Result of FASTA (omim) for
pFN21AE1381
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1381, 783 aa
1>>>pF1KE1381 783 - 783 aa - 783 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.6566+/-0.00035; mu= -4.3114+/- 0.022
mean_var=262.0619+/-53.127, 0's: 0 Z-trim(122.6): 35 B-trim: 0 in 0/59
Lambda= 0.079227
statistics sampled from 40951 (40986) to 40951 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.481), width: 16
Scan time: 15.990
The best scores are: opt bits E(85289)
NP_004283 (OMIM: 605965) ras and Rab interactor 1 ( 783) 5234 611.7 3.7e-174
XP_011543701 (OMIM: 605965) PREDICTED: ras and Rab ( 755) 5038 589.3 2e-167
XP_011543703 (OMIM: 605965) PREDICTED: ras and Rab ( 702) 4684 548.8 2.8e-155
XP_011543702 (OMIM: 605965) PREDICTED: ras and Rab ( 721) 2926 347.9 8.9e-95
XP_016874076 (OMIM: 605965) PREDICTED: ras and Rab ( 722) 2924 347.7 1e-94
XP_005260790 (OMIM: 610222,613075) PREDICTED: ras ( 689) 715 95.2 1e-18
XP_011527561 (OMIM: 610222,613075) PREDICTED: ras ( 842) 715 95.2 1.2e-18
XP_016883381 (OMIM: 610222,613075) PREDICTED: ras ( 842) 715 95.2 1.2e-18
XP_016883380 (OMIM: 610222,613075) PREDICTED: ras ( 850) 715 95.2 1.2e-18
NP_061866 (OMIM: 610222,613075) ras and Rab intera ( 895) 715 95.2 1.3e-18
XP_011527559 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18
XP_006723640 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18
XP_011527560 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18
XP_006723638 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18
XP_006723637 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18
XP_005260788 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18
XP_016883379 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18
XP_016883378 (OMIM: 610222,613075) PREDICTED: ras ( 925) 715 95.3 1.3e-18
NP_001229510 (OMIM: 610222,613075) ras and Rab int ( 944) 715 95.3 1.3e-18
XP_016883377 (OMIM: 610222,613075) PREDICTED: ras ( 944) 715 95.3 1.3e-18
XP_016883376 (OMIM: 610222,613075) PREDICTED: ras ( 944) 715 95.3 1.3e-18
XP_011527557 (OMIM: 610222,613075) PREDICTED: ras ( 962) 715 95.3 1.4e-18
XP_011535467 (OMIM: 610223) PREDICTED: ras and Rab ( 648) 500 70.6 2.4e-11
XP_016877143 (OMIM: 610223) PREDICTED: ras and Rab ( 883) 392 58.3 1.6e-07
XP_016877142 (OMIM: 610223) PREDICTED: ras and Rab ( 888) 392 58.3 1.6e-07
XP_016877141 (OMIM: 610223) PREDICTED: ras and Rab ( 941) 392 58.3 1.7e-07
NP_079108 (OMIM: 610223) ras and Rab interactor 3 ( 985) 392 58.3 1.8e-07
XP_016877140 (OMIM: 610223) PREDICTED: ras and Rab ( 954) 384 57.4 3.3e-07
XP_016883382 (OMIM: 610222,613075) PREDICTED: ras ( 692) 359 54.5 1.8e-06
NP_001306916 (OMIM: 610223) ras and Rab interactor ( 910) 304 48.3 0.00018
XP_011535466 (OMIM: 610223) PREDICTED: ras and Rab ( 909) 301 47.9 0.00023
>>NP_004283 (OMIM: 605965) ras and Rab interactor 1 [Hom (783 aa)
initn: 5234 init1: 5234 opt: 5234 Z-score: 3247.7 bits: 611.7 E(85289): 3.7e-174
Smith-Waterman score: 5234; 100.0% identity (100.0% similar) in 783 aa overlap (1-783:1-783)
10 20 30 40 50 60
pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
730 740 750 760 770 780
pF1KE1 AEE
:::
NP_004 AEE
>>XP_011543701 (OMIM: 605965) PREDICTED: ras and Rab int (755 aa)
initn: 5038 init1: 5038 opt: 5038 Z-score: 3126.9 bits: 589.3 E(85289): 2e-167
Smith-Waterman score: 5038; 100.0% identity (100.0% similar) in 754 aa overlap (30-783:2-755)
10 20 30 40 50 60
pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
:::::::::::::::::::::::::::::::
XP_011 MPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
10 20 30
70 80 90 100 110 120
pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
700 710 720 730 740 750
pF1KE1 AEE
:::
XP_011 AEE
>>XP_011543703 (OMIM: 605965) PREDICTED: ras and Rab int (702 aa)
initn: 4684 init1: 4684 opt: 4684 Z-score: 2908.7 bits: 548.8 E(85289): 2.8e-155
Smith-Waterman score: 4684; 100.0% identity (100.0% similar) in 702 aa overlap (82-783:1-702)
60 70 80 90 100 110
pF1KE1 PGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEA
::::::::::::::::::::::::::::::
XP_011 MLRTEPPGTFLVRKSNTRQCQALCMRLPEA
10 20 30
120 130 140 150 160 170
pF1KE1 SGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATH
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 KELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPG
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE1 DLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRES
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE1 SVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMS
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE1 AAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARA
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE1 MLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRL
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE1 ARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEG
400 410 420 430 440 450
540 550 560 570 580 590
pF1KE1 EGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSG
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE1 LGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEAS
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE1 IATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQG
580 590 600 610 620 630
720 730 740 750 760 770
pF1KE1 AVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPG
640 650 660 670 680 690
780
pF1KE1 EPEAEGSRAAEE
::::::::::::
XP_011 EPEAEGSRAAEE
700
>>XP_011543702 (OMIM: 605965) PREDICTED: ras and Rab int (721 aa)
initn: 2902 init1: 2902 opt: 2926 Z-score: 1822.5 bits: 347.9 E(85289): 8.9e-95
Smith-Waterman score: 4695; 92.1% identity (92.1% similar) in 783 aa overlap (1-783:1-721)
10 20 30 40 50 60
pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
:::::::::
XP_011 KLLSPKRLE---------------------------------------------------
490 500 510 520 530 540
pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 -----------LEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
430 440 450 460 470
550 560 570 580 590 600
pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
480 490 500 510 520 530
610 620 630 640 650 660
pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
540 550 560 570 580 590
670 680 690 700 710 720
pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
600 610 620 630 640 650
730 740 750 760 770 780
pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
660 670 680 690 700 710
pF1KE1 AEE
:::
XP_011 AEE
720
>>XP_016874076 (OMIM: 605965) PREDICTED: ras and Rab int (722 aa)
initn: 2896 init1: 2896 opt: 2924 Z-score: 1821.3 bits: 347.7 E(85289): 1e-94
Smith-Waterman score: 4702; 92.2% identity (92.2% similar) in 783 aa overlap (1-783:1-722)
10 20 30 40 50 60
pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
::::::::
XP_016 KLLSPKRL----------------------------------------------------
490 500 510 520 530 540
pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ---------VELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
430 440 450 460 470
550 560 570 580 590 600
pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
480 490 500 510 520 530
610 620 630 640 650 660
pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
540 550 560 570 580 590
670 680 690 700 710 720
pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
600 610 620 630 640 650
730 740 750 760 770 780
pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
660 670 680 690 700 710
pF1KE1 AEE
:::
XP_016 AEE
720
>>XP_005260790 (OMIM: 610222,613075) PREDICTED: ras and (689 aa)
initn: 766 init1: 460 opt: 715 Z-score: 457.0 bits: 95.2 E(85289): 1e-18
Smith-Waterman score: 847; 34.4% identity (63.1% similar) in 491 aa overlap (252-703:183-669)
230 240 250 260 270 280
pF1KE1 LCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPV-LPGAVPSQTER
: .. :: ..:: .: : : ..:
XP_005 PRLKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSES
160 170 180 190 200 210
290 300 310 320
pF1KE1 LPPCQLLRRESSVGYRVPAGSGPSLP---PMPSL-QEVDCGSP------SSSEEEGVPG-
:::. :.. : . . ..:. :: :: . :.: .: :..: .:
XP_005 RPPCHGGRQRLS-DMSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPI
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE1 ----SRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQD
.:.: . :.: . . :...:..: :...::... : : : .:. : : ::::
XP_005 KSKKKRSSSFVLPKLVKSQ--LQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQD
280 290 300 310 320
390 400 410 420 430
pF1KE1 LLTQVRAGPE-----PQELQGIRQALSRARAMLS--AELGP--EKLLSPKRLEHVLEKSL
.. .. . : . :: ::: ..... .:: .:: : :.:. ... ::::..
XP_005 YVSFLQENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAM
330 340 350 360 370 380
440 450 460 470 480 490
pF1KE1 HCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVR
: .::::. . : :. :::: .: :.:.:.: ..: .: :. :..:...
