Result of FASTA (omim) for
pFN21AE1908
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1908, 415 aa
1>>>pF1KE1908 415 - 415 aa - 415 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9115+/-0.000445; mu= 19.3158+/- 0.027
mean_var=75.6129+/-15.408, 0's: 0 Z-trim(109.6): 308 B-trim: 22 in 1/53
Lambda= 0.147495
statistics sampled from 17440 (17755) to 17440 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.552), E-opt: 0.2 (0.208), width: 16
Scan time: 8.070
The best scores are: opt bits E(85289)
NP_004373 (OMIM: 122561) corticotropin-releasing f ( 415) 2827 611.6 1.1e-174
NP_001138620 (OMIM: 122561) corticotropin-releasin ( 401) 2422 525.4 9.5e-149
NP_001138619 (OMIM: 122561) corticotropin-releasin ( 375) 2279 495.0 1.3e-139
NP_001289949 (OMIM: 122561) corticotropin-releasin ( 314) 2074 451.3 1.6e-126
NP_001189404 (OMIM: 602034) corticotropin-releasin ( 438) 2049 446.1 7.9e-125
NP_001189411 (OMIM: 602034) corticotropin-releasin ( 410) 2027 441.4 1.9e-123
NP_001189410 (OMIM: 602034) corticotropin-releasin ( 397) 2016 439.0 9.6e-123
XP_016867241 (OMIM: 602034) PREDICTED: corticotrop ( 397) 2016 439.0 9.6e-123
NP_001874 (OMIM: 602034) corticotropin-releasing f ( 411) 2016 439.1 9.8e-123
NP_001138618 (OMIM: 122561) corticotropin-releasin ( 444) 1852 404.2 3.3e-112
XP_011513430 (OMIM: 602034) PREDICTED: corticotrop ( 370) 1748 382.0 1.3e-105
NP_001189412 (OMIM: 602034) corticotropin-releasin ( 387) 1748 382.0 1.4e-105
XP_011513431 (OMIM: 602034) PREDICTED: corticotrop ( 387) 1748 382.0 1.4e-105
NP_001289947 (OMIM: 122561) corticotropin-releasin ( 240) 1642 359.3 6e-99
XP_016867240 (OMIM: 602034) PREDICTED: corticotrop ( 558) 1412 310.7 6e-84
XP_011513429 (OMIM: 602034) PREDICTED: corticotrop ( 559) 1401 308.3 3e-83
XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 721 163.5 8.9e-40
NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 721 163.5 8.9e-40
XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 721 163.5 8.9e-40
NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 721 163.5 9.1e-40
NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 721 163.5 9.5e-40
XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 718 162.9 1.5e-39
NP_001158210 (OMIM: 114131,166710) calcitonin rece ( 474) 716 162.5 2e-39
NP_001733 (OMIM: 114131,166710) calcitonin recepto ( 474) 716 162.5 2e-39
NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 715 162.2 2.2e-39
XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 712 161.6 3.3e-39
NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 709 160.9 5.2e-39
XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 700 159.1 2e-38
XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 700 159.1 2.1e-38
XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 690 156.9 8e-38
NP_001258680 (OMIM: 114190) calcitonin gene-relate ( 461) 672 153.1 1.3e-36
NP_005786 (OMIM: 114190) calcitonin gene-related p ( 461) 672 153.1 1.3e-36
XP_005246289 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36
XP_005246291 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36
XP_005246288 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36
XP_016858640 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36
NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 665 151.6 3.6e-36
XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 664 151.4 4.3e-36
NP_000814 (OMIM: 139191,612781) growth hormone-rel ( 423) 657 149.9 1.1e-35
NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 657 149.9 1.2e-35
XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 641 146.5 1.3e-34
XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 632 144.6 4.4e-34
XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 615 140.9 5.4e-33
NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 615 141.0 6e-33
XP_011513565 (OMIM: 139191,612781) PREDICTED: grow ( 359) 574 132.2 2.1e-30
NP_001158209 (OMIM: 114131,166710) calcitonin rece ( 508) 570 131.5 4.8e-30
XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 563 129.9 1.1e-29
NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 558 128.8 2.5e-29
XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 542 125.4 2.7e-28
XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 526 121.8 2e-27
>>NP_004373 (OMIM: 122561) corticotropin-releasing facto (415 aa)
initn: 2827 init1: 2827 opt: 2827 Z-score: 3257.1 bits: 611.6 E(85289): 1.1e-174
Smith-Waterman score: 2827; 100.0% identity (100.0% similar) in 415 aa overlap (1-415:1-415)
10 20 30 40 50 60
pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
310 320 330 340 350 360
370 380 390 400 410
pF1KE1 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
370 380 390 400 410
>>NP_001138620 (OMIM: 122561) corticotropin-releasing fa (401 aa)
initn: 2422 init1: 2422 opt: 2422 Z-score: 2791.5 bits: 525.4 E(85289): 9.5e-149
Smith-Waterman score: 2690; 96.6% identity (96.6% similar) in 415 aa overlap (1-415:1-401)
10 20 30 40 50 60
pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQ-----
310 320 330 340 350
370 380 390 400 410
pF1KE1 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---------VRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
360 370 380 390 400
>>NP_001138619 (OMIM: 122561) corticotropin-releasing fa (375 aa)
initn: 2279 init1: 2279 opt: 2279 Z-score: 2627.4 bits: 495.0 E(85289): 1.3e-139
Smith-Waterman score: 2437; 90.1% identity (90.4% similar) in 415 aa overlap (1-415:1-375)
10 20 30 40 50 60
pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
::::::::::::::::::::::::::::::::::::::::
NP_001 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNIS--------------------
10 20 30 40
70 80 90 100 110 120
pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
.:::::::::::::::::::::::::::::::::::::::
