Result of FASTA (omim) for
pFN21AE1880
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1880, 406 aa
1>>>pF1KE1880 406 - 406 aa - 406 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2422+/-0.000447; mu= 17.5323+/- 0.028
mean_var=84.6354+/-17.354, 0's: 0 Z-trim(111.7): 282 B-trim: 20 in 1/50
Lambda= 0.139411
statistics sampled from 20088 (20419) to 20088 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.239), width: 16
Scan time: 8.190
The best scores are: opt bits E(85289)
NP_005134 (OMIM: 140100,614081) haptoglobin isofor ( 406) 2795 572.5 6.3e-163
NP_001119574 (OMIM: 140100,614081) haptoglobin iso ( 347) 2188 450.4 3.2e-126
NP_001305067 (OMIM: 140100,614081) haptoglobin iso ( 347) 2178 448.4 1.3e-125
NP_066275 (OMIM: 140210) haptoglobin-related prote ( 348) 2006 413.8 3.3e-115
NP_001725 (OMIM: 120580,613783) complement C1s sub ( 688) 480 107.1 1.4e-22
XP_005253817 (OMIM: 120580,613783) PREDICTED: comp ( 688) 480 107.1 1.4e-22
NP_958850 (OMIM: 120580,613783) complement C1s sub ( 688) 480 107.1 1.4e-22
NP_006601 (OMIM: 605102,613791) mannan-binding lec ( 686) 453 101.7 5.8e-21
NP_001724 (OMIM: 216950,613785) complement C1r sub ( 705) 447 100.5 1.4e-20
XP_016875404 (OMIM: 216950,613785) PREDICTED: comp ( 719) 447 100.5 1.4e-20
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 399 90.6 6.8e-18
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 399 90.6 7.1e-18
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 399 90.6 7.8e-18
NP_062562 (OMIM: 227500,608446,613878) coagulation ( 444) 399 90.7 7.9e-18
NP_000122 (OMIM: 227500,608446,613878) coagulation ( 466) 399 90.7 8.2e-18
XP_011535776 (OMIM: 227500,608446,613878) PREDICTE ( 495) 399 90.7 8.6e-18
XP_006720026 (OMIM: 227500,608446,613878) PREDICTE ( 412) 394 89.6 1.5e-17
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 370 84.7 3.3e-16
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 362 83.1 1.1e-15
NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 360 82.8 1.9e-15
XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 360 82.8 1.9e-15
XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 360 82.9 2.1e-15
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 356 82.0 3.4e-15
XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 345 79.6 1e-14
XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 345 79.6 1e-14
NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 345 79.6 1e-14
XP_016862359 (OMIM: 257920,600521) PREDICTED: mann ( 668) 346 80.2 1.7e-14
NP_001870 (OMIM: 257920,600521) mannan-binding lec ( 699) 346 80.2 1.8e-14
XP_011511292 (OMIM: 257920,600521) PREDICTED: mann ( 706) 346 80.2 1.8e-14
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 334 77.6 6.5e-14
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 334 77.6 6.9e-14
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 334 77.6 7e-14
NP_057630 (OMIM: 608974) complement C1r subcompone ( 487) 331 77.0 1.1e-13
XP_016874886 (OMIM: 608974) PREDICTED: complement ( 504) 331 77.0 1.1e-13
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 317 74.0 5.1e-13
NP_001284569 (OMIM: 608974) complement C1r subcomp ( 445) 314 73.6 1.1e-12
XP_016874887 (OMIM: 608974) PREDICTED: complement ( 462) 314 73.6 1.1e-12
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 309 72.4 1.6e-12
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 307 72.3 3.8e-12
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 307 72.3 3.8e-12
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 307 72.3 3.8e-12
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 307 72.4 4.3e-12
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 307 72.4 4.4e-12
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 307 72.4 4.7e-12
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 307 72.4 4.7e-12
XP_016862361 (OMIM: 257920,600521) PREDICTED: mann ( 615) 294 69.7 2.3e-11
XP_016862358 (OMIM: 257920,600521) PREDICTED: mann ( 702) 294 69.7 2.5e-11
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 292 69.4 3.7e-11
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 292 69.4 3.7e-11
NP_001298186 (OMIM: 176930,188050,601367,613679,61 ( 606) 286 68.0 6.9e-11
>>NP_005134 (OMIM: 140100,614081) haptoglobin isoform 1 (406 aa)
initn: 2795 init1: 2795 opt: 2795 Z-score: 3046.0 bits: 572.5 E(85289): 6.3e-163
