Result of FASTA (omim) for
pFN21AE1748
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1748, 251 aa
1>>>pF1KE1748 251 - 251 aa - 251 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2423+/-0.000366; mu= 14.6183+/- 0.023
mean_var=63.2527+/-12.659, 0's: 0 Z-trim(113.2): 21 B-trim: 0 in 0/50
Lambda= 0.161263
statistics sampled from 22346 (22366) to 22346 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.262), width: 16
Scan time: 6.430
The best scores are: opt bits E(85289)
NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 1687 401.1 1e-111
NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 1117 268.4 6.7e-72
NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233) 231 62.3 8.8e-10
NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205) 227 61.3 1.5e-09
XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09
XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09
XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09
XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09
NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205) 227 61.3 1.5e-09
NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 222 60.2 3.4e-09
NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 222 60.2 3.9e-09
XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 222 60.2 3.9e-09
NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 217 59.1 9.9e-09
XP_011533582 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 206 56.5 5.2e-08
NP_143026 (OMIM: 259710,602642) tumor necrosis fac ( 244) 206 56.5 5.2e-08
XP_016876292 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 206 56.5 5.2e-08
XP_016876291 (OMIM: 259710,602642) PREDICTED: tumo ( 263) 206 56.5 5.5e-08
NP_003692 (OMIM: 259710,602642) tumor necrosis fac ( 317) 206 56.5 6.5e-08
NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281) 173 48.8 1.2e-05
NP_002332 (OMIM: 600978) lymphotoxin-beta isoform ( 244) 166 47.2 3.3e-05
>>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa)
initn: 1687 init1: 1687 opt: 1687 Z-score: 2126.8 bits: 401.1 E(85289): 1e-111
Smith-Waterman score: 1687; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251)
10 20 30 40 50 60
pF1KE1 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 AQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 HELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 ITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTK
190 200 210 220 230 240
250
pF1KE1 EDKTFFGAFLL
:::::::::::
NP_005 EDKTFFGAFLL
250
>>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa)
initn: 1117 init1: 1117 opt: 1117 Z-score: 1411.9 bits: 268.4 E(85289): 6.7e-72
Smith-Waterman score: 1117; 100.0% identity (100.0% similar) in 166 aa overlap (86-251:27-192)
60 70 80 90 100 110
pF1KE1 VSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFP
::::::::::::::::::::::::::::::
NP_001 MQLTKGRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFP
10 20 30 40 50
120 130 140 150 160 170
pF1KE1 ALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPD
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE1 SITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISL
120 130 140 150 160 170
240 250
pF1KE1 VDYTKEDKTFFGAFLL
::::::::::::::::
NP_001 VDYTKEDKTFFGAFLL
180 190
>>NP_000585 (OMIM: 157300,191160,600807,611162) tumor ne (233 aa)
initn: 211 init1: 110 opt: 231 Z-score: 296.6 bits: 62.3 E(85289): 8.8e-10
Smith-Waterman score: 270; 28.0% identity (58.1% similar) in 236 aa overlap (26-251:18-233)
10 20 30 40 50
pF1KE1 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCC-LVLLPFL--AGLTTYLLVS
:: .... . . : : :. :: :: :: . .
NP_000 MSTESMIRDVELAEEALPK-KTGGPQGSRRCLFLSLFSFLIVAGATTLFCLL
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 QLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPAL
.. . : .: . ..: : : . :. .::: ::... :. : :
NP_000 HFGVIGPQREEFPR-DLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQ--------L
60 70 80 90 100
120 130 140 150 160 170
pF1KE1 HWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSI
.: .. . :. : .. .. :..: : :.::::: :.:. : :. .
NP_000 QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQ----------GCPSTHVLL
110 120 130 140 150
180 190 200 210 220 230
pF1KE1 TVVITKVTDSYPEPTQLLMGTKSVCEV----GSN---WFQPIYLGAMFSLQEGDKLMVNV
: .:.... :: ..:: . :: :. :.. :..:::::..:.:..::.: ...
NP_000 THTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEI
160 170 180 190 200 210
240 250
pF1KE1 SDISLVDYTKEDKTFFGAFLL
. . .:... ...:: . :
NP_000 NRPDYLDFAESGQVYFGIIAL
220 230
>>NP_001153212 (OMIM: 153440,607507,608446,610988) lymph (205 aa)
initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09
Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205)
20 30 40 50 60 70
pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA
..:: . : : .::. : .: .
