Result of FASTA (omim) for
pFN21AE1887
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1887, 413 aa
1>>>pF1KE1887 413 - 413 aa - 413 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1135+/-0.000478; mu= 18.2558+/- 0.030
mean_var=113.1270+/-28.673, 0's: 0 Z-trim(109.2): 660 B-trim: 1038 in 1/48
Lambda= 0.120584
statistics sampled from 16534 (17320) to 16534 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.565), E-opt: 0.2 (0.203), width: 16
Scan time: 5.870
The best scores are: opt bits E(85289)
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 2774 494.6 1.9e-139
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 978 182.2 2.4e-45
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 733 139.5 1.5e-32
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 706 134.7 3.6e-31
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 706 134.8 3.9e-31
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 706 134.8 3.9e-31
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 706 134.9 4.1e-31
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 706 134.9 4.1e-31
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 705 134.6 4.2e-31
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 706 134.9 4.2e-31
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 706 134.9 4.2e-31
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 706 134.9 4.2e-31
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 706 134.9 4.2e-31
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 703 134.2 5.1e-31
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 703 134.2 5.3e-31
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 703 134.3 5.5e-31
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 703 134.3 5.6e-31
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 605 117.1 6.2e-26
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 605 117.1 6.3e-26
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 605 117.1 6.4e-26
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 605 117.1 6.7e-26
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 605 117.2 7e-26
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 605 117.2 7e-26
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 586 114.0 7.7e-25
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 581 113.1 1.4e-24
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 524 103.3 1.6e-21
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 503 99.4 1.4e-20
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 503 99.4 1.4e-20
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 503 99.4 1.5e-20
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 503 99.5 1.6e-20
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 503 99.5 1.6e-20
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 503 99.6 1.9e-20
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 503 99.6 2e-20
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 494 97.8 4.5e-20
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 494 97.8 4.5e-20
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 494 97.9 4.7e-20
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 467 93.2 1.3e-18
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 467 93.3 1.3e-18
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 467 93.3 1.4e-18
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 462 92.4 2.5e-18
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 461 92.1 2.5e-18
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 460 92.0 2.8e-18
NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 451 90.6 1e-17
NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 451 90.6 1e-17
XP_011542349 (OMIM: 100100,118494) PREDICTED: musc ( 590) 450 90.5 1.2e-17
>>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa)
initn: 2774 init1: 2774 opt: 2774 Z-score: 2624.4 bits: 494.6 E(85289): 1.9e-139
Smith-Waterman score: 2774; 99.8% identity (99.8% similar) in 413 aa overlap (1-413:1-413)
10 20 30 40 50 60
pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_000 MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
310 320 330 340 350 360
370 380 390 400 410
pF1KE1 GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
370 380 390 400 410
>>NP_000675 (OMIM: 109630,607276) beta-1 adrenergic rece (477 aa)
initn: 1324 init1: 957 opt: 978 Z-score: 935.1 bits: 182.2 E(85289): 2.4e-45
Smith-Waterman score: 1311; 54.4% identity (74.9% similar) in 390 aa overlap (4-365:35-413)
10 20 30
pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV
:.. : :: : .:..:. ..:: :.
NP_000 VLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPP-ASESPE-PLSQQ----WT
10 20 30 40 50
40 50 60 70 80 90
pF1KE1 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAH
.:::..:.:::: :: ::::::.:::: ::::.:: :: ::: ::::::: ::::::.
NP_000 AGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE1 ILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVI
.. : .:.:.::.:::.::::::::::::::::.:::.::::::.::::::. .:: .
NP_000 VVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 ILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLV
. :: .:.:.::::: :::.:: .:: :: . :::: ::.:::::::.:::::::
NP_000 VCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC
180 190 200 210 220 230
220 230 240 250
pF1KE1 IMVFVYSRVFQEAKRQLQKIDKSEGRF-------HVQNLSQVEQ----------------
::.::: :::.::..:..:::. : :: . : :
NP_000 IMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAAT
240 250 260 270 280 290
260 270 280 290 300
pF1KE1 ----DGRTGHGLRRSSKFC-LKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRK
.::.:. :: :.. :.:.:::::::::::.:::::::::..:.:.... .:.
