Result of FASTA (ccds) for
pFN21AE1552
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1552, 560 aa
1>>>pF1KE1552 560 - 560 aa - 560 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6579+/-0.00132; mu= 19.1863+/- 0.080
mean_var=207.6393+/-37.490, 0's: 0 Z-trim(109.2): 248 B-trim: 29 in 1/50
Lambda= 0.089006
statistics sampled from 10445 (10717) to 10445 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.329), width: 16
Scan time: 2.390
The best scores are: opt bits E(32554)
CCDS7577.1 HABP2 gene_id:3026|Hs108|chr10 ( 560) 4060 535.0 9.3e-152
CCDS53579.1 HABP2 gene_id:3026|Hs108|chr10 ( 534) 3893 513.5 2.6e-145
CCDS3369.1 HGFAC gene_id:3083|Hs108|chr4 ( 655) 1148 161.2 3.7e-39
CCDS75098.1 HGFAC gene_id:3083|Hs108|chr4 ( 662) 1100 155.0 2.6e-37
CCDS34120.1 KLKB1 gene_id:3818|Hs108|chr4 ( 638) 538 82.8 1.4e-15
CCDS58790.1 TMPRSS3 gene_id:64699|Hs108|chr21 ( 453) 536 82.3 1.4e-15
CCDS13686.1 TMPRSS3 gene_id:64699|Hs108|chr21 ( 454) 536 82.3 1.4e-15
CCDS33564.1 TMPRSS2 gene_id:7113|Hs108|chr21 ( 492) 530 81.6 2.5e-15
CCDS54486.1 TMPRSS2 gene_id:7113|Hs108|chr21 ( 529) 530 81.6 2.5e-15
CCDS74856.1 TMPRSS6 gene_id:164656|Hs108|chr22 ( 802) 532 82.2 2.6e-15
CCDS13941.1 TMPRSS6 gene_id:164656|Hs108|chr22 ( 811) 532 82.2 2.6e-15
CCDS75122.1 CORIN gene_id:10699|Hs108|chr4 ( 938) 529 81.9 3.7e-15
CCDS3477.1 CORIN gene_id:10699|Hs108|chr4 (1042) 529 82.0 3.9e-15
CCDS73391.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 413) 516 79.7 7.8e-15
CCDS73392.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 448) 516 79.7 8.1e-15
CCDS44735.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 457) 516 79.7 8.2e-15
CCDS8487.1 ST14 gene_id:6768|Hs108|chr11 ( 855) 516 80.2 1.1e-14
CCDS10431.1 TPSAB1 gene_id:7177|Hs108|chr16 ( 275) 508 78.4 1.3e-14
CCDS3847.1 F11 gene_id:2160|Hs108|chr4 ( 625) 511 79.3 1.5e-14
CCDS55788.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 532) 510 79.1 1.5e-14
CCDS41721.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 567) 510 79.1 1.6e-14
CCDS44881.1 TMPRSS12 gene_id:283471|Hs108|chr12 ( 348) 507 78.4 1.6e-14
CCDS58185.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 563) 509 79.0 1.7e-14
CCDS8812.1 CELA1 gene_id:1990|Hs108|chr12 ( 258) 504 77.8 1.8e-14
CCDS34302.1 F12 gene_id:2161|Hs108|chr5 ( 615) 505 78.5 2.5e-14
CCDS157.1 CELA2A gene_id:63036|Hs108|chr1 ( 269) 500 77.3 2.6e-14
CCDS14666.1 F9 gene_id:2158|Hs108|chrX ( 461) 494 76.9 5.8e-14
CCDS3518.1 TMPRSS11D gene_id:9407|Hs108|chr4 ( 418) 492 76.6 6.7e-14
CCDS12813.1 KLK8 gene_id:11202|Hs108|chr19 ( 260) 489 75.9 6.8e-14
CCDS42600.1 KLK8 gene_id:11202|Hs108|chr19 ( 305) 489 76.0 7.4e-14
CCDS45469.1 PRSS8 gene_id:5652|Hs108|chr16 ( 343) 489 76.1 7.9e-14
CCDS12088.1 TMPRSS9 gene_id:360200|Hs108|chr19 (1059) 495 77.7 8.1e-14
CCDS3964.1 GZMK gene_id:3003|Hs108|chr5 ( 264) 484 75.2 1.1e-13
CCDS73602.1 F7 gene_id:2155|Hs108|chr13 ( 382) 483 75.4 1.4e-13
CCDS9529.1 F7 gene_id:2155|Hs108|chr13 ( 444) 483 75.5 1.5e-13