NP_001 --------------------DNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
50 60 70 80
130 140 150 160 170 180
pF1KE1 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE1 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE1 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE1 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
270 280 290 300 310 320
370 380 390 400 410
pF1KE1 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
330 340 350 360 370
>>NP_001289949 (OMIM: 122561) corticotropin-releasing fa (314 aa)
initn: 2074 init1: 2074 opt: 2074 Z-score: 2392.7 bits: 451.3 E(85289): 1.6e-126
Smith-Waterman score: 2074; 99.7% identity (100.0% similar) in 307 aa overlap (109-415:8-314)
80 90 100 110 120 130
pF1KE1 TTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAF
.:::::::::::::::::::::::::::::
NP_001 MVSATIPQKKSKVHYHVAVIINYLGHCISLVALLVAF
10 20 30
140 150 160 170 180 190
pF1KE1 VLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYF
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE1 HVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKC
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE1 WFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLV
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE1 LLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRW
220 230 240 250 260 270
380 390 400 410
pF1KE1 HRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
:::::::::::::::::::::::::::::::::::::
NP_001 HRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
280 290 300 310
>>NP_001189404 (OMIM: 602034) corticotropin-releasing fa (438 aa)
initn: 1667 init1: 1667 opt: 2049 Z-score: 2362.0 bits: 446.1 E(85289): 7.9e-125
Smith-Waterman score: 2049; 71.9% identity (90.9% similar) in 395 aa overlap (24-415:45-438)
10 20 30 40 50
pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISG--LQCNASVDLI
.: .:.:... .:.:: ::...: :
NP_001 HLLLCLLCLLPPPLQYAAGQSQMPKDQPLWALLEQYCHTIMTLTNLSGPYSYCNTTLDQI
20 30 40 50 60 70
60 70 80 90 100 110
pF1KE1 GTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EK
::::::: :: :: :::: .: ::.:::: :.::::: ::.::...:::.:. ::.. ..
NP_001 GTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQR
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE1 KSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWF
: .::..:...::::::.:..::..::.::: :::::::::.::::::..:::::. ::
NP_001 KYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWF
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE1 VVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWM
..:: .. :::.:: ::: .:. .::: :::::::: ::::::::::.::::.:::: .
NP_001 LLQL-VDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCL
200 210 220 230 240 250
240 250 260 270 280 290
pF1KE1 FICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNI
:. ::: .:::::::::::::::.::.:::::.:: .:::::::.::::::::.:::::
NP_001 FLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNI
260 270 280 290 300 310
300 310 320 330 340 350
pF1KE1 VRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSF
:::::::::::::::::::::::::::::::::::::::::::::::..:...:::::::
NP_001 VRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSF
320 330 340 350 360 370
360 370 380 390 400 410
pF1KE1 LESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIK
:.:::::::::::::.:.:::::.:::::::::.::.:. .::::::::::::.::::::
NP_001 LQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIK
380 390 400 410 420 430
pF1KE1 QSTAV
:..::
NP_001 QTAAV
>>NP_001189411 (OMIM: 602034) corticotropin-releasing fa (410 aa)
initn: 2026 init1: 1368 opt: 2027 Z-score: 2337.1 bits: 441.4 E(85289): 1.9e-123
Smith-Waterman score: 2027; 74.7% identity (92.7% similar) in 372 aa overlap (44-415:40-410)
20 30 40 50 60 70
pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY
::...: :::::::: :: :: :::: .:
NP_001 LEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVA
::.:::: :.::::: ::.::...:::.:. ::....: .::..:...::::::.:..:
NP_001 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKRKYDLHYRIALVVNYLGHCVSVAA
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE1 LLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTA
:..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .:.
NP_001 LVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCITT
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE1 AYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYY
.::: :::::::: ::::::::::.::::.:::: .:. ::: .:::::::::::::::
NP_001 IFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYY
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE1 DNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAV
.::.:::::.:: .:::::::.::::::::.::::::::::::::::::::::::::::
NP_001 ENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAV
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE1 KATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSA
::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.:::::
NP_001 KATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSA
310 320 330 340 350 360
380 390 400 410
pF1KE1 IRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
.:::::::::.::.:. .::::::::::::.:::::::..::
NP_001 VRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
370 380 390 400 410
>>NP_001189410 (OMIM: 602034) corticotropin-releasing fa (397 aa)
initn: 1667 init1: 1667 opt: 2016 Z-score: 2324.6 bits: 439.0 E(85289): 9.6e-123
Smith-Waterman score: 2016; 74.5% identity (92.5% similar) in 373 aa overlap (44-415:26-397)
20 30 40 50 60 70
pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY
::...: :::::::: :: :: :::: .:
NP_001 MGREPWPEDRDLGFPQLFCQGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN
10 20 30 40 50
80 90 100 110 120 130
pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EKKSKVHYHVAVIINYLGHCISLV
::.:::: :.::::: ::.::...:::.:. ::.. ..: .::..:...::::::.:..
