Result of FASTA (omim) for
pFN21AE1334
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1334, 377 aa
1>>>pF1KE1334 377 - 377 aa - 377 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3813+/-0.000379; mu= 16.5632+/- 0.023
mean_var=79.5201+/-16.207, 0's: 0 Z-trim(113.7): 79 B-trim: 34 in 1/53
Lambda= 0.143825
statistics sampled from 23107 (23197) to 23107 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.272), width: 16
Scan time: 6.340
The best scores are: opt bits E(85289)
NP_001216 (OMIM: 602664) caspase-4 isoform alpha p ( 377) 2531 534.9 1.1e-151
NP_150649 (OMIM: 602664) caspase-4 isoform gamma p ( 321) 2168 459.6 4.7e-129
XP_011541321 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1933 410.8 2e-114
XP_016873886 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1933 410.8 2e-114
NP_001129581 (OMIM: 602665) caspase-5 isoform b pr ( 376) 1860 395.7 9.2e-110
NP_004338 (OMIM: 602665) caspase-5 isoform a precu ( 434) 1843 392.2 1.2e-108
NP_001129584 (OMIM: 602665) caspase-5 isoform f pr ( 447) 1843 392.2 1.2e-108
NP_001129582 (OMIM: 602665) caspase-5 isoform c [H ( 292) 1577 336.9 3.6e-92
NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383) 1236 266.2 8.8e-71
NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383) 1236 266.2 8.8e-71
XP_011541323 (OMIM: 602665) PREDICTED: caspase-5 i ( 319) 1207 260.2 5e-69
XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380) 1184 255.4 1.5e-67
XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374) 1134 245.1 2e-64
XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 1134 245.1 2.1e-64
XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 1134 245.1 2.1e-64
NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404) 1134 245.1 2.2e-64
NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404) 1134 245.1 2.2e-64
NP_150635 (OMIM: 147678) caspase-1 isoform gamma [ ( 311) 1126 243.3 5.6e-64
NP_001177945 (OMIM: 608633) inactive caspase-12 [H ( 341) 1015 220.3 5.1e-57
NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263) 695 153.9 4.1e-37
NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452) 314 75.0 3.9e-13
NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312) 295 70.9 4.5e-12
NP_150637 (OMIM: 147678) caspase-1 isoform epsilon ( 88) 287 68.8 5.3e-12
NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521) 249 61.5 5e-09
NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522) 249 61.5 5e-09
XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521) 248 61.3 5.8e-09
XP_006712859 (OMIM: 601762,603909,605027,613659) P ( 272) 230 57.4 4.6e-08
XP_011526163 (OMIM: 605848) PREDICTED: caspase-14 ( 230) 227 56.7 6.3e-08
NP_036246 (OMIM: 605848) caspase-14 precursor [Hom ( 242) 227 56.7 6.5e-08
NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478) 230 57.6 7.2e-08
NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479) 230 57.6 7.2e-08
NP_001217 (OMIM: 601532) caspase-6 isoform alpha p ( 293) 218 54.9 2.8e-07
XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
XP_005246945 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
XP_005246947 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479) 194 50.1 1.3e-05
XP_005246943 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05
XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 i ( 421) 193 49.9 1.3e-05
NP_001073594 (OMIM: 114480,114550,211980,601763,60 ( 538) 194 50.1 1.4e-05
XP_011510271 (OMIM: 114480,114550,211980,601763,60 ( 334) 191 49.4 1.5e-05
NP_001193453 (OMIM: 601762,603909,605027,613659) c ( 455) 185 48.2 4.5e-05
XP_005246951 (OMIM: 114480,114550,211980,601763,60 ( 280) 182 47.4 4.7e-05
NP_116787 (OMIM: 601532) caspase-6 isoform beta [H ( 204) 180 46.9 4.9e-05
NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464) 182 47.6 7e-05
NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464) 182 47.6 7e-05
XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464) 182 47.6 7e-05
>>NP_001216 (OMIM: 602664) caspase-4 isoform alpha precu (377 aa)
initn: 2531 init1: 2531 opt: 2531 Z-score: 2844.0 bits: 534.9 E(85289): 1.1e-151
Smith-Waterman score: 2531; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377)
10 20 30 40 50 60
pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
310 320 330 340 350 360
370
pF1KE1 TIERLSMTRYFYLFPGN
:::::::::::::::::
NP_001 TIERLSMTRYFYLFPGN
370
>>NP_150649 (OMIM: 602664) caspase-4 isoform gamma precu (321 aa)
initn: 2168 init1: 2168 opt: 2168 Z-score: 2438.0 bits: 459.6 E(85289): 4.7e-129
Smith-Waterman score: 2168; 100.0% identity (100.0% similar) in 321 aa overlap (57-377:1-321)
30 40 50 60 70 80
pF1KE1 DNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNK
::::::::::::::::::::::::::::::
NP_150 MADSMQEKQRMAGQMLLQTFFNIDQISPNK
10 20 30
90 100 110 120 130 140
pF1KE1 KAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 KAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEF
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE1 DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLV
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE1 LMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 LMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGEL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE1 WVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 WVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL
220 230 240 250 260 270
330 340 350 360 370
pF1KE1 ITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 ITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
280 290 300 310 320
>>XP_011541321 (OMIM: 602664) PREDICTED: caspase-4 isofo (286 aa)
initn: 1933 init1: 1933 opt: 1933 Z-score: 2175.1 bits: 410.8 E(85289): 2e-114
Smith-Waterman score: 1933; 100.0% identity (100.0% similar) in 286 aa overlap (92-377:1-286)
70 80 90 100 110 120
pF1KE1 QEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKER
::::::::::::::::::::::::::::::
XP_011 MEAGPPESGESTDALKLCPHEEFLRLCKER
10 20 30
130 140 150 160 170 180
pF1KE1 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE1 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE1 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE1 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT
220 230 240 250 260 270
370
pF1KE1 IERLSMTRYFYLFPGN
::::::::::::::::
XP_011 IERLSMTRYFYLFPGN
280
>>XP_016873886 (OMIM: 602664) PREDICTED: caspase-4 isofo (286 aa)
initn: 1933 init1: 1933 opt: 1933 Z-score: 2175.1 bits: 410.8 E(85289): 2e-114
Smith-Waterman score: 1933; 100.0% identity (100.0% similar) in 286 aa overlap (92-377:1-286)
70 80 90 100 110 120
pF1KE1 QEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKER
::::::::::::::::::::::::::::::
XP_016 MEAGPPESGESTDALKLCPHEEFLRLCKER
10 20 30
130 140 150 160 170 180
pF1KE1 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE1 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE1 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE1 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT
220 230 240 250 260 270
370
pF1KE1 IERLSMTRYFYLFPGN
::::::::::::::::
XP_016 IERLSMTRYFYLFPGN
280
>>NP_001129581 (OMIM: 602665) caspase-5 isoform b precur (376 aa)
initn: 1645 init1: 1645 opt: 1860 Z-score: 2091.6 bits: 395.7 E(85289): 9.2e-110
Smith-Waterman score: 1860; 74.0% identity (88.9% similar) in 377 aa overlap (1-377:1-376)
10 20 30 40 50 60
pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
::: ::.:: .:.:: :::: : ::.. :....::. ::::::::::.: :::. ...::
NP_001 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
.. :.:.: ::. ::..:.:: . : ..:::::::.:::. :::::.::::::::.
