Result of FASTA (omim) for
pFN21AE1868
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1868, 389 aa
1>>>pF1KE1868 389 - 389 aa - 389 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6796+/-0.000262; mu= 16.8096+/- 0.017
mean_var=92.7988+/-18.311, 0's: 0 Z-trim(122.1): 60 B-trim: 221 in 2/52
Lambda= 0.133138
statistics sampled from 39607 (39669) to 39607 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.465), width: 16
Scan time: 9.780
The best scores are: opt bits E(85289)
NP_003385 (OMIM: 225300,601906,617073) protein Wnt ( 389) 2794 546.1 5.3e-155
XP_016875408 (OMIM: 225300,601906,617073) PREDICTE ( 267) 1958 385.4 8.7e-107
XP_011537024 (OMIM: 225300,601906,617073) PREDICTE ( 267) 1958 385.4 8.7e-107
NP_079492 (OMIM: 150400,224750,257980,606268) prot ( 417) 1282 255.7 1.5e-67
XP_011510231 (OMIM: 150400,224750,257980,606268) P ( 385) 1254 250.3 5.8e-66
XP_011537026 (OMIM: 225300,601906,617073) PREDICTE ( 164) 956 192.7 5.2e-49
NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 740 151.5 2.9e-36
XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt ( 446) 740 151.6 3.4e-36
NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 736 150.7 4.9e-36
NP_006513 (OMIM: 604663) protein Wnt-6 precursor [ ( 365) 723 148.3 2.8e-35
XP_011532393 (OMIM: 228930,276820,601570) PREDICTE ( 282) 713 146.2 8.8e-35
NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 713 146.3 1e-34
NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 708 145.4 2e-34
XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt ( 353) 708 145.4 2e-34
XP_011539900 (OMIM: 158330,603490,611812) PREDICTE ( 296) 685 140.9 3.8e-33
NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 685 140.9 4.3e-33
XP_011539899 (OMIM: 158330,603490,611812) PREDICTE ( 373) 685 141.0 4.5e-33
NP_001278809 (OMIM: 601968) protein Wnt-2b isoform ( 299) 683 140.5 5e-33
NP_004176 (OMIM: 601968) protein Wnt-2b isoform WN ( 372) 683 140.6 5.9e-33
NP_078613 (OMIM: 601968) protein Wnt-2b isoform WN ( 391) 683 140.6 6.1e-33
NP_003382 (OMIM: 147870) protein Wnt-2 precursor [ ( 360) 672 138.5 2.5e-32
NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 669 137.9 3.8e-32
XP_011532389 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32
XP_011532390 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32
XP_006713387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32
XP_016862617 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32
XP_011532388 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32
XP_011532387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32
XP_011532391 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32
NP_003383 (OMIM: 164975,180700) protein Wnt-5a iso ( 380) 669 137.9 3.9e-32
XP_016862616 (OMIM: 164975,180700) PREDICTED: prot ( 394) 669 137.9 4e-32
NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 661 136.3 1.1e-31
NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 661 136.3 1.1e-31
XP_011543543 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 643 132.8 9e-31
XP_016873730 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 643 132.8 9e-31
XP_005274288 (OMIM: 603699) PREDICTED: protein Wnt ( 354) 643 132.9 1.2e-30
NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 643 132.9 1.2e-30
XP_011543542 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 643 132.9 1.2e-30
XP_011543540 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 643 132.9 1.2e-30
XP_011543541 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 643 132.9 1.2e-30
NP_057171 (OMIM: 606267) protein Wnt-16 isoform 2 ( 355) 623 129.0 1.7e-29
NP_476509 (OMIM: 606267) protein Wnt-16 isoform 1 ( 365) 623 129.1 1.7e-29
XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt ( 295) 557 116.3 9.6e-26
NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 557 116.4 1.1e-25
NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 520 109.3 1.5e-23
XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt ( 363) 520 109.3 1.5e-23
XP_016873732 (OMIM: 603699) PREDICTED: protein Wnt ( 185) 509 106.9 4e-23
XP_016873731 (OMIM: 603699) PREDICTED: protein Wnt ( 185) 509 106.9 4e-23
NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 455 96.8 8.6e-20
XP_011510232 (OMIM: 150400,224750,257980,606268) P ( 299) 446 95.0 2.5e-19
>>NP_003385 (OMIM: 225300,601906,617073) protein Wnt-10b (389 aa)
initn: 2794 init1: 2794 opt: 2794 Z-score: 2903.7 bits: 546.1 E(85289): 5.3e-155
