Result of FASTA (omim) for
pFN21AE1342
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1342, 187 aa
1>>>pF1KE1342 187 - 187 aa - 187 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9513+/-0.000297; mu= 14.6798+/- 0.019
mean_var=61.2562+/-12.543, 0's: 0 Z-trim(116.0): 9 B-trim: 125 in 1/56
Lambda= 0.163870
statistics sampled from 26872 (26881) to 26872 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.315), width: 16
Scan time: 5.910
The best scores are: opt bits E(85289)
NP_000782 (OMIM: 126060,613839) dihydrofolate redu ( 187) 1256 304.9 4.8e-83
NP_001182572 (OMIM: 616588) dihydrofolate reductas ( 187) 1130 275.1 4.4e-74
NP_789785 (OMIM: 616588) dihydrofolate reductase, ( 187) 1130 275.1 4.4e-74
XP_011510839 (OMIM: 616588) PREDICTED: dihydrofola ( 187) 1130 275.1 4.4e-74
NP_001277283 (OMIM: 126060,613839) dihydrofolate r ( 135) 904 221.6 4.1e-58
NP_001277286 (OMIM: 126060,613839) dihydrofolate r ( 129) 825 202.9 1.7e-52
>>NP_000782 (OMIM: 126060,613839) dihydrofolate reductas (187 aa)
initn: 1256 init1: 1256 opt: 1256 Z-score: 1611.9 bits: 304.9 E(85289): 4.8e-83
Smith-Waterman score: 1256; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187)
10 20 30 40 50 60
pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
130 140 150 160 170 180
pF1KE1 EVYEKND
:::::::
NP_000 EVYEKND
>>NP_001182572 (OMIM: 616588) dihydrofolate reductase, m (187 aa)
initn: 1130 init1: 1130 opt: 1130 Z-score: 1450.9 bits: 275.1 E(85289): 4.4e-74
Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187)
10 20 30 40 50 60
pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
:::::::::::::::::::: :::::::::::::::::::::::::::::.:::::
NP_001 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.:::::::
NP_001 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
:::::::: :::::::::::::::::::: :::::::::::::::::::::: : :::::
NP_001 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
130 140 150 160 170 180
pF1KE1 EVYEKND
:: ::.:
NP_001 EVCEKDD
>>NP_789785 (OMIM: 616588) dihydrofolate reductase, mito (187 aa)
initn: 1130 init1: 1130 opt: 1130 Z-score: 1450.9 bits: 275.1 E(85289): 4.4e-74
Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187)
10 20 30 40 50 60
pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
:::::::::::::::::::: :::::::::::::::::::::::::::::.:::::
NP_789 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.:::::::
NP_789 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
:::::::: :::::::::::::::::::: :::::::::::::::::::::: : :::::
NP_789 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
130 140 150 160 170 180
pF1KE1 EVYEKND
:: ::.:
NP_789 EVCEKDD
>>XP_011510839 (OMIM: 616588) PREDICTED: dihydrofolate r (187 aa)
initn: 1130 init1: 1130 opt: 1130 Z-score: 1450.9 bits: 275.1 E(85289): 4.4e-74
Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187)
10 20 30 40 50 60
pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
:::::::::::::::::::: :::::::::::::::::::::::::::::.:::::
XP_011 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.:::::::
XP_011 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
:::::::: :::::::::::::::::::: :::::::::::::::::::::: : :::::
XP_011 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
130 140 150 160 170 180
pF1KE1 EVYEKND
:: ::.:
XP_011 EVCEKDD
>>NP_001277283 (OMIM: 126060,613839) dihydrofolate reduc (135 aa)
initn: 904 init1: 904 opt: 904 Z-score: 1164.2 bits: 221.6 E(85289): 4.1e-58
Smith-Waterman score: 904; 100.0% identity (100.0% similar) in 135 aa overlap (53-187:1-135)
30 40 50 60 70 80
pF1KE1 LPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKE
::::::::::::::::::::::::::::::
NP_001 MGKKTWFSIPEKNRPLKGRINLVLSRELKE
10 20 30
90 100 110 120 130 140
pF1KE1 PPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQD
40 50 60 70 80 90
150 160 170 180
pF1KE1 FESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 FESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
100 110 120 130
>>NP_001277286 (OMIM: 126060,613839) dihydrofolate reduc (129 aa)
initn: 825 init1: 825 opt: 825 Z-score: 1063.6 bits: 202.9 E(85289): 1.7e-52
Smith-Waterman score: 825; 100.0% identity (100.0% similar) in 123 aa overlap (1-123:1-123)
10 20 30 40 50 60
pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
:::
NP_001 VYKIPRCSL
187 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:08:33 2016 done: Mon Nov 7 03:08:34 2016
Total Scan time: 5.910 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]