Result of FASTA (ccds) for
pFN21AE1437
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1437, 1011 aa
1>>>pF1KE1437 1011 - 1011 aa - 1011 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9418+/-0.00109; mu= 18.0352+/- 0.065
mean_var=76.2751+/-15.284, 0's: 0 Z-trim(102.5): 93 B-trim: 0 in 0/52
Lambda= 0.146853
statistics sampled from 6872 (6969) to 6872 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.214), width: 16
Scan time: 4.210
The best scores are: opt bits E(32554)
CCDS42775.1 RAPGEF4 gene_id:11069|Hs108|chr2 (1011) 6692 1428.3 0
CCDS42776.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 867) 5725 1223.4 0
CCDS63060.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 858) 5681 1214.1 0
CCDS63061.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 840) 5382 1150.7 0
CCDS74604.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 791) 5238 1120.2 0
CCDS31784.1 RAPGEF3 gene_id:10411|Hs108|chr12 ( 881) 2667 575.5 1.7e-163
CCDS41775.1 RAPGEF3 gene_id:10411|Hs108|chr12 ( 923) 2667 575.5 1.7e-163
CCDS55093.1 RAPGEF5 gene_id:9771|Hs108|chr7 ( 730) 1729 376.7 9.3e-104
CCDS77023.1 RAPGEFL1 gene_id:51195|Hs108|chr17 ( 505) 1226 270.1 8.1e-72
CCDS77022.1 RAPGEFL1 gene_id:51195|Hs108|chr17 ( 511) 1221 269.0 1.7e-71
CCDS11363.1 RAPGEFL1 gene_id:51195|Hs108|chr17 ( 456) 1197 263.9 5.3e-70
CCDS54899.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1504) 595 136.6 3.7e-31
CCDS54901.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1509) 595 136.6 3.7e-31
CCDS54900.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1609) 595 136.6 3.9e-31
CCDS43277.1 RAPGEF2 gene_id:9693|Hs108|chr4 (1499) 591 135.8 6.6e-31
CCDS54898.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1391) 588 135.1 9.6e-31
CCDS34225.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1601) 588 135.1 1.1e-30
CCDS48047.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1077) 415 98.4 8.3e-20
CCDS78450.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1094) 415 98.4 8.4e-20
CCDS48048.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1095) 415 98.4 8.5e-20
CCDS54897.1 RAPGEF6 gene_id:51735|Hs108|chr5 ( 827) 364 87.6 1.2e-16
CCDS4052.1 RASGRF2 gene_id:5924|Hs108|chr5 (1237) 362 87.2 2.3e-16
CCDS42065.1 RASGRF1 gene_id:5923|Hs108|chr15 ( 489) 346 83.7 1.1e-15
CCDS45320.1 RASGRF1 gene_id:5923|Hs108|chr15 (1257) 346 83.8 2.4e-15
CCDS10309.1 RASGRF1 gene_id:5923|Hs108|chr15 (1273) 346 83.8 2.4e-15
CCDS1802.1 SOS1 gene_id:6654|Hs108|chr2 (1333) 328 80.0 3.6e-14
CCDS65733.1 RALGPS2 gene_id:55103|Hs108|chr1 ( 557) 310 76.1 2.3e-13
CCDS1325.1 RALGPS2 gene_id:55103|Hs108|chr1 ( 583) 310 76.1 2.4e-13
CCDS55344.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 305) 300 73.8 6e-13
CCDS55346.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 529) 300 73.9 9.7e-13
CCDS55345.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 537) 300 73.9 9.8e-13
CCDS35143.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 557) 300 73.9 1e-12
CCDS9697.1 SOS2 gene_id:6655|Hs108|chr14 (1332) 305 75.2 1e-12
CCDS4452.1 RASGEF1C gene_id:255426|Hs108|chr5 ( 466) 282 70.1 1.2e-11
CCDS75151.1 RASGEF1B gene_id:153020|Hs108|chr4 ( 431) 278 69.2 2e-11
CCDS75152.1 RASGEF1B gene_id:153020|Hs108|chr4 ( 472) 278 69.2 2.2e-11
CCDS34022.1 RASGEF1B gene_id:153020|Hs108|chr4 ( 473) 278 69.2 2.2e-11
>>CCDS42775.1 RAPGEF4 gene_id:11069|Hs108|chr2 (1011 aa)
initn: 6692 init1: 6692 opt: 6692 Z-score: 7656.7 bits: 1428.3 E(32554): 0
Smith-Waterman score: 6692; 99.8% identity (99.8% similar) in 1011 aa overlap (1-1011:1-1011)
10 20 30 40 50 60
pF1KE1 MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 RQPIRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
CCDS42 RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 VVLKPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
910 920 930 940 950 960
970 980 990 1000 1010
pF1KE1 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
970 980 990 1000 1010
>>CCDS42776.1 RAPGEF4 gene_id:11069|Hs108|chr2 (867 aa)
initn: 5725 init1: 5725 opt: 5725 Z-score: 6550.5 bits: 1223.4 E(32554): 0
Smith-Waterman score: 5725; 99.5% identity (99.8% similar) in 866 aa overlap (146-1011:2-867)
120 130 140 150 160 170
pF1KE1 SILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIP
:..:::::::::::::::::::::::::::
CCDS42 MLYKKYRQYMAGLLAPPYGVMETGSNNDRIP
10 20 30
180 190 200 210 220 230
pF1KE1 DKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 DKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQC
