Result of FASTA (omim) for
pFN21AE1752
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1752, 257 aa
1>>>pF1KE1752 257 - 257 aa - 257 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3999+/-0.000327; mu= 13.8796+/- 0.020
mean_var=70.3096+/-14.388, 0's: 0 Z-trim(116.1): 298 B-trim: 89 in 2/49
Lambda= 0.152956
statistics sampled from 26737 (27052) to 26737 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.317), width: 16
Scan time: 6.230
The best scores are: opt bits E(85289)
NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 1735 391.7 6.9e-109
NP_001245280 (OMIM: 600311) granzyme M isoform 2 [ ( 218) 1486 336.7 2.1e-92
NP_001919 (OMIM: 134350,613912) complement factor ( 253) 644 150.9 2e-36
NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 632 148.3 1.3e-35
NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 571 134.8 1.5e-31
NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 540 128.0 1.7e-29
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 541 128.3 2.3e-29
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 529 125.6 1.1e-28
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 529 125.7 1.4e-28
NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 505 120.3 3.4e-27
NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 504 120.0 4e-27
NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 504 120.0 4e-27
NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 504 120.0 4.2e-27
NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 504 120.1 4.4e-27
NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 503 119.8 4.6e-27
NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 501 119.4 6e-27
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 499 119.1 1.3e-26
NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 496 118.3 1.4e-26
NP_059979 (OMIM: 610601) kallikrein-15 isoform 4 p ( 256) 496 118.3 1.4e-26
XP_006723328 (OMIM: 610601) PREDICTED: kallikrein- ( 256) 496 118.3 1.4e-26
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 499 119.1 1.4e-26
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 499 119.1 1.4e-26
NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 496 118.6 4.1e-26
NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 496 118.6 4.4e-26
NP_001264010 (OMIM: 610601) kallikrein-15 isoform ( 255) 488 116.5 4.7e-26
XP_011525387 (OMIM: 610601) PREDICTED: kallikrein- ( 255) 488 116.5 4.7e-26
XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 484 115.6 9.1e-26
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 481 115.0 1.4e-25
NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 480 114.8 1.7e-25
NP_001962 (OMIM: 130120) chymotrypsin-like elastas ( 258) 478 114.3 2.2e-25
NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 478 114.3 2.3e-25
NP_000292 (OMIM: 173350,217090) plasminogen isofor ( 810) 480 115.0 4.2e-25
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 472 113.0 6.3e-25
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 476 114.1 7.6e-25
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 476 114.2 7.7e-25
NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 469 112.3 8.9e-25
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 468 112.2 1.4e-24
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 468 112.2 1.6e-24
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 468 112.3 1.7e-24
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 468 112.3 1.7e-24
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 468 112.3 1.8e-24
NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 464 111.2 2.1e-24
NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 464 111.2 2.1e-24
XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 464 111.2 2.1e-24
XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 464 111.2 2.1e-24
NP_001070960 (OMIM: 605643) kallikrein-5 prepropro ( 293) 464 111.2 2.1e-24
NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 464 111.2 2.1e-24
NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 464 111.3 2.7e-24
NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 464 111.3 2.8e-24
NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 464 111.3 2.9e-24
>>NP_005308 (OMIM: 600311) granzyme M isoform 1 prepropr (257 aa)
initn: 1735 init1: 1735 opt: 1735 Z-score: 2075.8 bits: 391.7 E(85289): 6.9e-109
Smith-Waterman score: 1735; 100.0% identity (100.0% similar) in 257 aa overlap (1-257:1-257)
10 20 30 40 50 60
pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT
190 200 210 220 230 240
250
pF1KE1 AVAPYVSWIRKVTGRSA
:::::::::::::::::
NP_005 AVAPYVSWIRKVTGRSA
250
>>NP_001245280 (OMIM: 600311) granzyme M isoform 2 [Homo (218 aa)
initn: 1486 init1: 1486 opt: 1486 Z-score: 1779.9 bits: 336.7 E(85289): 2.1e-92
Smith-Waterman score: 1486; 100.0% identity (100.0% similar) in 218 aa overlap (40-257:1-218)
10 20 30 40 50 60
pF1KE1 VLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLA
::::::::::::::::::::::::::::::
NP_001 MASLQRNGSHLCGGVLVHPKWVLTAAHCLA
10 20 30
70 80 90 100 110 120
pF1KE1 QRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 LALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 MVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWI
160 170 180 190 200 210
250
pF1KE1 RKVTGRSA
::::::::
NP_001 RKVTGRSA
>>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa)
initn: 513 init1: 237 opt: 644 Z-score: 774.8 bits: 150.9 E(85289): 2e-36
Smith-Waterman score: 644; 42.4% identity (68.8% similar) in 250 aa overlap (7-252:8-251)
10 20 30 40 50
pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK
..::: ::: . .. .:.::::. :.::::::.: ::.:::::::: .
