Result of FASTA (omim) for
pFN21AE1955
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1955, 513 aa
1>>>pF1KE1955 513 - 513 aa - 513 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.8821+/-0.0003; mu= 3.2817+/- 0.019
mean_var=208.0029+/-42.807, 0's: 0 Z-trim(124.1): 76 B-trim: 453 in 1/55
Lambda= 0.088928
statistics sampled from 45148 (45231) to 45148 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.81), E-opt: 0.2 (0.53), width: 16
Scan time: 10.910
The best scores are: opt bits E(85289)
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 3570 470.2 6.2e-132
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 1643 223.0 1.5e-57
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 1591 216.3 1.5e-55
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 1175 162.7 1.1e-39
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 1153 160.1 1.1e-38
NP_001316683 (OMIM: 112265) bone morphogenetic pro ( 417) 1079 150.6 8.5e-36
XP_011513119 (OMIM: 112265) PREDICTED: bone morpho ( 357) 918 129.9 1.2e-29
NP_001316685 (OMIM: 112265) bone morphogenetic pro ( 348) 916 129.6 1.5e-29
XP_011540324 (OMIM: 602284) PREDICTED: bone morpho ( 357) 883 125.4 2.8e-28
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 634 93.5 1.3e-18
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 497 75.8 1.6e-13
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 497 75.9 2.4e-13
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 497 76.0 2.9e-13
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 497 76.0 2.9e-13
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 497 76.0 2.9e-13
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 492 75.2 3.4e-13
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 492 75.2 3.4e-13
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 492 75.3 3.9e-13
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 492 75.3 3.9e-13
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 492 75.3 3.9e-13
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 492 75.3 3.9e-13
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 444 69.1 2.6e-11
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 438 68.4 5.1e-11
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 437 68.3 5.7e-11
XP_016857645 (OMIM: 602284) PREDICTED: bone morpho ( 236) 428 66.9 7.5e-11
XP_005271206 (OMIM: 602284) PREDICTED: bone morpho ( 231) 425 66.5 9.6e-11
XP_011540327 (OMIM: 602284) PREDICTED: bone morpho ( 230) 420 65.9 1.5e-10
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 404 64.0 9.1e-10
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 393 62.6 2.7e-09
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 391 62.4 3.5e-09
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 384 61.4 6e-09
XP_016857644 (OMIM: 602284) PREDICTED: bone morpho ( 382) 364 58.8 3.3e-08
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 365 59.0 3.6e-08
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 361 58.5 4.3e-08
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 347 56.5 9.3e-08
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 347 56.6 1.4e-07
NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 342 56.0 2.5e-07
XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 342 56.0 2.5e-07
XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 342 56.1 2.8e-07
XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 342 56.1 3.1e-07
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 319 53.0 1.7e-06
NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 313 52.3 3e-06
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 312 52.2 3.5e-06
XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 305 51.2 4.8e-06
XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 308 51.7 5e-06
NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 308 51.7 5e-06
XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 305 51.2 6e-06
NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 305 51.2 6e-06
XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 305 51.2 6e-06
NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 305 51.2 6e-06
>>NP_001709 (OMIM: 112266) bone morphogenetic protein 6 (513 aa)
initn: 3570 init1: 3570 opt: 3570 Z-score: 2489.6 bits: 470.2 E(85289): 6.2e-132
Smith-Waterman score: 3570; 99.8% identity (100.0% similar) in 513 aa overlap (1-513:1-513)
10 20 30 40 50 60
pF1KE1 MPGLGRRAQWLCWWWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP
430 440 450 460 470 480
490 500 510
pF1KE1 TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
:::::::::::::::::::::::::::::::::
NP_001 TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
490 500 510
>>NP_066551 (OMIM: 112265) bone morphogenetic protein 5 (454 aa)
initn: 1074 init1: 810 opt: 1643 Z-score: 1154.2 bits: 223.0 E(85289): 1.5e-57
Smith-Waterman score: 1742; 59.4% identity (79.6% similar) in 451 aa overlap (64-513:36-454)
40 50 60 70 80 90
pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP
:.:.::::...:.::.:.::::.:::::::
NP_066 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA
::. ::. .::::::::::::.. ... .
NP_066 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E
70 80 90
160 170 180 190 200 210
pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA
:: . : .:. .... : ..: : .: . . ::.: .:. :::::
NP_066 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF
::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:.
NP_066 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV
:::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: .