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE1 CVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 CVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHE
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE1 DAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 DAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIK
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE1 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTL
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE1 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL
280 290 300 310 320 330
480 490 500 510 520 530
pF1KE1 VLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 VLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIM
340 350 360 370 380 390
540 550 560 570 580 590
pF1KE1 MHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQED
400 410 420 430 440 450
600 610 620 630 640 650
pF1KE1 DVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 DVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGD
460 470 480 490 500 510
660 670 680 690 700 710
pF1KE1 ERAQKRQPIRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMS
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
CCDS42 ERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMS
520 530 540 550 560 570
720 730 740 750 760 770
pF1KE1 SGGEKVVLKPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKD
:::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
CCDS42 SGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKD
580 590 600 610 620 630
780 790 800 810 820 830
pF1KE1 LAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 LAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCS
640 650 660 670 680 690
840 850 860 870 880 890
pF1KE1 QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAE
700 710 720 730 740 750
900 910 920 930 940 950
pF1KE1 FESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIA
760 770 780 790 800 810
960 970 980 990 1000 1010
pF1KE1 NTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 NTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
820 830 840 850 860
>>CCDS63060.1 RAPGEF4 gene_id:11069|Hs108|chr2 (858 aa)
initn: 5681 init1: 5681 opt: 5681 Z-score: 6500.2 bits: 1214.1 E(32554): 0
Smith-Waterman score: 5681; 99.8% identity (99.8% similar) in 858 aa overlap (154-1011:1-858)
130 140 150 160 170 180
pF1KE1 HATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLI
::::::::::::::::::::::::::::::
CCDS63 MAGLLAPPYGVMETGSNNDRIPDKENTPLI
10 20 30
190 200 210 220 230 240
pF1KE1 EPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 EPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE1 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE1 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE1 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE1 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE1 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE1 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE1 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE1 IRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
CCDS63 IRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL
520 530 540 550 560 570
730 740 750 760 770 780
pF1KE1 KPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 KPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY
580 590 600 610 620 630
790 800 810 820 830 840
pF1KE1 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL
640 650 660 670 680 690
850 860 870 880 890 900
pF1KE1 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS
700 710 720 730 740 750
910 920 930 940 950 960
pF1KE1 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY
760 770 780 790 800 810
970 980 990 1000 1010
pF1KE1 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
820 830 840 850
>>CCDS63061.1 RAPGEF4 gene_id:11069|Hs108|chr2 (840 aa)
initn: 5382 init1: 5382 opt: 5382 Z-score: 6158.0 bits: 1150.7 E(32554): 0
Smith-Waterman score: 5514; 97.7% identity (97.7% similar) in 858 aa overlap (154-1011:1-840)
130 140 150 160 170 180
pF1KE1 HATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLI
::::::::::::::::::::::::::
CCDS63 MAGLLAPPYGVMETGSNNDRIPDKEN----
10 20
190 200 210 220 230 240
pF1KE1 EPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD
::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 --------------VPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD
30 40 50 60 70
250 260 270 280 290 300
pF1KE1 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE
80 90 100 110 120 130