NP_001 MHSWERLAVLVL-LGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 WVLTAAHCLAQRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALL
:::.::::: . ......:: :.:..: . . . :. :: .: ....:: ::
NP_001 WVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDHDLLLL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 QLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRM
::. :. . ..::: . :: :: :..::::.....:: :... : :::
NP_001 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRAT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 CNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFK
:: .:... ..: .. .:. :::::::::::: :: ::.. .:::: . :
NP_001 CNRRTHHDGAITERLMCAESNRRDS--CKGDSGGPLVCGG--VLEGVVTSGSRVCGNRKK
180 190 200 210 220 230
240 250
pF1KE1 PPVATAVAPYVSWIRKVTGRSA
: . : :: :..:: .:
NP_001 PGIYTRVASYAAWIDSVLA
240 250
>>NP_001304264 (OMIM: 134350,613912) complement factor D (260 aa)
initn: 505 init1: 229 opt: 632 Z-score: 760.3 bits: 148.3 E(85289): 1.3e-35
Smith-Waterman score: 632; 43.5% identity (69.8% similar) in 232 aa overlap (25-252:32-258)
10 20 30 40 50
pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGV
.:.::::. :.::::::.: ::.::::::
NP_001 HSWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LVHPKWVLTAAHCLAQRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALEN
:: .:::.::::: . ......:: :.:..: . . . :. :: .: ....
NP_001 LVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 DLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQV
:: ::::. :. . ..::: . :: :: :..::::.....:: :... : :
NP_001 DLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 LDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVC
:: :: .:... ..: .. .:. :::::::::::: : :: ::.. .::::
NP_001 LDRATCNRRTHHDGAITERLMCAESNRRDS--CKGDSGGPLVCG-G-VLEGVVTSGSRVC
190 200 210 220 230
240 250
pF1KE1 TDIFKPPVATAVAPYVSWIRKVTGRSA
. :: . : :: :..:: .:
NP_001 GNRKKPGIYTRVASYAAWIDSVLA
240 250 260
>>NP_002095 (OMIM: 600784) granzyme K precursor [Homo sa (264 aa)
initn: 446 init1: 272 opt: 571 Z-score: 687.5 bits: 134.8 E(85289): 1.5e-31
Smith-Waterman score: 571; 40.2% identity (66.9% similar) in 254 aa overlap (7-250:8-255)
10 20 30 40 50
pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK
::. : .:: . :. .::::.:: :::::.:::.: .: :.:::::. :.
NP_002 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 WVLTAAHCLAQ--RMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPALENDLAL
:::::::: . . . .::: :.: .. :..:: : : : ::. :
NP_002 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQ-SNDIML
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDT
..:. .: .. .. : . :: .. .::.:...::: : . : : .:::. . ::.
NP_002 VKLQTAAKLNKHVKMLHIRSKTSL-RSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 RMCNNSRFWNGS--LSPSMVCLAADSKDQAP-CKGDSGGPLVCGKGRVLAGVLSFSSRVC
..::.. ..::. .. .::: :.:.: : :::::::::.: :: :. ...: ... :
NP_002 KLCNSQSYYNGDPFITKDMVC-AGDAKGQKDSCKGDSGGPLIC-KG-VFHAIVS-GGHEC
180 190 200 210 220 230
240 250
pF1KE1 TDIFKPPVATAVAP-YVSWIRKVTGRSA
:: . : .. : .::.