NP_001 LR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKK
70 80 90 100 110
130 140 150 160 170 180
pF1KE1 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
.::::::.:..: :::::::::.::::: :::: .::.:::.::.:: :.: :.:::
NP_001 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
::::::.:::::.::::::::::::::::::::::::::.: .:::::::::::::::::
NP_001 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
:::::::::::::::::::: ..:::::::::::: . ::::::::: :.: : : ::::
NP_001 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE1 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
::::::::::::::: : ::::::.::::::::: :::: :.:::::.:::.:.::::::
NP_001 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP
300 310 320 330 340 350
370
pF1KE1 TIERLSMTRYFYLFPGN
:::: ..:: :::::::
NP_001 TIERATLTRDFYLFPGN
360 370
>>NP_004338 (OMIM: 602665) caspase-5 isoform a precursor (434 aa)
initn: 1700 init1: 1645 opt: 1843 Z-score: 2071.7 bits: 392.2 E(85289): 1.2e-108
Smith-Waterman score: 1843; 74.0% identity (89.0% similar) in 373 aa overlap (5-377:63-434)
10 20 30
pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNV
::.:: .:.:: :::: : ::.. :....:
NP_004 HMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDV
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 LNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEA
:. ::::::::::.: :::. ...::.. :.:.: ::. ::..:.:: . : ..::
NP_004 LTLKEEEKKKYYDTKIEDKALILVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEA
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 GPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNG
:::::.:::. :::::.::::::::. .::::::.:..: :::::::::.::::: :::
NP_004 GPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNG
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 ADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILE
: .::.:::.::.:: :.: :.:::::::::.:::::.:::::::::::::::::::::
NP_004 AHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILE
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 GICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPAS
:::::.: .::::::::::::::::::::::::::::::::::::: ..:::::::::::
NP_004 GICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPAS
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 LEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYS
: . ::::::::: :.: : : ::::::::::::::::::: : ::::::.:::::::::
NP_004 LALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYS
340 350 360 370 380 390
340 350 360 370
pF1KE1 WCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
:::: :.:::::.:::.:.:::::::::: ..:: :::::::
NP_004 CCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
400 410 420 430
>>NP_001129584 (OMIM: 602665) caspase-5 isoform f precur (447 aa)
initn: 1681 init1: 1645 opt: 1843 Z-score: 2071.5 bits: 392.2 E(85289): 1.2e-108
Smith-Waterman score: 1843; 74.0% identity (89.0% similar) in 373 aa overlap (5-377:76-447)
10 20 30
pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNV
::.:: .:.:: :::: : ::.. :....:
NP_001 HMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDV
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE1 LNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEA
:. ::::::::::.: :::. ...::.. :.:.: ::. ::..:.:: . : ..::
NP_001 LTLKEEEKKKYYDTKIEDKALILVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEA
110 120 130 140 150 160
100 110 120 130 140 150
pF1KE1 GPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNG
:::::.:::. :::::.::::::::. .::::::.:..: :::::::::.::::: :::
NP_001 GPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNG
170 180 190 200 210 220
160 170 180 190 200 210
pF1KE1 ADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILE
: .::.:::.::.:: :.: :.:::::::::.:::::.:::::::::::::::::::::
NP_001 AHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILE
230 240 250 260 270 280
220 230 240 250 260 270
pF1KE1 GICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPAS
:::::.: .::::::::::::::::::::::::::::::::::::: ..:::::::::::
NP_001 GICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPAS
290 300 310 320 330 340
280 290 300 310 320 330
pF1KE1 LEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYS
: . ::::::::: :.: : : ::::::::::::::::::: : ::::::.:::::::::
NP_001 LALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYS
350 360 370 380 390 400
340 350 360 370
pF1KE1 WCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
:::: :.:::::.:::.:.:::::::::: ..:: :::::::
NP_001 CCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
410 420 430 440
>>NP_001129582 (OMIM: 602665) caspase-5 isoform c [Homo (292 aa)
initn: 1577 init1: 1577 opt: 1577 Z-score: 1775.8 bits: 336.9 E(85289): 3.6e-92
Smith-Waterman score: 1577; 81.1% identity (92.0% similar) in 286 aa overlap (92-377:7-292)
70 80 90 100 110 120
pF1KE1 QEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKER
.:::::::.:::. :::::.::::::::.