NP_001 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVA
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE1 ALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVT
::..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .:
NP_001 ALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCIT
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE1 AAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLY
. .::: :::::::: ::::::::::.::::.:::: .:. ::: .::::::::::::::
NP_001 TIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLY
180 190 200 210 220 230
260 270 280 290 300 310
pF1KE1 YDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKA
:.::.:::::.:: .:::::::.::::::::.:::::::::::::::::::::::::::
NP_001 YENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKA
240 250 260 270 280 290
320 330 340 350 360 370
pF1KE1 VKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRS
:::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.::::
NP_001 VKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRS
300 310 320 330 340 350
380 390 400 410
pF1KE1 AIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
:.:::::::::.::.:. .::::::::::::.:::::::..::
NP_001 AVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
360 370 380 390
>>XP_016867241 (OMIM: 602034) PREDICTED: corticotropin-r (397 aa)
initn: 1667 init1: 1667 opt: 2016 Z-score: 2324.6 bits: 439.0 E(85289): 9.6e-123
Smith-Waterman score: 2016; 74.5% identity (92.5% similar) in 373 aa overlap (44-415:26-397)
20 30 40 50 60 70
pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY
::...: :::::::: :: :: :::: .:
XP_016 MGREPWPEDRDLGFPQLFCQGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN
10 20 30 40 50
80 90 100 110 120 130
pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EKKSKVHYHVAVIINYLGHCISLV
::.:::: :.::::: ::.::...:::.:. ::.. ..: .::..:...::::::.:..
XP_016 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVA
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE1 ALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVT
::..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .:
XP_016 ALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCIT
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE1 AAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLY
. .::: :::::::: ::::::::::.::::.:::: .:. ::: .::::::::::::::
XP_016 TIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLY
180 190 200 210 220 230
260 270 280 290 300 310
pF1KE1 YDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKA
:.::.:::::.:: .:::::::.::::::::.:::::::::::::::::::::::::::
XP_016 YENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKA
240 250 260 270 280 290
320 330 340 350 360 370
pF1KE1 VKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRS
:::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.::::
XP_016 VKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRS
300 310 320 330 340 350
380 390 400 410
pF1KE1 AIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
:.:::::::::.::.:. .::::::::::::.:::::::..::
XP_016 AVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
360 370 380 390
>>NP_001874 (OMIM: 602034) corticotropin-releasing facto (411 aa)
initn: 1667 init1: 1667 opt: 2016 Z-score: 2324.5 bits: 439.1 E(85289): 9.8e-123
Smith-Waterman score: 2016; 74.5% identity (92.5% similar) in 373 aa overlap (44-415:40-411)
20 30 40 50 60 70
pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY
::...: :::::::: :: :: :::: .:
NP_001 LEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EKKSKVHYHVAVIINYLGHCISLV
::.:::: :.::::: ::.::...:::.:. ::.. ..: .::..:...::::::.:..
NP_001 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVA
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE1 ALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVT
::..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .:
NP_001 ALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCIT
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE1 AAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLY
. .::: :::::::: ::::::::::.::::.:::: .:. ::: .::::::::::::::
NP_001 TIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLY
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE1 YDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKA
:.::.:::::.:: .:::::::.::::::::.:::::::::::::::::::::::::::
NP_001 YENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKA
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE1 VKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRS
:::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.::::
NP_001 VKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRS
310 320 330 340 350 360
380 390 400 410
pF1KE1 AIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
:.:::::::::.::.:. .::::::::::::.:::::::..::
NP_001 AVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
370 380 390 400 410
>>NP_001138618 (OMIM: 122561) corticotropin-releasing fa (444 aa)
initn: 1852 init1: 1852 opt: 1852 Z-score: 2135.4 bits: 404.2 E(85289): 3.3e-112
Smith-Waterman score: 2759; 93.5% identity (93.5% similar) in 444 aa overlap (1-415:1-444)
10 20 30 40 50 60
pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
70 80 90 100 110 120
130 140 150
pF1KE1 IINYLGHCISLVALLVAFVLFLRLR-----------------------------SIRCLR
::::::::::::::::::::::::: ::::::
NP_001 IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE1 NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE1 YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE1 YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE1 VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
370 380 390 400 410 420
400 410
pF1KE1 ARAMSIPTSPTRVSFHSIKQSTAV
::::::::::::::::::::::::
NP_001 ARAMSIPTSPTRVSFHSIKQSTAV
430 440
415 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 11:03:42 2016 done: Sun Nov 6 11:03:43 2016
Total Scan time: 8.070 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]