Result of FASTA (omim) for
pFN21AE1906
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1906, 442 aa
1>>>pF1KE1906 442 - 442 aa - 442 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2229+/-0.000324; mu= 18.9780+/- 0.020
mean_var=73.6160+/-14.572, 0's: 0 Z-trim(115.8): 71 B-trim: 41 in 1/55
Lambda= 0.149482
statistics sampled from 26378 (26450) to 26378 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.31), width: 16
Scan time: 7.950
The best scores are: opt bits E(85289)
NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 3006 657.4 2.1e-188
NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 2052 451.7 1.7e-126
NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 1232 274.8 2.9e-73
NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 1232 274.8 2.9e-73
NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 699 159.8 1.1e-38
XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 692 158.3 3.2e-38
NP_001316867 (OMIM: 107970,190230,615582) transfor ( 309) 592 136.7 8.2e-32
XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 302 74.2 6.8e-13
NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 302 74.2 6.8e-13
NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 298 73.4 1.2e-12
XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 297 73.2 1.5e-12
NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 297 73.2 1.5e-12
XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 297 73.2 1.7e-12
XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 297 73.3 1.8e-12
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 275 68.5 4.6e-11
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 271 67.5 6.3e-11
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 266 66.5 1.6e-10
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 253 63.7 1.1e-09
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 253 63.7 1.2e-09
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 253 63.7 1.2e-09
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 253 63.7 1.2e-09
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 247 62.2 1.7e-09
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 246 62.0 2e-09
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 249 62.8 2e-09
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 247 62.4 2.8e-09
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 246 62.2 2.9e-09
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 246 62.2 3.1e-09
NP_005529 (OMIM: 601233) inhibin beta C chain prep ( 352) 242 61.3 4.8e-09
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 238 60.4 9.8e-09
NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 235 59.7 1.2e-08
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 235 59.7 1.3e-08
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 235 59.7 1.3e-08
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 235 59.8 1.5e-08
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 235 59.8 1.5e-08
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 235 59.8 1.5e-08
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 235 59.8 1.5e-08
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 228 58.3 4e-08
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 224 57.4 7.4e-08
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 217 56.0 2.5e-07
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 198 51.6 2.3e-06
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 198 51.8 3.4e-06
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 192 50.6 1.1e-05
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 189 49.9 1.5e-05
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 184 48.8 3e-05
XP_011540327 (OMIM: 602284) PREDICTED: bone morpho ( 230) 148 40.9 0.0044
XP_005271206 (OMIM: 602284) PREDICTED: bone morpho ( 231) 148 40.9 0.0044
XP_016857645 (OMIM: 602284) PREDICTED: bone morpho ( 236) 148 40.9 0.0044
XP_011540324 (OMIM: 602284) PREDICTED: bone morpho ( 357) 148 41.0 0.0061
XP_016857644 (OMIM: 602284) PREDICTED: bone morpho ( 382) 148 41.0 0.0065
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 148 41.0 0.0067
>>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa)
initn: 3006 init1: 3006 opt: 3006 Z-score: 3503.4 bits: 657.4 E(85289): 2.1e-188
Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 442 aa overlap (1-442:1-442)
10 20 30 40 50 60
pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY
370 380 390 400 410 420
430 440
pF1KE1 YIGKTPKIEQLSNMIVKSCKCS
::::::::::::::::::::::
NP_001 YIGKTPKIEQLSNMIVKSCKCS
430 440
>>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa)
initn: 2052 init1: 2052 opt: 2052 Z-score: 2391.9 bits: 451.7 E(85289): 1.7e-126
Smith-Waterman score: 2742; 93.4% identity (93.7% similar) in 442 aa overlap (1-442:1-414)
10 20 30 40 50 60
pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE-----
70 80 90 100 110
130 140 150 160 170 180
pF1KE1 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF
.::::::::::::::::::::::::::::::::::::
NP_003 -----------------------NAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF
120 130 140 150
190 200 210 220 230 240
pF1KE1 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY
340 350 360 370 380 390
430 440
pF1KE1 YIGKTPKIEQLSNMIVKSCKCS
::::::::::::::::::::::
NP_003 YIGKTPKIEQLSNMIVKSCKCS
400 410
>>NP_003230 (OMIM: 107970,190230,615582) transforming gr (412 aa)
initn: 1535 init1: 725 opt: 1232 Z-score: 1436.3 bits: 274.8 E(85289): 2.9e-73
Smith-Waterman score: 1516; 52.7% identity (75.2% similar) in 444 aa overlap (1-442:3-412)
10 20 30 40 50
pF1KE1 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY
:: .: .. .:...::.::::::.:::. .. .::.:::::::::::.::::::
NP_003 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 PEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETV
. :: .:...:::::.::.: ..: .: .: .. ::::::..:.::
NP_003 VMTH-VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDM---------
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 CPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEF
. .: .. ..: : . :: :.::..::: .:: .:::
NP_003 ----------IQGLAEHNELAVC------PKGITSKVFR---FNVSSVEKNRTNLFRAEF
120 130 140 150
180 190 200 210 220 230
pF1KE1 RVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE
::.:. ::... ::::::.:::. : :::: .: . ::. .:::::::::.:.:
NP_003 RVLRVPNPSSKRNEQRIELFQILRP-DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVRE
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE1 WLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKS
:: ... :::..::.:::: :: : :. :. : : .: .: :.:. . . :: .:
NP_003 WLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK-
220 230 240 250 260
300 310 320 330 340 350
pF1KE1 TRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKR
:... ..:::.::..: .::.. : ..:::::::. :::::...:::.:::::::..
NP_003 --KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQ
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE1 DLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPL
::::::.:::::: ::::.: :::: :.:: :: ::.::::.::::::::::: ::::::
NP_003 DLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL
330 340 350 360 370 380
420 430 440
pF1KE1 TILYYIGKTPKIEQLSNMIVKSCKCS
:::::.:.:::.::::::.:::::::
NP_003 TILYYVGRTPKVEQLSNMVVKSCKCS
390 400 410
>>NP_001316868 (OMIM: 107970,190230,615582) transforming (412 aa)
initn: 1535 init1: 725 opt: 1232 Z-score: 1436.3 bits: 274.8 E(85289): 2.9e-73
Smith-Waterman score: 1516; 52.7% identity (75.2% similar) in 444 aa overlap (1-442:3-412)
10 20 30 40 50
pF1KE1 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY
:: .: .. .:...::.::::::.:::. .. .::.:::::::::::.::::::
NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 PEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETV
. :: .:...:::::.::.: ..: .: .: .. ::::::..:.::
NP_001 VMTH-VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDM---------
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 CPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEF
. .: .. ..: : . :: :.::..::: .:: .:::
NP_001 ----------IQGLAEHNELAVC------PKGITSKVFR---FNVSSVEKNRTNLFRAEF
120 130 140 150
180 190 200 210 220 230
pF1KE1 RVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE
::.:. ::... ::::::.:::. : :::: .: . ::. .:::::::::.:.:
NP_001 RVLRVPNPSSKRNEQRIELFQILRP-DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVRE
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE1 WLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKS
:: ... :::..::.:::: :: : :. :. : : .: .: :.:. . . :: .:
NP_001 WLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK-
220 230 240 250 260
300 310 320 330 340 350
pF1KE1 TRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKR
:... ..:::.::..: .::.. : ..:::::::. :::::...:::.:::::::..