310 320 330 340 350 360
pF1KE1 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT
140 150 160 170 180 190
370 380 390 400 410 420
pF1KE1 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK
200 210 220 230 240 250
430 440 450 460 470 480
pF1KE1 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG
260 270 280 290 300 310
490 500 510 520 530 540
pF1KE1 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN
320 330 340 350 360 370
550 560 570 580 590 600
pF1KE1 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE
380 390 400 410 420 430
610 620 630 640 650 660
pF1KE1 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP
440 450 460 470 480 490
670 680 690 700 710 720
pF1KE1 IRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
CCDS63 IRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL
500 510 520 530 540 550
730 740 750 760 770 780
pF1KE1 KPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 KPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY
560 570 580 590 600 610
790 800 810 820 830 840
pF1KE1 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL
620 630 640 650 660 670
850 860 870 880 890 900
pF1KE1 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS
680 690 700 710 720 730
910 920 930 940 950 960
pF1KE1 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY
740 750 760 770 780 790
970 980 990 1000 1010
pF1KE1 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
800 810 820 830 840
>>CCDS74604.1 RAPGEF4 gene_id:11069|Hs108|chr2 (791 aa)
initn: 5238 init1: 5238 opt: 5238 Z-score: 5993.5 bits: 1120.2 E(32554): 0
Smith-Waterman score: 5238; 99.7% identity (99.7% similar) in 791 aa overlap (221-1011:1-791)
200 210 220 230 240 250
pF1KE1 PANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTP
::::::::::::::::::::::::::::::
CCDS74 MIRDRKYHLKTYRQCCVGTELVDWMMQQTP
10 20 30
260 270 280 290 300 310
pF1KE1 CVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 CVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDE
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE1 ELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 ELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAG
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE1 VLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 VLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDA
160 170 180 190 200 210
440 450 460 470 480 490
pF1KE1 PRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 PRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQG
220 230 240 250 260 270
500 510 520 530 540 550
pF1KE1 NSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 NSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPAL
280 290 300 310 320 330
560 570 580 590 600 610
pF1KE1 VAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 VAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVS
340 350 360 370 380 390
620 630 640 650 660 670
pF1KE1 DDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 DDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEV
400 410 420 430 440 450
680 690 700 710 720 730
pF1KE1 LFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSV
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 LFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSV
460 470 480 490 500 510
740 750 760 770 780 790
pF1KE1 FMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNC
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 FTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNC
520 530 540 550 560 570
800 810 820 830 840 850
pF1KE1 VHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 VHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKI
580 590 600 610 620 630
860 870 880 890 900 910
pF1KE1 AAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 AAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYR
640 650 660 670 680 690
920 930 940 950 960 970
pF1KE1 LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFN
700 710 720 730 740 750
980 990 1000 1010
pF1KE1 PDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
:::::::::::::::::::::::::::::::::::::::::
CCDS74 PDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
760 770 780 790
>>CCDS31784.1 RAPGEF3 gene_id:10411|Hs108|chr12 (881 aa)
initn: 2380 init1: 846 opt: 2667 Z-score: 3049.0 bits: 575.5 E(32554): 1.7e-163
Smith-Waterman score: 2717; 49.6% identity (76.4% similar) in 857 aa overlap (180-1008:32-881)
150 160 170 180 190 200
pF1KE1 YRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKI
::: . . : .... .. .:..::::.