Smith-Waterman score: 2794; 100.0% identity (100.0% similar) in 389 aa overlap (1-389:1-389)
10 20 30 40 50 60
pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTR
310 320 330 340 350 360
370 380
pF1KE1 VERCHCRFHWCCYVLCDECKVTEWVNVCK
:::::::::::::::::::::::::::::
NP_003 VERCHCRFHWCCYVLCDECKVTEWVNVCK
370 380
>>XP_016875408 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa)
initn: 1958 init1: 1958 opt: 1958 Z-score: 2038.1 bits: 385.4 E(85289): 8.7e-107
Smith-Waterman score: 1958; 100.0% identity (100.0% similar) in 267 aa overlap (123-389:1-267)
100 110 120 130 140 150
pF1KE1 NCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSG
::::::::::::::::::::::::::::::
XP_016 MLAAGVMHAVATACSLGKLVSCGCGWKGSG
10 20 30
160 170 180 190 200 210
pF1KE1 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE1 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE1 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR
160 170 180 190 200 210
340 350 360 370 380
pF1KE1 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
220 230 240 250 260
>>XP_011537024 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa)
initn: 1958 init1: 1958 opt: 1958 Z-score: 2038.1 bits: 385.4 E(85289): 8.7e-107
Smith-Waterman score: 1958; 100.0% identity (100.0% similar) in 267 aa overlap (123-389:1-267)
100 110 120 130 140 150
pF1KE1 NCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSG
::::::::::::::::::::::::::::::
XP_011 MLAAGVMHAVATACSLGKLVSCGCGWKGSG
10 20 30
160 170 180 190 200 210
pF1KE1 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE1 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE1 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR
160 170 180 190 200 210
340 350 360 370 380
pF1KE1 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
220 230 240 250 260
>>NP_079492 (OMIM: 150400,224750,257980,606268) protein (417 aa)
initn: 1791 init1: 664 opt: 1282 Z-score: 1333.8 bits: 255.7 E(85289): 1.5e-67
Smith-Waterman score: 1776; 60.4% identity (80.9% similar) in 404 aa overlap (5-389:14-417)
10 20 30 40
pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALS----NEILGLKLPGEPPLTANTV
:.:.: :. . :.:: : . :. :.:: :.:: :: :.::::
NP_079 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 CLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHS
:::: :::.::. .:.:.:::.:::.::..::.::::::.::::::::.:: ...:..:
NP_079 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 AILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKL--LQLQ
:..::::::::.... ::::.:::..::.:::: .::: . :... .: :: :::.
NP_079 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 ALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQA
::.:::.. :..: . ::: ::.::::::. :: :::.::.::::::: :::.:
NP_079 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE1 RMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFI
:::.::::::::.: ::..:::::::::::::.::::...::::.::: :: :. :: .:
NP_079 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI
250 260 270 280 290 300
290 300 310 320 330
pF1KE1 DTHNRNSGAFQPRLR-----------PRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGR
::::.: ..: ::: .. .:::::::::::::.: . : :: ::
NP_079 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR
310 320 330 340 350 360
340 350 360 370 380
pF1KE1 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
:::.: :::::.:::::::.::::: :::::::::::.:.:.::..::::.:::
NP_079 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
370 380 390 400 410
>>XP_011510231 (OMIM: 150400,224750,257980,606268) PREDI (385 aa)
initn: 1784 init1: 664 opt: 1254 Z-score: 1305.2 bits: 250.3 E(85289): 5.8e-66
Smith-Waterman score: 1748; 62.2% identity (82.4% similar) in 381 aa overlap (24-389:5-385)
10 20 30 40 50 60
pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG
::. :.:: :.:: :: :.:::::::: :::.::.
XP_011 MTPPSRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQME
10 20 30 40
70 80 90 100 110 120
pF1KE1 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS
.:.:.:::.:::.::..::.::::::.::::::::.:: ...:..: :..::::::::.
XP_011 VCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFA
50 60 70 80 90 100
130 140 150 160 170
pF1KE1 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKL--LQLQALSRGKSFPHSLP
... ::::.:::..::.:::: .::: . :... .: :: :::.::.:::.. :..:
XP_011 YAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 SPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQV
. ::: ::.::::::. :: :::.::.::::::: :::.::::.::::::::.