NP_001 --KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQ
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE1 DLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPL
::::::.:::::: ::::.: :::: :.:: :: ::.::::.::::::::::: ::::::
NP_001 DLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL
330 340 350 360 370 380
420 430 440
pF1KE1 TILYYIGKTPKIEQLSNMIVKSCKCS
:::::.:.:::.::::::.:::::::
NP_001 TILYYVGRTPKVEQLSNMVVKSCKCS
390 400 410
>>NP_000651 (OMIM: 131300,190180,219700) transforming gr (390 aa)
initn: 1016 init1: 653 opt: 699 Z-score: 815.4 bits: 159.8 E(85289): 1.1e-38
Smith-Waterman score: 1029; 42.8% identity (63.6% similar) in 439 aa overlap (9-442:18-390)
10 20 30 40 50
pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT
.:.: : .::::.:.::. :::::::::::::::.:.
NP_000 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
10 20 30 40 50 60
60 70 80 90 100
pF1KE1 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP
::: . : : .: :...:::::: ... ..: : : . .:::::: .. :
NP_000 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM-
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 PFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA
:: . . :. :. :. : :..: ... .
NP_000 ----VETHNEIYDKFKQSTHSI----------YM------F---------FNTSELREAV
120 130 140
170 180 190 200 210 220
pF1KE1 SN---LVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEW
. : .::.:..:: : .: ::..:::: .. . ::...... ::
NP_000 PEPVLLSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAPSDSPEW
150 160 170 180 190
230 240 250 260 270 280
pF1KE1 LSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTST
:::::: .:..:: . . ::..: :: : .... :.. :.: .:
NP_000 LSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQV---DINGFTT
200 210 220 230 240
290 300 310 320 330 340
pF1KE1 YTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCC
:: ::.. . : :::: : : . :..:.. ::::. ::: ... :::
NP_000 GRRGDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSSTEKNCC
250 260 270 280 290
350 360 370 380 390 400
pF1KE1 LRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASP
.: :::::..:::::::::::::.:::: : :::.:: :::.:.::.::: :: :::.:
NP_000 VRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAP
300 310 320 330 340 350
410 420 430 440
pF1KE1 CCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
::: : :::: :.::.:. ::.::::::::.:::::
NP_000 CCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
360 370 380 390
>>XP_011525544 (OMIM: 131300,190180,219700) PREDICTED: t (391 aa)
initn: 1016 init1: 653 opt: 692 Z-score: 807.2 bits: 158.3 E(85289): 3.2e-38
Smith-Waterman score: 1022; 42.6% identity (63.6% similar) in 439 aa overlap (9-442:18-391)
10 20 30 40 50
pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT
.:.: : .::::.:.::. :::::::::::::::.:.
XP_011 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
10 20 30 40 50 60
60 70 80 90 100
pF1KE1 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP
::: . : : .: :...:::::: ... ..: : : . .:::::: .. :
XP_011 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM-
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 PFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA
:: . . :. :. :. : :..: ... .
XP_011 ----VETHNEIYDKFKQSTHSI----------YM------F---------FNTSELREAV
120 130 140
170 180 190 200 210 220
pF1KE1 SN---LVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEW
. : .::.:..:: : .: ::..:::: .. . ::...... ::
XP_011 PEPVLLSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAPSDSPEW
150 160 170 180 190
230 240 250 260 270 280
pF1KE1 LSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTST
:::::: .:..:: . . ::..: :: : .... :.. . . : .:
XP_011 LSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQVDINA--GFTT
200 210 220 230 240
290 300 310 320 330 340
pF1KE1 YTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCC
:: ::.. . : :::: : : . :..:.. ::::. ::: ... :::
XP_011 GRRGDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSSTEKNCC
250 260 270 280 290
350 360 370 380 390 400
pF1KE1 LRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASP
.: :::::..:::::::::::::.:::: : :::.:: :::.:.::.::: :: :::.:
XP_011 VRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAP
300 310 320 330 340 350
410 420 430 440
pF1KE1 CCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
::: : :::: :.::.:. ::.::::::::.:::::
XP_011 CCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
360 370 380 390
>>NP_001316867 (OMIM: 107970,190230,615582) transforming (309 aa)
initn: 895 init1: 238 opt: 592 Z-score: 692.1 bits: 136.7 E(85289): 8.2e-32
Smith-Waterman score: 876; 44.7% identity (69.6% similar) in 342 aa overlap (1-339:3-309)
10 20 30 40 50
pF1KE1 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY
:: .: .. .:...::.::::::.:::. .. .::.:::::::::::.::::::
NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPE--
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 PEP-EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSET
: .:: .:...:::::.::.: ..: .: .: .. ::::::..:.::
NP_001 PTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDM--------
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 VCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAE
. .: .. ..: : . : ::.::..::: .:: .::
NP_001 -----------IQGLAEHNELAVC------PKGITSKVF---RFNVSSVEKNRTNLFRAE
120 130 140 150
180 190 200 210 220 230
pF1KE1 FRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVH
:::.:. ::... ::::::.:::. : :::: .: . ::. .:::::::::.:.