CCDS31 VLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQ
10 20 30 40 50 60
210 220 230 240 250 260
pF1KE1 LRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDG
:. .:. :..::::::::. ::::: : :::: .. ::::.:.::. ::::..:
CCDS31 LHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEG
70 80 90 100 110 120
270 280 290 300 310 320
pF1KE1 VLNHVDQEHHFQDK-YLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHM
.: :: .. :::. :::: .: : . .: .::: ... :::: :::: .
CCDS31 ALCHVKHDWAFQDRDAQFYRF------PGPEPEPVRTHEMEEELAEAVALLSQRGPDALL
130 140 150 160 170
330 340 350 360 370 380
pF1KE1 RMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQG
. ::::::::: ..:..:.::::::::..:::..::::::.::.:: :.:.:::::.::
CCDS31 TVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQG
180 190 200 210 220 230
390 400 410 420 430 440
pF1KE1 EEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRV
..::::::: ::::::: .:::.: :::::::::.:::::::::::.:.:::::::::::
CCDS31 DKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRV
240 250 260 270 280 290
450 460 470 480 490 500
pF1KE1 DKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKI
::.:::::..::::.:.::.:: . :::::.. : : . . ...:::::::::::
CCDS31 DKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPS-RPPTPGRNRYTVMSGTPEKI
300 310 320 330 340 350
510 520 530 540 550 560
pF1KE1 LEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMD
:: .::.. ... .. :.. :.::.. : ::::..::: ::. :.:..:. :.:::.
CCDS31 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST
360 370 380 390 400 410
570 580 590 600 610 620
pF1KE1 YALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEK
:. :......::: ::.:.::..:. : :. .::... :. :.:. :.:: :: ..
CCDS31 YVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRR
420 430 440 450 460 470
630 640 650 660 670 680
pF1KE1 IVK-QISEDAKAPQKKHKVLLQQFNTGDERAQKRQ-PIRGSDEVLFKVYCMDPTYTTIRV
. . . .:: : . : . . :: . :. .:.: . . : . :...
CCDS31 CHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQL
480 490 500 510 520 530
690 700 710 720 730 740
pF1KE1 PVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFMTLTINGRLFACPRE
::..::.::..:.:.. : .: ..::..:.:. . :.:. .: .: .: :::. .
CCDS31 PVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQ
540 550 560 570 580 590
750 760 770 780 790 800
pF1KE1 QFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNF
. : : :.: :::::.. ..:.:.:::: :.: .:: ::: .:..:::....: ...
CCDS31 EVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL
600 610 620 630 640 650
810 820 830 840 850 860
pF1KE1 KK-TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA
. :::::. :.:::::.:.::.::.::: . :.:::.::::.::: :: ::::::::
CCDS31 RDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA
660 670 680 690 700 710
870 880 890 900 910 920
pF1KE1 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP
...:::: :.:::: :::.:: : .:.:. .: :.::: :::.:::..::: ::.:::::
CCDS31 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMP
720 730 740 750 760 770
930 940 950 960 970 980
pF1KE1 LLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ---PFNPDAAQANKNHQD
::.::::: ::::.:...::.:::::::.: .:: ... ::. :..: ..... :.:
CCDS31 LLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHED
780 790 800 810 820 830
990 1000 1010
pF1KE1 ---------------VRS------YVRQLNVIDNQRTLSQMSHRLEPRRP
.:: ::.::.:::::: ::..:..:::
CCDS31 SQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
840 850 860 870 880
>>CCDS41775.1 RAPGEF3 gene_id:10411|Hs108|chr12 (923 aa)
initn: 2380 init1: 846 opt: 2667 Z-score: 3048.7 bits: 575.5 E(32554): 1.7e-163
Smith-Waterman score: 2717; 49.6% identity (76.4% similar) in 857 aa overlap (180-1008:74-923)
150 160 170 180 190 200
pF1KE1 YRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKI
::: . . : .... .. .:..::::.
