE2 GFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGS
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE2 FFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTF
330 340 350 360 370 380
540 550
pF1KE2 KEQNDKPYCQNCFLKLFC
::::::::::::::::::
XP_005 KEQNDKPYCQNCFLKLFC
390 400
>>NP_001230685 (OMIM: 602505) paxillin isoform 3 [Homo s (605 aa)
initn: 2695 init1: 2105 opt: 2105 Z-score: 1251.6 bits: 241.5 E(85289): 5.6e-63
Smith-Waterman score: 3728; 91.7% identity (91.9% similar) in 589 aa overlap (17-557:17-605)
10 20 30 40 50 60
pF1KE2 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG
::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TILDPLDQWQPSGSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 YGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQG
190 200 210 220 230 240
250 260 270
pF1KE2 EMSSPQRVTSTQQQTRISASSATRELDELMASLSDFK-----------------------
:::::::::::::::::::::::::::::::::::::
NP_001 EMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKGSWPLEEVVLLVSISSSVQEGEK
250 260 270 280 290 300
280 290 300 310
pF1KE2 -------------------------FMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLN
:::::::::::::::::::::::::::::::::::
NP_001 YPHPCAARHRTPSLRSPDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLN
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE2 KLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCE
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE2 KDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRK
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE2 DYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVH
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE2 YHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF
550 560 570 580 590 600
pF1KE2 LKLFC
:::::
NP_001 LKLFC
557 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:42:18 2016 done: Sun Nov 6 21:42:20 2016
Total Scan time: 10.970 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]