Result of FASTA (omim) for
pFN21AE1304
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1304, 289 aa
1>>>pF1KE1304 289 - 289 aa - 289 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4680+/-0.000347; mu= 14.2646+/- 0.022
mean_var=62.6905+/-13.157, 0's: 0 Z-trim(114.6): 15 B-trim: 538 in 1/55
Lambda= 0.161984
statistics sampled from 24554 (24560) to 24554 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.288), width: 16
Scan time: 6.750
The best scores are: opt bits E(85289)
NP_066952 (OMIM: 179030) inorganic pyrophosphatase ( 289) 2036 484.2 1.2e-136
NP_789845 (OMIM: 609988) inorganic pyrophosphatase ( 334) 1162 280.0 4.3e-75
NP_789842 (OMIM: 609988) inorganic pyrophosphatase ( 232) 644 158.9 8.6e-39
NP_008834 (OMIM: 609988) inorganic pyrophosphatase ( 305) 642 158.4 1.5e-38
NP_789843 (OMIM: 609988) inorganic pyrophosphatase ( 168) 449 113.2 3.4e-25
>>NP_066952 (OMIM: 179030) inorganic pyrophosphatase [Ho (289 aa)
initn: 2036 init1: 2036 opt: 2036 Z-score: 2574.0 bits: 484.2 E(85289): 1.2e-136
Smith-Waterman score: 2036; 100.0% identity (100.0% similar) in 289 aa overlap (1-289:1-289)
10 20 30 40 50 60
pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGI
190 200 210 220 230 240
250 260 270 280
pF1KE1 SCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN
250 260 270 280
>>NP_789845 (OMIM: 609988) inorganic pyrophosphatase 2, (334 aa)
initn: 1274 init1: 1133 opt: 1162 Z-score: 1469.2 bits: 280.0 E(85289): 4.3e-75
Smith-Waterman score: 1269; 61.5% identity (83.2% similar) in 291 aa overlap (1-272:32-322)
10 20 30
pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS
:. . ::::. : : .::.:.:: :.:::
NP_789 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS
10 20 30 40 50 60
40 50 60 70
pF1KE1 PFHDIPIYAD-----------------KDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDV
::::::. .. ...:.:.::.:::.:::::::::.:.::::: :
NP_789 PFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYV
70 80 90 100 110 120
80 90 100 110 120 130
pF1KE1 KKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARG
: ::::::::.:::::::::::..::::::: ..:: :.: ::::::::::::::. . :
NP_789 KDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSCG
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE1 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRY
:.: ::.:::::.:::::::::.::::..::.:....::.:::..::::::::..::: :
NP_789 EVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLY
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE1 KVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFK
:::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.:::.
NP_789 KVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFR
250 260 270 280 290 300
260 270 280
pF1KE1 CDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN
: . ::..:... : ::
NP_789 CTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
310 320 330
>>NP_789842 (OMIM: 609988) inorganic pyrophosphatase 2, (232 aa)
initn: 781 init1: 640 opt: 644 Z-score: 817.4 bits: 158.9 E(85289): 8.6e-39
Smith-Waterman score: 644; 59.9% identity (86.8% similar) in 152 aa overlap (124-272:69-220)
100 110 120 130 140 150
pF1KE1 YGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSK-VCARGEIIGVKVLGILAMIDEGET
...:: . . ::.: ::.:::::.::::::
NP_789 ERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGET
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE1 DWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKD
:::.::::..::.:....::.:::..::::::::..::: ::::::::::.::::.:::.
NP_789 DWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKN
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 KDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFKCDPDAARAIVDALP--PPC
: ::...:::::. ::::. :: :: .:.: :. .:.:::.: . ::..:... :
NP_789 KAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNK
160 170 180 190 200 210
280
pF1KE1 ESACTVPTDVDKWFHHQKN
::
NP_789 ESNEEEQVWHFLGK
220 230
>--
initn: 148 init1: 148 opt: 155 Z-score: 199.8 bits: 44.6 E(85289): 0.00022
Smith-Waterman score: 155; 59.5% identity (81.1% similar) in 37 aa overlap (1-37:32-68)
10 20 30
pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS
:. . ::::. : : .::.:.:: :.:::
NP_789 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 PFHDIPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGY
::::::.
NP_789 PFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDV
70 80 90 100 110 120
>>NP_008834 (OMIM: 609988) inorganic pyrophosphatase 2, (305 aa)
initn: 1105 init1: 640 opt: 642 Z-score: 813.0 bits: 158.4 E(85289): 1.5e-38
Smith-Waterman score: 1031; 54.3% identity (74.2% similar) in 291 aa overlap (1-272:32-293)
10 20 30
pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS
:. . ::::. : : .::.:.:: :.:::
NP_008 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS
10 20 30 40 50 60
40 50 60 70
pF1KE1 PFHDIPIYAD-----------------KDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDV
::::::. .. ...:.:.::.:::.:::::::::.:.::::: :
NP_008 PFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYV
70 80 90 100 110 120
80 90 100 110 120 130
pF1KE1 KKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARG
: ::::::::.:::::::::::..:: : : :
NP_008 KDGKLRYVANIFPYKGYIWNYGTLPQ--------------------ILSC---------G
130 140 150
140 150 160 170 180 190
pF1KE1 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRY
:.: ::.:::::.:::::::::.::::..::.:....::.:::..::::::::..::: :
NP_008 EVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLY
160 170 180 190 200 210
200 210 220 230 240 250
pF1KE1 KVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFK
:::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.:::.
NP_008 KVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFR
220 230 240 250 260 270
260 270 280
pF1KE1 CDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN
: . ::..:... : ::
NP_008 CTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
280 290 300
>>NP_789843 (OMIM: 609988) inorganic pyrophosphatase 2, (168 aa)
initn: 480 init1: 435 opt: 449 Z-score: 573.4 bits: 113.2 E(85289): 3.4e-25
Smith-Waterman score: 449; 57.0% identity (80.7% similar) in 114 aa overlap (164-272:43-156)
140 150 160 170 180 190
pF1KE1 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYN---DINDVKRLKPGYLEATVDWF
: . :: .:.:::..::::::::..::
NP_789 PAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFNIDDVKKFKPGYLEATLNWF
20 30 40 50 60 70
200 210 220 230 240 250
pF1KE1 RRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSES
: ::::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.:
NP_789 RLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDS
80 90 100 110 120 130
260 270 280
pF1KE1 PFKCDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN
::.: . ::..:... : ::
NP_789 PFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
140 150 160
289 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:56:33 2016 done: Mon Nov 7 02:56:34 2016
Total Scan time: 6.750 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]