NP_001 FRVLRVPNPSSKRNEQRIELFQILRP-DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVR
160 170 180 190 200
240 250 260 270 280 290
pF1KE1 EWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIK
::: ... :::..::.:::: :: : :. :. : : .: .: :.:. . . :: .:
NP_001 EWLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE1 STRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFK
:... ..:::.::..: .::.. : ..:::::::. ::::
NP_001 ---KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFR
270 280 290 300
360 370 380 390 400 410
pF1KE1 RDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEP
>>XP_006719257 (OMIM: 603936) PREDICTED: growth/differen (407 aa)
initn: 325 init1: 119 opt: 302 Z-score: 352.4 bits: 74.2 E(85289): 6.8e-13
Smith-Waterman score: 330; 25.4% identity (47.5% similar) in 448 aa overlap (16-442:54-407)
10 20 30 40
pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI
.:: . : . : :. :.:.:..::
XP_006 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI
30 40 50 60 70 80
50 60 70 80 90
pF1KE1 LSKLKLTSPPEDYPE------PEEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDE
::::.: :. : :. .:: ....... : :: : ..
XP_006 LSKLRLKEAPNISREVVKQLLPK-APPLQQILDLHDFQGDALQP---------EDFLEED
90 100 110 120 130
100 110 120 130 140 150
pF1KE1 EYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFR
::.: :.: .. . :.: : .:: :: : . . :
XP_006 EYHATTETVISM-----AQETDPAVQT-DGS--PLC-------CHF-------HFSPK--
140 150 160
160 170 180 190 200
pF1KE1 IVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPT-------
: : ....::.. :. : ::. :::. : ::.
XP_006 -VMF---------TKVLKAQLWVY--LRP---VPRPATVYLQILRLKPLTGEGTAGGGGG
170 180 190 200 210
210 220 230 240 250 260
pF1KE1 -QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNY
.:.: . .: . . :.: :.: ...: :... . : :..:. .: ::
XP_006 GRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN------AFDPS---
220 230 240 250 260
270 280 290 300 310 320
pF1KE1 IIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN
: . .. : : : . : .: ...
XP_006 ------------------------GTDLAVTSLGPGAEGLHPFMELRVL--------ENT
270 280 290
330 340 350 360 370 380
pF1KE1 RRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSD
.:..: : .. .. :: :: .::. .:: :: :: :.::.:.: : :.. .
XP_006 KRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQK
300 310 320 330 340 350
390 400 410 420 430 440
pF1KE1 TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS
:.. : . ::..::.:::. . :...::. : : .. .:.: : ::
XP_006 YPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
360 370 380 390 400
>>NP_005802 (OMIM: 603936) growth/differentiation factor (407 aa)
initn: 325 init1: 119 opt: 302 Z-score: 352.4 bits: 74.2 E(85289): 6.8e-13
Smith-Waterman score: 330; 25.4% identity (47.5% similar) in 448 aa overlap (16-442:54-407)
10 20 30 40
pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI
.:: . : . : :. :.:.:..::
NP_005 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI
30 40 50 60 70 80
50 60 70 80 90
pF1KE1 LSKLKLTSPPEDYPE------PEEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDE
::::.: :. : :. .:: ....... : :: : ..