Smith-Waterman score: 2795; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406)
10 20 30 40 50 60
pF1KE1 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
310 320 330 340 350 360
370 380 390 400
pF1KE1 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
370 380 390 400
>>NP_001119574 (OMIM: 140100,614081) haptoglobin isoform (347 aa)
initn: 2188 init1: 2188 opt: 2188 Z-score: 2387.1 bits: 450.4 E(85289): 3.2e-126
Smith-Waterman score: 2237; 85.5% identity (85.5% similar) in 406 aa overlap (1-406:1-347)
10 20 30 40 50 60
pF1KE1 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
::::::::::::::::::::::::::::::::::::::::::
NP_001 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHG------------------
10 20 30 40
70 80 90 100 110 120
pF1KE1 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
:::::::::::::::::::
NP_001 -----------------------------------------YVEHSVRYQCKNYYKLRTE
50 60
130 140 150 160 170 180
pF1KE1 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE1 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE1 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE1 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
250 260 270 280 290 300
370 380 390 400
pF1KE1 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
310 320 330 340
>>NP_001305067 (OMIM: 140100,614081) haptoglobin isoform (347 aa)
initn: 2178 init1: 2178 opt: 2178 Z-score: 2376.2 bits: 448.4 E(85289): 1.3e-125
Smith-Waterman score: 2238; 85.5% identity (85.5% similar) in 406 aa overlap (1-406:1-347)
10 20 30 40 50 60
pF1KE1 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
::::::::::::::::::::::::::::
NP_001 EGDGVYTLNDKKQWINKAVGDKLPECEA--------------------------------
70 80
130 140 150 160 170 180
pF1KE1 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
:::::::::::::::::::::::::::::::::
NP_001 ---------------------------VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
90 100 110 120
190 200 210 220 230 240
pF1KE1 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE1 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE1 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
250 260 270 280 290 300
370 380 390 400
pF1KE1 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
310 320 330 340
>>NP_066275 (OMIM: 140210) haptoglobin-related protein p (348 aa)
initn: 2070 init1: 2006 opt: 2006 Z-score: 2189.2 bits: 413.8 E(85289): 3.3e-115
Smith-Waterman score: 2028; 78.4% identity (81.8% similar) in 407 aa overlap (1-406:1-348)
10 20 30 40 50
pF1KE1 MSALGAVIALLLWG-QLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLR
:: :::::.::::: ::::. ::::::::.:: :::::::.::::: ::::::::.::
NP_066 MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 TEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
:::::::::::::::::::::::::::::
NP_066 TEGDGVYTLNDKKQWINKAVGDKLPECEA-------------------------------
70 80
120 130 140 150 160 170
pF1KE1 EGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKM
::::::::::::::::::::::::::::::::
NP_066 ----------------------------VCGKPKNPANPVQRILGGHLDAKGSFPWQAKM
90 100 110 120
180 190 200 210 220 230
pF1KE1 VSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 VSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLH
130 140 150 160 170 180
240 250 260 270 280 290
pF1KE1 PNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYV
::: ::::::::::::: :::::::::::::.::::::::::::::.. :::.:::::::
NP_066 PNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYV
190 200 210 220 230 240
300 310 320 330 340 350
pF1KE1 MLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAF
::::::: .:: :::::: :. :.:::::::::::::::::.::::::::::::::::::
NP_066 MLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAF
250 260 270 280 290 300
360 370 380 390 400
pF1KE1 AVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
::::::::::::.:::::::::::::::::::::::: :::::::::
NP_066 AVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN
310 320 330 340
>>NP_001725 (OMIM: 120580,613783) complement C1s subcomp (688 aa)
initn: 405 init1: 191 opt: 480 Z-score: 526.6 bits: 107.1 E(85289): 1.4e-22
Smith-Waterman score: 610; 32.1% identity (59.1% similar) in 408 aa overlap (33-406:294-682)
10 20 30 40 50
pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPK---P-----PEIAHGYVEHSVRYQCKN
::: : : :. . :. : .