CCDS41 VLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQ
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE1 LRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDG
:. .:. :..::::::::. ::::: : :::: .. ::::.:.::. ::::..:
CCDS41 LHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEG
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE1 VLNHVDQEHHFQDK-YLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHM
.: :: .. :::. :::: .: : . .: .::: ... :::: :::: .
CCDS41 ALCHVKHDWAFQDRDAQFYRF------PGPEPEPVRTHEMEEELAEAVALLSQRGPDALL
170 180 190 200 210
330 340 350 360 370 380
pF1KE1 RMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQG
. ::::::::: ..:..:.::::::::..:::..::::::.::.:: :.:.:::::.::
CCDS41 TVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQG
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE1 EEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRV
..::::::: ::::::: .:::.: :::::::::.:::::::::::.:.:::::::::::
CCDS41 DKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRV
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE1 DKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKI
::.:::::..::::.:.::.:: . :::::.. : : . . ...:::::::::::
CCDS41 DKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPS-RPPTPGRNRYTVMSGTPEKI
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE1 LEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMD
:: .::.. ... .. :.. :.::.. : ::::..::: ::. :.:..:. :.:::.
CCDS41 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE1 YALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEK
:. :......::: ::.:.::..:. : :. .::... :. :.:. :.:: :: ..
CCDS41 YVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRR
460 470 480 490 500 510
630 640 650 660 670 680
pF1KE1 IVK-QISEDAKAPQKKHKVLLQQFNTGDERAQKRQ-PIRGSDEVLFKVYCMDPTYTTIRV
. . . .:: : . : . . :: . :. .:.: . . : . :...
CCDS41 CHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQL
520 530 540 550 560 570
690 700 710 720 730 740
pF1KE1 PVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFMTLTINGRLFACPRE
::..::.::..:.:.. : .: ..::..:.:. . :.:. .: .: .: :::. .
CCDS41 PVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQ
580 590 600 610 620 630
750 760 770 780 790 800
pF1KE1 QFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNF
. : : :.: :::::.. ..:.:.:::: :.: .:: ::: .:..:::....: ...
CCDS41 EVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL
640 650 660 670 680 690
810 820 830 840 850 860
pF1KE1 KK-TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA
. :::::. :.:::::.:.::.::.::: . :.:::.::::.::: :: ::::::::
CCDS41 RDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA
700 710 720 730 740 750
870 880 890 900 910 920
pF1KE1 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP
...:::: :.:::: :::.:: : .:.:. .: :.::: :::.:::..::: ::.:::::
CCDS41 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMP
760 770 780 790 800 810
930 940 950 960 970 980
pF1KE1 LLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ---PFNPDAAQANKNHQD
::.::::: ::::.:...::.:::::::.: .:: ... ::. :..: ..... :.:
CCDS41 LLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHED
820 830 840 850 860 870
990 1000 1010
pF1KE1 ---------------VRS------YVRQLNVIDNQRTLSQMSHRLEPRRP
.:: ::.::.:::::: ::..:..:::
CCDS41 SQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
880 890 900 910 920
>>CCDS55093.1 RAPGEF5 gene_id:9771|Hs108|chr7 (730 aa)
initn: 1531 init1: 959 opt: 1729 Z-score: 1976.2 bits: 376.7 E(32554): 9.3e-104
Smith-Waterman score: 1904; 42.5% identity (72.8% similar) in 757 aa overlap (258-1009:2-729)
230 240 250 260 270 280
pF1KE1 HLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFY
:.:.::.::. :.. :::. .::: :.::
CCDS55 MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFY
10 20 30
290 300 310 320 330 340
pF1KE1 RFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEII
.: .:: . : : :. .:: :. . :: :. : : . . :. ..: :
CCDS55 QFSSDEC--SYLYCEFER---EEEWQNGVKLLLQLVPLIPARGGICELSHQK-IEDSEES
40 50 60 70 80
350 360 370 380 390 400
pF1KE1 YEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIY
.:. : .:...:.::::.:. .... .. ..: ::... .. . . .:
CCDS55 SDEI-----LVRLTSAVQRELAAVIALKARKSA----IEQDEENNDKHVAVTEAESVPDS
90 100 110 120 130
410 420 430 440 450 460
pF1KE1 GKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL-RDVEANTVR
::.: :.: :..:.. ::. : ..: .::..::.. .. .: :..::.
