Result of FASTA (omim) for
pFN21AE1592
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1592, 404 aa
1>>>pF1KE1592 404 - 404 aa - 404 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1986+/-0.000399; mu= 18.1313+/- 0.025
mean_var=68.7640+/-13.430, 0's: 0 Z-trim(111.7): 121 B-trim: 0 in 0/53
Lambda= 0.154666
statistics sampled from 20227 (20352) to 20227 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.239), width: 16
Scan time: 7.390
The best scores are: opt bits E(85289)
NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404) 2686 608.6 8.9e-174
NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404) 2686 608.6 8.9e-174
XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374) 2494 565.7 6.6e-161
XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 2494 565.7 7e-161
XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 2494 565.7 7e-161
XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380) 1992 453.7 3.5e-127
NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383) 1992 453.7 3.5e-127
NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383) 1992 453.7 3.5e-127
NP_150635 (OMIM: 147678) caspase-1 isoform gamma [ ( 311) 1972 449.2 6.6e-126
NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263) 1177 271.7 1.5e-72
NP_001216 (OMIM: 602664) caspase-4 isoform alpha p ( 377) 1134 262.2 1.5e-69
NP_150649 (OMIM: 602664) caspase-4 isoform gamma p ( 321) 1132 261.7 1.8e-69
XP_016873886 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1123 259.7 6.6e-69
XP_011541321 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1123 259.7 6.6e-69
NP_001129581 (OMIM: 602665) caspase-5 isoform b pr ( 376) 1089 252.2 1.6e-66
NP_004338 (OMIM: 602665) caspase-5 isoform a precu ( 434) 1089 252.2 1.8e-66
NP_001129584 (OMIM: 602665) caspase-5 isoform f pr ( 447) 1089 252.2 1.8e-66
NP_001129582 (OMIM: 602665) caspase-5 isoform c [H ( 292) 1078 249.7 7.1e-66
NP_001177945 (OMIM: 608633) inactive caspase-12 [H ( 341) 895 208.9 1.6e-53
XP_011541323 (OMIM: 602665) PREDICTED: caspase-5 i ( 319) 656 155.5 1.7e-37
NP_443121 (OMIM: 615680) caspase recruitment domai ( 97) 563 134.4 1.1e-31
NP_001017534 (OMIM: 615680) caspase recruitment do ( 197) 552 132.2 1.1e-30
NP_001007233 (OMIM: 609490) caspase recruitment do ( 110) 543 130.0 2.8e-30
XP_011541140 (OMIM: 609490) PREDICTED: caspase rec ( 125) 543 130.0 3.1e-30
XP_011540885 (OMIM: 615680) PREDICTED: caspase rec ( 265) 540 129.6 9e-30
NP_150637 (OMIM: 147678) caspase-1 isoform epsilon ( 88) 495 119.2 3.9e-27
NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452) 368 91.4 4.9e-18
NP_067546 (OMIM: 605354) caspase recruitment domai ( 90) 315 79.1 4.9e-15
NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312) 318 80.1 8.3e-15
NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478) 283 72.4 2.6e-12
NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479) 283 72.4 2.6e-12
XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521) 283 72.4 2.8e-12
NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521) 283 72.4 2.8e-12
NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522) 283 72.4 2.8e-12
XP_006712859 (OMIM: 601762,603909,605027,613659) P ( 272) 278 71.1 3.6e-12
NP_036246 (OMIM: 605848) caspase-14 precursor [Hom ( 242) 266 68.4 2.1e-11
XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 i ( 421) 265 68.4 3.9e-11
XP_011526163 (OMIM: 605848) PREDICTED: caspase-14 ( 230) 254 65.7 1.3e-10
XP_011510271 (OMIM: 114480,114550,211980,601763,60 ( 334) 253 65.6 2e-10
XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464) 254 65.9 2.3e-10
NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464) 254 65.9 2.3e-10
NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464) 254 65.9 2.3e-10
NP_001219 (OMIM: 114480,114550,211980,601763,60727 ( 496) 254 65.9 2.4e-10
XP_005246942 (OMIM: 114480,114550,211980,601763,60 ( 523) 254 66.0 2.5e-10
XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10
XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10
XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10
XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10
XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10
NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479) 253 65.7 2.7e-10
>>NP_150634 (OMIM: 147678) caspase-1 isoform alpha precu (404 aa)
initn: 2686 init1: 2686 opt: 2686 Z-score: 3240.8 bits: 608.6 E(85289): 8.9e-174
Smith-Waterman score: 2686; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404)
10 20 30 40 50 60
pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
310 320 330 340 350 360
370 380 390 400
pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
::::::::::::::::::::::::::::::::::::::::::::
NP_150 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
370 380 390 400
>>NP_001244047 (OMIM: 147678) caspase-1 isoform alpha pr (404 aa)
initn: 2686 init1: 2686 opt: 2686 Z-score: 3240.8 bits: 608.6 E(85289): 8.9e-174
Smith-Waterman score: 2686; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404)
10 20 30 40 50 60
pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
310 320 330 340 350 360
370 380 390 400
pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
370 380 390 400
>>XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 isofo (374 aa)
initn: 2494 init1: 2494 opt: 2494 Z-score: 3009.7 bits: 565.7 E(85289): 6.6e-161
Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 373 aa overlap (32-404:2-374)
10 20 30 40 50 60
pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV
::::::::::::::::::::::::::::::
XP_016 MTRVLNKEEMEKVKRENATVMDKTRALIDSV
10 20 30
70 80 90 100 110 120
pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
280 290 300 310 320 330
370 380 390 400
pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
:::::::::::::::::::::::::::::::::::::::::::
XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
340 350 360 370
>>XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 isofo (401 aa)
initn: 2494 init1: 2494 opt: 2494 Z-score: 3009.3 bits: 565.7 E(85289): 7e-161
Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 373 aa overlap (32-404:29-401)
10 20 30 40 50 60
pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV
::::::::::::::::::::::::::::::
XP_016 MYRPCQKGRRSILSVSVTQEGRREKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSV
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
300 310 320 330 340 350
370 380 390 400
pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
:::::::::::::::::::::::::::::::::::::::::::
XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
360 370 380 390 400
>>XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 isofo (401 aa)
initn: 2494 init1: 2494 opt: 2494 Z-score: 3009.3 bits: 565.7 E(85289): 7e-161
Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 373 aa overlap (32-404:29-401)
10 20 30 40 50 60
pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV
::::::::::::::::::::::::::::::
XP_016 MYRPCQKGRRSILSVSVTQEGRREKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSV
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
300 310 320 330 340 350
370 380 390 400
pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
:::::::::::::::::::::::::::::::::::::::::::
XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
360 370 380 390 400
>>XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 isofo (380 aa)
initn: 2340 init1: 1972 opt: 1992 Z-score: 2404.3 bits: 453.7 E(85289): 3.5e-127
Smith-Waterman score: 2302; 94.4% identity (94.4% similar) in 373 aa overlap (32-404:29-380)
10 20 30 40 50 60
pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV
::::::::::::::::::::::::::::::
XP_016 MYRPCQKGRRSILSVSVTQEGRREKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSV
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
:::::::::::::::::::::::::::::: :::::::::
XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDNP
60 70 80 90
130 140 150 160 170 180
pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA
280 290 300 310 320 330
370 380 390 400
pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
:::::::::::::::::::::::::::::::::::::::::::
XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
340 350 360 370 380
>>NP_001214 (OMIM: 147678) caspase-1 isoform beta precur (383 aa)
initn: 2532 init1: 1972 opt: 1992 Z-score: 2404.2 bits: 453.7 E(85289): 3.5e-127
Smith-Waterman score: 2494; 94.8% identity (94.8% similar) in 404 aa overlap (1-404:1-383)
10 20 30 40 50 60
pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
::::::::::::::::::::::::::::::: ::::::::
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDN
70 80 90
130 140 150 160 170 180
pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
280 290 300 310 320 330
370 380 390 400
pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
340 350 360 370 380
>>NP_001244048 (OMIM: 147678) caspase-1 isoform beta pre (383 aa)
initn: 2532 init1: 1972 opt: 1992 Z-score: 2404.2 bits: 453.7 E(85289): 3.5e-127
Smith-Waterman score: 2494; 94.8% identity (94.8% similar) in 404 aa overlap (1-404:1-383)
10 20 30 40 50 60
pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
::::::::::::::::::::::::::::::: ::::::::
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDN
70 80 90
130 140 150 160 170 180
pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
280 290 300 310 320 330
370 380 390 400
pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
340 350 360 370 380
>>NP_150635 (OMIM: 147678) caspase-1 isoform gamma [Homo (311 aa)
initn: 2076 init1: 1972 opt: 1972 Z-score: 2381.4 bits: 449.2 E(85289): 6.6e-126
Smith-Waterman score: 1972; 100.0% identity (100.0% similar) in 292 aa overlap (113-404:20-311)
90 100 110 120 130 140
pF1KE1 LAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ
::::::::::::::::::::::::::::::
NP_150 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ
10 20 30 40
150 160 170 180 190 200
pF1KE1 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE1 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE1 NMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 NMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH
170 180 190 200 210 220
330 340 350 360 370 380
pF1KE1 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG
230 240 250 260 270 280
390 400
pF1KE1 RAQMPTTERVTLTRCFYLFPGH
::::::::::::::::::::::
NP_150 RAQMPTTERVTLTRCFYLFPGH
290 300 310
>>NP_150636 (OMIM: 147678) caspase-1 isoform delta [Homo (263 aa)
initn: 1287 init1: 1163 opt: 1177 Z-score: 1423.7 bits: 271.7 E(85289): 1.5e-72
Smith-Waterman score: 1542; 83.6% identity (83.6% similar) in 292 aa overlap (113-404:20-263)
90 100 110 120 130 140
pF1KE1 LAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ
::::::::::::::::::::::::::::::
NP_150 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ
10 20 30 40
150 160 170 180 190 200
pF1KE1 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE1 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE1 NMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH
::::::::::::::::::::::::::
NP_150 NMLNTKNCPSLKDKPKVIIIQACRGD----------------------------------
170 180 190
330 340 350 360 370 380
pF1KE1 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG
::::::::::::::::::::::::::::::::::::::::::::::
NP_150 --------------NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG
200 210 220 230 240
390 400
pF1KE1 RAQMPTTERVTLTRCFYLFPGH
::::::::::::::::::::::
NP_150 RAQMPTTERVTLTRCFYLFPGH
250 260
404 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 15:00:42 2016 done: Sun Nov 6 15:00:44 2016
Total Scan time: 7.390 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]