XP_011 EHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQA
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 VTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPR
: ::..:::::::::::::.::::...::::.::: :: :. :: .: ::::.: ..:
XP_011 VMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNGGQLEPG
230 240 250 260 270 280
300 310 320 330 340
pF1KE1 LR-----------PRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCG
::: .. .:::::::::::::.: . : :: :: :::.: ::::
XP_011 PAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCG
290 300 310 320 330 340
350 360 370 380
pF1KE1 SLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
:.:::::::.::::: :::::::::::.:.:.::..::::.:::
XP_011 SMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
350 360 370 380
>>XP_011537026 (OMIM: 225300,601906,617073) PREDICTED: p (164 aa)
initn: 976 init1: 956 opt: 956 Z-score: 1000.9 bits: 192.7 E(85289): 5.2e-49
Smith-Waterman score: 956; 99.3% identity (99.3% similar) in 143 aa overlap (1-143:1-143)
10 20 30 40 50 60
pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSP
::::::::::::::::::::: :
XP_011 FSMLAAGVMHAVATACSLGKLGSSPGHPGTNANPQQQGGAPGGN
130 140 150 160
>>NP_149122 (OMIM: 606359) protein Wnt-3a precursor [Hom (352 aa)
initn: 973 init1: 380 opt: 740 Z-score: 772.1 bits: 151.5 E(85289): 2.9e-36
Smith-Waterman score: 947; 38.4% identity (61.6% similar) in 385 aa overlap (19-389:7-352)
10 20 30 40 50
pF1KE1 MLEEPRPRPPPSGLAGLLFLALCS--RALSNEILGLKLPGEPPLTA----NTVCLTLSGL
:: ::: .::.. . .: : .. .: .. ::
NP_149 MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGL
10 20 30 40
60 70 80 90 100 110
pF1KE1 SKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGF
.:: .: .. :. .:..:...:::::.: .::::.... . : . .: ..
NP_149 VPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDS--LAIFGPVLDKAT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 RESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFP
::::: .. .::: ::. .:. : . :::. . .:
NP_149 RESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQG----------------------
110 120 130 140
180 190 200 210 220 230
pF1KE1 HSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRV
::: : :.::::..:..:: ::.: :.:: : .. : :::..
NP_149 ----SPGKG----------WKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEA
150 160 170 180 190
240 250 260 270 280 290
pF1KE1 GRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRA--IFIDTHNRNS
:::... ... :::::: ::::. :::: . :.:::.: :... : . .. : :.:
NP_149 GRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKH-RES
200 210 220 230 240
300 310 320 330 340
pF1KE1 GAFQPRLRPR----RLSGE--LVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGS
.. :::: .. : :::.: ::.::: .: :: ::: :.:: .:. .:::
NP_149 RGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDL
250 260 270 280 290 300
350 360 370 380
pF1KE1 LCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
::::::::. . : :.:.: ::::::: :.:: . :..::
NP_149 LCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
310 320 330 340 350
>>XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt-3a (446 aa)
initn: 973 init1: 380 opt: 740 Z-score: 770.7 bits: 151.6 E(85289): 3.4e-36
Smith-Waterman score: 947; 38.4% identity (61.6% similar) in 385 aa overlap (19-389:7-352)
10 20 30 40 50
pF1KE1 MLEEPRPRPPPSGLAGLLFLALCS--RALSNEILGLKLPGEPPLTA----NTVCLTLSGL
:: ::: .::.. . .: : .. .: .. ::
XP_011 MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGL
10 20 30 40
60 70 80 90 100 110
pF1KE1 SKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGF
.:: .: .. :. .:..:...:::::.: .::::.... . : . .: ..
XP_011 VPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDS--LAIFGPVLDKAT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 RESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFP
::::: .. .::: ::. .:. : . :::. . .:
XP_011 RESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQG----------------------
110 120 130 140
180 190 200 210 220 230
pF1KE1 HSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRV
::: : :.::::..:..:: ::.: :.:: : .. : :::..