NP_005 LSKLRLKEAPNISREVVKQLLPK-APPLQQILDLHDFQGDALQP---------EDFLEED
90 100 110 120 130
100 110 120 130 140 150
pF1KE1 EYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFR
::.: :.: .. . :.: : .:: :: : . . :
NP_005 EYHATTETVISM-----AQETDPAVQT-DGS--PLC-------CHF-------HFSPK--
140 150 160
160 170 180 190 200
pF1KE1 IVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPT-------
: : ....::.. :. : ::. :::. : ::.
NP_005 -VMF---------TKVLKAQLWVY--LRP---VPRPATVYLQILRLKPLTGEGTAGGGGG
170 180 190 200 210
210 220 230 240 250 260
pF1KE1 -QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNY
.:.: . .: . . :.: :.: ...: :... . : :..:. .: ::
NP_005 GRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN------AFDPS---
220 230 240 250 260
270 280 290 300 310 320
pF1KE1 IIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN
: . .. : : : . : .: ...
NP_005 ------------------------GTDLAVTSLGPGAEGLHPFMELRVL--------ENT
270 280 290
330 340 350 360 370 380
pF1KE1 RRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSD
.:..: : .. .. :: :: .::. .:: :: :: :.::.:.: : :.. .
NP_005 KRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQK
300 310 320 330 340 350
390 400 410 420 430 440
pF1KE1 TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS
:.. : . ::..::.:::. . :...::. : : .. .:.: : ::
NP_005 YPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
360 370 380 390 400
>>NP_005250 (OMIM: 601788,614160) growth/differentiation (375 aa)
initn: 360 init1: 113 opt: 298 Z-score: 348.3 bits: 73.4 E(85289): 1.2e-12
Smith-Waterman score: 339; 23.5% identity (49.6% similar) in 425 aa overlap (24-442:39-375)
10 20 30 40 50
pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQILSKLKLTS
:.. : .. :::::. ::::::.: .
NP_005 YIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLET
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 PPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFF
:. ..: ... :.:... .: . . :..:.:
NP_005 APNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHAT-----------
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 PSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNL
.:: ..: :. .:. : .:. : . . .... ..
NP_005 -TET---IITMPT---------ESDFLM-QVDGKPKCCFFKFSSKIQYN---------KV
120 130 140 150
180 190 200 210 220
pF1KE1 VKAEFRVFRLQNPKARVPEQRIELYQILKS-KDLTSPTQRYIDSKVVKTRAE---GEWLS
:::.. .. : ... ...: :: : :: . .: . : : :
NP_005 VKAQLWIY--LRPVETPTTVFVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQS
160 170 180 190 200
230 240 250 260 270 280
pF1KE1 FDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYT
.:: ....::.. . :::..:. . .....: . : :
NP_005 IDVKTVLQNWLKQPESNLGIEIK--------------ALDENGHDLAVTFPG--------
210 220 230 240
290 300 310 320 330 340
pF1KE1 SGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLR
:.. : .: : ... .: .:..: . ..... ::
NP_005 PGED-----------GLNPFL--------EVKVTDTPKRSRRDFGLDCDEHSTESRCCRY
250 260 270 280
350 360 370 380 390 400
pF1KE1 PLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCC
:: .::. .:: :: :: :.::.:.: : ... . :.. : . ::..::.:::
NP_005 PLTVDFEA-FGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH---LVHQANPRGSAGPCC
290 300 310 320 330 340
410 420 430 440
pF1KE1 VSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS
. . :...::. :: : .. :.: : ::
NP_005 TPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
350 360 370
442 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:11:26 2016 done: Sun Nov 6 21:11:28 2016
Total Scan time: 7.950 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]