NP_066 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ
: :: .. ..::::::.:: .::::::::::.::: .:..: :...:..:.::.:.. :
NP_066 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVR-AANKRKNQNRNKSSSHQ
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH
: .:.::..:::.:: : ::.::::::::.:::::::::::.:::: :::::::::::::
NP_066 DSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAH
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE1 MNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC
:::::::::::::::: :..:::::::::::::::::::::.::::::::::::::.:::
NP_066 MNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC
400 410 420 430 440 450
pF1KE1 H
:
NP_066 H
>>NP_001710 (OMIM: 112267) bone morphogenetic protein 7 (431 aa)
initn: 1829 init1: 1591 opt: 1591 Z-score: 1118.5 bits: 216.3 E(85289): 1.5e-55
Smith-Waterman score: 1772; 60.2% identity (78.9% similar) in 450 aa overlap (64-513:39-431)
40 50 60 70 80 90
pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP
:.:..:::..::.::::.::::.:::::::
NP_001 AAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRP
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGAS
:: : :: :. .:::.::::::::... :.:..
NP_001 RP-H-LQ--------------------------GKHNSAPMFMLDLYNAMAV---EEGGG
70 80 90
160 170 180 190 200 210
pF1KE1 EGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDAD
: . :.:..:. :.: .: ::.: ::: ::.:::
NP_001 PGGQGFSYPYKAVFSTQ------------------GP--------PLASLQDSHFLTDAD
100 110 120 130
220 230 240 250 260 270
pF1KE1 MVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL
::::::::::.:::: . ::.::.:.::.:::::.::::::::::: . : :.::
NP_001 MVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFR
140 150 160 170 180 190
280 290 300 310 320 330
pF1KE1 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVT
::.::::::: :.:::::::.:..:::::::: :::::::: :::.:.::.:::::: :
NP_001 ISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVET
200 210 220 230 240 250
340 350 360 370 380 390
pF1KE1 RDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQD
:: ..:. :::.:: :: .::::::::::..::: :. ::..:..:.:.:... ..:.
NP_001 LDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQE
260 270 280 290 300 310
400 410 420 430 440 450
pF1KE1 VARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHM
. :...... .::. . ::.::::::::.:::::::::::.:::: ::.:::.::::..:
NP_001 ALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYM
320 330 340 350 360 370
460 470 480 490 500 510
pF1KE1 NATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
:::::::::::::..::: :::::::::.:::::::::::.:::::::::::::::::::
NP_001 NATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
380 390 400 410 420 430
>>XP_016866687 (OMIM: 112265) PREDICTED: bone morphogene (239 aa)
initn: 833 init1: 810 opt: 1175 Z-score: 833.7 bits: 162.7 E(85289): 1.1e-39
Smith-Waterman score: 1175; 73.2% identity (90.8% similar) in 228 aa overlap (286-513:13-239)
260 270 280 290 300 310
pF1KE1 FRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSN
::.:::::::: . : . ::: ::::.:::
XP_016 MEAERAQVLPTVRDADLFLLDTRKAQALDVGWLVFDITVTSN
10 20 30 40
320 330 340 350 360 370
pF1KE1 LWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRS
::..::.:.:::: . : :: .. ..::::::.:: .::::::::::.::: .:..:.
XP_016 HWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRA
50 60 70 80 90 100
380 390 400 410 420 430
pF1KE1 ASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKG
:. .:..:.::.:.. :: .:.::..:::.:: : ::.::::::::.:::::::::::.:
XP_016 AN-KRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEG
110 120 130 140 150 160
440 450 460 470 480 490
pF1KE1 YAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNS
::: ::::::::::::::::::::::::::::: :..:::::::::::::::::::::.:
XP_016 YAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSS
170 180 190 200 210 220
500 510
pF1KE1 NVILKKYRNMVVRACGCH
:::::::::::::.::::
XP_016 NVILKKYRNMVVRSCGCH
230
>>NP_001711 (OMIM: 602284) bone morphogenetic protein 8B (402 aa)
initn: 1376 init1: 948 opt: 1153 Z-score: 815.2 bits: 160.1 E(85289): 1.1e-38
Smith-Waterman score: 1282; 46.5% identity (68.4% similar) in 471 aa overlap (44-513:18-402)
20 30 40 50 60 70
pF1KE1 WWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKT
:: ::.:: . :: :: ::: .
NP_001 MTALPGPLWLLGLALCALG-GGGPG-LRPPPGCPQ-------RRLGA
10 20 30
80 90 100 110 120 130
pF1KE1 QEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAP
.:.:..:.:::.::::: :::: ::: ..:: :::
NP_001 RERRDVQREILAVLGLPGRPRP------RAPPA---------ASRLP---------ASAP
40 50 60 70
140 150 160 170 180 190
pF1KE1 LFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSG
:::::::.:...:.::::: : : ::
NP_001 LFMLDLYHAMAGDDDEDGA---------PAE------RR---------------------
80 90
200 210 220 230 240 250
pF1KE1 SGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTA
:. ::.::::::.:: :. .. .. : :::.:.:.::: ::.:::
NP_001 ---------------LGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA
100 110 120 130 140
260 270 280 290 300 310
pF1KE1 AEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITAT
::::::: . . :.:. .:..::.::...:.::::.:: ... :..:::: .:.::.
