Result of FASTA (omim) for
pFN21AE1609
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1609, 114 aa
1>>>pF1KE1609 114 - 114 aa - 114 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7280+/-0.000253; mu= 13.5598+/- 0.016
mean_var=58.1226+/-11.731, 0's: 0 Z-trim(120.8): 12 B-trim: 144 in 1/53
Lambda= 0.168229
statistics sampled from 36546 (36558) to 36546 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.429), width: 16
Scan time: 4.510
The best scores are: opt bits E(85289)
NP_003013 (OMIM: 300190) SH3 domain-binding glutam ( 114) 747 188.3 2.3e-48
XP_011529316 (OMIM: 300190) PREDICTED: SH3 domain- ( 151) 662 167.7 4.7e-42
XP_011529315 (OMIM: 300190) PREDICTED: SH3 domain- ( 176) 662 167.8 5.3e-42
NP_001304669 (OMIM: 602230) SH3 domain-binding glu ( 208) 509 130.7 9.1e-31
NP_031367 (OMIM: 602230) SH3 domain-binding glutam ( 239) 502 129.1 3.3e-30
XP_016866833 (OMIM: 615678) PREDICTED: SH3 domain- ( 107) 443 114.5 3.6e-26
NP_113657 (OMIM: 615678) SH3 domain-binding glutam ( 107) 443 114.5 3.6e-26
XP_011534467 (OMIM: 615678) PREDICTED: SH3 domain- ( 99) 375 98.0 3.1e-21
NP_001304670 (OMIM: 602230) SH3 domain-binding glu ( 97) 279 74.7 3.2e-14
NP_001304671 (OMIM: 602230) SH3 domain-binding glu ( 128) 272 73.0 1.3e-13
NP_001001713 (OMIM: 602230) SH3 domain-binding glu ( 128) 272 73.0 1.3e-13
NP_112576 (OMIM: 615679) SH3 domain-binding glutam ( 93) 184 51.6 2.7e-07
>>NP_003013 (OMIM: 300190) SH3 domain-binding glutamic a (114 aa)
initn: 747 init1: 747 opt: 747 Z-score: 989.3 bits: 188.3 E(85289): 2.3e-48
Smith-Waterman score: 747; 100.0% identity (100.0% similar) in 114 aa overlap (1-114:1-114)
10 20 30 40 50 60
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
70 80 90 100 110
>>XP_011529316 (OMIM: 300190) PREDICTED: SH3 domain-bind (151 aa)
initn: 662 init1: 662 opt: 662 Z-score: 876.0 bits: 167.7 E(85289): 4.7e-42
Smith-Waterman score: 662; 100.0% identity (100.0% similar) in 99 aa overlap (16-114:53-151)
10 20 30 40
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEEN
::::::::::::::::::::::::::::::
XP_011 TIYMHTHKSFINLTTIYMHTHKTFVRTQNQIKKKQQDVLGFLEANKIGFEEKDIAANEEN
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE1 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE
90 100 110 120 130 140
110
pF1KE1 AEVQAKQQA
:::::::::
XP_011 AEVQAKQQA
150
>>XP_011529315 (OMIM: 300190) PREDICTED: SH3 domain-bind (176 aa)
initn: 662 init1: 662 opt: 662 Z-score: 875.1 bits: 167.8 E(85289): 5.3e-42
Smith-Waterman score: 662; 100.0% identity (100.0% similar) in 99 aa overlap (16-114:78-176)
10 20 30 40
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEEN
::::::::::::::::::::::::::::::
XP_011 TIYMHTHKSFINLTTIYMHTHKTFVRTQNQIKKKQQDVLGFLEANKIGFEEKDIAANEEN
50 60 70 80 90 100
50 60 70 80 90 100
pF1KE1 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE
110 120 130 140 150 160
110
pF1KE1 AEVQAKQQA
:::::::::
XP_011 AEVQAKQQA
170
>>NP_001304669 (OMIM: 602230) SH3 domain-binding glutami (208 aa)
initn: 554 init1: 509 opt: 509 Z-score: 673.4 bits: 130.7 E(85289): 9.1e-31
Smith-Waterman score: 509; 66.4% identity (87.9% similar) in 107 aa overlap (1-107:64-170)
10 20 30
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEAN
:::.:..:.:::: ::.::::.:.::::::
NP_001 LACLCHCQDLSSGAFPNRGVLGGVLFPTVEMVIKVFVATSSGSIAIRKKQQEVVGFLEAN
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 KIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNA
:: :.: :::..:.::.::::::: ...: .: ::::::::: :: ::.:.:: :.:.:
NP_001 KIDFKELDIAGDEDNRRWMRENVPGEKKPQNGIPLPPQIFNEEQYCGDFDSFFSAKEENI
100 110 120 130 140 150
100 110
pF1KE1 VYAFLGLTAPPGSKEAEVQAKQQA
.:.::::. :: ::: :
NP_001 IYSFLGLAPPPDSKEEEGETATEETEEIAMEGAEGEAEEEEETAEGEEPGEDEDS
160 170 180 190 200
>>NP_031367 (OMIM: 602230) SH3 domain-binding glutamic a (239 aa)
initn: 519 init1: 502 opt: 502 Z-score: 663.3 bits: 129.1 E(85289): 3.3e-30