NP_002 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN
240 250 260
>>NP_004908 (OMIM: 204700,603767) kallikrein-4 isoform 1 (254 aa)
initn: 417 init1: 235 opt: 540 Z-score: 650.7 bits: 128.0 E(85289): 1.7e-29
Smith-Waterman score: 540; 38.8% identity (69.4% similar) in 255 aa overlap (9-256:15-254)
10 20 30 40 50
pF1KE1 MEACVSSLLVLAL-GALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGG
:.:.. :.: :: .:::.:.. :::.:..:.: .. .:.:
NP_004 MATAGNPWGWFLGYLILGVAGSLVSGSC--SQIINGEDCSPHSQPWQAALVMENELFCSG
10 20 30 40 50
60 70 80 90 100
pF1KE1 VLVHPKWVLTAAHCLAQRMAQLRLVLGLHTLDS---PGLTFHIKAA--IQHPRYKPVPAL
:::::.:::.::::. . .. . ::::.:.. :: . ..:. ..::.:. : :
NP_004 VLVHPQWVLSAAHCFQNSYT---IGLGLHSLEADQEPG-SQMVEASLSVRHPEYNR-PLL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 ENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDL
::: :..:: .:. : ::: ... : : .::. : ..:::: .::. ::. ...
NP_004 ANDLMLIKLDESVSESDTIRSISIAS--QCPTAGNSCLVSGWGLL-ANGRMPTVLQCVNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 QVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAP-CKGDSGGPLVCGKGRVLAGVLSFSS
.:.. ..: :.... ::: : :. ..:: :.:::::::.:. : : :..::..
NP_004 SVVSEEVC--SKLYDPLYHPSMFC-AGGGQDQKDSCNGDSGGPLICN-GY-LQGLVSFGK
180 190 200 210 220
230 240 250
pF1KE1 RVCTDIFKPPVATAVAPYVSWIRKVTGRSA
: .. : : : . .. ::.:.. :
NP_004 APCGQVGVPGVYTNLCKFTEWIEKTVQAS
230 240 250
>>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa)
initn: 502 init1: 280 opt: 541 Z-score: 648.2 bits: 128.3 E(85289): 2.3e-29
Smith-Waterman score: 541; 34.8% identity (65.6% similar) in 256 aa overlap (2-251:192-445)
10 20 30
pF1KE1 MEACVSSLLV-LALGALSVGSSFGTQIIGGR
:.:.:. .: : : . .....:.::
NP_001 EGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGN
170 180 190 200 210 220
40 50 60 70 80
pF1KE1 EVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRM--AQLRLVLGLHTL-DSP
. . :..:::: .: ::::: .. : :..:::::. . . . . .:: .: :.:
NP_001 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP
230 240 250 260 270 280
90 100 110 120 130 140
pF1KE1 GLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSM
. . .. . : .::: : ::.::..: : . .. :.:. ::.... : :
NP_001 APSHLVEKIVYHSKYKP-KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT
290 300 310 320 330 340
150 160 170 180 190 200
pF1KE1 AGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDS
.::: :..:: : :: . . ......::. ..: .::::.: . . :.:::
NP_001 SGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDS
350 360 370 380 390 400
210 220 230 240 250
pF1KE1 GGPLVCGKGRV--LAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA
:::::: . :. :.:. ::. :... :: : : :. ...::..