NP_001 KSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLD
270 280 290 300 310 320
60 70 80 90 100
pF1KE1 YYKLRTEGD-GVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS-------
... .:: :. .. . : .: ..:: .:. : : : : .: ::
NP_001 GFEV-VEGRVGATSFYSTCQSNGKWSNSKL-KCQPVD-CGIPESIENGKVEDPESTLFGS
330 340 350 360 370 380
110 120 130 140 150 160
pF1KE1 -VRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILG
.:: :.. :: ... : : : .. .:.:...: .::.: ::: :..: . :::.:
NP_001 VIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIG
390 400 410 420 430 440
170 180 190 200 210 220
pF1KE1 GHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLY
: .:::: : : .:..:::: :.::.: .. .. : . . . :
NP_001 GSDADIKNFPWQ---VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSR
450 460 470 480 490
230 240 250 260 270
pF1KE1 VGKKQLVEIEKVVLHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKD
..:.... :.: .::... . ::.:..::. :... : ::::: :.:
NP_001 LAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSD
500 510 520 530 540 550
280 290 300 310 320 330
pF1KE1 YAEV-GRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGV
: . : .: .:::::. . . .:: . :::: .: : :. : . .
NP_001 YNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADA
560 570 580 590 600
340 350 360 370 380
pF1KE1 QP-ILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGV
. ... . .::: : . :.: ::.:.::::.: .. : .::.:..:. .:.. ::.
NP_001 EAYVFTPNMICAGGEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGL
610 620 630 640 650 660
390 400
pF1KE1 YVKVTSIQDWVQKTIAEN
:..: . ::..::. ::
NP_001 YTRVKNYVDWIMKTMQENSTPRED
670 680
>>XP_005253817 (OMIM: 120580,613783) PREDICTED: compleme (688 aa)
initn: 405 init1: 191 opt: 480 Z-score: 526.6 bits: 107.1 E(85289): 1.4e-22
Smith-Waterman score: 610; 32.1% identity (59.1% similar) in 408 aa overlap (33-406:294-682)
10 20 30 40 50
pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPK---P-----PEIAHGYVEHSVRYQCKN
::: : : :. . :. : .
XP_005 KSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLD
270 280 290 300 310 320
60 70 80 90 100
pF1KE1 YYKLRTEGD-GVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS-------
... .:: :. .. . : .: ..:: .:. : : : : .: ::
XP_005 GFEV-VEGRVGATSFYSTCQSNGKWSNSKL-KCQPVD-CGIPESIENGKVEDPESTLFGS
330 340 350 360 370 380
110 120 130 140 150 160
pF1KE1 -VRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILG
.:: :.. :: ... : : : .. .:.:...: .::.: ::: :..: . :::.:
XP_005 VIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIG
390 400 410 420 430 440
170 180 190 200 210 220
pF1KE1 GHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLY
: .:::: : : .:..:::: :.::.: .. .. : . . . :
XP_005 GSDADIKNFPWQ---VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSR
450 460 470 480 490
230 240 250 260 270
pF1KE1 VGKKQLVEIEKVVLHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKD
..:.... :.: .::... . ::.:..::. :... : ::::: :.:
XP_005 LAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSD
500 510 520 530 540 550
280 290 300 310 320 330
pF1KE1 YAEV-GRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGV
: . : .: .:::::. . . .:: . :::: .: : :. : . .
XP_005 YNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADA
560 570 580 590 600
340 350 360 370 380
pF1KE1 QP-ILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGV
. ... . .::: : . :.: ::.:.::::.: .. : .::.:..:. .:.. ::.
XP_005 EAYVFTPNMICAGGEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGL
610 620 630 640 650 660
390 400
pF1KE1 YVKVTSIQDWVQKTIAEN
:..: . ::..::. ::
XP_005 YTRVKNYVDWIMKTMQENSTPRED
670 680
>>NP_958850 (OMIM: 120580,613783) complement C1s subcomp (688 aa)
initn: 405 init1: 191 opt: 480 Z-score: 526.6 bits: 107.1 E(85289): 1.4e-22
Smith-Waterman score: 610; 32.1% identity (59.1% similar) in 408 aa overlap (33-406:294-682)
10 20 30 40 50
pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPK---P-----PEIAHGYVEHSVRYQCKN
::: : : :. . :. : .