Smith-Waterman score: 502; 65.4% identity (87.9% similar) in 107 aa overlap (1-107:64-170)
10 20 30
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEAN
:::.:..:.:::: ::.::::.:.::::::
NP_031 LACLCHCQDLSSGAFPNRGVLGGVLFPTVEMVIKVFVATSSGSIAIRKKQQEVVGFLEAN
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 KIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNA
:: :.: :::..:.::.::::::: ...: .: ::::::::: :: ::.:.:: :.:.:
NP_031 KIDFKELDIAGDEDNRRWMRENVPGEKKPQNGIPLPPQIFNEEQYCGDFDSFFSAKEENI
100 110 120 130 140 150
100 110
pF1KE1 VYAFLGLTAPPGSKEAEVQAKQQA
.:.::::. :: :: .:
NP_031 IYSFLGLAPPPDSKGSEKAEEGGETEAQKEGSEDVGNLPEAQEKNEEEGETATEETEEIA
160 170 180 190 200 210
>>XP_016866833 (OMIM: 615678) PREDICTED: SH3 domain-bind (107 aa)
initn: 442 init1: 442 opt: 443 Z-score: 590.9 bits: 114.5 E(85289): 3.6e-26
Smith-Waterman score: 443; 63.6% identity (86.0% similar) in 107 aa overlap (1-107:1-106)
10 20 30 40 50 60
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA
:::::.:::::: .:::::::::. ::::::: ::: ::. .::.:.:: .::: ...:.
XP_016 MVIRVFIASSSGFVAIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPT
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
: :::::::: ..: ::::.:::..:.:.:..:::: : ...::
XP_016 QGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLK-PRLASKAEP
70 80 90 100
>>NP_113657 (OMIM: 615678) SH3 domain-binding glutamic a (107 aa)
initn: 442 init1: 442 opt: 443 Z-score: 590.9 bits: 114.5 E(85289): 3.6e-26
Smith-Waterman score: 443; 63.6% identity (86.0% similar) in 107 aa overlap (1-107:1-106)
10 20 30 40 50 60
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA
:::::.:::::: .:::::::::. ::::::: ::: ::. .::.:.:: .::: ...:.
NP_113 MVIRVFIASSSGFVAIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPT
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
: :::::::: ..: ::::.:::..:.:.:..:::: : ...::
NP_113 QGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLK-PRLASKAEP
70 80 90 100
>>XP_011534467 (OMIM: 615678) PREDICTED: SH3 domain-bind (99 aa)
initn: 374 init1: 374 opt: 375 Z-score: 502.2 bits: 98.0 E(85289): 3.1e-21
Smith-Waterman score: 375; 60.9% identity (84.8% similar) in 92 aa overlap (16-107:8-98)
10 20 30 40 50 60
pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA
::::::::. ::::::: ::: ::. .::.:.:: .::: ...:.
XP_011 MTNSRQKIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPT
10 20 30 40 50
70 80 90 100 110
pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
: :::::::: ..: ::::.:::..:.:.:..:::: : ...::
XP_011 QGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLK-PRLASKAEP
60 70 80 90
>>NP_001304670 (OMIM: 602230) SH3 domain-binding glutami (97 aa)
initn: 307 init1: 279 opt: 279 Z-score: 376.4 bits: 74.7 E(85289): 3.2e-14
Smith-Waterman score: 279; 64.4% identity (83.1% similar) in 59 aa overlap (49-107:1-59)
20 30 40 50 60 70
pF1KE1 KQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGD
:::::: ...: .: ::::::::: :: ::
NP_001 MRENVPGEKKPQNGIPLPPQIFNEEQYCGD
10 20 30
80 90 100 110
pF1KE1 YDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
.:.:: :.:.: .:.::::. :: ::: :
NP_001 FDSFFSAKEENIIYSFLGLAPPPDSKEEEGETATEETEEIAMEGAEGEAEEEEETAEGEE
40 50 60 70 80 90
>>NP_001304671 (OMIM: 602230) SH3 domain-binding glutami (128 aa)
initn: 285 init1: 272 opt: 272 Z-score: 365.5 bits: 73.0 E(85289): 1.3e-13
Smith-Waterman score: 272; 62.7% identity (83.1% similar) in 59 aa overlap (49-107:1-59)
20 30 40 50 60 70
pF1KE1 KQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGD
:::::: ...: .: ::::::::: :: ::
NP_001 MRENVPGEKKPQNGIPLPPQIFNEEQYCGD
10 20 30
80 90 100 110
pF1KE1 YDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
.:.:: :.:.: .:.::::. :: :: .:
NP_001 FDSFFSAKEENIIYSFLGLAPPPDSKGSEKAEEGGETEAQKEGSEDVGNLPEAQEKNEEE
40 50 60 70 80 90
114 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:45:58 2016 done: Sun Nov 6 12:45:59 2016
Total Scan time: 4.510 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]