CCDS9528.1 F7 gene_id:2155|Hs108|chr13 ( 466) 483 75.5 1.6e-13
CCDS76482.1 TMPRSS4 gene_id:56649|Hs108|chr11 ( 290) 480 74.8 1.6e-13
CCDS53717.1 TMPRSS4 gene_id:56649|Hs108|chr11 ( 397) 480 75.0 1.9e-13
CCDS74669.1 PRSS56 gene_id:646960|Hs108|chr2 ( 603) 482 75.6 1.9e-13
CCDS44743.1 TMPRSS4 gene_id:56649|Hs108|chr11 ( 432) 480 75.1 2e-13
CCDS53716.1 TMPRSS4 gene_id:56649|Hs108|chr11 ( 435) 480 75.1 2e-13
CCDS31684.1 TMPRSS4 gene_id:56649|Hs108|chr11 ( 437) 480 75.1 2e-13
CCDS83495.1 F9 gene_id:2158|Hs108|chrX ( 423) 478 74.8 2.3e-13
CCDS83291.1 PLAT gene_id:5327|Hs108|chr8 ( 473) 477 74.8 2.7e-13
CCDS12822.1 KLK13 gene_id:26085|Hs108|chr19 ( 277) 473 73.9 2.9e-13
CCDS14101.1 ACR gene_id:49|Hs108|chr22 ( 421) 473 74.2 3.6e-13
CCDS10852.1 CTRL gene_id:1506|Hs108|chr16 ( 264) 466 72.9 5.3e-13
CCDS5976.1 PRSS55 gene_id:203074|Hs108|chr8 ( 352) 467 73.3 5.6e-13
CCDS2145.1 PROC gene_id:5624|Hs108|chr2 ( 461) 468 73.6 5.9e-13
CCDS10481.1 PRSS22 gene_id:64063|Hs108|chr16 ( 317) 465 72.9 6.4e-13
>>CCDS7577.1 HABP2 gene_id:3026|Hs108|chr10 (560 aa)
initn: 4060 init1: 4060 opt: 4060 Z-score: 2838.0 bits: 535.0 E(32554): 9.3e-152
Smith-Waterman score: 4060; 100.0% identity (100.0% similar) in 560 aa overlap (1-560:1-560)
10 20 30 40 50 60
pF1KE1 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
490 500 510 520 530 540
550 560
pF1KE1 TQVTKFLNWIKATIKSESGF
::::::::::::::::::::
CCDS75 TQVTKFLNWIKATIKSESGF
550 560
>>CCDS53579.1 HABP2 gene_id:3026|Hs108|chr10 (534 aa)
initn: 3893 init1: 3893 opt: 3893 Z-score: 2722.3 bits: 513.5 E(32554): 2.6e-145
Smith-Waterman score: 3893; 100.0% identity (100.0% similar) in 534 aa overlap (27-560:1-534)
10 20 30 40 50 60
pF1KE1 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
::::::::::::::::::::::::::::::::::
CCDS53 MSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
10 20 30
70 80 90 100 110 120
pF1KE1 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE1 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
460 470 480 490 500 510
550 560
pF1KE1 TQVTKFLNWIKATIKSESGF
::::::::::::::::::::
CCDS53 TQVTKFLNWIKATIKSESGF
520 530
>>CCDS3369.1 HGFAC gene_id:3083|Hs108|chr4 (655 aa)
initn: 787 init1: 203 opt: 1148 Z-score: 816.6 bits: 161.2 E(32554): 3.7e-39
Smith-Waterman score: 1148; 36.6% identity (61.8% similar) in 503 aa overlap (75-555:162-646)
50 60 70 80 90 100
pF1KE1 SYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDC--LVHGSTFTCSCLAP
::: .:: .::.: ... :::
CCDS33 WCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRA
140 150 160 170 180 190
110 120 130 140 150
pF1KE1 FSGNKCQKVQNTCKDNP------CGRGQCLITQSPPYYRCVCKHPYTGPS-CSQVV-PVC
:.:. : . : :. : . :. .: : . : . : . .:
CCDS33 FTGKDCG--TEKCFDETRYEYLEGGDRWARVRQGH-VEQCEC---FGGRTWCEGTRHTAC
200 210 220 230 240
160 170 180 190 200 210
pF1KE1 RPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDD-CYVGDGYSYRGKMNRTVNQH
.:: ::.:: . .:::: : :..:.: :. :..:.: .::: . ...
