Result of FASTA (omim) for
pFN21AE1282
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1282, 794 aa
1>>>pF1KE1282 794 - 794 aa - 794 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.3039+/-0.000409; mu= -7.8248+/- 0.026
mean_var=560.5673+/-117.891, 0's: 0 Z-trim(125.6): 12 B-trim: 1672 in 1/60
Lambda= 0.054170
statistics sampled from 49600 (49625) to 49600 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.582), width: 16
Scan time: 12.990
The best scores are: opt bits E(85289)
NP_078772 (OMIM: 611720) interferon regulatory fac ( 796) 5436 439.9 2e-122
NP_001070865 (OMIM: 615332) interferon regulatory ( 571) 750 73.5 2.8e-12
NP_892017 (OMIM: 615332) interferon regulatory fac ( 587) 750 73.5 2.9e-12
NP_056464 (OMIM: 615331) interferon regulatory fac ( 584) 616 63.1 4.1e-09
>>NP_078772 (OMIM: 611720) interferon regulatory factor (796 aa)
initn: 4833 init1: 4833 opt: 5436 Z-score: 2318.8 bits: 439.9 E(85289): 2e-122
Smith-Waterman score: 5436; 99.7% identity (99.7% similar) in 796 aa overlap (1-794:1-796)
10 20 30 40 50 60
pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 HGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 HGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 QQQQQ--LNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL
::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 QQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 GSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 GSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 NPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 NPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 GTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 GTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSES
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 LRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLF
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 IEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 IEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE1 AVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 AVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAAAS
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE1 LRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE1 PPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 PPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSP
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE1 VSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 VSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHE
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE1 RLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEI
730 740 750 760 770 780
780 790
pF1KE1 ATILAGDVKVKKERDP
::::::::::::::::
NP_078 ATILAGDVKVKKERDP
790
>>NP_001070865 (OMIM: 615332) interferon regulatory fact (571 aa)
initn: 1575 init1: 673 opt: 750 Z-score: 341.3 bits: 73.5 E(85289): 2.8e-12
Smith-Waterman score: 1476; 41.4% identity (55.6% similar) in 795 aa overlap (2-793:4-570)
10 20 30 40 50
pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLK
..: ...::::::::::::::::::::::.:::::::::::::::.:::::::::::
NP_001 MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 RAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQ
:::::: .:::: : .:::.::: .:.. :::
NP_001 RAHGCFPEGRSP---P-------------GAAASAAAKPPPLSAKDILLQQQ--------
70 80 90
120 130 140 150 160 170
pF1KE1 QQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL
:::.: . : ::..:::: : :::: . : : : .::
NP_001 -----QQLGHGGPEAAP---RAPQALERYPL------AAAAERPPRLGSDFGSSRPAASL
100 110 120 130 140
180 190 200 210 220 230
pF1KE1 GSSSHTARLP-NGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGL
.. : ::. :::: : : :::::::::: ::: :.
NP_001 AQPPTPQPPPVNGILVPNGFSK---LEEPPELNRQSPNP---------RRG-HA------
150 160 170 180
240 250 260 270 280 290
pF1KE1 PNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACL
:::.:.: :.:: :. : : ::: :
NP_001 ------------VPPTLVP--LMNGSAT------PLPTALG------------------L
190 200
300 310 320 330 340 350
pF1KE1 GGTPGVSATSSSASSSTS-SSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELS
:: ..: .. :.....: .:. . .:: :::.::::. ....::.: :
NP_001 GGRAAASLAAVSGTAAASLGSAQPTDLGAH-KRPASVSSS---AAVEHEQREAAA-----
210 220 230 240 250
360 370 380 390 400 410
pF1KE1 ESLRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELK
.: : :
NP_001 -------KEKQPPPPAHR------------------------------------------
260
420 430 440 450 460 470
pF1KE1 LFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLL
: .. :.:.:.:. .. : : : : : ::
NP_001 -------GPADSLSTAAGAAE------LSAEGAGKSRG---------SGEQDWVN----R
270 280 290 300
480 490 500 510 520 530
pF1KE1 PEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAA
:..:: .:..: . . : . . :. ..:
NP_001 PKTVR-------------------------DTLLALHQHGHSGPFESKFKKE-PALTAVA
310 320 330
540 550 560 570 580 590
pF1KE1 ASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMS-AGGFAAPGHAAGGPP
. :::: :::: .. : :.. : : :.....:.::. :. ...:..
