Result of FASTA (omim) for
pFN21AE1552
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1552, 560 aa
1>>>pF1KE1552 560 - 560 aa - 560 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9800+/-0.000501; mu= 10.9112+/- 0.031
mean_var=216.2884+/-41.915, 0's: 0 Z-trim(115.9): 489 B-trim: 130 in 2/53
Lambda= 0.087208
statistics sampled from 26046 (26640) to 26046 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.312), width: 16
Scan time: 9.120
The best scores are: opt bits E(85289)
NP_004123 (OMIM: 188050,603924,616535) hyaluronan- ( 560) 4060 524.6 3.1e-148
NP_001171131 (OMIM: 188050,603924,616535) hyaluron ( 534) 3893 503.6 6.4e-142
NP_001519 (OMIM: 604552) hepatocyte growth factor ( 655) 1148 158.4 6.7e-38
NP_001284368 (OMIM: 604552) hepatocyte growth fact ( 662) 1100 152.3 4.4e-36
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 536 81.0 6.6e-15
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 538 81.4 6.6e-15
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 538 81.4 6.6e-15
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 536 81.2 8e-15
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 536 81.2 8e-15
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 538 81.6 8.3e-15
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 538 81.6 8.4e-15
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 538 81.6 8.4e-15
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 530 80.3 1.2e-14
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 530 80.4 1.4e-14
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 530 80.4 1.4e-14
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 530 80.4 1.4e-14
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 530 80.5 1.5e-14
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 532 81.0 1.6e-14
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 532 81.0 1.6e-14
NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 529 80.7 2.3e-14
NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 529 80.7 2.5e-14
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 516 78.6 4.3e-14
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 516 78.6 4.6e-14
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 516 78.6 4.6e-14
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 516 79.0 6.8e-14
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 508 77.4 6.8e-14
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 511 78.1 7.9e-14
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 511 78.2 8.5e-14
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 510 78.0 8.5e-14
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 511 78.2 8.6e-14
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 511 78.2 8.6e-14
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 510 78.0 8.9e-14
NP_001962 (OMIM: 130120) chymotrypsin-like elastas ( 258) 504 76.8 9.3e-14
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 509 77.9 9.6e-14
NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 500 76.3 1.3e-13
NP_000496 (OMIM: 234000,610618,610619) coagulation ( 615) 505 77.4 1.4e-13
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 495 75.7 2.1e-13
XP_016864340 (OMIM: 605369) PREDICTED: transmembra ( 234) 492 75.2 2.5e-13
XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 492 75.4 2.9e-13
NP_000124 (OMIM: 122700,300746,300807,306900) coag ( 461) 494 75.9 3.2e-13
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 489 74.9 3.4e-13
NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 492 75.6 3.5e-13
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 494 76.0 3.6e-13
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 495 76.2 3.7e-13
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 489 75.0 3.8e-13
NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 489 75.0 3.9e-13
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 489 75.1 4.1e-13
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 495 76.5 4.8e-13
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 495 76.5 4.9e-13
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 487 74.9 5e-13
>>NP_004123 (OMIM: 188050,603924,616535) hyaluronan-bind (560 aa)
initn: 4060 init1: 4060 opt: 4060 Z-score: 2782.3 bits: 524.6 E(85289): 3.1e-148
Smith-Waterman score: 4060; 100.0% identity (100.0% similar) in 560 aa overlap (1-560:1-560)
10 20 30 40 50 60
pF1KE1 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
490 500 510 520 530 540
550 560
pF1KE1 TQVTKFLNWIKATIKSESGF
::::::::::::::::::::
NP_004 TQVTKFLNWIKATIKSESGF
550 560
>>NP_001171131 (OMIM: 188050,603924,616535) hyaluronan-b (534 aa)
initn: 3893 init1: 3893 opt: 3893 Z-score: 2668.9 bits: 503.6 E(85289): 6.4e-142
Smith-Waterman score: 3893; 100.0% identity (100.0% similar) in 534 aa overlap (27-560:1-534)
10 20 30 40 50 60
pF1KE1 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
::::::::::::::::::::::::::::::::::
NP_001 MSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
10 20 30
70 80 90 100 110 120
pF1KE1 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE1 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
460 470 480 490 500 510
550 560
pF1KE1 TQVTKFLNWIKATIKSESGF
::::::::::::::::::::
NP_001 TQVTKFLNWIKATIKSESGF
520 530
>>NP_001519 (OMIM: 604552) hepatocyte growth factor acti (655 aa)
initn: 787 init1: 203 opt: 1148 Z-score: 801.5 bits: 158.4 E(85289): 6.7e-38
Smith-Waterman score: 1148; 36.6% identity (61.8% similar) in 503 aa overlap (75-555:162-646)
50 60 70 80 90 100
pF1KE1 SYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDC--LVHGSTFTCSCLAP
::: .:: .::.: ... :::
NP_001 WCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRA
140 150 160 170 180 190
110 120 130 140 150
pF1KE1 FSGNKCQKVQNTCKDNP------CGRGQCLITQSPPYYRCVCKHPYTGPS-CSQVV-PVC
:.:. : . : :. : . :. .: : . : . : . .:
NP_001 FTGKDCG--TEKCFDETRYEYLEGGDRWARVRQGH-VEQCEC---FGGRTWCEGTRHTAC
200 210 220 230 240
160 170 180 190 200 210
pF1KE1 RPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDD-CYVGDGYSYRGKMNRTVNQH
.:: ::.:: . .:::: : :..:.: :. :..:.: .::: . ...