CCDS55 QAGVMCKLQERDEIGRIELVQK--------LAKENYQFLQTDKKEQEKSEHQDDEVTTVQ
140 150 160 170 180
470 480 490 500 510 520
pF1KE1 LKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEAT
.::.::.::::.:: . : . :... . .:.:.::::::::::.:. ..:: . .. :
CCDS55 VKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKET
190 200 210 220 230 240
530 540 550 560 570 580
pF1KE1 DSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAA
...:.::.. . ::: . .:: ::. :: :. :: : :. : ::.:..:: :: :
CCDS55 ETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKE-ENSDVP-RRKRKVLHLVSQWIA
250 260 270 280 290 300
590 600 610 620 630 640
pF1KE1 MYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIV---KQISEDAKAPQKK
.: : : ::. : ::. .: .: ::. :...: :..::. .. . : .::::
CCDS55 LYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKK
310 320 330 340 350 360
650 660 670 680 690 700
pF1KE1 HKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKL
.:.:..::. .. :.: . ..:.. .:: . .:..... :.. ..:....::.:.
CCDS55 NKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKI
370 380 390 400 410 420
710 720 730 740 750 760
pF1KE1 GSGE-GLIIVKMSSGGEKVVLKPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTV
.: : .: .. .::: :.:::. . .: .::... .. :.:.:. :.:
CCDS55 QYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQ
430 440 450 460 470 480
770 780 790 800 810 820
pF1KE1 GTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNE
.. . :.. ::: .. .:: ::: .:: :::: ::.:.. . ::::.:.:.: ::
CCDS55 RSMRILG-MNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNE
490 500 510 520 530 540
830 840 850 860 870 880
pF1KE1 IQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTW
.:.::.::: :::::.:::::.::::::::::: .::::::::::::....::::. ::
CCDS55 VQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTW
550 560 570 580 590 600
890 900 910 920 930 940
pF1KE1 EKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI
::.:.::::...:.::: ::: ::.::: . :..:: :::::::.::.:: :::::::.
CCDS55 EKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL
610 620 630 640 650 660
950 960 970 980 990 1000
pF1KE1 DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQM
::::::::..:::.:.::.:. :.. :. : . :.::...::: .: :::.:..: ..
CCDS55 DNLVNFEKLHMIADTVRTLRHCRTNQFG-DLSP--KEHQELKSYVNHLYVIDSQQALFEL
670 680 690 700 710 720
1010
pF1KE1 SHRLEPRRP
:::.:::
CCDS55 SHRIEPRV
730
>>CCDS77023.1 RAPGEFL1 gene_id:51195|Hs108|chr17 (505 aa)
initn: 1141 init1: 760 opt: 1226 Z-score: 1402.8 bits: 270.1 E(32554): 8.1e-72
Smith-Waterman score: 1300; 41.5% identity (74.0% similar) in 492 aa overlap (527-1007:17-501)
500 510 520 530 540 550
pF1KE1 KYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHA
: .:.:... : .:.:. .. : : .
CCDS77 MMLRPGYPLSQESFPIDILLDDIVLTHSLFLPTEKFLQEL--HQYF
10 20 30 40
560 570 580 590 600 610
pF1KE1 QPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMI
. : : . .:. :. . ..:.. : ::::.. . .....:. . : .
CCDS77 VRAGGMEGPE---GLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLY
50 60 70 80 90 100
620 630 640 650 660 670
pF1KE1 AALKEQLPELEKIVK----QISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLF
.:.:. .:...:. .: :. . :.:. : :...: : : : .:::::..