NP_001 MAALLQIEAGPPESAESTNILKLCPREEFLRLCKKN
10 20 30
130 140 150 160 170 180
pF1KE1 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA
.::::::.:..: :::::::::.::::: :::: .::.:::.::.:: :.: :.::::
NP_001 HDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTA
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE1 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR
:::::.:::::.::::::::::::::::::::::::::.: .::::::::::::::::::
NP_001 RDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNR
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE1 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI
::::::::::::::::::: ..:::::::::::: . ::::::::: :.: : : :::::
NP_001 NCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFI
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE1 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT
:::::::::::::: : ::::::.::::::::: :::: :.:::::.:::.:.:::::::
NP_001 AFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPT
220 230 240 250 260 270
370
pF1KE1 IERLSMTRYFYLFPGN
::: ..:: :::::::
NP_001 IERATLTRDFYLFPGN
280 290
>>NP_001244048 (OMIM: 147678) caspase-1 isoform beta pre (383 aa)
initn: 1228 init1: 1109 opt: 1236 Z-score: 1391.7 bits: 266.2 E(85289): 8.8e-71
Smith-Waterman score: 1236; 51.0% identity (73.4% similar) in 384 aa overlap (1-377:1-383)
10 20 30 40 50 60
pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
::. ..: ..:.:. ..:.::.:.. ::: .: :: : .: . ::.:.. ::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 MQEKQRMAGQMLLQTFFNIDQ-------ISPNKKAHPNMEAGPPESGESTDALKLCPHEE
. : .: :. . . . :. .: .: . : : :: : .::: ::
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSG-SEGNVKLCSLEE
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 FLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSV
:. :... ::::: ....:::::::::: ::: .: :.::. ::::: ::..: :::
NP_001 AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 DVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDT
::..:::: :: . :.::: :::::.:::::::.::::: ::::: :.:. ::.: ..
NP_001 DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 IFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYK
::...:..:: ::::::::::.::::: . : .: .:: . : ..:..:.::. :
NP_001 IFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKK
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 THVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETP
.:.:::::::::::: ::::: ::::.:: .:: .:.:. : .::.::::. ::: :
NP_001 AHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQP
300 310 320 330 340 350
360 370
pF1KE1 RAKAQMPTIERLSMTRYFYLFPGN
..::::: ::...:: ::::::.
NP_001 DGRAQMPTTERVTLTRCFYLFPGH
360 370 380
>>NP_001214 (OMIM: 147678) caspase-1 isoform beta precur (383 aa)
initn: 1228 init1: 1109 opt: 1236 Z-score: 1391.7 bits: 266.2 E(85289): 8.8e-71
Smith-Waterman score: 1236; 51.0% identity (73.4% similar) in 384 aa overlap (1-377:1-383)
10 20 30 40 50 60
pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
::. ..: ..:.:. ..:.::.:.. ::: .: :: : .: . ::.:.. ::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 MQEKQRMAGQMLLQTFFNIDQ-------ISPNKKAHPNMEAGPPESGESTDALKLCPHEE
. : .: :. . . . :. .: .: . : : :: : .::: ::
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSG-SEGNVKLCSLEE
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 FLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSV
:. :... ::::: ....:::::::::: ::: .: :.::. ::::: ::..: :::
NP_001 AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 DVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDT
::..:::: :: . :.::: :::::.:::::::.::::: ::::: :.:. ::.: ..
NP_001 DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 IFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYK
::...:..:: ::::::::::.::::: . : .: .:: . : ..:..:.::. :
NP_001 IFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKK
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 THVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETP
.:.:::::::::::: ::::: ::::.:: .:: .:.:. : .::.::::. ::: :
NP_001 AHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQP
300 310 320 330 340 350
360 370
pF1KE1 RAKAQMPTIERLSMTRYFYLFPGN
..::::: ::...:: ::::::.
NP_001 DGRAQMPTTERVTLTRCFYLFPGH
360 370 380
377 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:58:39 2016 done: Mon Nov 7 00:58:41 2016
Total Scan time: 6.340 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]