Result of FASTA (omim) for
pFN21AE1452
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1452, 249 aa
1>>>pF1KE1452 249 - 249 aa - 249 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4389+/-0.000317; mu= 5.4952+/- 0.020
mean_var=131.5051+/-25.763, 0's: 0 Z-trim(119.7): 25 B-trim: 0 in 0/56
Lambda= 0.111841
statistics sampled from 33930 (33955) to 33930 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.398), width: 16
Scan time: 7.220
The best scores are: opt bits E(85289)
NP_006254 (OMIM: 600654) proteasome activator comp ( 249) 1634 274.2 1.5e-73
NP_001268457 (OMIM: 600654) proteasome activator c ( 233) 1468 247.4 1.6e-65
NP_788955 (OMIM: 600654) proteasome activator comp ( 250) 1468 247.4 1.7e-65
NP_001268458 (OMIM: 600654) proteasome activator c ( 236) 1025 175.9 5.4e-44
NP_005780 (OMIM: 605129) proteasome activator comp ( 254) 679 120.1 3.7e-27
NP_001253974 (OMIM: 605129) proteasome activator c ( 265) 657 116.6 4.5e-26
NP_002809 (OMIM: 602161) proteasome activator comp ( 239) 547 98.8 9.1e-21
XP_006720276 (OMIM: 602161) PREDICTED: proteasome ( 162) 542 97.9 1.1e-20
NP_001317158 (OMIM: 605129) proteasome activator c ( 193) 498 90.9 1.8e-18
NP_789839 (OMIM: 605129) proteasome activator comp ( 267) 396 74.5 2.1e-13
>>NP_006254 (OMIM: 600654) proteasome activator complex (249 aa)
initn: 1634 init1: 1634 opt: 1634 Z-score: 1441.5 bits: 274.2 E(85289): 1.5e-73
Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:1-249)
10 20 30 40 50 60
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP
190 200 210 220 230 240
pF1KE1 RGETKGMIY
:::::::::
NP_006 RGETKGMIY
>>NP_001268457 (OMIM: 600654) proteasome activator compl (233 aa)
initn: 1468 init1: 1468 opt: 1468 Z-score: 1297.2 bits: 247.4 E(85289): 1.6e-65
Smith-Waterman score: 1468; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223)
10 20 30 40 50 60
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP
:::::::::::::::::::::::::::::::::::::::::::
NP_001 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRLCYMTSS
190 200 210 220 230
pF1KE1 RGETKGMIY
>>NP_788955 (OMIM: 600654) proteasome activator complex (250 aa)
initn: 1468 init1: 1468 opt: 1468 Z-score: 1296.7 bits: 247.4 E(85289): 1.7e-65
Smith-Waterman score: 1468; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223)
10 20 30 40 50 60
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_788 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_788 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_788 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP
:::::::::::::::::::::::::::::::::::::::::::
NP_788 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRQGQGRGGQRQLSQA
190 200 210 220 230 240
pF1KE1 RGETKGMIY
NP_788 THSLTLQARG
250
>>NP_001268458 (OMIM: 600654) proteasome activator compl (236 aa)
initn: 1021 init1: 1021 opt: 1025 Z-score: 910.8 bits: 175.9 E(85289): 5.4e-44
Smith-Waterman score: 1519; 94.8% identity (94.8% similar) in 249 aa overlap (1-249:1-236)
10 20 30 40 50 60
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
::::::::::::::::::::::::::::::::: ::::::::::::::
NP_001 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQ-------------LEGFHTQISKYFSE
130 140 150 160
190 200 210 220 230 240
pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP
170 180 190 200 210 220
pF1KE1 RGETKGMIY
:::::::::
NP_001 RGETKGMIY
230
>>NP_005780 (OMIM: 605129) proteasome activator complex (254 aa)
initn: 672 init1: 473 opt: 679 Z-score: 608.6 bits: 120.1 E(85289): 3.7e-27
Smith-Waterman score: 679; 40.9% identity (74.2% similar) in 252 aa overlap (2-249:3-254)
10 20 30 40 50
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:.....
NP_005 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ
...:::::. .... .:. :: ... . : : : .. :...: ...
NP_005 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS
..::::. .::. : : :.:: ::::::::::::..::.. . ..... .. :::
NP_005 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFE
.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: :..:.:.::::.:
NP_005 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
190 200 210 220 230 240
240
pF1KE1 KLKKPRGETKGMIY
:.:.::. . .:
NP_005 KIKRPRSSNAETLY
250
>>NP_001253974 (OMIM: 605129) proteasome activator compl (265 aa)
initn: 672 init1: 473 opt: 657 Z-score: 589.1 bits: 116.6 E(85289): 4.5e-26
Smith-Waterman score: 657; 41.5% identity (73.9% similar) in 241 aa overlap (13-249:25-265)
10 20 30 40
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPA
::: ::: . ...:.:....::::. :::.:::::
NP_001 MEKWILKKIKYLQSGGLSASYYSYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 LNEANLSNLKAPLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPV
:: .:..... ...:::::. .... .:. :: ... . : : : .