NP_001 LSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGL
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE1 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV
.:: ::: :: :: . . : :.: : .::::: ::.:::.. : .. ..:::: .
NP_001 SCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRL
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE1 SACSAQDVAY--PEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQAS
:: . . :. : : :: ..::. . . .. :: :: .: :.::: :.
NP_001 EACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAA
370 380 390 400 410 420
340 350 360 370 380
pF1KE1 LQSSLPLTISMPQGHFCGGALIHPCWVLTAAHC-TDIKTRH-LKVVLGDQDLKKEEFHEQ
. . ::.:.:.: :::..:::: . : ..::::.. ... :
NP_001 IYIG---------DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQ
430 440 450 460 470
390 400 410 420 430 440
pF1KE1 SFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPD-GS-FPSGSE
.: .:: . :. :. . : :..:..:: .:: .:..:. .:::. :: ::.: .
NP_001 TFGIEKYIPYTLYSVFNPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHK
480 490 500 510 520 530
450 460 470 480 490 500
pF1KE1 CHISGWG-VTETGKG-SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDT
:.:.::: . :. .: : .: .: : :.:. :.: ..: :. .:.::: .. . :.
NP_001 CQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKS-DA
540 550 560 570 580 590
510 520 530 540 550 560
pF1KE1 CQGDSGGPLTCEKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF
:::::::::.:::.:. :.:::.::: ::. .:::::.:.....::. :.
NP_001 CQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVA
600 610 620 630 640 650
NP_001 PS
>>NP_001284368 (OMIM: 604552) hepatocyte growth factor a (662 aa)
initn: 718 init1: 237 opt: 1100 Z-score: 768.8 bits: 152.3 E(85289): 4.4e-36
Smith-Waterman score: 1137; 36.3% identity (61.8% similar) in 510 aa overlap (75-555:162-653)
50 60 70 80 90 100
pF1KE1 SYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDC--LVHGSTFTCSCLAP
::: .:: .::.: ... :::
NP_001 WCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRA
140 150 160 170 180 190
110 120 130 140 150
pF1KE1 FSGNKCQKVQNTCKDNP------CGRGQCLITQSPPYYRCVCKHPYTGPS-CSQVV-PVC
:.:. : . : :. : . :. .: : . : . : . .:
NP_001 FTGKDCG--TEKCFDETRYEYLEGGDRWARVRQGH-VEQCEC---FGGRTWCEGTRHTAC
200 210 220 230 240
160 170 180 190 200 210
pF1KE1 RPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDD-CYVGDGYSYRGKMNRTVNQH
.:: ::.:: . .:::: : :..:.: :. :..:.: .::: . ...
NP_001 LSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGL
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE1 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV
.:: ::: :: :: . . : :.: : .::::: ::.:::.. : .. ..:::: .
NP_001 SCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRL
310 320 330 340 350 360
280 290 300 310 320
pF1KE1 SACSAQ-----DVAYPEESP----TEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAG
::. . ... . :: : : :: ..::. . . .. :: :: .: :
NP_001 EACDLETEGRESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPG
370 380 390 400 410 420
330 340 350 360 370 380
pF1KE1 KHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTAAHC-TDIKTRH-LKVVLGDQDLK
.::: :.. . ::.:.:.: :::..:::: . : ..::::.. ..
NP_001 SHPWLAAIYIG---------DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFN
430 440 450 460 470
390 400 410 420 430 440
pF1KE1 KEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPD-GS
. :.: .:: . :. :. . : :..:..:: .:: .:..:. .:::. ::
NP_001 RTTDVTQTFGIEKYIPYTLYSVFNPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGS
480 490 500 510 520 530
450 460 470 480 490
pF1KE1 -FPSGSECHISGWG-VTETGKG-SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNL
::.: .:.:.::: . :. .: : .: .: : :.:. :.: ..: :. .:.::: .