NP_001 RTARKRKPSPEP-EGEVGPPKINGEA--QPWLSTSTEGLKIPMTPTSSFVS---------
340 350 360 370 380
600 610 620 630 640 650
pF1KE1 PPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNS
:::: .::::::::::.: ::: ::::::. :::. : .:. ::...::::: ::::
NP_001 PPPPTASPHSNRTTPPEAA-QNGQSPMAALILVADNAGGSHASKDANQVHSTT---RRNS
390 400 410 420 430
660 670 680 690 700 710
pF1KE1 SSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTI
.:: ::.:. .::::. : .:. . :.. ::: ..::: .:.:.:::::.
NP_001 NSPPSPSSM-NQRRLGPR------EVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTL
440 450 460 470 480 490
720 730 740 750 760 770
pF1KE1 CHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQ
:::::::::::::::::::::::::::.::: :::.::::::::::::::::::::::::
NP_001 CHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQ
500 510 520 530 540 550
780 790
pF1KE1 GEIATILAGDVKVKKERDP
::::::::::::::::::
NP_001 GEIATILAGDVKVKKERDS
560 570
>>NP_892017 (OMIM: 615332) interferon regulatory factor (587 aa)
initn: 1581 init1: 673 opt: 750 Z-score: 341.2 bits: 73.5 E(85289): 2.9e-12
Smith-Waterman score: 1500; 41.7% identity (56.2% similar) in 797 aa overlap (2-793:4-586)
10 20 30 40 50
pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLK
..: ...::::::::::::::::::::::.:::::::::::::::.:::::::::::
NP_892 MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 RAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQ
:::::: .:::: : .:::.::: .:.. :::
NP_892 RAHGCFPEGRSP---P-------------GAAASAAAKPPPLSAKDILLQQQ--------
70 80 90
120 130 140 150 160 170
pF1KE1 QQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL
:::.: . : ::..:::: : :::: . : : : .::
NP_892 -----QQLGHGGPEAAP---RAPQALERYPL------AAAAERPPRLGSDFGSSRPAASL
100 110 120 130 140
180 190 200 210 220 230
pF1KE1 GSSSHTARLP-NGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGL
.. : ::. :::: : : :::::::::: ::: :.
NP_892 AQPPTPQPPPVNGILVPNGFSK---LEEPPELNRQSPNP---------RRG-HA------
150 160 170 180
240 250 260 270 280 290
pF1KE1 PNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACL
:::.:.: :.:: :. : : ::: :
NP_892 ------------VPPTLVP--LMNGSAT------PLPTALG------------------L
190 200
300 310 320 330 340 350
pF1KE1 GGTPGVSATSSSASSSTS-SSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELS
:: ..: .. :.....: .:. . .:: :::.::::. ....::.: :
NP_892 GGRAAASLAAVSGTAAASLGSAQPTDLGAH-KRPASVSSS---AAVEHEQREAAA-----
210 220 230 240 250
360 370 380 390 400 410
pF1KE1 ESLRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELK
.: : :
NP_892 -------KEKQPPPPAHR------------------------------------------
260
420 430 440 450 460 470
pF1KE1 LFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLL
: .. :.:.:.:. .. : : : : : ::
NP_892 -------GPADSLSTAAGAAE------LSAEGAGKSRG---------SGEQDWVNR----
270 280 290 300
480 490 500 510 520 530
pF1KE1 PEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGT--GALPPAAPSGRG
:..:: .: : :. .... :. : : .: ....
NP_892 PKTVR--------DTLLALHQHGHSGPFES----KFKKEPALTAGRLLGFEANGANGSKA
310 320 330 340
540 550 560 570 580 590
pF1KE1 AAASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMS-AGGFAAPGHAAGG
.: . :::: :::: .. : :.. : : :.....:.::. :. ...:..