NP_958 KSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLD
270 280 290 300 310 320
60 70 80 90 100
pF1KE1 YYKLRTEGD-GVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS-------
... .:: :. .. . : .: ..:: .:. : : : : .: ::
NP_958 GFEV-VEGRVGATSFYSTCQSNGKWSNSKL-KCQPVD-CGIPESIENGKVEDPESTLFGS
330 340 350 360 370 380
110 120 130 140 150 160
pF1KE1 -VRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILG
.:: :.. :: ... : : : .. .:.:...: .::.: ::: :..: . :::.:
NP_958 VIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIG
390 400 410 420 430 440
170 180 190 200 210 220
pF1KE1 GHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLY
: .:::: : : .:..:::: :.::.: .. .. : . . . :
NP_958 GSDADIKNFPWQ---VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSR
450 460 470 480 490
230 240 250 260 270
pF1KE1 VGKKQLVEIEKVVLHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKD
..:.... :.: .::... . ::.:..::. :... : ::::: :.:
NP_958 LAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSD
500 510 520 530 540 550
280 290 300 310 320 330
pF1KE1 YAEV-GRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGV
: . : .: .:::::. . . .:: . :::: .: : :. : . .
NP_958 YNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADA
560 570 580 590 600
340 350 360 370 380
pF1KE1 QP-ILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGV
. ... . .::: : . :.: ::.:.::::.: .. : .::.:..:. .:.. ::.
NP_958 EAYVFTPNMICAGGEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGL
610 620 630 640 650 660
390 400
pF1KE1 YVKVTSIQDWVQKTIAEN
:..: . ::..::. ::
NP_958 YTRVKNYVDWIMKTMQENSTPRED
670 680
>>NP_006601 (OMIM: 605102,613791) mannan-binding lectin (686 aa)
initn: 439 init1: 121 opt: 453 Z-score: 497.3 bits: 101.7 E(85289): 5.8e-21
Smith-Waterman score: 538; 29.1% identity (58.1% similar) in 406 aa overlap (33-405:300-685)
10 20 30 40 50 60
pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEH-SVRYQCKNYYKLRTE
:: : .:.: ...: :. ... :
NP_006 KSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCE
270 280 290 300 310 320
70 80 90 100
pF1KE1 GDGVYTLNDK---KQW--INKAVG--DK-LPECEADDGCPKPPEIAHGYVEH--------
: :. . :.. . . : :. .: : : : : .. : ::.
NP_006 -TGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVD-CGPPDDLPSGRVEYITGPGVTT
330 340 350 360 370 380
110 120 130 140 150 160
pF1KE1 ---SVRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDK-LPECEAVCGKPKNPANPVQ
..:.:.. .: .... :: :. . . : .. :.: :: :: ::: ..
NP_006 YKAVIQYSCEETFYTMKVN-DGKYVCEADGFWTSSK-GEKSLPVCEPVCGLSARTTG--G
390 400 410 420 430 440
170 180 190 200 210
pF1KE1 RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDI-AP
:: ::. :.::::. ... . :....:. ..:.::.:. .. .....:.: ::
NP_006 RIYGGQKAKPGDFPWQVLILG--GTTAAGALLYDNWVLTAAHAVY-EQKHDASALDIRMG
450 460 470 480 490 500
220 230 240 250 260 270
pF1KE1 TLTLYVGKKQLVEIEKVVLHPNYSQ-----VDIGLIKLKQKVSVNERVMPICLPSKD---
:: . . : : .: .:.. ::.::::..:: .: . ::::: :.
NP_006 TLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAES
510 520 530 540 550 560
280 290 300 310 320 330
pF1KE1 YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQ
. .. .: .:::: . .. .: :: .:..:...: :: : : :
NP_006 FMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYE--------KPPYPRGS-
570 580 590 600 610
340 350 360 370 380
pF1KE1 PILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDK-SCAVA-EYGVY
.. . .:::. . .:.: ::.:.:.. : : . :.. ::.:. . .:. : .::::
NP_006 --VTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVY
620 630 640 650 660
390 400
pF1KE1 VKVTSIQDWVQKTIAEN
.:: . :... :..
NP_006 TKVINYIPWIENIISDF
670 680
>>NP_001724 (OMIM: 216950,613785) complement C1r subcomp (705 aa)
initn: 526 init1: 204 opt: 447 Z-score: 490.6 bits: 100.5 E(85289): 1.4e-20
Smith-Waterman score: 658; 31.3% identity (61.4% similar) in 422 aa overlap (33-405:309-703)
10 20 30 40 50
pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVR--YQ--------C
::.: . . . .... :: :
NP_001 SSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATC
280 290 300 310 320 330
60 70 80 90 100
pF1KE1 KNYYKLRTEGDGVY-----TLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS-
:. :.: ::. : . .: : ..: .:.:. : : .: .. .: ...
