Result of FASTA (omim) for
pFN21AE1386
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1386, 205 aa
1>>>pF1KE1386 205 - 205 aa - 205 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8889+/-0.000309; mu= 11.3724+/- 0.019
mean_var=80.8835+/-16.058, 0's: 0 Z-trim(118.1): 35 B-trim: 36 in 1/53
Lambda= 0.142608
statistics sampled from 30689 (30724) to 30689 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.36), width: 16
Scan time: 6.460
The best scores are: opt bits E(85289)
XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78
NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205) 1356 287.9 7.9e-78
XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78
NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205) 1356 287.9 7.9e-78
XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78
XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78
NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233) 305 71.7 1.1e-12
NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281) 244 59.1 7.7e-09
NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 226 55.4 9.1e-08
NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 215 53.1 3.5e-07
NP_002332 (OMIM: 600978) lymphotoxin-beta isoform ( 244) 189 47.8 1.7e-05
NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 170 43.9 0.00026
XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 170 43.9 0.00026
NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 166 43.0 0.0004
NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 157 41.2 0.0019
>>XP_011512920 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78
Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
130 140 150 160 170 180
190 200
pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL
:::::::::::::::::::::::::
XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL
190 200
>>NP_000586 (OMIM: 153440,607507,608446,610988) lymphoto (205 aa)
initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78
Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
130 140 150 160 170 180
190 200
pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL
:::::::::::::::::::::::::
NP_000 LSTHTDGIPHLVLSPSTVFFGAFAL
190 200
>>XP_011512918 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78
Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
130 140 150 160 170 180
190 200
pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL
:::::::::::::::::::::::::
XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL
190 200
>>NP_001153212 (OMIM: 153440,607507,608446,610988) lymph (205 aa)
initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78
Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
130 140 150 160 170 180
190 200
pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL
:::::::::::::::::::::::::
NP_001 LSTHTDGIPHLVLSPSTVFFGAFAL
190 200
>>XP_011512917 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78
Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
130 140 150 160 170 180
190 200
pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL
:::::::::::::::::::::::::
XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL
190 200
>>XP_011512919 (OMIM: 153440,607507,608446,610988) PREDI (205 aa)
initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78
Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
130 140 150 160 170 180
190 200
pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL
:::::::::::::::::::::::::
XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL
190 200
>>NP_000585 (OMIM: 157300,191160,600807,611162) tumor ne (233 aa)
initn: 288 init1: 178 opt: 305 Z-score: 348.8 bits: 71.7 E(85289): 1.1e-12
Smith-Waterman score: 305; 32.4% identity (62.8% similar) in 207 aa overlap (8-205:38-233)
10 20 30
pF1KE1 MTPPERLFLPRVRGTTLHLLL-LGLLLVLLPGAQGLP
:: . .::: :: .: :. : . .:
NP_000 RDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFG---VIGPQREEFP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 -GVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLS
..: ::..:. . . ::.::....:. ...: : :.: .: :
NP_000 RDLSLISPLAQAVRSSSRT----PSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 NNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSS----
.:.:.::. :.:..::::.:.:.. : :. . :.: .. .. .: .: :::.
NP_000 DNQLVVPSEGLYLIYSQVLFKGQG-CP---STHVLLTHTISRIAVSYQTKVNLLSAIKSP
130 140 150 160 170
160 170 180 190 200
pF1KE1 -QKMVYPGLQ-EPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPS-TVFFGAFAL
:. . : . .:: . .: :..::: .::.::.. . .: .. : :.:: .::
NP_000 CQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
180 190 200 210 220 230
>>NP_000630 (OMIM: 134638,211980,601859) tumor necrosis (281 aa)
initn: 217 init1: 121 opt: 244 Z-score: 279.7 bits: 59.1 E(85289): 7.7e-09
Smith-Waterman score: 244; 29.5% identity (61.4% similar) in 166 aa overlap (43-205:123-281)
20 30 40 50 60 70
pF1KE1 RGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQ--HPKMHLAHSTLKPAAHLIGD
.:.. .: ::. .. :. .::: :
NP_000 ALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGK
100 110 120 130 140 150
80 90 100 110 120
pF1KE1 P-SKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPL
:.. : :. .: : .: . ....:.. .:.:::::.: : :. . . :
NP_000 SNSRSMPLEWE-DTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQ------SCNNL
160 170 180 190 200
130 140 150 160 170 180
pF1KE1 YLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIP
:.:.: . .:.:: . .. .. : : . : .: : ::.:.::..:.: .... .
NP_000 PLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELS
210 220 230 240 250 260
190 200
pF1KE1 HLVLSPSTVFFGAFAL
. . : .::: . :
NP_000 LVNFEESQTFFGLYKL
270 280
>>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa)
initn: 228 init1: 122 opt: 226 Z-score: 260.4 bits: 55.4 E(85289): 9.1e-08
Smith-Waterman score: 227; 28.6% identity (53.9% similar) in 217 aa overlap (7-205:42-251)
10 20 30
pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQ--G
..:: . : : .::. : .: .
NP_005 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA
20 30 40 50 60 70
40 50 60 70 80
pF1KE1 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL
: : ..:: :. ..:. ::. :. :. .. .: :. . ::
NP_005 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT
80 90 100 110 120
90 100 110 120 130
pF1KE1 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS
.. .. .:. ::.: :: ::.::::.: : .: :. .: . .: .
NP_005 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE1 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV
..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . .
NP_005 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT
190 200 210 220 230 240
200
pF1KE1 FFGAFAL
::::: :
NP_005 FFGAFLL
250
>>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa)
initn: 186 init1: 122 opt: 215 Z-score: 250.0 bits: 53.1 E(85289): 3.5e-07
Smith-Waterman score: 216; 29.9% identity (56.1% similar) in 164 aa overlap (52-205:36-192)
30 40 50 60 70 80
pF1KE1 LGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRA
:. ::. :. :. .. .: :.
NP_001 GRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEH
10 20 30 40 50 60
90 100 110 120 130
pF1KE1 NTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLA
. :: .. .. .:. ::.: :: ::.::::.: : .: :. .: .
NP_001 ELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVI
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE1 HEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-
.: ...:: . :: . : : . :.. .: :: :.: .::.: .... : .
NP_001 TKV---TDSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVD
130 140 150 160 170
200
pF1KE1 VLSPSTVFFGAFAL
. . .::::: :
NP_001 YTKEDKTFFGAFLL
180 190
205 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:18:29 2016 done: Sun Nov 6 22:18:30 2016
Total Scan time: 6.460 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]