Result of FASTA (omim) for
pFN21AE1494
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1494, 247 aa
1>>>pF1KE1494 247 - 247 aa - 247 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3124+/-0.000316; mu= 15.2207+/- 0.020
mean_var=79.6002+/-15.948, 0's: 0 Z-trim(116.6): 298 B-trim: 47 in 1/54
Lambda= 0.143753
statistics sampled from 27638 (27958) to 27638 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.328), width: 16
Scan time: 6.550
The best scores are: opt bits E(85289)
NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 1697 361.1 1.1e-99
NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 1586 338.0 8.7e-93
NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 1172 252.2 6.3e-67
NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 990 214.4 1.5e-55
XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 989 214.2 1.5e-55
XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 917 199.3 5.7e-51
NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 826 180.4 2.5e-45
NP_001257709 (OMIM: 116831) granzyme H isoform 2 p ( 182) 739 162.3 5.4e-40
NP_001257710 (OMIM: 116831) granzyme H isoform 3 p ( 160) 629 139.4 3.6e-33
NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 583 130.0 3.9e-30
NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 554 124.0 2.6e-28
NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 554 124.0 2.6e-28
NP_002768 (OMIM: 177020) myeloblastin precursor [H ( 256) 544 121.9 1.1e-27
NP_001919 (OMIM: 134350,613912) complement factor ( 253) 529 118.8 9e-27
NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 526 118.2 1.4e-26
NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 525 118.0 1.6e-26
NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 525 118.0 1.6e-26
NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 525 118.0 1.7e-26
NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 523 117.6 2.3e-26
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 522 117.4 2.5e-26
NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 521 117.2 2.8e-26
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 520 117.0 3.8e-26
XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 521 117.4 4.6e-26
NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 511 115.1 1.2e-25
NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 504 113.7 3.3e-25
NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 482 109.1 7.6e-24
NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 476 107.8 1.9e-23
NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 473 107.2 2.8e-23
NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 473 107.2 2.8e-23
NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 472 107.0 3.3e-23
NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 472 107.1 3.8e-23
NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 470 106.6 4.2e-23
NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 467 106.0 6.5e-23
NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 467 106.0 6.5e-23
XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 468 106.3 7.2e-23
NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 462 104.9 1.4e-22
NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 459 104.4 2.4e-22
XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 459 104.4 2.4e-22
XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 459 104.4 2.4e-22
NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 459 104.4 2.4e-22
NP_001070960 (OMIM: 605643) kallikrein-5 prepropro ( 293) 459 104.4 2.4e-22
NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 458 104.1 2.4e-22
XP_011526438 (OMIM: 177020) PREDICTED: myeloblasti ( 206) 448 102.0 8.8e-22
NP_001295012 (OMIM: 118938) chymase isoform 2 [Hom ( 136) 432 98.5 6.4e-21
NP_001245280 (OMIM: 600311) granzyme M isoform 2 [ ( 218) 427 97.6 1.9e-20
NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 426 97.5 2.4e-20
XP_011525387 (OMIM: 610601) PREDICTED: kallikrein- ( 255) 426 97.5 2.4e-20
NP_001264010 (OMIM: 610601) kallikrein-15 isoform ( 255) 426 97.5 2.4e-20
XP_006723328 (OMIM: 610601) PREDICTED: kallikrein- ( 256) 424 97.1 3.3e-20
NP_059979 (OMIM: 610601) kallikrein-15 isoform 4 p ( 256) 424 97.1 3.3e-20
>>NP_004122 (OMIM: 123910) granzyme B isoform 1 prepropr (247 aa)
initn: 1697 init1: 1697 opt: 1697 Z-score: 1910.9 bits: 361.1 E(85289): 1.1e-99
Smith-Waterman score: 1697; 99.2% identity (100.0% similar) in 247 aa overlap (1-247:1-247)
10 20 30 40 50 60
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_004 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
190 200 210 220 230 240
pF1KE1 KKTMKRH
::::::.
NP_004 KKTMKRY
>>NP_001332940 (OMIM: 123910) granzyme B isoform 2 [Homo (235 aa)
initn: 1585 init1: 1585 opt: 1586 Z-score: 1786.8 bits: 338.0 E(85289): 8.7e-93
Smith-Waterman score: 1586; 98.7% identity (100.0% similar) in 230 aa overlap (18-247:6-235)
10 20 30 40 50 60
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVL
.::::::::::::::::::::::::::::::::::::.:::::
NP_001 MQTFPSGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
10 20 30 40
70 80 90 100 110 120
pF1KE1 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE1 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE1 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
170 180 190 200 210 220
pF1KE1 KKTMKRH
::::::.