XP_005 HKCILKPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIK
390 400 410 420 430 440
500 510 520 530 540 550
pF1KE1 QKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELL
:.. . . ::: .: ::..:::.: ..... :. :::.:::.:. :.:.::. ::
XP_005 VKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELD
450 460 470 480 490 500
560 570 580 590 600 610
pF1KE1 LEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQR
: ::: :::.:::: ::::::::: ..:.:.... . .. : .: : .: :..:
XP_005 TEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLS-SETRDTLRQWHKR
510 520 530 540 550 560
620 630 640 650 660 670
pF1KE1 R-----LPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTF
: .:.. ::. ::::.:. .::::.::: : : . . :.:: ::.: .:. .
XP_005 RTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEY
570 580 590 600 610 620
680 690 700 710 720
pF1KE1 GLFLYKEQGYHRLPPGALAHRL---------PTTGYLVYRRAEWPETQGAVTEEEGSGQS
.:::. .. ...: . ... : ..::.:
XP_005 SLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTT
630 640 650 660 670 680
730 740 750 760 770 780
pF1KE1 EARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAE
XP_005 S
>>XP_011527561 (OMIM: 610222,613075) PREDICTED: ras and (842 aa)
initn: 1094 init1: 460 opt: 715 Z-score: 455.7 bits: 95.2 E(85289): 1.2e-18
Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:75-822)
70 80 90 100 110 120
pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV
: ..: .::: : . . : ::
XP_011 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL
::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..::::
XP_011 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA
110 120 130 140 150 160
190 200 210 220
pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF
. : : .. : : :: :.:.:.::. . :..::::.::::
XP_011 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF
170 180 190 200 210 220
230 240 250 260
pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P----------
:: : :: . :. .. . .: :: :: ::: . :
XP_011 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS
230 240 250 260 270 280
270 280 290 300 310
pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL
.:::. :. .:: .: .. : . : .. .:. :. : :
XP_011 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL
290 300 310 320 330
320 330 340
pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR--------------------
. :::... :..:: .:. : .: : : ::.:
XP_011 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM
340 350 360 370 380 390
350
pF1KE1 PL----------------------------------------------LRSMSAAFCSLL
:: :...:..: :..
XP_011 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM
400 410 420 430 440 450
360 370 380 390 400 410
pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML
.::... : : : .:. : : :::: .. .. . : . :: ::: ..... .:
XP_011 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL
460 470 480 490 500 510
420 430 440 450 460
pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL
: .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.:
XP_011 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL
520 530 540 550 560 570
470 480 490 500 510 520
pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ
.:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: .....
XP_011 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN
580 590 600 610 620 630
530 540 550 560 570 580
pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL
:. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:.
XP_011 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI
640 650 660 670 680 690
590 600 610 620 630 640
pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL
... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.:::
XP_011 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL
700 710 720 730 740 750
650 660 670 680 690
pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT
: : . . :.:: ::.: .:. ..:::. .. ...: . ... :
XP_011 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH
760 770 780 790 800 810
700 710 720 730 740 750
pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT
..::.:
XP_011 IFHFVYKRIKNDPYGIIFQNGEEDLTTS
820 830 840
>>XP_016883381 (OMIM: 610222,613075) PREDICTED: ras and (842 aa)
initn: 1094 init1: 460 opt: 715 Z-score: 455.7 bits: 95.2 E(85289): 1.2e-18
Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:75-822)
70 80 90 100 110 120
pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV
: ..: .::: : . . : ::
XP_016 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL
::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..::::
XP_016 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA
110 120 130 140 150 160
190 200 210 220
pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF
. : : .. : : :: :.:.:.::. . :..::::.::::
XP_016 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF
170 180 190 200 210 220
230 240 250 260
pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P----------
:: : :: . :. .. . .: :: :: ::: . :
XP_016 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS
230 240 250 260 270 280
270 280 290 300 310
pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL
.:::. :. .:: .: .. : . : .. .:. :. : :
XP_016 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL
290 300 310 320 330
320 330 340
pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR--------------------
. :::... :..:: .:. : .: : : ::.:
XP_016 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM
340 350 360 370 380 390
350
pF1KE1 PL----------------------------------------------LRSMSAAFCSLL
:: :...:..: :..
XP_016 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM
400 410 420 430 440 450
360 370 380 390 400 410
pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML
.::... : : : .:. : : :::: .. .. . : . :: ::: ..... .:
XP_016 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL
460 470 480 490 500 510
420 430 440 450 460
pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL
: .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.:
XP_016 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL
520 530 540 550 560 570
470 480 490 500 510 520
pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ
.:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: .....
XP_016 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN
580 590 600 610 620 630
530 540 550 560 570 580
pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL
:. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:.