CCDS77 QGLREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFC
110 120 130 140 150 160
680 690 700 710 720
pF1KE1 KVYCMDPTYTTIRVPVATSVKEVISAVADKL-------GSGEGLIIVKMSSGGEKVVLKP
.:: : .:.::: ...::......:..:: : ..::.: .::.::::.:.:
CCDS77 RVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQP
170 180 190 200 210 220
730 740 750 760 770 780
pF1KE1 NDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDW
.. :: .: ::..:::: :.....:.::::. . : . .. . .:.: ..: . :
CCDS77 TEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDT-EIHRVEPEDVANHLTAFHW
230 240 250 260 270 280
790 800 810 820 830 840
pF1KE1 ELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLK
::: ::::::.. ..: . .. ::::.:.:.: .:. ::.::. :: .::.::::
CCDS77 ELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLK
290 300 310 320 330 340
850 860 870 880 890 900
pF1KE1 KFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRN
::::::: ::. ..: ::.:.::::.:.::::: :::::::.:::... .::.: :: ::
CCDS77 KFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRN
350 360 370 380 390 400
910 920 930 940 950 960
pF1KE1 HRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYR
:..:: ...:..::.:::.::..::.:: :::.::..:.:::.::.. .:. .::.: ::
CCDS77 HKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYR
410 420 430 440 450 460
970 980 990 1000 1010
pF1KE1 SQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
:.:. : .:. :: ....::::..::::: : ..:..::
CCDS77 SRPLCLDM-EASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
470 480 490 500
>>CCDS77022.1 RAPGEFL1 gene_id:51195|Hs108|chr17 (511 aa)
initn: 1141 init1: 760 opt: 1221 Z-score: 1397.0 bits: 269.0 E(32554): 1.7e-71
Smith-Waterman score: 1295; 41.4% identity (74.1% similar) in 490 aa overlap (529-1007:25-507)
500 510 520 530 540 550
pF1KE1 TVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQP
.:.:... : .:.:. .. : : .
CCDS77 MLIHPRGLPSSSHRRKINSTYFYILLDDIVLTHSLFLPTEKFLQEL--HQYFVR
10 20 30 40 50
560 570 580 590 600 610
pF1KE1 SQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAA
. : : . .:. :. . ..:.. : ::::.. . .....:. . : . .
CCDS77 AGGMEGPE---GLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQG
60 70 80 90 100
620 630 640 650 660 670
pF1KE1 LKEQLPELEKIVK----QISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKV
:.:. .:...:. .: :. . :.:. : :...: : : : .:::::.. .:
CCDS77 LREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRV
110 120 130 140 150 160
680 690 700 710 720
pF1KE1 YCMDPTYTTIRVPVATSVKEVISAVADKL-------GSGEGLIIVKMSSGGEKVVLKPND
: : .:.::: ...::......:..:: : ..::.: .::.::::.:.:..
CCDS77 YMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTE
170 180 190 200 210 220
730 740 750 760 770 780
pF1KE1 VSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWEL
:: .: ::..:::: :.....:.::::. . : . .. . .:.: ..: . :::
CCDS77 DCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDT-EIHRVEPEDVANHLTAFHWEL
230 240 250 260 270 280
790 800 810 820 830 840
pF1KE1 FNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
: ::::::.. ..: . .. ::::.:.:.: .:. ::.::. :: .::.::::::
CCDS77 FRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKF
290 300 310 320 330 340
850 860 870 880 890 900
pF1KE1 IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHR
::::: ::. ..: ::.:.::::.:.::::: :::::::.:::... .::.: :: :::.
CCDS77 IKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHK
350 360 370 380 390 400
910 920 930 940 950 960
pF1KE1 AYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ
.:: ...:..::.:::.::..::.:: :::.::..:.:::.::.. .:. .::.: :::.
CCDS77 SYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSR
410 420 430 440 450 460
970 980 990 1000 1010
pF1KE1 PFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
:. : .:. :: ....::::..::::: : ..:..::
CCDS77 PLCLDM-EASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
470 480 490 500 510
1011 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:35:22 2016 done: Mon Nov 7 00:35:23 2016
Total Scan time: 4.210 Total Display time: 0.340
Function used was FASTA [36.3.4 Apr, 2011]