CCDS33 LSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGL
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE1 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV
.:: ::: :: :: . . : :.: : .::::: ::.:::.. : .. ..:::: .
CCDS33 SCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRL
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE1 SACSAQDVAY--PEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQAS
:: . . :. : : :: ..::. . . .. :: :: .: :.::: :.
CCDS33 EACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAA
370 380 390 400 410 420
340 350 360 370 380
pF1KE1 LQSSLPLTISMPQGHFCGGALIHPCWVLTAAHC-TDIKTRH-LKVVLGDQDLKKEEFHEQ
. . ::.:.:.: :::..:::: . : ..::::.. ... :
CCDS33 IYIG---------DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQ
430 440 450 460 470
390 400 410 420 430 440
pF1KE1 SFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPD-GS-FPSGSE
.: .:: . :. :. . : :..:..:: .:: .:..:. .:::. :: ::.: .
CCDS33 TFGIEKYIPYTLYSVFNPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHK
480 490 500 510 520 530
450 460 470 480 490 500
pF1KE1 CHISGWG-VTETGKG-SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDT
:.:.::: . :. .: : .: .: : :.:. :.: ..: :. .:.::: .. . :.
CCDS33 CQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKS-DA
540 550 560 570 580 590
510 520 530 540 550 560
pF1KE1 CQGDSGGPLTCEKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF
:::::::::.:::.:. :.:::.::: ::. .:::::.:.....::. :.
CCDS33 CQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVA
600 610 620 630 640 650
CCDS33 PS
>>CCDS75098.1 HGFAC gene_id:3083|Hs108|chr4 (662 aa)
initn: 718 init1: 237 opt: 1100 Z-score: 783.2 bits: 155.0 E(32554): 2.6e-37
Smith-Waterman score: 1137; 36.3% identity (61.8% similar) in 510 aa overlap (75-555:162-653)
50 60 70 80 90 100
pF1KE1 SYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDC--LVHGSTFTCSCLAP
::: .:: .::.: ... :::
CCDS75 WCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRA
140 150 160 170 180 190
110 120 130 140 150
pF1KE1 FSGNKCQKVQNTCKDNP------CGRGQCLITQSPPYYRCVCKHPYTGPS-CSQVV-PVC
:.:. : . : :. : . :. .: : . : . : . .:
CCDS75 FTGKDCG--TEKCFDETRYEYLEGGDRWARVRQGH-VEQCEC---FGGRTWCEGTRHTAC
200 210 220 230 240
160 170 180 190 200 210
pF1KE1 RPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDD-CYVGDGYSYRGKMNRTVNQH
.:: ::.:: . .:::: : :..:.: :. :..:.: .::: . ...
CCDS75 LSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGL
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE1 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV
.:: ::: :: :: . . : :.: : .::::: ::.:::.. : .. ..:::: .
CCDS75 SCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRL
310 320 330 340 350 360
280 290 300 310 320
pF1KE1 SACSAQ-----DVAYPEESP----TEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAG
::. . ... . :: : : :: ..::. . . .. :: :: .: :
CCDS75 EACDLETEGRESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPG
370 380 390 400 410 420
330 340 350 360 370 380
pF1KE1 KHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTAAHC-TDIKTRH-LKVVLGDQDLK
.::: :.. . ::.:.:.: :::..:::: . : ..::::.. ..
