FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1701, 206 aa
  1>>>pF1KE1701 206 - 206 aa - 206 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8958+/-0.000335; mu= 16.2282+/- 0.021
 mean_var=68.6373+/-13.538, 0's: 0 Z-trim(116.3): 26  B-trim: 0 in 0/53
 Lambda= 0.154808
 statistics sampled from 27280 (27302) to 27280 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.32), width:  16
 Scan time:  5.030

The best scores are:                                      opt bits E(85289)
NP_056279 (OMIM: 609675) sclerostin domain-contain ( 206) 1430 327.8 7.7e-90
XP_016867432 (OMIM: 609675) PREDICTED: sclerostin  ( 206) 1430 327.8 7.7e-90
NP_079513 (OMIM: 122860,239100,269500,605740) scle ( 213)  462 111.6 9.5e-25


>>NP_056279 (OMIM: 609675) sclerostin domain-containing   (206 aa)
 initn: 1430 init1: 1430 opt: 1430  Z-score: 1733.9  bits: 327.8 E(85289): 7.7e-90
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 206 aa overlap (1-206:1-206)

               10        20        30        40        50        60
pF1KE1 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE
              130       140       150       160       170       180

              190       200      
pF1KE1 SMSPAKPVQHHRERKRASKSSKHSMS
       ::::::::::::::::::::::::::
NP_056 SMSPAKPVQHHRERKRASKSSKHSMS
              190       200      

>>XP_016867432 (OMIM: 609675) PREDICTED: sclerostin doma  (206 aa)
 initn: 1430 init1: 1430 opt: 1430  Z-score: 1733.9  bits: 327.8 E(85289): 7.7e-90
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 206 aa overlap (1-206:1-206)

               10        20        30        40        50        60
pF1KE1 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE
              130       140       150       160       170       180

              190       200      
pF1KE1 SMSPAKPVQHHRERKRASKSSKHSMS
       ::::::::::::::::::::::::::
XP_016 SMSPAKPVQHHRERKRASKSSKHSMS
              190       200      

>>NP_079513 (OMIM: 122860,239100,269500,605740) sclerost  (213 aa)
 initn: 469 init1: 227 opt: 462  Z-score: 565.3  bits: 111.6 E(85289): 9.5e-25
Smith-Waterman score: 464; 40.1% identity (63.8% similar) in 207 aa overlap (11-202:3-203)

               10            20                 30        40       
pF1KE1 MLPPAIHFYLLPLA----CILMKSCL---------AFKNDATEILYSHVVKPVPAHP-SS
                 ::::    :.:... .         :::::::::.      : :     .
NP_079         MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELEN
                       10        20        30        40        50  

         50        60        70        80        90       100      
pF1KE1 NSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLP
       :.:.:.:.::::   .  .. .   . .::::. :.:..:: : : .:. ::::.:.: :
NP_079 NKTMNRAENGGRP-PHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGP
             60         70        80        90       100       110 

        110       120       130       140       150        160     
pF1KE1 LPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDG-STRTYKITVVTACKC
         .::: :: :   :.: : :. ..::. :. :.::.:: :  : . :. :. .:..:::
NP_079 ARLLPNAIGRG---KWW-RPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKC
             120           130       140       150       160       

         170       180       190       200            
pF1KE1 KRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS      
       :: :: ::.:  .  .   :.: . .. : :: .:.:          
NP_079 KRLTRFHNQSELKDFGTEAARPQKGRKPRPRA-RSAKANQAELENAY
       170       180       190        200       210   




206 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 16:26:25 2016 done: Sun Nov  6 16:26:25 2016
 Total Scan time:  5.030 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]