NP_001 LNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGML
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 NCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLH
. :...: .....::::. .::. : : :.:: ::::::::::::..::.. . ...
NP_001 KSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 TKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYA
.. .. :::.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: :.
NP_001 SEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYV
190 200 210 220 230 240
230 240
pF1KE1 VLYDIILKNFEKLKKPRGETKGMIY
.:.:.::::.::.:.::. . .:
NP_001 TLHDMILKNIEKIKRPRSSNAETLY
250 260
>>NP_002809 (OMIM: 602161) proteasome activator complex (239 aa)
initn: 763 init1: 536 opt: 547 Z-score: 493.9 bits: 98.8 E(85289): 9.1e-21
Smith-Waterman score: 736; 48.0% identity (74.0% similar) in 246 aa overlap (4-249:7-239)
10 20 30 40 50
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNL
.:.. ::. .:.:::..: ..:..: ..:.:: :. .:.: .:: :.:..:
NP_002 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 KAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRL
.::::::.::: . .. : ::..:: . :: . :::.. :: .
NP_002 RAPLDIPIPDPPPKDDEMETDKQEKKEVHK-------------CGFLPGNEKVLSLLALV
70 80 90 100
120 130 140 150 160 170
pF1KE1 KPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKY
:::. . :. :: ::.: ::.:::::.::::.::::.: .....::.:.:.: ::::
NP_002 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKL
::::::::.::.:. :: ::: :::: ::: : ..: ::...: :: :: :: .:.::.
NP_002 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKI
170 180 190 200 210 220
240
pF1KE1 KKPRGETKGMIY
.:.:: : .:
NP_002 VNPKGEEKPSMY
230
>>XP_006720276 (OMIM: 602161) PREDICTED: proteasome acti (162 aa)
initn: 555 init1: 536 opt: 542 Z-score: 492.0 bits: 97.9 E(85289): 1.1e-20
Smith-Waterman score: 542; 53.3% identity (75.8% similar) in 165 aa overlap (85-249:4-162)
60 70 80 90 100 110
pF1KE1 SNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLL
::.:::. . :: . :::.. ::
XP_006 METDKQEKKEVHK------CGFLPGNEKVLSLL
10 20
120 130 140 150 160 170
pF1KE1 QRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQI
.:::. . :. :: ::.: ::.:::::.::::.::::.: .....::.:.:.: :
XP_006 ALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTI
30 40 50 60 70 80
180 190 200 210 220 230
pF1KE1 SKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNF
:::::::::::.::.:. :: ::: :::: ::: : ..: ::...: :: :: :: .:.
XP_006 SKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNL
90 100 110 120 130 140
240
pF1KE1 EKLKKPRGETKGMIY
::. .:.:: : .:
XP_006 EKIVNPKGEEKPSMY
150 160
>>NP_001317158 (OMIM: 605129) proteasome activator compl (193 aa)
initn: 506 init1: 473 opt: 498 Z-score: 452.5 bits: 90.9 E(85289): 1.8e-18
Smith-Waterman score: 498; 39.9% identity (71.5% similar) in 193 aa overlap (61-249:1-193)
40 50 60 70 80
pF1KE1 SYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEE--RKKQQEKEDKDE
...:::::. .... .:. ::
NP_001 MNLPVPDPILLTNSHDGLDGPTYKKRRLDE
10 20 30
90 100 110 120 130 140
pF1KE1 KKKGEDEDKG--PPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGN
... . : : : .. :...: .....::::. .::. : : :.:: ::::::::
NP_001 CEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGN
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE1 NFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDE
::::..::.. . ..... .. :::.:. :. :.: :: ::: :::. : :.::
NP_001 NFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDE
100 110 120 130 140 150
210 220 230 240
pF1KE1 AEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY
:: ..::.. :.:: :..:.:.::::.::.:.::. . .:
NP_001 KEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
160 170 180 190
>>NP_789839 (OMIM: 605129) proteasome activator complex (267 aa)
initn: 644 init1: 392 opt: 396 Z-score: 361.5 bits: 74.5 E(85289): 2.1e-13
Smith-Waterman score: 643; 38.9% identity (70.6% similar) in 265 aa overlap (2-249:3-267)
10 20 30 40 50
pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:.....
NP_789 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ
...:::::. .... .:. :: ... . : : : .. :...: ...
NP_789 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 RLKPEIKDVIEQLNL-------------VTTWLQLQIPRIEDGNNFGVAVQEKVFELMTS
..::::. .::. : : :.:: ::::::::::::..::.. . .
NP_789 KVKPEIRLLIEKCNTPSGKGPHICFDLQVKMWVQLLIPRIEDGNNFGVSIQEETVAELRT
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 LHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNA
.... .. :::.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.::
NP_789 VESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQ
190 200 210 220 230 240
230 240
pF1KE1 YAVLYDIILKNFEKLKKPRGETKGMIY
:..:.:.::::.::.:.::. . .:
NP_789 YVTLHDMILKNIEKIKRPRSSNAETLY
250 260
249 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:06:20 2016 done: Mon Nov 7 03:06:21 2016
Total Scan time: 7.220 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]