CCDS75 SHPWLAAIYIG---------DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFN
430 440 450 460 470
390 400 410 420 430 440
pF1KE1 KEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPD-GS
. :.: .:: . :. :. . : :..:..:: .:: .:..:. .:::. ::
CCDS75 RTTDVTQTFGIEKYIPYTLYSVFNPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGS
480 490 500 510 520 530
450 460 470 480 490
pF1KE1 -FPSGSECHISGWG-VTETGKG-SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNL
::.: .:.:.::: . :. .: : .: .: : :.:. :.: ..: :. .:.::: .
CCDS75 TFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYF
540 550 560 570 580 590
500 510 520 530 540 550
pF1KE1 QKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIK
. . :.:::::::::.:::.:. :.:::.::: ::. .:::::.:.....::. :.
CCDS75 DCKS-DACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIR
600 610 620 630 640 650
560
pF1KE1 SESGF
CCDS75 PPRRLVAPS
660
>>CCDS34120.1 KLKB1 gene_id:3818|Hs108|chr4 (638 aa)
initn: 395 init1: 158 opt: 538 Z-score: 393.3 bits: 82.8 E(32554): 1.4e-15
Smith-Waterman score: 550; 33.1% identity (60.9% similar) in 320 aa overlap (252-559:342-630)
230 240 250 260 270 280
pF1KE1 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDV
.:: ::.... : : .
CCDS34 VKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDG-----------SPTRI
320 330 340 350 360
290 300 310 320 330 340
pF1KE1 AYPEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQASLQSSLPLTIS
:: .. . : .: . : . . : . :: :: .:. :. :::.::: .:
CCDS34 AYGTQGSSGYSLRL---CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT----
370 380 390 400 410
350 360 370 380 390
pF1KE1 MPQGHFCGGALIHPCWVLTAAHCTD---IKT--RHLKVVLGDQDLKKEEFHEQSFRVEKI
: :.:::.:: :::::::: : .. : . .:. .:. :. : ...:
CCDS34 -AQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQ---IKEI
420 430 440 450 460
400 410 420 430 440 450
pF1KE1 FKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSG--SECHISGW
. ...:. . ..::::.::. :.. ... : .:::. . : ..: ..::
CCDS34 IIHQNYKVSE--GNHDIALIKLQAPLN-----YTEFQKPICLPSKGDTSTIYTNCWVTGW
470 480 490 500 510 520
460 470 480 490 500 510
pF1KE1 GVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGG
: . : :. . : ... :..: :..: :. : . :.::: .. :.:.:.:::::
CCDS34 GFSKEKGEIQNILQKVNIPLVTNEECQKRY-QDYKITQRMVCAG-YKEGGKDACKGDSGG
530 540 550 560 570 580
520 530 540 550 560
pF1KE1 PLTCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATIKSESGF
::.:...: . . ::.::: :..: :::::.:.....:: .: .:
CCDS34 PLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
590 600 610 620 630
>>CCDS58790.1 TMPRSS3 gene_id:64699|Hs108|chr21 (453 aa)
initn: 504 init1: 158 opt: 536 Z-score: 393.3 bits: 82.3 E(32554): 1.4e-15
Smith-Waterman score: 569; 40.7% identity (64.8% similar) in 253 aa overlap (313-557:216-450)
290 300 310 320 330 340
pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP
:: :: : .. :::::::
CCDS58 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF---------
190 200 210 220 230
350 360 370 380 390
pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS
:: :.:::..: : :..:::::. :. . . .: .: . : :::: .:
CCDS58 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS
240 250 260 270 280 290
400 410 420 430 440 450
pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET
.:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.::
CCDS58 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED
300 310 320 330 340
460 470 480 490 500 510
pF1KE1 GKGSRQLLD-AKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCE
: . .:. : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.:.
CCDS58 GGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVCQ
350 360 370 380 390 400
520 530 540 550 560
pF1KE1 KDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF
. . . : .:.:. :.. .:::::.::.::.::. .. .