NP_001 KKTMKRY
230
>>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa)
initn: 1172 init1: 831 opt: 1172 Z-score: 1322.5 bits: 252.2 E(85289): 6.3e-67
Smith-Waterman score: 1172; 71.1% identity (85.8% similar) in 246 aa overlap (1-246:1-245)
10 20 30 40 50 60
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVL
:::.:::::::: : : . :::::::::::::::::.... ..:: :::::.:.. ::::
NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
::::: ::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_219 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
: ::.::::::.:::::::: ::::::: .. .. . ::::: .:::.: .:: ..
NP_219 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGN
130 140 150 160 170
190 200 210 220 230 240
pF1KE1 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
:. . :.:::::. .:.:::::::::::. :::::.::: ..: :: . ::: :. ::
NP_219 YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI
180 190 200 210 220 230
pF1KE1 KKTMKRH
:.::::
NP_219 KRTMKRL
240
>>NP_001902 (OMIM: 116830) cathepsin G preproprotein [Ho (255 aa)
initn: 1032 init1: 663 opt: 990 Z-score: 1118.3 bits: 214.4 E(85289): 1.5e-55
Smith-Waterman score: 990; 57.5% identity (83.0% similar) in 247 aa overlap (1-245:1-243)
10 20 30 40 50 60
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVL
:::.:::::::: :.:::::::.:..::::::::::.: . . .::::::...::::
NP_001 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
::::::::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...:
NP_001 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
.: :.:. :: . ..:: :.:::::... . . . ::.::.. ::.::.: :: .
NP_001 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQC---LRIF
130 140 150 160 170
190 200 210 220 230
pF1KE1 --YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH
:: ..:::: . .:..:::::::::.::.::.::::::...:.::.. :.::::.
NP_001 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP
180 190 200 210 220 230
240
pF1KE1 WIKKTMKRH
::. ::.
NP_001 WIRTTMRSFKLLDQMETPL
240 250
>>XP_011534985 (OMIM: 116831) PREDICTED: granzyme H isof (212 aa)
initn: 989 init1: 648 opt: 989 Z-score: 1118.3 bits: 214.2 E(85289): 1.5e-55
Smith-Waterman score: 989; 69.3% identity (85.4% similar) in 212 aa overlap (35-246:1-211)
10 20 30 40 50 60
pF1KE1 LLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVLTAAH
::.... ..:: :::::.:.. ::::::::
XP_011 MAFVQFLQEKSRKRCGGILVRKDFVLTAAH
10 20 30
70 80 90 100 110 120
pF1KE1 CWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAV
: ::::::::::::::::: ::::::::::::::::::::::::::::::::::: : ::
XP_011 CQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 QPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDST
.::::::.:::::::: ::::::: .. .. . ::::: .:::.: .:: .. :. .
XP_011 RPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGNYSRA
100 110 120 130 140
190 200 210 220 230 240
pF1KE1 IELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTM
:.:::::. .:.:::::::::::. :::::.::: ..: :: . ::: :. :::.::
XP_011 TEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTM
150 160 170 180 190 200
pF1KE1 KRH
::
XP_011 KRL
210
>>XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G iso (269 aa)
initn: 984 init1: 590 opt: 917 Z-score: 1036.1 bits: 199.3 E(85289): 5.7e-51
Smith-Waterman score: 952; 54.4% identity (78.5% similar) in 261 aa overlap (1-245:1-257)
10 20 30 40
pF1KE1 MQPILLLLAFLLLPRADAG--------------EIIGGHEAKPHSRPYMAYLMIWDQKSL
:::.:::::::: :.:: :::::.:..::::::::::.: . .
XP_011 MQPLLLLLAFLLPTGAEAGSASIELSAKCFLPGEIIGGRESRPHSRPYMAYLQIQSPAGQ
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 KRCGGFLIQDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFS
.::::::...::::::::::::.::::::::::...: ::: : ..: : :: :: ....
XP_011 SRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 NDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMT
:::::::: :...:.: :.:. :: . ..:: :.:::::... . . . ::.::..
XP_011 NDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLR
130 140 150 160 170
170 180 190 200 210 220
pF1KE1 VQEDRKCESDLRHY--YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNG
::.::.: :: . :: ..:::: . .:..:::::::::.::.::.::::::...:
XP_011 VQRDRQC---LRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSG
180 190 200 210 220 230
230 240
pF1KE1 MPPRACTKVSSFVHWIKKTMKRH
.::.. :.::::. ::. ::.