NP_000 APLANGRAGK--RRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPD
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE1 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSG
......::.::.::.:::.::::::::: ::: ::: : .: ....:. . ::
NP_000 RLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCAR---RAARRRHATHGDRPRASG
360 370 380 390 400 410
370 380 390 400 410
pF1KE1 YHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
NP_000 CLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFAS
420 430 440 450 460 470
>>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece (408 aa)
initn: 1068 init1: 533 opt: 733 Z-score: 705.5 bits: 139.5 E(85289): 1.5e-32
Smith-Waterman score: 1049; 47.9% identity (71.7% similar) in 357 aa overlap (4-341:5-361)
10 20 30 40 50
pF1KE1 MGQPGNGSAFLLAPN-GSHAPDHDVTQQRDEV-WVVGM-GIVMSLIVLAIVFGNVLVIT
: ..:.. :. . ::. :. : : ... : ...: ::: : ::.:::.
NP_000 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 AIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLC
::: ::::.:: :.:::: ::::::: ::: .:. : : .: ::.:::.::::
NP_000 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 VTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA
:::::::::..:::::.:.:.:..: .:.:: ::. ...::.::. .:: ::. .:.:.
NP_000 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 -THQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDK
. :: :..: :: : .:. :.. :: ::::.::..:.:::.::: : :::. .
NP_000 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
190 200 210 220 230 240
240 250 260 270 280
pF1KE1 SEGRFHVQNLSQVEQ--------------DGRTGHGLRRSSKFCLKEHKALKTLGIIMGT
::: .. . . .: . : : . . :.::.:: :::.::::
NP_000 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE1 FTLCWLPFFIVNIVHVIQD-NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL
:::::::::..:..... .:. ... :::.::.::.::::::::::::: ::..::
NP_000 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNID
:
NP_000 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
370 380 390 400
>>NP_955525 (OMIM: 602164) 5-hydroxytryptamine receptor (378 aa)
initn: 589 init1: 254 opt: 706 Z-score: 680.5 bits: 134.7 E(85289): 3.6e-31
Smith-Waterman score: 706; 36.7% identity (65.6% similar) in 343 aa overlap (40-365:26-360)
10 20 30 40 50 60
pF1KE1 FLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV-T
.: ..: ..::.::..:. ..:. . :
NP_955 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKT
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 NYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA
::::.::: :::.... :.:::: .... .: .:. .: ::.::: .:::: :: :.
NP_955 NYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCIS
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 VDRYFAIT-SPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-----THQEAI
.:::.:: .:. :.. .: . ... :.. . :::::.. : ... .
NP_955 LDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKF
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 NCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHV
: .: : : :..:. :::. :.:.::.:...::..: :.. ::.. ..:. . : .
NP_955 NQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQ-RAGA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 QNLSQVEQ-DGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN
.. :. .. : .. : .: : :: ::: :::: : ::: :::..::: . :
NP_955 SSESRPQSADQHSTHRMRT-------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY
240 250 260 270 280
310 320 330 340 350
pF1KE1 LIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLC-----LRRSSLKAYGNGYS
. .:. . :.::.:::.::..: . .:: :: .:: :: :. . :
NP_955 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 S---NGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSL
. ::.: ::
NP_955 TTTINGSTHVLSGCSPVSSFLLLFCNRPVPV
350 360 370
>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa)
initn: 659 init1: 372 opt: 706 Z-score: 679.9 bits: 134.8 E(85289): 3.9e-31
Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371)
10 20 30 40 50
pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA
.:. . . . :: : . . .:.... ..: :.::.::: .
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV
.: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...::::
XP_006 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT
:::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . .
XP_006 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------
.. : :: . .:.. :.. :::.::.:.. .: ::. :::. .
XP_006 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280
pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF
: :::.. :.: .: : . . : : :: .:.:: :::::..: :
XP_006 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL
.:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..:
XP_006 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
350 360 370 380 390
pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD
:: :.. . .. ::. . . : :
XP_006 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 659 init1: 372 opt: 706 Z-score: 679.9 bits: 134.8 E(85289): 3.9e-31
Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371)
10 20 30 40 50
pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA
.:. . . . :: : . . .:.... ..: :.::.::: .