CCDS58 ERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
410 420 430 440 450
>>CCDS13686.1 TMPRSS3 gene_id:64699|Hs108|chr21 (454 aa)
initn: 497 init1: 114 opt: 536 Z-score: 393.3 bits: 82.3 E(32554): 1.4e-15
Smith-Waterman score: 569; 41.3% identity (64.2% similar) in 254 aa overlap (313-557:216-451)
290 300 310 320 330 340
pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP
:: :: : .. :::::::
CCDS13 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF---------
190 200 210 220 230
350 360 370 380 390
pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS
:: :.:::..: : :..:::::. :. . . .: .: . : :::: .:
CCDS13 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS
240 250 260 270 280 290
400 410 420 430 440 450
pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET
.:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.::
CCDS13 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED
300 310 320 330 340
460 470 480 490 500 510
pF1KE1 GKG--SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTC
: : : : : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.:
CCDS13 GAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVC
350 360 370 380 390 400
520 530 540 550 560
pF1KE1 EKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF
.. . . : .:.:. :.. .:::::.::.::.::. .. .
CCDS13 QERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
410 420 430 440 450
>>CCDS33564.1 TMPRSS2 gene_id:7113|Hs108|chr21 (492 aa)
initn: 377 init1: 173 opt: 530 Z-score: 388.8 bits: 81.6 E(32554): 2.5e-15
Smith-Waterman score: 572; 32.6% identity (55.2% similar) in 420 aa overlap (159-557:113-491)
130 140 150 160 170 180
pF1KE1 QSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQN-GATCSRHKRRSKFTCACPDQFKGKFC
:.: : :. :. :: :... :
CCDS33 KALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECD-----SSGTCINPSNW----C
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 EIGSDDCYVGDGYSYRGKM---NRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIG-EH
. : . : :. . .. : .. .. . : . :...: . : . .: ..
CCDS33 D-GVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKN
140 150 160 170 180 190
250 260 270 280 290
pF1KE1 NFCRNPDA--DEKPWCFIKVT----NDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPG
:: . : :.:.. : . . .:::.. :. : .
CCDS33 NFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVV---------SLRCI-
200 210 220 230 240
300 310 320 330 340 350
pF1KE1 FDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWV
.:: . . :. .:: :: .. : :::.::. . . : :::..: : :.
CCDS33 --ACGVNLNSSRQ-SRIVGGESALPGAWPWQVSLH--------VQNVHVCGGSIITPEWI
250 260 270 280 290
360 370 380 390 400 410
pF1KE1 LTAAHCTDIKTR---HLKVVLGDQDLKKE-EFHEQSFRVEKIFKYSHYNERDEIPHNDIA
.:::::.. : . : :.. :. ...:::.. :: : .. .::::
CCDS33 VTAAHCVEKPLNNPWHWTAFAG--ILRQSFMFYGAGYQVEKVI--SHPNYDSKTKNNDIA
300 310 320 330 340
420 430 440 450 460
pF1KE1 LLKL-KPVDGHCALESKYVKTVCLPDGSFPSGSE--CHISGWGVTET-GKGSRQLLDAKV
:.:: ::. . :: ::::. .. : : :::::.:: :: :. : :::
CCDS33 LMKLQKPL-----TFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKV
350 360 370 380 390 400
470 480 490 500 510 520
pF1KE1 KLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSW
:: . :::: .::..: .::::: :: . :.:::::::::. :.. ... : .::
CCDS33 LLIETQRCNSRYVYDNLITPAMICAGFLQG-NVDSCQGDSGGPLVTSKNNIWWLIGDTSW
410 420 430 440 450 460
530 540 550 560
pF1KE1 GLECGK--RPGVYTQVTKFLNWIKATIKSESGF
: :.: ::::: .: : .:: ....
CCDS33 GSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
470 480 490
>>CCDS54486.1 TMPRSS2 gene_id:7113|Hs108|chr21 (529 aa)
initn: 377 init1: 173 opt: 530 Z-score: 388.5 bits: 81.6 E(32554): 2.5e-15
Smith-Waterman score: 572; 32.6% identity (55.2% similar) in 420 aa overlap (159-557:150-528)
130 140 150 160 170 180
pF1KE1 QSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQN-GATCSRHKRRSKFTCACPDQFKGKFC
:.: : :. :. :: :... :
CCDS54 KALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECD-----SSGTCINPSNW----C
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 EIGSDDCYVGDGYSYRGKM---NRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIG-EH
. : . : :. . .. : .. .. . : . :...: . : . .: ..