XP_011 ----SPGKG----------WKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEA
150 160 170 180 190
240 250 260 270 280 290
pF1KE1 GRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRA--IFIDTHNRNS
:::... ... :::::: ::::. :::: . :.:::.: :... : . .. : :.:
XP_011 GRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKH-RES
200 210 220 230 240
300 310 320 330 340
pF1KE1 GAFQPRLRPR----RLSGE--LVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGS
.. :::: .. : :::.: ::.::: .: :: ::: :.:: .:. .:::
XP_011 RGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDL
250 260 270 280 290 300
350 360 370 380
pF1KE1 LCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
::::::::. . : :.:.: ::::::: :.:: . :..::
XP_011 LCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCKPCHSWATGREGRRRWST
310 320 330 340 350 360
XP_011 LGCGPRDGCLRTGHSGPCRSLAWIWSPGSQGHDLLEQLPRSGGLGQCSSLQNWTAVSGCL
370 380 390 400 410 420
>>NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt-3 p (355 aa)
initn: 953 init1: 391 opt: 736 Z-score: 767.9 bits: 150.7 E(85289): 4.9e-36
Smith-Waterman score: 923; 38.8% identity (60.4% similar) in 374 aa overlap (24-389:28-355)
10 20 30 40 50
pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSK
: ::... .: : :: .: .. ::
NP_110 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSL---GSQPL----LCGSIPGLVP
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 RQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRE
.:: .: .. :. .:......:::::.: .::::.... . : . .: .. ::
NP_110 KQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDS--LAIFGPVLDKATRE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHS
::: .. .::: ::. .:. : . ::: . .:
NP_110 SAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKG------------------------
120 130 140
180 190 200 210 220 230
pF1KE1 LPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGR
: :: : :.::::..: ::: ::.: :.:: : .. : :::..::
NP_110 -P-PGEG----------WKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGR
150 160 170 180 190
240 250 260 270 280 290
pF1KE1 QVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRA--IFIDTHNRNSGA
.. .... :::::: ::::. :::: : :.:::.: :... : . .. : :.: .
NP_110 TTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKH-RESRG
200 210 220 230 240 250
300 310 320 330 340
pF1KE1 FQPRLRPRR------LSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLC
. :: . .:::.:.::.::: .: :: ::: :.:: ::. .::: ::
NP_110 WVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLC
260 270 280 290 300 310
350 360 370 380
pF1KE1 CGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
::::::. . : :.::: ::::::: :.:: :..::
NP_110 CGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
320 330 340 350
>>NP_006513 (OMIM: 604663) protein Wnt-6 precursor [Homo (365 aa)
initn: 1014 init1: 326 opt: 723 Z-score: 754.3 bits: 148.3 E(85289): 2.8e-35
Smith-Waterman score: 997; 42.6% identity (63.5% similar) in 392 aa overlap (9-388:3-364)
10 20 30 40 50
pF1KE1 MLEEPRPRPP-PSGLAGLLFLALCSRALSNEILGLKLPGEPPLTAN--TVCLTLSGLSKR
:: :: :. ::.: :: .. :: ::. . ..: :. :
NP_006 MLPPLPSRLGLLLLLLLCP----AHVGGLWWAVGSPLVMDPTSICRKARRLAGR
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 QLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGG-GRLPHHSAILKRGFRE
: :: .:.:.: .: ...:.::: :.: .:::::. . :: ::.. .::
NP_006 QAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGR------ILQQDIRE
60 70 80 90 100
120 130 140 150 160 170
pF1KE1 SAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHS
.:: :.. :::. :::. :::.:.:..::: . : :: : ...: .
NP_006 TAFVFAITAAGASHAVTQACSMGELLQCGC------QAPRGRAP-------PRPSGLPGT
110 120 130 140 150
180 190 200 210 220 230
pF1KE1 LPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREA-PR-DIQARMRIHNNRV
:.: :: . :: . .::::::. :.:::.. :: :.:.:. : ::.: ...:::..
NP_006 -PGP-PGPAGSPEGSAAWEWGGCGDDVDFGDEKSRLFMDARHKRGRGDIRALVQLHNNEA
160 170 180 190 200
240 250 260 270 280 290
pF1KE1 GRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSG-
:: .: . . .::::: :::: ..:::. : :: ::: : ::. : . . :.:
NP_006 GRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV--MGTNDGK
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE1 AFQPRLRPRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGR
:. : .: . : .:.: ::::: . :::::::::::... :.:: :::::
NP_006 ALLPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGR
270 280 290 300 310 320
360 370 380
pF1KE1 GHNVLRQTRV---ERCHCRFHWCCYVLCDECKVTEWVNVCK
:: :: : : : ::::::: : : .:.: . ...:
NP_006 GH---RQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLCL
330 340 350 360
389 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:51:51 2016 done: Sun Nov 6 14:51:52 2016
Total Scan time: 9.780 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]