NP_892 VARTARKRKPSPEP-EGEVGPPKINGEAQ--PWLSTSTEGLKIPMTPTSSFVS-------
350 360 370 380 390
600 610 620 630 640 650
pF1KE1 PPPPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARR
:::: .::::::::::.: ::: ::::::. :::. : .:. ::...::::: ::
NP_892 --PPPPTASPHSNRTTPPEAA-QNGQSPMAALILVADNAGGSHASKDANQVHSTT---RR
400 410 420 430 440 450
660 670 680 690 700 710
pF1KE1 NSSSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCC
::.:: ::.:. .::::. : .:. . :.. ::: ..::: .:.:.::::
NP_892 NSNSPPSPSSM-NQRRLGPR------EVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCC
460 470 480 490 500
720 730 740 750 760 770
pF1KE1 TICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAF
:.:::::::::::::::::::::::::::.::: :::.::::::::::::::::::::::
NP_892 TLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAF
510 520 530 540 550 560
780 790
pF1KE1 MQGEIATILAGDVKVKKERDP
::::::::::::::::::::
NP_892 MQGEIATILAGDVKVKKERDS
570 580
>>NP_056464 (OMIM: 615331) interferon regulatory factor (584 aa)
initn: 1595 init1: 577 opt: 616 Z-score: 284.6 bits: 63.1 E(85289): 4.1e-09
Smith-Waterman score: 1679; 43.4% identity (60.2% similar) in 797 aa overlap (4-794:2-584)
10 20 30 40 50 60
pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRA
:.:..:::: :::::::.:::::.::::: :::::::.:::::::..:..::::::.
NP_056 MASVQASRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRS
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 HGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQ
: . .::::::: : :. :::::: : : : : .
NP_056 H-VLPEGRSPGPP--------------ALKHPATKDLAAAAAQGPQLPPPQAQPQPS---
60 70 80 90 100
130 140 150 160 170
pF1KE1 QQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPV--SL
:.. .. :: .:: ..... :. : : . .:
NP_056 ----------GTG-----GGVSGQDRYDRATSSG-------------RLPLPSPALEYTL
110 120 130
180 190 200 210 220 230
pF1KE1 GSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLP
:: :: :::: :: :.. ..::. :..
NP_056 GS-----RLANGLGR---------EE---------------AVAEGARRALLGSM-----
140 150
240 250 260 270 280 290
pF1KE1 NPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLG
:: .::.:: .::: .::::: :
NP_056 -PG-------LMPPGLL---------AAAV------SGLGSRG---------------LT
160 170 180
300 310 320 330 340 350
pF1KE1 GTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSES
.::.: . :: . ..: :.: ..::::. ::::.:.
NP_056 LAPGLSPA----------------------RP--LFGSDFEKE--KQQRNADCLAELNEA
190 200 210
360 370 380 390 400 410
pF1KE1 LRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKP-GMDYELKL
.:.::::: ..:: ::. ::.:..:.:..:::::::.:.::::::::...: :...::::
NP_056 MRGRAEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKL
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE1 FIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGL-SSGFKYLEYEKKHGSGDWRLLGDLL
: ::: ::::::... .::.::..: ... :..: ::::::::::..::::.:: ::.::
NP_056 FTEYPCGSGNVYAGVLAVARQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELL
280 290 300 310 320 330
480 490 500 510 520 530
pF1KE1 PEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAA
..:: :.: .: :. ::: : : ::.: : :: ::: :. :
NP_056 TDGVRSFREPAP-AEALPQQY--------PEP------APAALCGP---PPRAPS-RNLA
340 350 360 370
540 550 560 570 580 590
pF1KE1 ASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPP
. :.::::::: : : . ::::...:.: ::
NP_056 PTPRRRKASPEPEGEAAGKMTT-EEQQQRHWVA-----------------PG--------
380 390 400
600 610 620 630 640 650
pF1KE1 PPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSS
::.: .: : . :::.::: .::..:: ::::: .. . .: ...
NP_056 -----GPYSAET-P------GVPSPIAALKNVAEALG--HSPKDPGG---GGGPVRAGGA
410 420 430 440 450
660 670 680 690 700 710
pF1KE1 SPV--SPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCT
::. : :. : :.::..:::. : :.: : . : . . . ..:::::
NP_056 SPAASSTAQPPTQHRLVARNGE-----AEVSPTA--GAEAVSGGG-SGTGATPGAPLCCT
460 470 480 490 500
720 730 740 750 760 770
pF1KE1 ICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFM
.:.:::::::::::::::.:::::::::: ::::: .::::::::.:::::::.::::::
NP_056 LCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFM
510 520 530 540 550 560
780 790
pF1KE1 QGEIATILAGDVKVKKERDP
:::::::::::.::::::::
NP_056 QGEIATILAGDIKVKKERDP
570 580
794 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:20:16 2016 done: Mon Nov 7 16:20:18 2016
Total Scan time: 12.990 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]