XP_011 VPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
240 250 260
>>NP_001827 (OMIM: 118938) chymase isoform 1 preproprote (247 aa)
initn: 833 init1: 420 opt: 826 Z-score: 934.6 bits: 180.4 E(85289): 2.5e-45
Smith-Waterman score: 826; 53.3% identity (74.8% similar) in 246 aa overlap (1-245:3-245)
10 20 30 40 50
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYL-MIWDQKSLKRCGGFLIQDD
. :. ::: ::: ::.::::::: : ::::::::::: .. .. : ::::::. .
NP_001 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 FVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK
:::::::: : ::.:::::::: :.: : : . : . . :: :: ... .:::::.:..:
NP_001 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 AKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDL
:. : :: : .::. : ::. : :::::.:. : : ::::::. ... . : : .
NP_001 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQAC-SHF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 RHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFV
: . : ...::::.:. :..:::::::::.: ::::::::::... :: . :..: .
NP_001 RDF-DHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYR
180 190 200 210 220 230
240
pF1KE1 HWIKKTMKRH
::.. ..
NP_001 PWINQILQAN
240
>>NP_001257709 (OMIM: 116831) granzyme H isoform 2 precu (182 aa)
initn: 737 init1: 737 opt: 739 Z-score: 838.9 bits: 162.3 E(85289): 5.4e-40
Smith-Waterman score: 813; 57.7% identity (65.9% similar) in 246 aa overlap (1-246:1-181)
10 20 30 40 50 60
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVL
:::.:::::::: : : . :::::::::::::::::.... ..:: :::::.:.. ::::
NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
::::: ::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
: ::.::::::.:::
NP_001 TTAVRPLRLPSSKAQ---------------------------------------------
130
190 200 210 220 230 240
pF1KE1 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
:::::::::. :::::.::: ..: :: . ::: :. ::
NP_001 --------------------GDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI
140 150 160 170
pF1KE1 KKTMKRH
:.::::
NP_001 KRTMKRL
180
>>NP_001257710 (OMIM: 116831) granzyme H isoform 3 precu (160 aa)
initn: 629 init1: 629 opt: 629 Z-score: 716.4 bits: 139.4 E(85289): 3.6e-33
Smith-Waterman score: 661; 50.4% identity (57.7% similar) in 246 aa overlap (1-246:1-159)
10 20 30 40 50 60
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVL
:::.:::::::: : : . :::::::::::::::::.... ..:: :::::.:.. ::::
NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
::::: ::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQ-------
70 80 90 100 110
130 140 150 160 170 180
pF1KE1 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KE1 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
:::::::::. :::::.::: ..: :: . ::: :. ::
NP_001 --------------------GDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI
120 130 140 150
pF1KE1 KKTMKRH
:.::::
NP_001 KRTMKRL
160
>>NP_006135 (OMIM: 140050) granzyme A precursor [Homo sa (262 aa)
initn: 571 init1: 296 opt: 583 Z-score: 661.9 bits: 130.0 E(85289): 3.9e-30
Smith-Waterman score: 583; 42.0% identity (70.8% similar) in 250 aa overlap (6-245:14-259)
10 20 30 40 50
pF1KE1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGF
.....::.:. .::::.:. :::::::. : . :.:.. :.:
NP_006 MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSL-DRKTI--CAGA
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 LIQDDFVLTAAHC-WGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIML
:: :.::::::: .. .: ::::.: ..:::.:.. ::. .:.: :.: . .:. :
NP_006 LIAKDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDR
::: .::: .. : :.::.. .:::: :.:::::.: .. : ::.::..:. ::
NP_006 LQLTEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITII-DR
120 130 140 150 160 170
180 190 200 210 220
pF1KE1 KCESDLRHY-YDSTIEL---CVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN--GM
: .: :: .. .: . :.:. . . : .::::.::.:. : .:..:.: .: :
NP_006 KVCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGD
180 190 200 210 220 230
230 240
pF1KE1 P--PRACTKVSS-FVHWIKKTMKRH
: : . .:. ..:: :.:
NP_006 PRGPGVYILLSKKHLNWIIMTIKGAV
240 250 260
247 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:29:23 2016 done: Sun Nov 6 22:29:25 2016
Total Scan time: 6.550 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]