NP_001 TFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYF
540 550 560 570 580 590
500 510 520 530 540 550
pF1KE1 QKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIK
. . :.:::::::::.:::.:. :.:::.::: ::. .:::::.:.....::. :.
NP_001 DCKS-DACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIR
600 610 620 630 640 650
560
pF1KE1 SESGF
NP_001 PPRRLVAPS
660
>>NP_115780 (OMIM: 605511) transmembrane protease serine (327 aa)
initn: 497 init1: 114 opt: 536 Z-score: 388.6 bits: 81.0 E(85289): 6.6e-15
Smith-Waterman score: 569; 41.3% identity (64.2% similar) in 254 aa overlap (313-557:89-324)
290 300 310 320 330 340
pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP
:: :: : .. :::::::
NP_115 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF---------
60 70 80 90 100
350 360 370 380 390
pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS
:: :.:::..: : :..:::::. :. . . .: .: . : :::: .:
NP_115 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS
110 120 130 140 150 160
400 410 420 430 440 450
pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET
.:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.::
NP_115 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED
170 180 190 200 210 220
460 470 480 490 500 510
pF1KE1 GKG--SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTC
: : : : : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.:
NP_115 GAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVC
230 240 250 260 270 280
520 530 540 550 560
pF1KE1 EKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF
.. . . : .:.:. :.. .:::::.::.::.::. .. .
NP_115 QERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
290 300 310 320
>>NP_001305325 (OMIM: 229000,612423) plasma kallikrein i (436 aa)
initn: 395 init1: 158 opt: 538 Z-score: 388.6 bits: 81.4 E(85289): 6.6e-15
Smith-Waterman score: 550; 33.1% identity (60.9% similar) in 320 aa overlap (252-559:140-428)
230 240 250 260 270 280
pF1KE1 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDV
.:: ::.... : : .
NP_001 VKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDG-----------SPTRI
110 120 130 140 150
290 300 310 320 330 340
pF1KE1 AYPEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQASLQSSLPLTIS
:: .. . : .: . : . . : . :: :: .:. :. :::.::: .:
NP_001 AYGTQGSSGYSLRL---CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT----
160 170 180 190 200 210
350 360 370 380 390
pF1KE1 MPQGHFCGGALIHPCWVLTAAHCTD---IKT--RHLKVVLGDQDLKKEEFHEQSFRVEKI
: :.:::.:: :::::::: : .. : . .:. .:. :. : ...:
NP_001 -AQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQ---IKEI
220 230 240 250 260
400 410 420 430 440 450
pF1KE1 FKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSG--SECHISGW
. ...:. . ..::::.::. :.. ... : .:::. . : ..: ..::
NP_001 IIHQNYKVSE--GNHDIALIKLQAPLN-----YTEFQKPICLPSKGDTSTIYTNCWVTGW
270 280 290 300 310 320
460 470 480 490 500 510
pF1KE1 GVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGG
: . : :. . : ... :..: :..: :. : . :.::: .. :.:.:.:::::
NP_001 GFSKEKGEIQNILQKVNIPLVTNEECQKRY-QDYKITQRMVCAG-YKEGGKDACKGDSGG
330 340 350 360 370
520 530 540 550 560
pF1KE1 PLTCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATIKSESGF
::.:...: . . ::.::: :..: :::::.:.....:: .: .:
NP_001 PLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
380 390 400 410 420 430
>>XP_016863673 (OMIM: 229000,612423) PREDICTED: plasma k (436 aa)
initn: 395 init1: 158 opt: 538 Z-score: 388.6 bits: 81.4 E(85289): 6.6e-15
Smith-Waterman score: 550; 33.1% identity (60.9% similar) in 320 aa overlap (252-559:140-428)
230 240 250 260 270 280
pF1KE1 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDV
.:: ::.... : : .