NP_001 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G
10 20 30
80 90 100 110 120
pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT
: : ..:: :. ..:. ::. :. :. .. .: :. . ::
NP_001 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T
.. .. .:. ::.: :: ::.::::.: : .: :. .: . .: .
NP_001 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT
..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . .
NP_001 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV
140 150 160 170 180 190
250
pF1KE1 FFGAFLL
::::: :
NP_001 FFGAFAL
200
>>XP_011512917 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09
Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205)
20 30 40 50 60 70
pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA
..:: . : : .::. : .: .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G
10 20 30
80 90 100 110 120
pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT
: : ..:: :. ..:. ::. :. :. .. .: :. . ::
XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T
.. .. .:. ::.: :: ::.::::.: : .: :. .: . .: .
XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT
..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . .
XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV
140 150 160 170 180 190
250
pF1KE1 FFGAFLL
::::: :
XP_011 FFGAFAL
200
>>XP_011512918 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09
Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205)
20 30 40 50 60 70
pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA
..:: . : : .::. : .: .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G
10 20 30
80 90 100 110 120
pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT
: : ..:: :. ..:. ::. :. :. .. .: :. . ::
XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T
.. .. .:. ::.: :: ::.::::.: : .: :. .: . .: .
XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT
..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . .
XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV
140 150 160 170 180 190
250
pF1KE1 FFGAFLL
::::: :
XP_011 FFGAFAL
200
>>XP_011512920 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09
Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205)
20 30 40 50 60 70
pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA
..:: . : : .::. : .: .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G
10 20 30
80 90 100 110 120
pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT
: : ..:: :. ..:. ::. :. :. .. .: :. . ::
XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T
.. .. .:. ::.: :: ::.::::.: : .: :. .: . .: .
XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT
..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . .
XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV
140 150 160 170 180 190
250
pF1KE1 FFGAFLL
::::: :
XP_011 FFGAFAL
200
>>XP_011512919 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09
Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205)
20 30 40 50 60 70
pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA
..:: . : : .::. : .: .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G
10 20 30
80 90 100 110 120
pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT
: : ..:: :. ..:. ::. :. :. .. .: :. . ::
XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T
.. .. .:. ::.: :: ::.::::.: : .: :. .: . .: .
XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT
..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . .
XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV
140 150 160 170 180 190
250
pF1KE1 FFGAFLL
::::: :
XP_011 FFGAFAL
200
>>NP_000586 (OMIM: 153440,607507,608446,610988) lymphoto (205 aa)
initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09
Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205)
20 30 40 50 60 70
pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA
..:: . : : .::. : .: .
NP_000 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G
10 20 30
80 90 100 110 120
pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT
: : ..:: :. ..:. ::. :. :. .. .: :. . ::
NP_000 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T
.. .. .:. ::.: :: ::.::::.: : .: :. .: . .: .
NP_000 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT
..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . .
NP_000 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV
140 150 160 170 180 190
250
pF1KE1 FFGAFLL
::::: :
NP_000 FFGAFAL
200
>>NP_742011 (OMIM: 604520) tumor necrosis factor ligand (204 aa)
initn: 192 init1: 88 opt: 222 Z-score: 286.1 bits: 60.2 E(85289): 3.4e-09
Smith-Waterman score: 238; 31.3% identity (57.5% similar) in 179 aa overlap (78-251:41-204)
50 60 70 80 90 100
pF1KE1 AGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPT
: : .:. :. .: :::: . .. :
NP_742 FVVDGQTDIPFTRLGRSHRRQSCSVARDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLT
20 30 40 50 60 70
110 120 130 140 150 160
pF1KE1 QHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQ
. : : :: .::::: .. ..: . :.. ..: :.:::.: . :.
NP_742 G---SGGPLL-WETQLGLAFLRG-LSYHDGALVVTKAGYYYIYSKVQLGGV---------
80 90 100 110
170 180 190 200 210 220
pF1KE1 AGRP-NKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSN----WFQPIYLGAMFSLQE
: : . ..:: . : : ::: .::.. .: : ... :.. .::.. :.
NP_742 -GCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEA
120 130 140 150 160 170
230 240 250
pF1KE1 GDKLMVNVSDISLVDYTKEDKTFFGAFLL
:.:..: : : :: ...::::..
NP_742 GEKVVVRVLDERLVRLRDGTRSYFGAFMV
180 190 200
251 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 15:43:22 2016 done: Sun Nov 6 15:43:23 2016
Total Scan time: 6.430 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]