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV
.: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...::::
NP_150 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT
:::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . .
NP_150 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------
.. : :: . .:.. :.. :::.::.:.. .: ::. :::. .
NP_150 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280
pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF
: :::.. :.: .: : . . : : :: .:.:: :::::..: :
NP_150 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL
.:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..:
NP_150 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
350 360 370 380 390
pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD
:: :.. . .. ::. . . : :
NP_150 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa)
initn: 659 init1: 372 opt: 706 Z-score: 679.6 bits: 134.9 E(85289): 4.1e-31
Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371)
10 20 30 40 50
pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA
.:. . . . :: : . . .:.... ..: :.::.::: .
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV
.: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...::::
NP_150 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT
:::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . .
NP_150 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------
.. : :: . .:.. :.. :::.::.:.. .: ::. :::. .
NP_150 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280
pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF
: :::.. :.: .: : . . : : :: .:.:: :::::..: :
NP_150 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL
.:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..:
NP_150 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
350 360 370 380 390
pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD
:: :.. . .. ::. . . : :
NP_150 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor (466 aa)
initn: 659 init1: 372 opt: 706 Z-score: 679.5 bits: 134.9 E(85289): 4.1e-31
Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371)
10 20 30 40 50
pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA
.:. . . . :: : . . .:.... ..: :.::.::: .
NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV
.: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...::::
NP_000 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT
:::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . .
NP_000 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------
.. : :: . .:.. :.. :::.::.:.. .: ::. :::. .
NP_000 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280
pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF
: :::.. :.: .: : . . : : :: .:.:: :::::..: :
NP_000 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL
.:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..:
NP_000 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
350 360 370 380 390
pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD
:: :.. . .. ::. . . : :
NP_000 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>NP_000861 (OMIM: 602164) 5-hydroxytryptamine receptor (388 aa)
initn: 589 init1: 254 opt: 705 Z-score: 679.4 bits: 134.6 E(85289): 4.2e-31
Smith-Waterman score: 705; 35.7% identity (63.7% similar) in 375 aa overlap (40-397:26-387)
10 20 30 40 50 60
pF1KE1 FLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV-T
.: ..: ..::.::..:. ..:. . :
NP_000 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKT
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 NYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA
::::.::: :::.... :.:::: .... .: .:. .: ::.::: .:::: :: :.
NP_000 NYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCIS
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 VDRYFAIT-SPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-----THQEAI
.:::.:: .:. :.. .: . ... :.. . :::::.. : ... .
NP_000 LDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKF
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 NCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHV
: .: : : :..:. :::. :.:.::.:...::..: :.. ::.. ..:. . : .
NP_000 NQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQ-RAGA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 QNLSQVEQ-DGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN
.. :. .. : .. : .: : :: ::: :::: : ::: :::..::: . :
NP_000 SSESRPQSADQHSTHRMRT-------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY
240 250 260 270 280
310 320 330 340 350
pF1KE1 LIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLC-----LRRSSLKAYGNGYS
. .:. . :.::.:::.::..: . .:: :: .:: :: :. . :
NP_000 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 S---NGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSL
. ::.: :: . . :. :.: .:. : :::
NP_000 TTTINGSTHVLRDA-VECGGQWESQCHP-PATSPLVAAQ---PSDT
350 360 370 380
pF1KE1 L
>>XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 659 init1: 372 opt: 706 Z-score: 679.4 bits: 134.9 E(85289): 4.2e-31
Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371)
10 20 30 40 50
pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA
.:. . . . :: : . . .:.... ..: :.::.::: .
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV
.: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...::::
XP_016 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT
:::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . .
XP_016 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------
.. : :: . .:.. :.. :::.::.:.. .: ::. :::. .
XP_016 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280
pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF
: :::.. :.: .: : . . : : :: .:.:: :::::..: :
XP_016 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL
.:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..:
XP_016 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
350 360 370 380 390
pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD
:: :.. . .. ::. . . : :
XP_016 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
413 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:05:27 2016 done: Sun Nov 6 17:05:28 2016
Total Scan time: 5.870 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]