NP_001 GGPLVCQERRLWKLVGATSFGIG-CAEVNKPGVYTRVTSFLDWIHEQMERDLKT
410 420 430 440 450
>>NP_115780 (OMIM: 605511) transmembrane protease serine (327 aa)
initn: 462 init1: 160 opt: 529 Z-score: 636.0 bits: 125.6 E(85289): 1.1e-28
Smith-Waterman score: 529; 34.6% identity (65.4% similar) in 257 aa overlap (2-251:65-319)
10 20 30
pF1KE1 MEACVSSLLV-LALGALSVGSSFGTQIIGGR
:.:.:. .: : : . .....:.::
NP_115 EGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGN
40 50 60 70 80 90
40 50 60 70 80
pF1KE1 EVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRM--AQLRLVLGLHTL-DSP
. . :..:::: .: ::::: .. : :..:::::. . . . . .:: .: :.:
NP_115 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP
100 110 120 130 140 150
90 100 110 120 130 140
pF1KE1 GLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSM
. . .. . : .::: : ::.::..: : . .. :.:. ::.... : :
NP_115 APSHLVEKIVYHSKYKP-KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT
160 170 180 190 200 210
150 160 170 180 190 200
pF1KE1 AGWGLTHQG-GRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGD
.::: :..: : : :: . . ......::. ..: .::::.: . . :.::
NP_115 SGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGD
220 230 240 250 260 270
210 220 230 240 250
pF1KE1 SGGPLVCGKGRV--LAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA
::::::: . :. :.:. ::. :... :: : : :. ...::..
NP_115 SGGPLVCQERRLWKLVGATSFGIG-CAEVNKPGVYTRVTSFLDWIHEQMERDLKT
280 290 300 310 320
>>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa)
initn: 462 init1: 160 opt: 529 Z-score: 633.9 bits: 125.7 E(85289): 1.4e-28
Smith-Waterman score: 529; 34.6% identity (65.4% similar) in 257 aa overlap (2-251:192-446)
10 20 30
pF1KE1 MEACVSSLLV-LALGALSVGSSFGTQIIGGR
:.:.:. .: : : . .....:.::
NP_076 EGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGN
170 180 190 200 210 220
40 50 60 70 80
pF1KE1 EVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRM--AQLRLVLGLHTL-DSP
. . :..:::: .: ::::: .. : :..:::::. . . . . .:: .: :.:
NP_076 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP
230 240 250 260 270 280
90 100 110 120 130 140
pF1KE1 GLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSM
. . .. . : .::: : ::.::..: : . .. :.:. ::.... : :
NP_076 APSHLVEKIVYHSKYKP-KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT
290 300 310 320 330 340
150 160 170 180 190 200
pF1KE1 AGWGLTHQG-GRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGD
.::: :..: : : :: . . ......::. ..: .::::.: . . :.::
NP_076 SGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGD
350 360 370 380 390 400
210 220 230 240 250
pF1KE1 SGGPLVCGKGRV--LAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA
::::::: . :. :.:. ::. :... :: : : :. ...::..
NP_076 SGGPLVCQERRLWKLVGATSFGIG-CAEVNKPGVYTRVTSFLDWIHEQMERDLKT
410 420 430 440 450
>>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa)
initn: 343 init1: 151 opt: 505 Z-score: 609.2 bits: 120.3 E(85289): 3.4e-27
Smith-Waterman score: 505; 39.1% identity (64.5% similar) in 256 aa overlap (8-255:5-245)
10 20 30 40 50
pF1KE1 MEACVSSLLVLALGALSVGSSFGTQ-IIGGREVIPHSRPYMAS---LQRNGSHLCGGVLV
::.::. :. :. ::. ::::.:. :::::::: ::... . :::.::
NP_219 MQPFLLLLAF-LLTPGA--GTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILV
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 HPKWVLTAAHCLAQRMAQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLA
. .::::::: . ... ..:: :.. : . .: : :: :.: . ::.
NP_219 RKDFVLTAAHCQG---SSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNP-KNFSNDIM
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDT
::::. :.: . ..::: :::.. : : ::.:::: . .. :. .:.:. : :
NP_219 LLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMS-TLATTLQEVLLTV--Q
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 RMCNNSRFWNGSLS-PSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTD
. :. :...:. : . .:.. .: :. :::::::::: : :.::.... :
NP_219 KDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKD--VAQGILSYGNKKGTP
170 180 190 200 210 220
240 250
pF1KE1 IFKPPVATAVAPYVSWIRKVTGRSA
: : :. .. ::... :
NP_219 ---PGVYIKVSHFLPWIKRTMKRL
230 240
257 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:37:53 2016 done: Sun Nov 6 13:37:54 2016
Total Scan time: 6.230 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]