Result of FASTA (omim) for
pFN21AE1739
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1739, 244 aa
1>>>pF1KE1739 244 - 244 aa - 244 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5820+/-0.0003; mu= 14.7050+/- 0.019
mean_var=91.4792+/-18.078, 0's: 0 Z-trim(120.0): 24 B-trim: 573 in 1/50
Lambda= 0.134095
statistics sampled from 34664 (34688) to 34664 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.407), width: 16
Scan time: 6.880
The best scores are: opt bits E(85289)
NP_002332 (OMIM: 600978) lymphotoxin-beta isoform ( 244) 1627 324.0 1.5e-88
NP_033666 (OMIM: 600978) lymphotoxin-beta isoform ( 77) 337 74.0 8.6e-14
XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05
NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205) 189 45.7 7.4e-05
XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05
XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05
XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05
NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205) 189 45.7 7.4e-05
NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 166 41.2 0.0015
NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 166 41.3 0.0019
>>NP_002332 (OMIM: 600978) lymphotoxin-beta isoform a [H (244 aa)
initn: 1627 init1: 1627 opt: 1627 Z-score: 1710.6 bits: 324.0 E(85289): 1.5e-88
Smith-Waterman score: 1627; 100.0% identity (100.0% similar) in 244 aa overlap (1-244:1-244)
10 20 30 40 50 60
pF1KE1 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
190 200 210 220 230 240
pF1KE1 VMVG
::::
NP_002 VMVG
>>NP_033666 (OMIM: 600978) lymphotoxin-beta isoform b [H (77 aa)
initn: 337 init1: 337 opt: 337 Z-score: 368.6 bits: 74.0 E(85289): 8.6e-14
Smith-Waterman score: 337; 77.3% identity (86.7% similar) in 75 aa overlap (1-75:1-75)
10 20 30 40 50 60
pF1KE1 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
:::::::::::::::::::::::::::::::::::::::::::::::::::::: .. .
NP_033 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLGFRSCQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
.: : . ..::
NP_033 RRSQKQISAPGSQLPTS
70
>>XP_011512918 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05
Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202)
40 50 60 70 80
pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG
::::. :.:. . ...:. :. .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS
10 20 30 40 50
90 100 110 120 130 140
pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR
::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :.
XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK
60 70 80 90 100 110
150 160 170 180 190
pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP
: : . ..: .. : : :: : : .: :: . . : : :
XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE
120 130 140 150 160
200 210 220 230 240
pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG
: :. :. :: .:... .. . : .: .. . .::::
XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL
170 180 190 200
>>NP_001153212 (OMIM: 153440,607507,608446,610988) lymph (205 aa)
initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05
Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202)
40 50 60 70 80
pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG
::::. :.:. . ...:. :. .
NP_001 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS
10 20 30 40 50
90 100 110 120 130 140
pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR
::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :.
NP_001 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK
60 70 80 90 100 110
150 160 170 180 190
pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP
: : . ..: .. : : :: : : .: :: . . : : :
NP_001 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE
120 130 140 150 160
200 210 220 230 240
pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG
: :. :. :: .:... .. . : .: .. . .::::
NP_001 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL
170 180 190 200
>>XP_011512917 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05
Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202)
40 50 60 70 80
pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG
::::. :.:. . ...:. :. .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS
10 20 30 40 50
90 100 110 120 130 140
pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR
::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :.
XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK
60 70 80 90 100 110
150 160 170 180 190
pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP
: : . ..: .. : : :: : : .: :: . . : : :
XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE
120 130 140 150 160
200 210 220 230 240
pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG
: :. :. :: .:... .. . : .: .. . .::::
XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL
170 180 190 200
>>XP_011512919 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05
Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202)
40 50 60 70 80
pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG
::::. :.:. . ...:. :. .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS
10 20 30 40 50
90 100 110 120 130 140
pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR
::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :.
XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK
60 70 80 90 100 110
150 160 170 180 190
pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP
: : . ..: .. : : :: : : .: :: . . : : :
XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE
120 130 140 150 160
200 210 220 230 240
pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG
: :. :. :: .:... .. . : .: .. . .::::
XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL
170 180 190 200
>>XP_011512920 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05
Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202)
40 50 60 70 80
pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG
::::. :.:. . ...:. :. .
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS
10 20 30 40 50
90 100 110 120 130 140
pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR
::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :.
XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK
60 70 80 90 100 110
150 160 170 180 190
pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP
: : . ..: .. : : :: : : .: :: . . : : :
XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE
120 130 140 150 160
200 210 220 230 240
pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG
: :. :. :: .:... .. . : .: .. . .::::
XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL
170 180 190 200
>>NP_000586 (OMIM: 153440,607507,608446,610988) lymphoto (205 aa)
initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05
Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202)
40 50 60 70 80
pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG
::::. :.:. . ...:. :. .
NP_000 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS
10 20 30 40 50
90 100 110 120 130 140
pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR
::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :.
NP_000 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK
60 70 80 90 100 110
150 160 170 180 190
pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP
: : . ..: .. : : :: : : .: :: . . : : :
NP_000 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE
120 130 140 150 160
200 210 220 230 240
pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG
: :. :. :: .:... .. . : .: .. . .::::
NP_000 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL
170 180 190 200
>>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa)
initn: 85 init1: 43 opt: 166 Z-score: 184.5 bits: 41.2 E(85289): 0.0015
Smith-Waterman score: 176; 27.1% identity (55.9% similar) in 170 aa overlap (88-243:36-192)
60 70 80 90 100
pF1KE1 TADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLI---GAP---LKGQ--GLGWETTKE
: ::: .: .:.: .: ::
NP_001 GRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELG
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE1 QAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPP-----GGGDPQGRSVTLRSSLY
:: . .... . : .:..: :..: : .:: . .: :. . .. .
NP_001 LAFTKNRMNYTN-KFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPN-KPDSITVVIT
70 80 90 100 110 120
170 180 190 200 210 220
pF1KE1 RAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNIS
.. .: : : :: :...: : : :. . .:.. .:..:....::.:
NP_001 KVTDSY-P-EPTQLLMGTKSVCEV---------GSNWFQPIYLGAMFSLQEGDKLMVNVS
130 140 150 160 170
230 240
pF1KE1 HPDMVDFAR-GKTFFGAVMVG
..::... :::::: ..
NP_001 DISLVDYTKEDKTFFGAFLL
180 190
>>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa)
initn: 61 init1: 43 opt: 166 Z-score: 183.0 bits: 41.3 E(85289): 0.0019
Smith-Waterman score: 176; 27.1% identity (55.9% similar) in 170 aa overlap (88-243:95-251)
60 70 80 90 100
pF1KE1 TADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLI---GAP---LKGQ--GLGWETTKE
: ::: .: .:.: .: ::
NP_005 ACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 QAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPP-----GGGDPQGRSVTLRSSLY
:: . .... . : .:..: :..: : .:: . .: :. . .. .
NP_005 LAFTKNRMNYTN-KFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPN-KPDSITVVIT
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 RAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNIS
.. .: : : :: :...: : : :. . .:.. .:..:....::.:
NP_005 KVTDSY-P-EPTQLLMGTKSVCEV---------GSNWFQPIYLGAMFSLQEGDKLMVNVS
190 200 210 220 230
230 240
pF1KE1 HPDMVDFAR-GKTFFGAVMVG
..::... :::::: ..
NP_005 DISLVDYTKEDKTFFGAFLL
240 250
244 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:58:03 2016 done: Sun Nov 6 09:58:04 2016
Total Scan time: 6.880 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]