XP_016 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI
640 650 660 670 680 690
590 600 610 620 630 640
pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL
... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.:::
XP_016 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL
700 710 720 730 740 750
650 660 670 680 690
pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT
: : . . :.:: ::.: .:. ..:::. .. ...: . ... :
XP_016 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH
760 770 780 790 800 810
700 710 720 730 740 750
pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT
..::.:
XP_016 IFHFVYKRIKNDPYGIIFQNGEEDLTTS
820 830 840
>>XP_016883380 (OMIM: 610222,613075) PREDICTED: ras and (850 aa)
initn: 1094 init1: 460 opt: 715 Z-score: 455.7 bits: 95.2 E(85289): 1.2e-18
Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:83-830)
70 80 90 100 110 120
pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV
: ..: .::: : . . : ::
XP_016 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL
::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..::::
XP_016 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA
120 130 140 150 160 170
190 200 210 220
pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF
. : : .. : : :: :.:.:.::. . :..::::.::::
XP_016 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF
180 190 200 210 220 230
230 240 250 260
pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P----------
:: : :: . :. .. . .: :: :: ::: . :
XP_016 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS
240 250 260 270 280
270 280 290 300 310
pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL
.:::. :. .:: .: .. : . : .. .:. :. : :
XP_016 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL
290 300 310 320 330 340
320 330 340
pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR--------------------
. :::... :..:: .:. : .: : : ::.:
XP_016 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM
350 360 370 380 390 400
350
pF1KE1 PL----------------------------------------------LRSMSAAFCSLL
:: :...:..: :..
XP_016 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML
.::... : : : .:. : : :::: .. .. . : . :: ::: ..... .:
XP_016 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL
470 480 490 500 510 520
420 430 440 450 460
pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL
: .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.:
XP_016 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL
530 540 550 560 570 580
470 480 490 500 510 520
pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ
.:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: .....
XP_016 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN
590 600 610 620 630 640
530 540 550 560 570 580
pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL
:. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:.
XP_016 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI
650 660 670 680 690 700
590 600 610 620 630 640
pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL
... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.:::
XP_016 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL
710 720 730 740 750 760
650 660 670 680 690
pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT
: : . . :.:: ::.: .:. ..:::. .. ...: . ... :
XP_016 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH
770 780 790 800 810 820
700 710 720 730 740 750
pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT
..::.:
XP_016 IFHFVYKRIKNDPYGIIFQNGEEDLTTS
830 840 850
>>NP_061866 (OMIM: 610222,613075) ras and Rab interactor (895 aa)
initn: 1094 init1: 460 opt: 715 Z-score: 455.3 bits: 95.2 E(85289): 1.3e-18
Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:128-875)
70 80 90 100 110 120
pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV
: ..: .::: : . . : ::
NP_061 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF
100 110 120 130 140 150
130 140 150 160 170 180
pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL
::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..::::
NP_061 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA
160 170 180 190 200 210
190 200 210 220
pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF
. : : .. : : :: :.:.:.::. . :..::::.::::
NP_061 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF
220 230 240 250 260 270
230 240 250 260
pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P----------
:: : :: . :. .. . .: :: :: ::: . :
NP_061 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS
280 290 300 310 320 330
270 280 290 300 310
pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL
.:::. :. .:: .: .. : . : .. .:. :. : :
NP_061 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL
340 350 360 370 380
320 330 340
pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR--------------------
. :::... :..:: .:. : .: : : ::.:
NP_061 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM
390 400 410 420 430 440
350
pF1KE1 PL----------------------------------------------LRSMSAAFCSLL
:: :...:..: :..
NP_061 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM
450 460 470 480 490 500
360 370 380 390 400 410
pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML
.::... : : : .:. : : :::: .. .. . : . :: ::: ..... .:
NP_061 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL
510 520 530 540 550 560
420 430 440 450 460
pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL
: .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.:
NP_061 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL
570 580 590 600 610 620
470 480 490 500 510 520
pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ
.:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: .....
NP_061 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN
630 640 650 660 670 680
530 540 550 560 570 580
pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL
:. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:.
NP_061 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI
690 700 710 720 730 740
590 600 610 620 630 640
pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL
... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.:::
NP_061 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL
750 760 770 780 790 800
650 660 670 680 690
pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT
: : . . :.:: ::.: .:. ..:::. .. ...: . ... :
NP_061 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH
810 820 830 840 850 860
700 710 720 730 740 750
pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT
..::.:
NP_061 IFHFVYKRIKNDPYGIIFQNGEEDLTTS
870 880 890
783 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:25:40 2016 done: Mon Nov 7 01:25:43 2016
Total Scan time: 15.990 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]