NP_001 KQGYQL-IEGNQVLHSFTAVCQDDGTW-HRA----MPRCKIKD-CGQPRNLPNGDFRYTT
340 350 360 370 380 390
110 120 130 140
pF1KE1 ----------VRYQCKN-YYKLRTEG------DGVYTLNNEKQWINKAVGDKLPECEAVC
..: :.. :::..:.. .:::: . . : :. :.:.:.: ::
NP_001 TMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVC
400 410 420 430 440 450
150 160 170 180 190 200
pF1KE1 GKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHS
::: ::.. :::.::. :.::::. ... :. :: :....:.::.:..:. ..
NP_001 GKPVNPVEQRQRIIGGQKAKMGNFPWQV-FTNIHGRGGGA-LLGDRWILTAAHTLYPKEH
460 470 480 490 500
210 220 230 240 250
pF1KE1 ENATAKDIAPTLTLYVGKKQLVE--------IEKVVLHPNYSQV-------DIGLIKLKQ
: :.. : .: ...:. .. : :..: .::.: : ::.:..:..
NP_001 E---AQSNA-SLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELEN
510 520 530 540 550 560
260 270 280 290 300 310
pF1KE1 KVSVNERVMPICLPSKD-YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY
.:... ..:::::..: . ..: .:::::.: . :.. :..: ::::. . :
NP_001 SVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE-KIAHDLRFVRLPVANPQACENWL
570 580 590 600 610 620
320 330 340 350 360 370
pF1KE1 EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATG
.:.. . ..... :::: . ..:.: ::.:..:::.: . : : :::
NP_001 RGKNRMD------------VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATG
630 640 650 660 670
380 390 400
pF1KE1 ILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
:.:. .:. . :: :.:: . ::..: . :
NP_001 IVSWGIGCSRG-YGFYTKVLNYVDWIKKEMEEED
680 690 700
>>XP_016875404 (OMIM: 216950,613785) PREDICTED: compleme (719 aa)
initn: 526 init1: 204 opt: 447 Z-score: 490.5 bits: 100.5 E(85289): 1.4e-20
Smith-Waterman score: 658; 31.3% identity (61.4% similar) in 422 aa overlap (33-405:323-717)
10 20 30 40 50
pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVR--YQ--------C
::.: . . . .... :: :
XP_016 SSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATC
300 310 320 330 340 350
60 70 80 90 100
pF1KE1 KNYYKLRTEGDGVY-----TLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS-
:. :.: ::. : . .: : ..: .:.:. : : .: .. .: ...
XP_016 KQGYQL-IEGNQVLHSFTAVCQDDGTW-HRA----MPRCKIKD-CGQPRNLPNGDFRYTT
360 370 380 390 400
110 120 130 140
pF1KE1 ----------VRYQCKN-YYKLRTEG------DGVYTLNNEKQWINKAVGDKLPECEAVC
..: :.. :::..:.. .:::: . . : :. :.:.:.: ::
XP_016 TMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVC
410 420 430 440 450 460
150 160 170 180 190 200
pF1KE1 GKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHS
::: ::.. :::.::. :.::::. ... :. :: :....:.::.:..:. ..
XP_016 GKPVNPVEQRQRIIGGQKAKMGNFPWQV-FTNIHGRGGGA-LLGDRWILTAAHTLYPKEH
470 480 490 500 510 520
210 220 230 240 250
pF1KE1 ENATAKDIAPTLTLYVGKKQLVE--------IEKVVLHPNYSQV-------DIGLIKLKQ
: :.. : .: ...:. .. : :..: .::.: : ::.:..:..
XP_016 E---AQSNA-SLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELEN
530 540 550 560 570
260 270 280 290 300 310
pF1KE1 KVSVNERVMPICLPSKD-YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY
.:... ..:::::..: . ..: .:::::.: . :.. :..: ::::. . :
XP_016 SVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE-KIAHDLRFVRLPVANPQACENWL
580 590 600 610 620 630
320 330 340 350 360 370
pF1KE1 EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATG
.:.. . ..... :::: . ..:.: ::.:..:::.: . : : :::
XP_016 RGKNRMD------------VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATG
640 650 660 670 680
380 390 400
pF1KE1 ILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
:.:. .:. . :: :.:: . ::..: . :
XP_016 IVSWGIGCSRG-YGFYTKVLNYVDWIKKEMEEED
690 700 710
406 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:06:28 2016 done: Sun Nov 6 21:06:29 2016
Total Scan time: 8.190 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]