XP_016 VKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDG-----------SPTRI
110 120 130 140 150
290 300 310 320 330 340
pF1KE1 AYPEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQASLQSSLPLTIS
:: .. . : .: . : . . : . :: :: .:. :. :::.::: .:
XP_016 AYGTQGSSGYSLRL---CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT----
160 170 180 190 200 210
350 360 370 380 390
pF1KE1 MPQGHFCGGALIHPCWVLTAAHCTD---IKT--RHLKVVLGDQDLKKEEFHEQSFRVEKI
: :.:::.:: :::::::: : .. : . .:. .:. :. : ...:
XP_016 -AQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQ---IKEI
220 230 240 250 260
400 410 420 430 440 450
pF1KE1 FKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSG--SECHISGW
. ...:. . ..::::.::. :.. ... : .:::. . : ..: ..::
XP_016 IIHQNYKVSE--GNHDIALIKLQAPLN-----YTEFQKPICLPSKGDTSTIYTNCWVTGW
270 280 290 300 310 320
460 470 480 490 500 510
pF1KE1 GVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGG
: . : :. . : ... :..: :..: :. : . :.::: .. :.:.:.:::::
XP_016 GFSKEKGEIQNILQKVNIPLVTNEECQKRY-QDYKITQRMVCAG-YKEGGKDACKGDSGG
330 340 350 360 370
520 530 540 550 560
pF1KE1 PLTCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATIKSESGF
::.:...: . . ::.::: :..: :::::.:.....:: .: .:
XP_016 PLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
380 390 400 410 420 430
>>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa)
initn: 504 init1: 158 opt: 536 Z-score: 387.1 bits: 81.2 E(85289): 8e-15
Smith-Waterman score: 569; 40.7% identity (64.8% similar) in 253 aa overlap (313-557:216-450)
290 300 310 320 330 340
pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP
:: :: : .. :::::::
NP_001 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF---------
190 200 210 220 230
350 360 370 380 390
pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS
:: :.:::..: : :..:::::. :. . . .: .: . : :::: .:
NP_001 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS
240 250 260 270 280 290
400 410 420 430 440 450
pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET
.:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.::
NP_001 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED
300 310 320 330 340
460 470 480 490 500 510
pF1KE1 GKGSRQLLD-AKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCE
: . .:. : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.:.
NP_001 GGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVCQ
350 360 370 380 390 400
520 530 540 550 560
pF1KE1 KDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF
. . . : .:.:. :.. .:::::.::.::.::. .. .
NP_001 ERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
410 420 430 440 450
>>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa)
initn: 497 init1: 114 opt: 536 Z-score: 387.1 bits: 81.2 E(85289): 8e-15
Smith-Waterman score: 569; 41.3% identity (64.2% similar) in 254 aa overlap (313-557:216-451)
290 300 310 320 330 340
pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP
:: :: : .. :::::::
NP_076 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF---------
190 200 210 220 230
350 360 370 380 390
pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS
:: :.:::..: : :..:::::. :. . . .: .: . : :::: .:
NP_076 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS
240 250 260 270 280 290
400 410 420 430 440 450
pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET
.:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.::
NP_076 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED
300 310 320 330 340
460 470 480 490 500 510
pF1KE1 GKG--SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTC
: : : : : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.:
NP_076 GAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVC
350 360 370 380 390 400
520 530 540 550 560
pF1KE1 EKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF
.. . . : .:.:. :.. .:::::.::.::.::. .. .
NP_076 QERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
410 420 430 440 450
>>NP_000883 (OMIM: 229000,612423) plasma kallikrein isof (638 aa)
initn: 395 init1: 158 opt: 538 Z-score: 386.8 bits: 81.6 E(85289): 8.3e-15
Smith-Waterman score: 550; 33.1% identity (60.9% similar) in 320 aa overlap (252-559:342-630)
230 240 250 260 270 280
pF1KE1 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDV
.:: ::.... : : .
NP_000 VKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDG-----------SPTRI
320 330 340 350 360
290 300 310 320 330 340
pF1KE1 AYPEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQASLQSSLPLTIS
:: .. . : .: . : . . : . :: :: .:. :. :::.::: .:
NP_000 AYGTQGSSGYSLRL---CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT----
370 380 390 400 410
350 360 370 380 390
pF1KE1 MPQGHFCGGALIHPCWVLTAAHCTD---IKT--RHLKVVLGDQDLKKEEFHEQSFRVEKI
: :.:::.:: :::::::: : .. : . .:. .:. :. : ...:
NP_000 -AQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQ---IKEI
420 430 440 450 460
400 410 420 430 440 450
pF1KE1 FKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSG--SECHISGW
. ...:. . ..::::.::. :.. ... : .:::. . : ..: ..::
NP_000 IIHQNYKVSE--GNHDIALIKLQAPLN-----YTEFQKPICLPSKGDTSTIYTNCWVTGW
470 480 490 500 510 520
460 470 480 490 500 510
pF1KE1 GVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGG
: . : :. . : ... :..: :..: :. : . :.::: .. :.:.:.:::::
NP_000 GFSKEKGEIQNILQKVNIPLVTNEECQKRY-QDYKITQRMVCAG-YKEGGKDACKGDSGG
530 540 550 560 570 580
520 530 540 550 560
pF1KE1 PLTCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATIKSESGF
::.:...: . . ::.::: :..: :::::.:.....:: .: .:
NP_000 PLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
590 600 610 620 630
560 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:27:01 2016 done: Sun Nov 6 22:27:02 2016
Total Scan time: 9.120 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]