NP_001 AEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAA
150 160 170 180 190 200
320 330 340 350 360 370
pF1KE1 SNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTT
:. :.. ....::.: : :.:: : : :::.:. .: ..:::.:.::..: .::
NP_001 SDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTP
210 220 230 240 250 260
380 390 400 410 420 430
pF1KE1 RSASSRRRQQSRNRSTQSQDVARVSSA-SDYNSSELKTACRKHELYVSFQDLGWQDWIIA
:.. ::.: . .:.. .. :. . .: ..:. . .::.:::::::::::: ::.::
NP_001 RAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIA
270 280 290 300 310 320
440 450 460 470 480 490
pF1KE1 PKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFD
:.::.: ::.:::::::.. ::::::::.:.::::: :. ::: :::::::.: ::::.:
NP_001 PQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYD
330 340 350 360 370 380
500 510
pF1KE1 DNSNVILKKYRNMVVRACGCH
...::::.:.:::::.:::::
NP_001 SSNNVILRKHRNMVVKACGCH
390 400
>>NP_001316683 (OMIM: 112265) bone morphogenetic protein (417 aa)
initn: 1326 init1: 782 opt: 1079 Z-score: 763.7 bits: 150.6 E(85289): 8.5e-36
Smith-Waterman score: 1408; 51.7% identity (71.6% similar) in 451 aa overlap (64-513:36-417)
40 50 60 70 80 90
pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP
:.:.::::...:.::.:.::::.:::::::
NP_001 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA
::. ::. .::::::::::::.. ... .
NP_001 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E
70 80 90
160 170 180 190 200 210
pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA
:: . : .:. .... : ..: : .: . . ::.: .:. :::::
NP_001 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF
::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:.
NP_001 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV
:::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: .
NP_001 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ
: :: .. ..::::::.:: .::::::::::.::: .:..: :...:..:.::.:.. :
NP_001 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVR-AANKRKNQNRNKSSSHQ
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH
: .:.::..:::.:: : ::.::::::::.:::::
NP_001 DSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQ-------------------------
340 350 360
460 470 480 490 500 510
pF1KE1 MNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC
:::: :..:::::::::::::::::::::.::::::::::::::.:::
NP_001 ------------VHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC
370 380 390 400 410
pF1KE1 H
:
NP_001 H
>>XP_011513119 (OMIM: 112265) PREDICTED: bone morphogene (357 aa)
initn: 1089 init1: 782 opt: 918 Z-score: 653.0 bits: 129.9 E(85289): 1.2e-29
Smith-Waterman score: 1017; 49.4% identity (74.1% similar) in 340 aa overlap (64-402:36-343)
40 50 60 70 80 90
pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP
:.:.::::...:.::.:.::::.:::::::
XP_011 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA
::. ::. .::::::::::::.. ... .
XP_011 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E
70 80 90
160 170 180 190 200 210
pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA
:: . : .:. .... : ..: : .: . . ::.: .:. :::::
XP_011 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF
::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:.
XP_011 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV
:::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: .
XP_011 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ
: :: .. ..::::::.:: .::::::::::.::: .:..:.:. .:..:.::.:.. :
XP_011 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAAN-KRKNQNRNKSSSHQ
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH
: .:.::...
XP_011 DSSRMSSVGETLHKTTRWNSLDFS
340 350
>>NP_001316685 (OMIM: 112265) bone morphogenetic protein (348 aa)
initn: 1046 init1: 782 opt: 916 Z-score: 651.8 bits: 129.6 E(85289): 1.5e-29
Smith-Waterman score: 1015; 49.9% identity (73.9% similar) in 337 aa overlap (64-399:36-340)
40 50 60 70 80 90
pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP
:.:.::::...:.::.:.::::.:::::::
NP_001 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA
::. ::. .::::::::::::.. ... .
NP_001 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E
70 80 90
160 170 180 190 200 210
pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA
:: . : .:. .... : ..: : .: . . ::.: .:. :::::
NP_001 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF
::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:.
NP_001 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV
:::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: .
NP_001 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ
: :: .. ..::::::.:: .::::::::::.::: .:..: :...:..:.::.:.. :
NP_001 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVR-AANKRKNQNRNKSSSHQ
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH
: .:.::
NP_001 DSSRMSSVGGSSDVS
340
>>XP_011540324 (OMIM: 602284) PREDICTED: bone morphogene (357 aa)
initn: 1080 init1: 652 opt: 883 Z-score: 628.7 bits: 125.4 E(85289): 2.8e-28
Smith-Waterman score: 1012; 43.4% identity (65.6% similar) in 422 aa overlap (44-464:18-353)
20 30 40 50 60 70
pF1KE1 WWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKT
:: ::.:: . :: :: ::: .