CCDS54 D-GVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKN
180 190 200 210 220
250 260 270 280 290
pF1KE1 NFCRNPDA--DEKPWCFIKVT----NDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPG
:: . : :.:.. : . . .:::.. :. : .
CCDS54 NFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVV---------SLRCI-
230 240 250 260 270
300 310 320 330 340 350
pF1KE1 FDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWV
.:: . . :. .:: :: .. : :::.::. . . : :::..: : :.
CCDS54 --ACGVNLNSSRQ-SRIVGGESALPGAWPWQVSLH--------VQNVHVCGGSIITPEWI
280 290 300 310 320
360 370 380 390 400 410
pF1KE1 LTAAHCTDIKTR---HLKVVLGDQDLKKE-EFHEQSFRVEKIFKYSHYNERDEIPHNDIA
.:::::.. : . : :.. :. ...:::.. :: : .. .::::
CCDS54 VTAAHCVEKPLNNPWHWTAFAG--ILRQSFMFYGAGYQVEKVI--SHPNYDSKTKNNDIA
330 340 350 360 370 380
420 430 440 450 460
pF1KE1 LLKL-KPVDGHCALESKYVKTVCLPDGSFPSGSE--CHISGWGVTET-GKGSRQLLDAKV
:.:: ::. . :: ::::. .. : : :::::.:: :: :. : :::
CCDS54 LMKLQKPL-----TFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKV
390 400 410 420 430
470 480 490 500 510 520
pF1KE1 KLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSW
:: . :::: .::..: .::::: :: . :.:::::::::. :.. ... : .::
CCDS54 LLIETQRCNSRYVYDNLITPAMICAGFLQG-NVDSCQGDSGGPLVTSKNNIWWLIGDTSW
440 450 460 470 480 490
530 540 550 560
pF1KE1 GLECGK--RPGVYTQVTKFLNWIKATIKSESGF
: :.: ::::: .: : .:: ....
CCDS54 GSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
500 510 520
>>CCDS74856.1 TMPRSS6 gene_id:164656|Hs108|chr22 (802 aa)
initn: 383 init1: 107 opt: 532 Z-score: 388.3 bits: 82.2 E(32554): 2.6e-15
Smith-Waterman score: 532; 40.8% identity (62.0% similar) in 255 aa overlap (313-554:567-801)
290 300 310 320 330 340
pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP
:: :: :. :. :::::::
CCDS74 KPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQV---------
540 550 560 570 580
350 360 370 380 390
pF1KE1 QG-HFCGGALIHPCWVLTAAHCTD----IKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFK
.: :.:::::: ::.::::: . .: : :: ... : ::.: ...
CCDS74 RGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLL
590 600 610 620 630 640
400 410 420 430 440 450
pF1KE1 YSHYNERDEIPHN-DIALLKLKPVDGHCALESKYVKTVCLPDGS--FPSGSECHISGWG-
. :.:.: :. :.:::.: : ...: :. :::: : : : .: :.:::
CCDS74 HP-YHEED--SHDYDVALLQL----DHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGA
650 660 670 680 690 700
460 470 480 490 500 510
pF1KE1 VTETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPL
. : : : : . :.:: . ::. ..: ... :.::: .: .:.:::::::::
CCDS74 LREGGPISNALQKVDVQLIPQDLCS--EVYRYQVTPRMLCAG-YRKGKKDACQGDSGGPL
710 720 730 740 750
520 530 540 550 560
pF1KE1 TCEK-DGTYYVYGIVSWGLECGKRP---GVYTQVTKFLNWIKATIKSESGF
.:. .: ... :.::::: :: :: ::::..: ..::. ..
CCDS74 VCKALSGRWFLAGLVSWGLGCG-RPNYFGVYTRITGVISWIQQVVT
760 770 780 790 800
560 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:27:00 2016 done: Sun Nov 6 22:27:01 2016
Total Scan time: 2.390 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]