XP_011 MTALPGPLWLLGLALCALG-GGGPG-LRPPPGCPQ-------RRLGA
10 20 30
80 90 100 110 120 130
pF1KE1 QEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAP
.:.:..:.:::.::::: :::: ::: ..:: :::
XP_011 RERRDVQREILAVLGLPGRPRPR------APPA---------ASRLP---------ASAP
40 50 60 70
140 150 160 170 180 190
pF1KE1 LFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSG
:::::::.:...:.::::: : : ::
XP_011 LFMLDLYHAMAGDDDEDGA---------PAE------RR---------------------
80 90
200 210 220 230 240 250
pF1KE1 SGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTA
:. ::.::::::.:: :. .. .. : :::.:.:.::: ::.:::
XP_011 ---------------LGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA
100 110 120 130 140
260 270 280 290 300 310
pF1KE1 AEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITAT
::::::: . . :.:. .:..::.::...:.::::.:: ... :..:::: .:.::.
XP_011 AEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAA
150 160 170 180 190 200
320 330 340 350 360 370
pF1KE1 SNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTT
:. :.. ....::.: : :.:: : : :::.:. .: ..:::.:.::..: .::
XP_011 SDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTP
210 220 230 240 250 260
380 390 400 410 420 430
pF1KE1 RSASSRRRQQSRNRSTQSQDVARVSSA-SDYNSSELKTACRKHELYVSFQDLGWQDWIIA
:.. ::.: . .:.. .. :. . .: ..:. . .::.:::::::::::: ::.::
XP_011 RAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIA
270 280 290 300 310 320
440 450 460 470 480 490
pF1KE1 PKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFD
:.::.: ::.:::::::.. ::::::::.:.:
XP_011 PQGYSAYYCEGECSFPLDSCMNATNHAILQSLEVQR
330 340 350
500 510
pF1KE1 DNSNVILKKYRNMVVRACGCH
>>XP_011540326 (OMIM: 602284) PREDICTED: bone morphogene (427 aa)
initn: 1271 init1: 631 opt: 634 Z-score: 455.0 bits: 93.5 E(85289): 1.3e-18
Smith-Waterman score: 1124; 42.5% identity (63.6% similar) in 497 aa overlap (44-513:18-427)
20 30 40 50 60 70
pF1KE1 WWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKT
:: ::.:: . :: :: ::: .
XP_011 MTALPGPLWLLGLALCALG-GGGPG-LRPPPGCPQ-------RRLGA
10 20 30
80 90 100 110 120 130
pF1KE1 QEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAP
.:.:..:.:::.::::: :::: ::: ..:: :::
XP_011 RERRDVQREILAVLGLPGRPRP------RAPPA---------ASRLP---------ASAP
40 50 60 70
140 150 160 170 180 190
pF1KE1 LFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSG
:::::::.:...:.::::: : : ::
XP_011 LFMLDLYHAMAGDDDEDGA---------PAE------RR---------------------
80 90
200 210 220 230 240 250
pF1KE1 SGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTA
:. ::.::::::.:: :. .. .. : :::.:.:.::: ::.:::
XP_011 ---------------LGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA
100 110 120 130 140
260 270 280 290 300 310
pF1KE1 AEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITAT
::::::: . . :.:. .:..::.::...:.::::.:: ... :..:::: .:.::.
XP_011 AEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAA
150 160 170 180 190 200
320 330 340 350
pF1KE1 SNLWVVTPQHNMGLQLSVVTRDG--------------------VHVHPRAAGLVGRDGPY
:. :.. ....::.: : :.:: . : . .: . ::
XP_011 SDCWLLKRHKDLGLRLYVETEDGETWTGWGWTKDSRLQMWKLRLSRTPWVLSLHA-PGPA
210 220 230 240 250 260
360 370 380 390 400
pF1KE1 D---KQPFMVAF---FKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSA-SDYNSS
. ..:.. . .: .:: :.. ::.: . .:.. .. :. . .: ..:
XP_011 QAPAERPLLCLLQGHCPASPSPIRTPRAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGS
270 280 290 300 310 320
410 420 430 440 450 460
pF1KE1 ELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVH
. . .::.:::::::::::: ::.:::.::.: ::.:::::::.. ::::::::.:.:::
XP_011 HGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVH
330 340 350 360 370 380
470 480 490 500 510
pF1KE1 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
:: :. ::: :::::::.: ::::.:...::::.:.:::::.:::::
XP_011 LMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
390 400 410 420
513 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:59:56 2016 done: Sun Nov 6 16:59:57 2016
Total Scan time: 10.910 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]